{"title":"蛋白酶体抑制联合免疫疗法治疗多发性骨髓瘤的研究现状","authors":"David Kegyes , Diana Gulei , Rares Drula , Diana Cenariu , Bogdan Tigu , Delia Dima , Alina Tanase , Sorina Badelita , Anca-Dana Buzoianu , Stefan Ciurea , Gabriel Ghiaur , Evangelos Terpos , Aaron Ciechanover , Hermann Einsele , Ciprian Tomuleasa","doi":"10.1016/j.blre.2023.101100","DOIUrl":null,"url":null,"abstract":"<div><p><span>Multiple myeloma (MM) is a malignant plasma cell disorder accounting for around 1.8% of all neoplastic diseases. Nowadays, clinicians have a broad arsenal of </span>drugs<span><span><span><span><span> at their disposal for the treatment<span> of MM, such as proteasome inhibitors, </span></span>immunomodulatory drugs<span>, monoclonal antibodies, bispecific antibodies, CAR T-cell therapies and antibody-drug conjugates. In this paper we briefly highlight essential clinical elements relating to proteasome inhibitors, such as </span></span>bortezomib<span>, carfilzomib and </span></span>ixazomib<span><span>. Studies suggest that the early use of immunotherapy<span> may improve outcomes significantly. Therefore, in our review we specifically focus on the combination therapy of proteasome inhibitors with novel immunotherapies and/or transplant. A high number of patients develop PI resistance. Thus, we also review new generation PIs, such as marizomib, </span></span>oprozomib (ONX0912) and </span></span>delanzomib (CEP-18770) and their combinations with immunotherapies.</span></p></div>","PeriodicalId":56139,"journal":{"name":"Blood Reviews","volume":null,"pages":null},"PeriodicalIF":6.9000,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"Proteasome inhibition in combination with immunotherapies: State-of-the-Art in multiple myeloma\",\"authors\":\"David Kegyes , Diana Gulei , Rares Drula , Diana Cenariu , Bogdan Tigu , Delia Dima , Alina Tanase , Sorina Badelita , Anca-Dana Buzoianu , Stefan Ciurea , Gabriel Ghiaur , Evangelos Terpos , Aaron Ciechanover , Hermann Einsele , Ciprian Tomuleasa\",\"doi\":\"10.1016/j.blre.2023.101100\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p><span>Multiple myeloma (MM) is a malignant plasma cell disorder accounting for around 1.8% of all neoplastic diseases. Nowadays, clinicians have a broad arsenal of </span>drugs<span><span><span><span><span> at their disposal for the treatment<span> of MM, such as proteasome inhibitors, </span></span>immunomodulatory drugs<span>, monoclonal antibodies, bispecific antibodies, CAR T-cell therapies and antibody-drug conjugates. In this paper we briefly highlight essential clinical elements relating to proteasome inhibitors, such as </span></span>bortezomib<span>, carfilzomib and </span></span>ixazomib<span><span>. Studies suggest that the early use of immunotherapy<span> may improve outcomes significantly. Therefore, in our review we specifically focus on the combination therapy of proteasome inhibitors with novel immunotherapies and/or transplant. A high number of patients develop PI resistance. Thus, we also review new generation PIs, such as marizomib, </span></span>oprozomib (ONX0912) and </span></span>delanzomib (CEP-18770) and their combinations with immunotherapies.</span></p></div>\",\"PeriodicalId\":56139,\"journal\":{\"name\":\"Blood Reviews\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":6.9000,\"publicationDate\":\"2023-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Blood Reviews\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0268960X23000619\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"HEMATOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Blood Reviews","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0268960X23000619","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"HEMATOLOGY","Score":null,"Total":0}
Proteasome inhibition in combination with immunotherapies: State-of-the-Art in multiple myeloma
Multiple myeloma (MM) is a malignant plasma cell disorder accounting for around 1.8% of all neoplastic diseases. Nowadays, clinicians have a broad arsenal of drugs at their disposal for the treatment of MM, such as proteasome inhibitors, immunomodulatory drugs, monoclonal antibodies, bispecific antibodies, CAR T-cell therapies and antibody-drug conjugates. In this paper we briefly highlight essential clinical elements relating to proteasome inhibitors, such as bortezomib, carfilzomib and ixazomib. Studies suggest that the early use of immunotherapy may improve outcomes significantly. Therefore, in our review we specifically focus on the combination therapy of proteasome inhibitors with novel immunotherapies and/or transplant. A high number of patients develop PI resistance. Thus, we also review new generation PIs, such as marizomib, oprozomib (ONX0912) and delanzomib (CEP-18770) and their combinations with immunotherapies.
期刊介绍:
Blood Reviews, a highly regarded international journal, serves as a vital information hub, offering comprehensive evaluations of clinical practices and research insights from esteemed experts. Specially commissioned, peer-reviewed articles authored by leading researchers and practitioners ensure extensive global coverage across all sub-specialties of hematology.