在护理研究中整合神经成像措施。

IF 1.9 4区 医学 Q2 NURSING
Biological research for nursing Pub Date : 2023-07-01 Epub Date: 2022-11-18 DOI:10.1177/10998004221140608
Karl Cristie F Figuracion, Hilaire Thompson, Christine L Mac Donald
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引用次数: 0

摘要

背景:全球医学和科学的进步延长了人类的寿命。随着人口的老龄化,认知能力下降的风险也随之而来。在护理研究中,采用神经影像学测量方法评估认知变化的情况十分有限。本综述旨在向护士科学家介绍用于评估大脑与认知变化之间关联的神经影像测量方法:使用以下关键词在 CINAHL、Web of Science 和 PubMed 数据库中搜索相关文献:"神经影像学措施"、"衰老"、"认知"、"定性评分"、"认知能力"、"分子"、"结构 "和 "功能":神经成像测量可分为结构成像、功能成像和分子成像方法。结构成像技术可将大脑的解剖区域可视化。对选定的结构序列进行目视检查和容积分割,提取白质高密度和脑萎缩等信息。功能成像技术利用血氧依赖性信号评估大脑区域和潜在过程。分子成像技术是对特定区域的细胞和分子水平的生物过程进行实时可视化。与神经变性相关的生物学指标包括谷氨酰胺水平降低、总胆碱升高和肌醇升高:护理学处于解决影响认知能力逐渐衰退风险增加人群整个生命周期健康结果的上游因素的前沿。护士研究人员可以通过利用以前收集的神经影像临床数据进行研究,从而更方便地使用这些定性和定量方法,以更好地描述症状进展、疾病风险和健康结果之间的关联。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Integrating Neuroimaging Measures in Nursing Research.

Background: Medical and scientific advancement worldwide has led to a longer lifespan. With the population aging comes the risk of developing cognitive decline. The incorporation of neuroimaging measures in evaluating cognitive changes is limited in nursing research. The aim of this review is to introduce nurse scientists to neuroimaging measures employed to assess the association between brain and cognitive changes.

Methods: Relevant literature was identified by searching CINAHL, Web of Science, and PubMed databases using the following keywords: "neuroimaging measures," "aging," "cognition," "qualitative scoring," "cognitive ability," "molecular," "structural," and "functional."

Results: Neuroimaging measures can be categorized into structural, functional, and molecular imaging approaches. The structural imaging technique visualizes the anatomical regions of the brain. Visual examination and volumetric segmentation of select structural sequences extract information such as white matter hyperintensities and cerebral atrophy. Functional imaging techniques evaluate brain regions and underlying processes using blood-oxygen-dependent signals. Molecular imaging technique is the real-time visualization of biological processes at the cellular and molecular levels in a given region. Examples of biological measures associated with neurodegeneration include decreased glutamine level, elevated total choline, and elevated Myo-inositol.

Discussion: Nursing is at the forefront of addressing upstream factors impacting health outcomes across a lifespan of a population at increased risk of progressive cognitive decline. Nurse researchers can become more facile in using these measures both in qualitative and quantitative methodology by leveraging previously gathered neuroimaging clinical data for research purposes to better characterize the associations between symptom progression, disease risk, and health outcomes.

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来源期刊
CiteScore
5.10
自引率
4.00%
发文量
58
审稿时长
>12 weeks
期刊介绍: Biological Research For Nursing (BRN) is a peer-reviewed quarterly journal that helps nurse researchers, educators, and practitioners integrate information from many basic disciplines; biology, physiology, chemistry, health policy, business, engineering, education, communication and the social sciences into nursing research, theory and clinical practice. This journal is a member of the Committee on Publication Ethics (COPE)
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