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Prophylactic administration of tranexamic acid preserves platelet numbers during extracorporeal circulation in rabbits. 预防性给药氨甲环酸可保持兔体外循环期间血小板数量。
ASAIO transactions Pub Date : 1991-07-01
F B Plötz, W van Oeveren, L S Aloe, M K Riley, K A Hultquist, R H Bartlett, C R Wildevuur
{"title":"Prophylactic administration of tranexamic acid preserves platelet numbers during extracorporeal circulation in rabbits.","authors":"F B Plötz,&nbsp;W van Oeveren,&nbsp;L S Aloe,&nbsp;M K Riley,&nbsp;K A Hultquist,&nbsp;R H Bartlett,&nbsp;C R Wildevuur","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Neonatal extracorporeal life support is associated with platelet consumption and hemostatic disorders. This study in rabbits was undertaken to evaluate the effect of heparin coating and of the plasminogen and plasmin inhibitor, tranexamic acid on platelet consumption during extracorporeal circulation. Fibrinogen consumption was prevented by heparin coating, but platelet consumption was only prevented after the prophylactic administration of tranexamic acid. The authors concluded that inhibition of the fibrinolytic system had a specific effect on preserving platelet numbers, rather than improving the thromboresistance of the artificial surface. The main advantage of a heparin coating is the anticoagulant activity of the surface. Thus systemic heparinization can be reduced or omitted.</p>","PeriodicalId":77493,"journal":{"name":"ASAIO transactions","volume":"37 3","pages":"M416-7"},"PeriodicalIF":0.0,"publicationDate":"1991-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12914002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Zinc-mediated lymphocyte energy charge modification in dialysis patients. 锌介导的透析患者淋巴细胞能量电荷改变。
ASAIO transactions Pub Date : 1991-07-01
M Bonomini, P F Palmieri, M Evangelista, V Manfrini, A Albertazzi
{"title":"Zinc-mediated lymphocyte energy charge modification in dialysis patients.","authors":"M Bonomini,&nbsp;P F Palmieri,&nbsp;M Evangelista,&nbsp;V Manfrini,&nbsp;A Albertazzi","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The authors studied the effects of 6 months of zinc therapy on cell-mediated immunity in regular dialysis therapy patients. Serum zinc was significantly enhanced (p less than 0.01) at 2 months. While cells, OKT3, and OKT4 did not show significant variation, but after 6 months of therapy a significant (p less than 0.02) decrease of OKT8 cells, with enhancement of the OKT4/OKT8 ratio, and a significant (p less than 0.01) increase in the Multitest Composite score were found. At the same time, a significant elevation (p less than 0.001) of adenosine triphosphate (ATP), and a reduction (p less than 0.01) of lymphocyte adenosine monophosphate was seen; consequently, energy charge levels increased. Zinc-induced improvement of uremic lymphocyte function is likely mediated by an increase in intracellular ATP.</p>","PeriodicalId":77493,"journal":{"name":"ASAIO transactions","volume":"37 3","pages":"M387-9"},"PeriodicalIF":0.0,"publicationDate":"1991-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12914060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Real-time in vitro observation of cavitation in a prosthetic heart valve. 人工心脏瓣膜空化的实时体外观察。
ASAIO transactions Pub Date : 1991-07-01
T C Lamson, D R Stinebring, S Deutsch, G Rosenberg, J M Tarbell
{"title":"Real-time in vitro observation of cavitation in a prosthetic heart valve.","authors":"T C Lamson,&nbsp;D R Stinebring,&nbsp;S Deutsch,&nbsp;G Rosenberg,&nbsp;J M Tarbell","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A technique for real-time in vitro observation of cavitation on a prosthetic heart valve operating in a ventricular assist device under normal physiologic conditions has been developed. Considering the documented observation of cavitation erosion in heart valve components from human explants, and the potential risk of blood damage that cavitation presents, the technique developed in this study may prove useful in the design of prosthetic heart valves and ventricular assist devices. Cavitation of a glycerol blood analog fluid has been documented for a Medtronic/Hall prosthetic heart valve operating in a Penn State Electric Ventricular Assist Device. The ventricular assist device was operated in a mock circulatory system under normal physiologic conditions. The valve was located in the mitral position, with the cavitation occurring on the inlet side after valve closure. Bubble cavitation was seen on the valve occluder face, and vortex cavitation was observed at two locations in the vicinity of the valve occluder and housing. The cavity growth and collapse cycle for these forms of vaporous cavitation was less than 1 msec. Stroboscopic photography and stroboscopic videography with frame grabbing were used to document the cavity life cycle. With beat rate held constant, the cavity duration time was found to decrease with increasing mean venous return pressure.</p>","PeriodicalId":77493,"journal":{"name":"ASAIO transactions","volume":"37 3","pages":"M351-3"},"PeriodicalIF":0.0,"publicationDate":"1991-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12914344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A completely implantable total artificial heart system. 一个完全植入式的人工心脏系统。
ASAIO transactions Pub Date : 1991-07-01
A Snyder, G Rosenberg, W Weiss, W Pierce, W Pae, J Marlotte, R Nazarian, S Ford
{"title":"A completely implantable total artificial heart system.","authors":"A Snyder,&nbsp;G Rosenberg,&nbsp;W Weiss,&nbsp;W Pierce,&nbsp;W Pae,&nbsp;J Marlotte,&nbsp;R Nazarian,&nbsp;S Ford","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The authors developed, built, and tested in vivo a completely implanted total artificial heart (TAH) system. The system used a reduced size version of a roller screw energy converter and mating sac blood pumps. The motor drive, pumps, and a compliance chamber were implanted intrathoracically. A canister containing controlling electronics and an emergency battery was implanted in the abdomen. The secondary coil of an inductive energy transmission and telemetry system was placed over the ribs. The system was implanted in three calves, that survived 0.5-13 days with the system. The system maintained safe left atrial pressures and adequate cardiac outputs during each animal's entire course.</p>","PeriodicalId":77493,"journal":{"name":"ASAIO transactions","volume":"37 3","pages":"M237-8"},"PeriodicalIF":0.0,"publicationDate":"1991-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12914787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical effects of recombinant human erythropoietin in hemodialysis patients. Results of the "Abruzzo" Multicenter Trial. 重组人促红细胞生成素在血液透析患者中的临床效果。“Abruzzo”多中心试验结果
ASAIO transactions Pub Date : 1991-07-01
B Di Paolo, L Di Liberato, R Summa, G Catucci, G Del Rosso, P Muscianese, A Albertazzi
{"title":"Clinical effects of recombinant human erythropoietin in hemodialysis patients. Results of the \"Abruzzo\" Multicenter Trial.","authors":"B Di Paolo,&nbsp;L Di Liberato,&nbsp;R Summa,&nbsp;G Catucci,&nbsp;G Del Rosso,&nbsp;P Muscianese,&nbsp;A Albertazzi","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Anemia in regular dialysis treatment (RDT) patients is primarily due to a deficiency in renal-derived recombinant human erythropoietin (EPO). The aim of this study was to evaluate the results of a multicenter trial in 81 end-stage renal disease (ESRD) patients on RDT. An \"open\" study was conducted over 2 years; starting dose of r-HuEPO was 50 IU/kg/three times weekly i.v. and eventually was increased in steps of 25 Ul/kg/dialysis until 300 Ul/kg/week. Mean weekly dose per patient was 15 Ul/kg, with mean Hb increase of 27.5%. Mean hematocrit (Hct) levels increased in these patients from 22.9 +/- 2.5 to 31.7 +/- 2.8 (p less than 0.001) after 2 years of therapy. Both spontaneous and evoked potentials improved. The response to r-HuEPO is dose dependent; hypertension and hyperkalemia are the most common side effects, but they are easily controlled. Central nervous system function before and after treatment is improved, and seems consistent with an enhancement of patients' quality of life.</p>","PeriodicalId":77493,"journal":{"name":"ASAIO transactions","volume":"37 3","pages":"M380-1"},"PeriodicalIF":0.0,"publicationDate":"1991-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12914800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bioartificial thyroid. The in vitro culture of microencapsulated rabbit thyroid tissue. 人工甲状腺。兔甲状腺组织微囊化的体外培养。
ASAIO transactions Pub Date : 1991-07-01
G X Chen, Y Peng, P L Lou, J P Liu
{"title":"Bioartificial thyroid. The in vitro culture of microencapsulated rabbit thyroid tissue.","authors":"G X Chen,&nbsp;Y Peng,&nbsp;P L Lou,&nbsp;J P Liu","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A new technique of encapsulating thyroid tissue with an artificial membrane for protection against immune attack is reported. The membrane was made of calcium alginate and a poly-L-lysin coating. The membrane prevents the diffusion of large molecules such as hemoglobin but freely permits the passage of smaller molecules such as T4 and culture medium 1640. Because larger molecules are barred, the contents of the microcapsules are safe from immune system rejection. In vitro cultured, microencapsulated rabbit thyroid tissue secreted T3 and T4, achieving a concentration of 8.68 +/- 2.93 nmol/L and 245.23 +/- 124.87 nmol/L, after 3 days; this level remained steady for 6 to 9 days of incubation. These microcapsules show promise as a treatment modality and as a possible solution to the problem of immuno-isolation.</p>","PeriodicalId":77493,"journal":{"name":"ASAIO transactions","volume":"37 3","pages":"M439-40"},"PeriodicalIF":0.0,"publicationDate":"1991-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12915139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nondestructive analysis of mitral valve collagen fiber orientation. 二尖瓣胶原纤维定向的无损分析。
ASAIO transactions Pub Date : 1991-07-01
R P Cochran, K S Kunzelman, C J Chuong, M S Sacks, R C Eberhart
{"title":"Nondestructive analysis of mitral valve collagen fiber orientation.","authors":"R P Cochran,&nbsp;K S Kunzelman,&nbsp;C J Chuong,&nbsp;M S Sacks,&nbsp;R C Eberhart","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Collagen is the most abundant and highest modulus component in mitral valve (MV) tissue. MV leaflet and chordal collagen ultrastructure were analyzed by small angle light scattering (SALS) and polarized light microscopy (PLM) to provide collagen fiber architecture mapping. It was hypothesized that structural arrangement strongly influences MV tissue mechanical properties and thus physiologic function.</p>","PeriodicalId":77493,"journal":{"name":"ASAIO transactions","volume":"37 3","pages":"M447-8"},"PeriodicalIF":0.0,"publicationDate":"1991-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12913761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
In vivo results of hydrogel composite pericardial substitutes. 水凝胶复合心包代用品的体内实验结果。
ASAIO transactions Pub Date : 1991-07-01
M A Blue, E J Guilbeau, T A Brandon, A S Walker, G Bjotvedt, R L Fisk
{"title":"In vivo results of hydrogel composite pericardial substitutes.","authors":"M A Blue,&nbsp;E J Guilbeau,&nbsp;T A Brandon,&nbsp;A S Walker,&nbsp;G Bjotvedt,&nbsp;R L Fisk","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In this study, two improved pericardial patches were developed and evaluated for their efficacy as pericardial substitutes. The patches are composites consisting of a hydrogel (PHEMA) that coats an underlying mesh (either ETFE or PET). Studies were conducted using subcutaneous implants in rats and pericardial patch implants in greyhound dogs. Adhesions between the substitute and pericardium and the epicardium were minimal. The ETFE composite patch caused an unacceptable epicardial reaction. The PET patch results were encouraging; the epicardium was largely unaffected by the patch.</p>","PeriodicalId":77493,"journal":{"name":"ASAIO transactions","volume":"37 3","pages":"M152-3"},"PeriodicalIF":0.0,"publicationDate":"1991-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12913945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cytokine levels during hemodialysis. 血液透析期间细胞因子水平。
ASAIO transactions Pub Date : 1991-07-01
N D Vaziri, C J Kaupke, S Yousefi, E Gonzales, T C Cesario
{"title":"Cytokine levels during hemodialysis.","authors":"N D Vaziri,&nbsp;C J Kaupke,&nbsp;S Yousefi,&nbsp;E Gonzales,&nbsp;T C Cesario","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The authors measured plasma IL-1 (interleukin-1), IL-2, IL-2 receptor (IL-2R), IL-4, IL-6, tumor necrosis factor (TNF), and granulocyte macrophage colony stimulating factor (GMCSF) in 10 stable patients during hemodialysis (HD) using new or reused polyacrylonitrile (PAN) or cuprophan (CU) dialyzers. Five HD patients with wasting syndrome, and 16 normal controls, were included. Hemodialysis patients showed a marked elevation of IL-2R. No IL-4, IL-6, or GMCSF were detected in any group. Tumor necrosis factor and IL-2 in the HD group were comparable with control values. No difference was found in the TNF levels in HD patients with and without wasting syndrome. Cytokine levels were unaffected by either new or used PAN or CU dialyzers.</p>","PeriodicalId":77493,"journal":{"name":"ASAIO transactions","volume":"37 3","pages":"M389-91"},"PeriodicalIF":0.0,"publicationDate":"1991-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12913995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chronic evaluation of a compact nonseal magnet pump as a nonpulsatile pump for long-term use. 长期使用紧凑型非密封磁力泵作为无脉动泵的慢性评价。
ASAIO transactions Pub Date : 1991-07-01
Y Taenaka, E Tatsumi, M Sakaki, E Sasaki, T Masuzawa, T Nakatani, H Akagi, M Goto, Y Matsuo, K Inoue
{"title":"Chronic evaluation of a compact nonseal magnet pump as a nonpulsatile pump for long-term use.","authors":"Y Taenaka,&nbsp;E Tatsumi,&nbsp;M Sakaki,&nbsp;E Sasaki,&nbsp;T Masuzawa,&nbsp;T Nakatani,&nbsp;H Akagi,&nbsp;M Goto,&nbsp;Y Matsuo,&nbsp;K Inoue","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Use of a nonpulsatile pump is one of the most interesting approaches in the development of artificial hearts. A centrifugal pump without a seal around the rotating part was evaluated in five goats. The size of the pump is 8.4 cm x phi 7.0 cm, including an electric motor. A polypropylene impeller with four fins on the top of a column in which a magnetic ring is embedded spins by coupling with a rotating magnet outside the housing. In the goats, the pump was placed paracorporeally to provide total left heart bypass at a flow rate of 4.6-7.6 L/min, and activated clotting time was controlled at 200-300 sec by continuous heparin infusion. Although the first three goats died within 3 days due to bleeding, embolism, and a jammed impeller, respectively, a pump could be driven for 14 days in the fourth goat, and another pump with a rotational control feedback system ran for 32 days in the fifth goat. Plasma free hemoglobin levels were 13.8 +/- 4.3 mg/dl and 9.5 +/- 2.5 mg/dl, and platelet counts were 53.8 +/- 24.7 x 10(4)/mm3 and 62.0 +/- 22.0 x 10(4)/mm3 after 12 hours and 7 days pumping, respectively. No thrombus was observed in the blood chamber in the last two cases. In conclusion, this pump has possibilities as a nonpulsatile pump for long-term use.</p>","PeriodicalId":77493,"journal":{"name":"ASAIO transactions","volume":"37 3","pages":"M243-5"},"PeriodicalIF":0.0,"publicationDate":"1991-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12914051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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