Journal of lung cancer最新文献_第9页

Journal of lung cancer Pub Date : 2008-12-01 DOI: 10.6058/JLC.2008.7.2.98

S. Song, Y. Noh, E. Choi, Jong Hoon Kim, S. Ahn, Sang‐wook Lee, C. Suh

{"title":"Gemcitabine-Related Radiation Recall in a Patient with Metastatic Non-small Cell Lung Cancer","authors":"S. Song, Y. Noh, E. Choi, Jong Hoon Kim, S. Ahn, Sang‐wook Lee, C. Suh","doi":"10.6058/JLC.2008.7.2.98","DOIUrl":"https://doi.org/10.6058/JLC.2008.7.2.98","url":null,"abstract":"A sixty-seven year old male was treated with palliative radiation therapy due to his right hip joint pain, and the pain was caused by osteolytic right acetabular metastasis. He underwent 30 Gy irradiation and then his painful symptoms disappeared at the 1 month follow-up after radiation therapy. He next received received systemic chemotherapy with 3 cycles of gemcitabine plus cisplatin and then 6 cycles of docetaxel. He visited the emergency room at the time of 4 months after the completion of radiation therapy with complaints of relapsed right hip joint pain. On MRI, localized muscular swelling with infiltration and without contrast-enhancement was seen within the previous radiation field, and the clinical impression was radiation-recall myositis. We provided symptomatic treatment and his right hip joint pain with disability disappeared 2 weeks after the treatment. No relapse of the right hip joint pain developed during the patient’s survival period. We experienced a case of radiation-recall myositis that was related to gemcitabine use after radiation therapy.","PeriodicalId":90901,"journal":{"name":"Journal of lung cancer","volume":"7 1","pages":"98-100"},"PeriodicalIF":0.0,"publicationDate":"2008-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.6058/JLC.2008.7.2.98","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71160100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

A Case of Pneumatosis Intestinalis Induced by Chemotherapy in a Patient with Lung Cancer 肺癌化疗致肠内肺病1例

Journal of lung cancer Pub Date : 2008-12-01 DOI: 10.6058/JLC.2008.7.2.101

M. Kwon, S. Kwon, E. Choi, M. Na, J. Son

{"title":"A Case of Pneumatosis Intestinalis Induced by Chemotherapy in a Patient with Lung Cancer","authors":"M. Kwon, S. Kwon, E. Choi, M. Na, J. Son","doi":"10.6058/JLC.2008.7.2.101","DOIUrl":"https://doi.org/10.6058/JLC.2008.7.2.101","url":null,"abstract":"Pneumatosis intestinalis is an uncommon condition that is characterized by the presence of gas within the bowel wall. We experienced a case of pneumatosis intestinalis after cession of chemotherapy and we herein report on this case. A 58-year old man was admitted to our hospital for the evaluation of incidentally recognized pneumatosis intestinalis. He was diagnosed as having non small cell lung cancer in August 2006 and he received radiation therapy for concomitant brain metastasis and SVC syndrome in September 2006. He achieved a partial response after completing 6 cycles of chemotherapy with gemcitabine and cisplatin. Newly enlarged lymph nodes were observed on the follow-up CT, and chemotherapy with paclitaxel and carboplatin was started in July 2007. Due to the lack of a response, the therapeutic regimen was switched to oral erlotinib. After 1 month of treatment, the follow-up CT for response evaluation revealed pneumatosis intestinalis in the ascending colon without any subjective symptoms such as fever or abdominal pain. The laboratory results were within the normal range except for a slight increase of leukocytes. He underwent right hemicolectomy, but he didn’t survive his postoperative acute renal failure and pneumonia.","PeriodicalId":90901,"journal":{"name":"Journal of lung cancer","volume":"7 1","pages":"101-102"},"PeriodicalIF":0.0,"publicationDate":"2008-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71159738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

The Effect of Nutritional Support with Oral High Protein Liquid on Patients Who are Undergoing Radiotherapy for Lung Cancer 口服高蛋白液营养支持对肺癌放疗患者的影响

Journal of lung cancer Pub Date : 2008-12-01 DOI: 10.6058/JLC.2008.7.2.86

Youngkee Oh, Soohyun Kim, Sun-Young Lee, H. Jang, Sun-Mi Cho, You-Young Choi, Wonhyuk Choi, S. Yun

引用次数: 0

Pilomatrix Carcinoma with Lung and Lymph Node Metastases 伴肺和淋巴结转移的毛基质癌

Journal of lung cancer Pub Date : 2008-12-01 DOI: 10.6058/JLC.2008.7.2.90

Ki Uk Kim, M. Lee, Yun-Seong Kim, Hye-Kyung Park, Chang Hoon Lee, Yeongcheon Kim, Y. Jeong, Soon-Kew Park

引用次数: 2

A Case of Double Primary Lung Cancer that was Diagnosed by Percutaneous Localization with using a Hook Wire. 经皮钩丝定位诊断双原发肺癌1例。

Journal of lung cancer Pub Date : 2008-12-01 DOI: 10.6058/JLC.2008.7.2.93

Go Eun Lee, S. Kwon, E. Choi, M. Na, Young Jun Cho, Young Jin Kim, Hyun Min Cho, J. Son

引用次数: 0

Detection of Serum Free DNA Hypermethylation in Surgically Resected Adenocarcinoma of the Lung 手术切除肺腺癌患者血清游离DNA超甲基化的检测

Journal of lung cancer Pub Date : 2008-12-01 DOI: 10.6058/JLC.2008.7.2.65

Sun Jung Park, Y. T. Kim, Ju-Yong Park, H. Wi, C. Kang, S. Sung, Joo Hyun Kim

{"title":"Detection of Serum Free DNA Hypermethylation in Surgically Resected Adenocarcinoma of the Lung","authors":"Sun Jung Park, Y. T. Kim, Ju-Yong Park, H. Wi, C. Kang, S. Sung, Joo Hyun Kim","doi":"10.6058/JLC.2008.7.2.65","DOIUrl":"https://doi.org/10.6058/JLC.2008.7.2.65","url":null,"abstract":"Purpose: Aberrant DNA methylation patterns have been commonly associated with human cancers. We have investigated the frequency of DNA hypermethylation in promoter regions from adenocarcinomas of the lung and then attempted to detect the same epigenetic changes from patient serum samples. Materials and Methods: We collected tissues from 72 cases of lung adenocarcinomas. The cancer and normal lung tissues were tested for DNA hypermethylation using methylation-specific PCR (MSP). The genes investigated were DAPK, RARβP2 and p16. We selected 12 patients where promoter hypermethylation was present for all three genes and four patients where hypermethylation was not seen for any of the three genes. Serum-free DNA was extracted and was tested for promoter hypermethylation. The status of serum-free DNA methylation was analyzed; the hypermethylation status was compared to clinical variables and cancer outcomes. Results: DNA hypermethylation was observed in 32% of samples for DAPK, 63% of samples for RARβP2 and 83% of samples for p16 from the cancer tissues. Among the 12 matched serum samples where the primary tumor showed hypermethylation in all three gene promoter regions, we were able to detect five incidences of serum DNA hypermethylation in four patients. The four patients had TNM stage II or higher disease. None of the patients with stage I disease showed serum-free DNA hypermethylation. Conclusion: Aberrant promoter hypermethylation was frequently observed in surgically resected adenocarcinoma of the lung. Concurrent serum-free DNA hypermethylation was detected in 34% of patients where the primary tumor showed hypermethylation in all three gene promoter regions. The findings suggest that the serum-free DNA methylation status might be used as a potential target for the diagnosis of lung cancer. However, the low sensitivity should be improved for use in a clinical application. (J Lung Cancer 2008;7(2):65 �� 70)","PeriodicalId":90901,"journal":{"name":"Journal of lung cancer","volume":"7 1","pages":"65-70"},"PeriodicalIF":0.0,"publicationDate":"2008-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.6058/JLC.2008.7.2.65","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71159799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mutational Analysis of JAK1 Exons 10 and 13 in Non-small Cell Lung Cancers 非小细胞肺癌JAK1外显子10和13的突变分析

Journal of lung cancer Pub Date : 2008-12-01 DOI: 10.6058/JLC.2008.7.2.71

Ji-Eun Oh, H. Yoon, I. Woo, S. Kim, N. Yoo, S. Lee

引用次数: 0

Alterations of the Apoptosis Genes and Their Products in Non-small Cell Lung Cancer Tissues 非小细胞肺癌组织中凋亡基因及其产物的改变

Journal of lung cancer Pub Date : 2008-12-01 DOI: 10.6058/JLC.2008.7.2.59

N. Yoo, S. Lee

引用次数: 0

Development of a Multidisciplinary Care System for Lung Cancer Patients 肺癌患者多学科护理系统的发展

Journal of lung cancer Pub Date : 2008-12-01 DOI: 10.6058/JLC.2008.7.2.75

K. Na, S. Ahn, Y. Kim, H. Bom, Chan Choi, K. S. Kim, I. Oh, Sang‐Yun Song, Song Choi, Y. Choi, S. Jeong, M. Yoon, Sun-Mi Back, Kang-Eun Kong, Young-chul Kim

{"title":"Development of a Multidisciplinary Care System for Lung Cancer Patients","authors":"K. Na, S. Ahn, Y. Kim, H. Bom, Chan Choi, K. S. Kim, I. Oh, Sang‐Yun Song, Song Choi, Y. Choi, S. Jeong, M. Yoon, Sun-Mi Back, Kang-Eun Kong, Young-chul Kim","doi":"10.6058/JLC.2008.7.2.75","DOIUrl":"https://doi.org/10.6058/JLC.2008.7.2.75","url":null,"abstract":"Purpose: Since the year 2000, lung cancer has been the leading cause of cancer death in South Korea and also in many other parts of the world. Materials and Methods: We developed a multidisciplinary (MD) care system for lung cancer patients in 1996. Here, we report the results obtained in the process of development of MD team (MDT). Results: The MDT was launched with including medical doctors, chest surgeons, radiation oncologists, radiologists, nuclear medicine specialists and physician assistants. To facilitate co-operation between the MDT members, a specialized out-patient clinic was located within a sector of the hospital. A common ward was allocated for lung cancer patients regardless of the department of the attending physician. Shared electronic medical record forms that were specialized for lung cancer were developed. The MDT operates weekly lung cancer conferences and multidisciplinary out-patient clinics. To make diagnostic or therapeutic decisions early on, the electronic medical records of the patients were previewed or consulted by the specialists before they meet the individual patients. Conclusion: Despite every effort, we still need to shorten the waiting time from presentation to the first treatment and we need to improve the patients’ satisfaction. We also have a mission to develop our own regulations and guidelines for our lung cancer MD care system. Clinical trials and basic research should also be encouraged along with improving the quality of life of the team members. (J Lung Cancer 2008;7(2):75 �� 80)","PeriodicalId":90901,"journal":{"name":"Journal of lung cancer","volume":"98 1","pages":"75-80"},"PeriodicalIF":0.0,"publicationDate":"2008-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.6058/JLC.2008.7.2.75","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71160003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Esophageal Cancer with Left Main Bronchus Obstruction 食管癌合并左主支气管梗阻

Journal of lung cancer Pub Date : 2008-06-01 DOI: 10.6058/JLC.2008.7.1.34

Seung-Ji Kang, I. Oh, K. S. Kim, Young-chul Kim

{"title":"Esophageal Cancer with Left Main Bronchus Obstruction","authors":"Seung-Ji Kang, I. Oh, K. S. Kim, Young-chul Kim","doi":"10.6058/JLC.2008.7.1.34","DOIUrl":"https://doi.org/10.6058/JLC.2008.7.1.34","url":null,"abstract":"A 66-year-old man with recurrent esophageal cancer was admitted to our health care facility for evaluation of resting dyspnea. He had undergone an esophagectomy with cervical esophagogastrostomy in May 2007 and had undergone radical radiation treatment from June to August 2007. After 6 months, he complained of cough and dyspnea. A metastatic lymphadenopathy, 4 cm in size, was in the para-aortic space and compressed the left main bronchus, resulting in total atelectasis of the left lung, as demonstrated on follow-up chest simple x-ray and CT (Fig. 1, 2). He initially received one cycle of chemotherapy consisting of docetaxel and cisplatin, but there was no change in the lung atelectasis and the dyspnea had worsened. The decision was therefore made to perform a rigid bronchoscopy. Under general anesthesia, an endobronchial obstructive lesion was removed using a mechanical core-out technique with rigid bronchoscopy (Fig. 3). After the procedure, the atelectasis resolved nearly completely, and neither severe bleeding nor other complications were noted (Fig. 4). The dyspnea was relieved from ATS (American thoracic society) grade 4 to grade 2. Following this treatment, chemotherapy for recurrent esophageal cancer was resumed.","PeriodicalId":90901,"journal":{"name":"Journal of lung cancer","volume":"7 1","pages":"34-35"},"PeriodicalIF":0.0,"publicationDate":"2008-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.6058/JLC.2008.7.1.34","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71159520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0