从转移抑制领域的角度看问题。

IF 7.7 2区医学 Q1 ONCOLOGY

Cancer and Metastasis Reviews Pub Date : 2023-12-01 DOI:10.1007/s10555-023-10131-0

Imran Khan, Patricia S Steeg

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引用次数: 0

摘要

转移是癌症患者死亡的主要原因。转移抑制因子是一些基因，当它们在转移性肿瘤细胞中重新表达到在非转移性肿瘤细胞中观察到的水平时，能显著减少转移，而不影响原发肿瘤的生长。对 30 多种转移抑制因子的分析表明，它们的作用机制复杂，包括多种信号通路、转录模式、转录后调控机制以及基因组稳定性的潜在贡献。在肿瘤中重建有效的转移抑制途径的策略的临床试验最好针对辅助治疗，目的是抑制隐匿性微转移灶的生长。

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A perspective on the metastasis suppressor field.

Metastasis is the leading cause of cancer patient mortality. Metastasis suppressors are genes that, upon reexpression in metastatic tumor cells to levels observed in their nonmetastatic counterparts, significantly reduce metastasis without affecting the growth of the primary tumor. Analysis of > 30 metastasis suppressors revealed complex mechanisms of action that include multiple signaling pathways, transcriptional patterns, posttranscriptional regulatory mechanisms, and potential contributions of genomic stability. Clinical testing of strategies to re-establish a validated metastasis suppressor pathway in tumors is best directed to the adjuvant setting, with the goal of inhibiting the outgrowth of occult micrometastases.

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来源期刊

Cancer and Metastasis Reviews 医学-肿瘤学

CiteScore

17.00

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Contemporary biomedical research is on the threshold of an era in which physiological and pathological processes can be analyzed in increasingly precise and mechanistic terms.The transformation of biology from a largely descriptive, phenomenological discipline to one in which the regulatory principles can be understood and manipulated with predictability brings a new dimension to the study of cancer and the search for effective therapeutic modalities for this disease. Cancer and Metastasis Reviews provides a forum for critical review and discussion of these challenging developments. A major function of the journal is to review some of the more important and interesting recent developments in the biology and treatment of malignant disease, as well as to highlight new and promising directions, be they technological or conceptual. Contributors are encouraged to review their personal work and be speculative.