Brain network and modulation最新文献

{"title":"Application of repetitive peripheral magnetic stimulation for recovery of motor function after stroke based on neuromodulation: a narrative review","authors":"Jiazhen Pan, Yanyan Jia, Hao Liu","doi":"10.4103/2773-2398.340140","DOIUrl":"https://doi.org/10.4103/2773-2398.340140","url":null,"abstract":"Repetitive peripheral magnetic stimulation (rPMS) is a non-invasive and painless approach that can penetrate deeper structures to improve motor function in people with physical impairment due to stroke. A review of available literature was undertaken to discuss the potential mechanisms of rPMS-based neuromodulation and the application of rPMS in the recovery of motor function (e.g., muscle strength, spasticity, motor control and joint mobility, glenohumeral subluxation) after stroke. Issues of concern about parameters and safety of rPMS were also overviewed. Existing evidence has shown that suprathreshold rPMS can be a potential intervention for motor recovery in patients with stroke because of its neuromodulatory effects. However, the rPMS parameters employed by each research team are highly variable for specific lesions. Thus, more high-quality studies on the optimal rPMS protocols for different impairments are warranted in the future.","PeriodicalId":93737,"journal":{"name":"Brain network and modulation","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80183176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prehabilitation and rehabilitation using data-driven, parcel-guided transcranial magnetic stimulation treatment for brain tumor surgery: proof of concept case report","authors":"N. Dadario, I. Young, Xia Zhang, C. Teo, S. Doyen, M. Sughrue","doi":"10.4103/2773-2398.340144","DOIUrl":"https://doi.org/10.4103/2773-2398.340144","url":null,"abstract":"Improved knowledge of the neuroplastic potential of the brain connectome has facilitated the advancement of neuromodulatory treatments for brain tumor patients especially in the perioperative period. More recently, the idea of inducing neuroplastic changes before surgery as “prehabilitation” has been suggested in low-grade gliomas with favorable data. However, it is uncertain the degree to which this treatment with transcranial magnetic stimulation (TMS) would benefit patients with high-grade gliomas, especially with additional rehabilitation after surgery and targets defined by personalized connectomic data. The current report details a case of a patient with recurrent glioblastoma in the right motor area 2 years after previous total resection. Given the desire for a more aggressive recurrent surgery in a highly functional area, the authors decided to proceed with “prehabilitation” by stimulating the surrounding motor cortices around the lesion to turn down the motor cortex connectivity before the recurrent surgery and then completing “rehabilitation” after the surgery. Structural-functional connectomic analyses were completed using Infinitome software based on an individualized patient brain atlas using machine-learning based parcellations. Repetitive TMS was employed, specifically using continuous and intermittent theta burst stimulation protocols. Prehabilitation consisted of using continuous theta burst stimulation at the estimated surgical entry point parcel and intermittent theta burst stimulation at adjacent parcellations for a total of 10 days with 5 sessions per day per target leading up until the surgery. A gross-total resection was obtained, but the patient woke up with left-sided hemiparesis. Resting-state functional magnetic resonance imaging derived connectivity demonstrated a case of a primarily pure cingulate-motor resection causing hemiplegia with an intact corticospinal tract and supplementary motor area. Functional connectivity outliers in cingulate-motor parcels were identified and compared with connectivity matrices from a healthy control atlas. Anomalies, parcels defined as functioning significantly outside a normal range, were chosen as rehabilitation TMS targets to be similarly treated for a total of 10 days with 5 sessions per day per target approximately two weeks after surgery. By using continuous theta burst stimulation on hyperconnected parcels and intermittent theta burst stimulation on hypoconnected parcels, the patient demonstrated significant motor improvement with only 4+/5 strength in the left arm 1 month after surgery. This report demonstrates for the first time the feasibility of using TMS treatment for glioblastoma surgery near “eloquent” cortices as a means of prehabilitation before surgery and rehabilitation after surgery. This parcel-guided approach for TMS treatment based on the cortical site of entry and individualized connectivity analyses allowed for maximal tumor resection and minimal long-term neuro","PeriodicalId":93737,"journal":{"name":"Brain network and modulation","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77176742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of Meige’s syndrome by facial and trigeminal nerve combing followed by transplantation of autologous adipose-derived mesenchymal stem cells: a prospective nonrandomized controlled study","authors":"Jin Zhu, Bei-Yao Gao, Xin Zhang, Chengcheng Sun, Hua Zhao, Ming-J Chen, Yan Yuan, Ping Zhou, Yanliu Luo, Dongsheng Xu, Shi-ting Li","doi":"10.4103/2773-2398.340141","DOIUrl":"https://doi.org/10.4103/2773-2398.340141","url":null,"abstract":"Increasing attention has recently been focused on reducing abnormal neuroexcitability in patients with Meige’s syndrome using nerve combing surgery. However, nerve injury caused by nerve combing is of critical concern. Animal studies have shown that stem cells can repair cranial nerves; autologous adipose-derived mesenchymal stem cells have been proved to be safe and effective in clinical trials. A total of 38 patients with Meige’s syndrome were enrolled in this prospective nonrandomized controlled study and divided into a non–stem cell group (n = 30) and a stem cell group (n = 8). Patients in the non-stem cell group underwent facial and trigeminal nerve combing only; patients in the stem cell group underwent adipose-derived mesenchymal stem cell implantation after facial and trigeminal nerve combing. A blepharospasm disability index score was used to evaluate effectiveness of the surgery, and a House–Brackmann grade was used to evaluate facial nerve injury. These data were recorded before the operation and at 7 days, 3 months, and 6 months after the operation. The overall improvement percentage of blepharospasm was 93% at 6-month follow-up in the non-stem cell group. A greater number of nerve combing events during the operation led to better outcomes but increased risk of facial paralysis. Patients in the stem cell group had better facial nerve function at the 6-month follow-up (House–Brackmann grade, P = 0.003) and better blepharospasm improvement at 3 and 6 months than those in the non–stem cell group (blepharospasm disability index score, P = 0.003 and P < 0.001, respectively). Cerebrospinal fluid protein analysis showed that levels of several cytokines were significantly increased after adipose-derived mesenchymal stem cell transplantation, including interleukin-6 (P < 0.01) and interferon gamma-induced protein 10 (P < 0.0001) and the growth factors insulin-like growth factor-1 (P < 0.0001), insulin-like growth factor-binding protein-1 (P < 0.0001), growth/differentiation factor-15 (P < 0.001), and angiopoietin-like 4 (P < 0.001). Facial and trigeminal nerve combing combined with adipose-derived mesenchymal stem cell transplantation is a safe and effective remedy to improve recovery from Meige’s syndrome.","PeriodicalId":93737,"journal":{"name":"Brain network and modulation","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78851959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of neuromodulation to drive neural plasticity in stroke recovery: a narrative review","authors":"Cong Wang","doi":"10.4103/2773-2398.339171","DOIUrl":"https://doi.org/10.4103/2773-2398.339171","url":null,"abstract":"Stroke is one of the leading causes of death and adult disability globally, representing one of the highest burdens of disease worldwide. Recent advancements of neuromodulation techniques emerge as promising tools for enhancing stroke recovery, such as transcranial electric stimulation and transcranial magnetic stimulation, which can induce short- and long-term changes of synaptic excitability to restore the impaired functions in stroke patients. The review focuses on discussing the neuroplastic mechanisms of those brain stimulation techniques in stroke rehabilitation, also including some new options for neuromodulation which have great potential in stroke rehabilitation, such as optogenetic stimulation and environmental stimulation. In general, these techniques allow the excitation and synchronization of the neural activity after stroke, which could potentially induce long-term potentiation. As a result, the neuroplastic effect can lead to better functional connection in the brain network in assisting stroke recovery. Future directions include the clarification of the pathways of synaptic plasticity in the whole brain network following neuromodulation after stroke, and investigation of the different roles of distinctive cell populations in neural plasticity enhancement. Additional studies are essential for developing standard protocols in neuromodulation based on a better understanding of the molecular and cellular processes for the ultimate optimization of clinical efficacy.","PeriodicalId":93737,"journal":{"name":"Brain network and modulation","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84744268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"APPLICATION OF DIGITAL STRUCTURE SIMULATION AS A TOOL FOR THE EXPLORATION OF WIDE SPAN STRUCTURE IDEAS","authors":"S. Wahadamaputera, B. Subekti, D. D. Permata","doi":"10.14710/mdl.21.2.2021.155-161","DOIUrl":"https://doi.org/10.14710/mdl.21.2.2021.155-161","url":null,"abstract":"Review on structure behaviour and visual appearance of a building is needed in generating creativity in the making of an architectural design. The use of any specific structure software will facilitate this in the process. This research aims to prove the effectiveness with which designers can compose alternative forms of architectural appearance through the use of the software. One of the tools in the creative process used in the exploration of 2-dimensional frame structures is DR FRAME. The observations were carried in the Structure and Construction IV Studio at Itenas Architecture Study Program Bandung through a digital simulation using DR. FRAME software demo version. Several students are invited to explore various forms of wide-span truss structures at the level of unified integration. The results through the program execution show various diagrams which can be implemented in the design of the form and the type of structural components. DR.FRAME software enriches ideas in the wide-span structure design which provides an understanding of the relationship between structural behaviour and the appearance of architectural design. The use of other supporting software is supposed to be applied as an alternative search for various structural design ideas for architecture students","PeriodicalId":93737,"journal":{"name":"Brain network and modulation","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83172747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PERSEPSI MASYARAKAT AWAM TERHADAP STANDAR DESAIN DAN KESIAPAN NEW-NORMAL PADA BIOSKOP DI INDONESIA","authors":"D. P. E. Laksmiyanti, Nareswarananindya Nareswarananindya, M. J. Hidayat","doi":"10.14710/mdl.21.2.2021.134-141","DOIUrl":"https://doi.org/10.14710/mdl.21.2.2021.134-141","url":null,"abstract":"Wabah COVID 19 telah membuat banyak perubahan di segala sektor. Demi tetap berjalannya perekonomian, beberapa tempat usaha dan ruang publik lainnya dibuka di akhir tahun 2020, walau dalam kenyataannya Indonesia masih dalam status darurat COVID 19. Pemerintah sudah menyatakan ”berkawanlah dengan covid”, namun hal ini bukan berarti masyarakat menjadi tidak hati-hati dan tidak peduli dengan isu kesehatan. Segala aktifitas di ruang publik tetap perlu dibatasi dan disesuaikan dengan standar protokol kesehatan yang baru. Salah satu ruang publik yang akan beroperasi akhir tahun ini adalah bioskop. Sebagian masyarakat sudah merasa aman, namun beberapa juga masih meragukan mengingat persyaratan ruang bioskop yang harus tertutup, tidak ada pencahayaan dan penghawaan alami demi kualitas visual dan akustik di dalamnya, serta kemungkinnan berkumpulnya banyak orang dalam satu ruangan tertutup dalam durasi dua hingga tiga jam. Kurangnya sirkulasi udara juga menjadi salah satu penyebab sick building syndrome, namun bukan berarti hal ini tidak dapat diatasi dengan desain arsitektural.Metode yang dilakukan pada penelitian ini secara umum deskriptif kuantitatif dengan menyebarkan quisioner pada 117 responden yang usianya berkisar antara 17-59 tahun. Tujuan penelitian ini adalah untuk merangkum persepsi masyarakat awam mengenai standar new normal, penerapan protocol kesehatan, serta desain interior bioskop yang memberikan kenyamanan dan rasa aman bagi pengguna","PeriodicalId":93737,"journal":{"name":"Brain network and modulation","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82534649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"FLEKSIBILITAS PANEL DINDING PADA RUANG AUDITORIUM KESENIAN JAWA TIMUR BERDASARKAN ARAH SUMBER BUNYI","authors":"Galuh Fajarwati, Asri Dinapradipta","doi":"10.14710/mdl.21.2.2021.162-170","DOIUrl":"https://doi.org/10.14710/mdl.21.2.2021.162-170","url":null,"abstract":"","PeriodicalId":93737,"journal":{"name":"Brain network and modulation","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83687804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MONTAGE AS SPATIAL RECONSTRUCTION OPERATION METHOD IN DESIGNING CINEMATIC ARCHITECTURE","authors":"N. Lestari, K. D. Paramita, P. Atmodiwirjo","doi":"10.14710/mdl.21.2.2021.142-154","DOIUrl":"https://doi.org/10.14710/mdl.21.2.2021.142-154","url":null,"abstract":"This article investigated montage to understand and arrange cinematic architecture through operations of spatial reconstruction to present a sequence of spatial experiences. Montage is a part of discourses related to cinematic, film, and architecture. This article explored the montage approach as the primary basis in the architectural design process through spatial experience. The discussion is based on the idea that montage is emphasized in three things, i.e., sequence, multiple layers of meaning, and movement. These three aspects were further observed through the montage precedent comprising various cinematic precedents based on montage in architecture, i.e., Manhattan Transcripts and Parc de La Villette from Bernard Tschumi, Villa Savoye from Le Corbusier, and Maison Bordeaux from Rem Koolhaas. The finding of this study is a synthesis of some of these precedents that resulted in an understanding of space reconstruction operations, i.e., dismantlement, disappearance, and reassembly, all three of which exist as strategies that will be part of the production process to develop montage-based cinematic architectural design, creating new spatial sequence that provide alternative spatial experience. This article expands the knowledge regarding montages that cinematics and films can be a development in architectural design.","PeriodicalId":93737,"journal":{"name":"Brain network and modulation","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74426689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DIGITAL FABRICATION AS A LEARNING MEDIA FOR LIGHTWEIGHT STRUCTURE WITH CASE STUDY OF SHELL STRUCTURE","authors":"Stephanus Evert Indrawan, Lmf Purwanto","doi":"10.14710/mdl.21.2.2021.126-133","DOIUrl":"https://doi.org/10.14710/mdl.21.2.2021.126-133","url":null,"abstract":"The lightweight structure system is an effort to optimize the structure to distribute the load efficiently. Unfortunately, students often have difficulty imagining the learning outcomes application in the real world when studying light structural systems. However, the use of the scalar model can still explain several essential aspects of a lightweight structural system, one of which is the effect of connection and formation of material components on the structural capability. Therefore, this paper aims to bridge the learning process by utilizing digital devices from the concept stage of structural modeling with the help of software (Rhinoceros, Grasshopper, and Kangaroo) to the realization process using laser cutting. The method used is a semi-experimental method that applies Hooke's law principle, which produces a shell structure system with a digital fabrication approach that utilizes a lightweight material, namely, corrugated paper board, as the primary material. This paper concludes that digital technology and digital fabrication processes can help students understand the concept of lightweight structures because they can use computer simulations, cut them using laser cutting, and assemble them in the field in a series of simultaneous processes. ","PeriodicalId":93737,"journal":{"name":"Brain network and modulation","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78400576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ARSITEKTUR UMA LULIK FUILORO, LOSPALOS KOTA, TIMOR-LESTE","authors":"Maria immaculata Ririk Winandari, Andre Mariano Dos Santos Belo","doi":"10.14710/mdl.21.2.2021.120-125","DOIUrl":"https://doi.org/10.14710/mdl.21.2.2021.120-125","url":null,"abstract":"Uma Lulik is a sacred house for the people of Timor-Leste. This house is the unification of Nain (owner, ruler or supreme), Beala (ancestor), Lulik (sacred \"nature and its contents\"), Lisan (tradition \"family or human life\".). Uma Lulik in Fuiloro is built or renovated every 10 to 20 years depending on the lia nain and fatal building problems that occur in Uma Lulik, to serve as a bond between families. Uma Lulik remains a comfortable place for people to carry out rituals with their ancestors, those who are here and those who have gone. The purpose of this study was to find the architectural characteristics of uma lulik in the fuiloro tribe, Lospalos City. Interpretive history method is used by looking at interpreting past conditions with the present. The result showed that Uma lulik in Fuiloro tribe characteristic has a single stilt-shaped building as a place for sacral ceremonies and storage of sacred goods. The interior consists of kitchen and Labor Dato. The shape of the roof is pointed with 55° as high as + 7m-9m. This building has square floor plan + 3m x 3m or + 4m x 4m, rectangular wall + 3m x 4m, and column of 4 round wood arrangements as high as + 3m-4m. Materials consist of ulin wood (ai-bessi), rose wood (ai-ná), acadiro (ai-acadirum), bamboo (au-maus), palapeira/palapa (ai-car) and gamuteira/ gamuti (au-naulurir). Ornaments are woven long ropes and carvings. Structural systems are ‘ikat’ and portal systems.","PeriodicalId":93737,"journal":{"name":"Brain network and modulation","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73226504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}