细胞因子作为骨肉瘤患者预后的生物标志物:系统回顾和荟萃分析。

IF 1.9 4区 医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY
Gang Liu, Ben Liu, BinBin Liu, Liyuan Tang, Zhiwei Liu, Haiyang Dai
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引用次数: 0

摘要

骨肉瘤是儿童和青少年中最常见的原发性骨恶性肿瘤。细胞因子对骨肉瘤预后的影响已有研究和报道。本荟萃分析旨在评估细胞因子作为骨肉瘤生物标志物的预后价值。检索PubMed、Embase和Cochrane图书馆等数据库,研究骨肉瘤中细胞因子的预后价值。从符合条件的研究中,提取了总生存期(OS)、无病生存期和无转移生存期(MFS)的数据。计算合并风险比(hr)和95%置信区间(ci)。该分析共纳入了11项研究,涉及755名患者。肿瘤中巨噬细胞迁移抑制因子(macrophage migration inhibitory factor, MIF)高表达与缩短OS (HR = 2.01, 95% CI: 1.18-3.42, P = 0.010)和MFS (HR = 2.51, 95% CI: 1.47-4.01, P = 0.001)显著相关。骨肉瘤患者血清中T细胞免疫球蛋白和粘蛋白结构域3 (Tim-3)水平升高与疾病进展风险增加相关(HR = 3.14, 95% CI: 2.88-3.03, P 0.001)。然而,白细胞介素6 (IL-6)和肿瘤坏死因子与骨肉瘤的预后无显著相关性。由于研究缺乏,其他相关细胞因子[干扰素-α/β受体、组织因子、巨噬细胞抑制细胞因子1 (MIC-1)、IL-23]无法联合使用。综上所述,肿瘤中MIF水平和血清中Tim-3水平可能是骨肉瘤预后不良的潜在生物标志物。为了证实这一发现并将这些生物标志物应用于临床,还需要进行更多的大规模、高质量的研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Cytokines as Prognostic Biomarkers in Osteosarcoma Patients: A Systematic Review and Meta-analysis.

Osteosarcoma is the most prevalent type of primary bone malignancy in children and adolescents. The effect of cytokines on osteosarcoma prognosis has been studied and reported. This meta-analysis aimed to assess the prognostic value of cytokines as osteosarcoma biomarkers. Databases including PubMed, Embase, and Cochrane Library were searched for studies on the prognostic value of cytokines in osteosarcoma. From the eligible studies, data on overall survival (OS), disease-free survival, and metastasis-free survival (MFS) were extracted. Pooled hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated. A total of 11 studies involving 755 patients were included in this analysis. High macrophage migration inhibitory factor (MIF) expression in tumors was significantly associated with shortened OS (HR = 2.01, 95% CI: 1.18-3.42, P = 0.010) and MFS (HR = 2.51, 95% CI: 1.47-4.01, P = 0.001). Elevated T cell immunoglobulin and mucin domain-3 (Tim-3) levels in serum correlated with increased risk of disease progression in patients with osteosarcoma (HR = 3.14, 95% CI: 2.88-3.03, P < 0.001). However, interleukin 6 (IL-6) and tumor necrosis factor were not substantially associated with osteosarcoma prognosis. Owing to a paucity of research, other relevant cytokines [interferon-α/β receptor, tissue factor, macrophage inhibitory cytokine 1 (MIC-1), and IL-23] could not be combined. In conclusion, MIF levels in tumors and Tim-3 levels in serum can be potential biomarkers of poor prognosis in osteosarcoma. To confirm this finding and implement these biomarkers into clinical applications, additional large-scale, high-quality studies are needed.

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来源期刊
CiteScore
3.80
自引率
0.00%
发文量
78
审稿时长
2.2 months
期刊介绍: Journal of Interferon & Cytokine Research (JICR) provides the latest groundbreaking research on all aspects of IFNs and cytokines. The Journal delivers current findings on emerging topics in this niche community, including the role of IFNs in the therapy of diseases such as multiple sclerosis, the understanding of the third class of IFNs, and the identification and function of IFN-inducible genes.
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