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The newly designed univalved artificial heart. 新设计的无瓣人工心脏。
ASAIO transactions Pub Date : 1991-07-01
S Nitta, H Hashimoto, T Sonobe, Y Katahira, T Yambe, S Naganuma, M Tanaka, N Sato, M Miura, H Mohri
{"title":"The newly designed univalved artificial heart.","authors":"S Nitta,&nbsp;H Hashimoto,&nbsp;T Sonobe,&nbsp;Y Katahira,&nbsp;T Yambe,&nbsp;S Naganuma,&nbsp;M Tanaka,&nbsp;N Sato,&nbsp;M Miura,&nbsp;H Mohri","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A univalved artificial heart (AH) powered electromagnetically in the frequency range of 1-30 Hz was developed to obtain a totally implantable AH. This small sized AH consisted of a vibrating tube, coils, magnets, and a jellyfish valve as an outlet AH valve. The fluid mechanical, hemodynamic, and hematologic properties were evaluated in a mock circulation and 10 animal experiments using adult goats. This vibrating electromagnetic AH could generate more than 10 L/min as an output volume, with 10 Hz vibration using 20 volts supplied voltage. It could also provide two kinds of flow and pressure patterns, in constant-peak and periodic-peak patterns. The values of free hemoglobin remained within acceptable limits. The authors concluded that this new type of pump was useful as a totally implantable AH, ventricular assist, or organ assist system.</p>","PeriodicalId":77493,"journal":{"name":"ASAIO transactions","volume":"37 3","pages":"M240-1"},"PeriodicalIF":0.0,"publicationDate":"1991-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12914790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development of a totally implantable total artificial heart controller. 全植入式全人工心脏控制器的研制。
ASAIO transactions Pub Date : 1991-07-01
S H Lee, W W Choi, B G Min
{"title":"Development of a totally implantable total artificial heart controller.","authors":"S H Lee,&nbsp;W W Choi,&nbsp;B G Min","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Using a one chip microcontroller, 87C196 (One chip EPROM), and an erasable and programmable logic device (EPLD), an implantable control system to drive a pendulum type electromechanical total artificial heart was developed. This control system consists of four parts: a main management system, a motor driver with power regulator, a state monitoring system, and a communication portion. The main system has a speed detector, proportional and integral (PI) control, pulse width modulation (PWM) generation, serial communication, and an analog data processor. Two kinds of power system are used, separated by eight photocoupler arrays to improve system stability. When the performance of each compartment was compared with that of the previously used Z80 microprocessor based control system, good correspondence was shown. Logic power consumption was reduced to one third that of the previous controller. Using mock circulation tests, the overall performance of the control system was evaluated.</p>","PeriodicalId":77493,"journal":{"name":"ASAIO transactions","volume":"37 3","pages":"M505-7"},"PeriodicalIF":0.0,"publicationDate":"1991-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12914806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A new treatment strategy using both intermittent short dialysis and continuous ambulatory hemofiltration. 间歇性短时间透析和连续动态血液滤过的新治疗策略。
ASAIO transactions Pub Date : 1991-07-01
I Takai, T Shinzato, H Morita, Y Fujita, I Inoue, H Kobayakawa, K Maeda
{"title":"A new treatment strategy using both intermittent short dialysis and continuous ambulatory hemofiltration.","authors":"I Takai,&nbsp;T Shinzato,&nbsp;H Morita,&nbsp;Y Fujita,&nbsp;I Inoue,&nbsp;H Kobayakawa,&nbsp;K Maeda","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The authors devised a new treatment strategy using continuous ambulatory hemofiltration (CAHF) in between short hemodialyses (short HD). For CAHF, a small wearable hemofilter (0.1 m2) was developed using a membrane permeable to low molecular weight proteins. During short HD, no body water was removed, but saline, equivalent to 3% body weight, was administered at a constant rate. During CAHF, 1 L of replacement fluid was administered intravenously after every meal to increase the replacement volume. Switch from the conventional to new strategy resulted in far more stable blood pressure during short HD, a decrease in time averaged body weight, and a decrease in a decrease in time averaged blood urea nitrogen and plasma beta 2-m levels.</p>","PeriodicalId":77493,"journal":{"name":"ASAIO transactions","volume":"37 3","pages":"M325-7"},"PeriodicalIF":0.0,"publicationDate":"1991-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12913754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The effect of surface hydrophilicity on biomaterial-leukocyte interactions. 表面亲水性对生物材料-白细胞相互作用的影响。
ASAIO transactions Pub Date : 1991-07-01
F Lim, S L Cooper
{"title":"The effect of surface hydrophilicity on biomaterial-leukocyte interactions.","authors":"F Lim,&nbsp;S L Cooper","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Leukocyte adhesion onto a series of polyetherurethanes containing various ratios of polyethylene oxide (PEO) to polytetramethylene oxide (PTMO) in the soft segment was evaluated using an in vitro series shunt. The deposition of polymorphonuclear (PMN) and mononuclear (MN) leukocytes was measured quantitatively using labelling techniques. Results showed that H/H-1, the most hydrophobic surface, adsorbed higher amounts of PMN leukocytes. It was also observed that for most materials the number of PMN and MN leukocytes deposited reached a plateau within 15 minutes. Unlike MN adherence, the presence of plasma proteins increased the number of PMN leukocytes deposited on the materials.</p>","PeriodicalId":77493,"journal":{"name":"ASAIO transactions","volume":"37 3","pages":"M146-7"},"PeriodicalIF":0.0,"publicationDate":"1991-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12913942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Staphylococcus epidermidis biofilms: unexpected outcome of double and triple antibiotic combinations with rifampin. 表皮葡萄球菌生物膜:双重和三重抗生素联合利福平的意外结果。
ASAIO transactions Pub Date : 1991-07-01
R F Gagnon, G K Richards, L Wiesenfeld
{"title":"Staphylococcus epidermidis biofilms: unexpected outcome of double and triple antibiotic combinations with rifampin.","authors":"R F Gagnon,&nbsp;G K Richards,&nbsp;L Wiesenfeld","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Staphylococcus epidermidis, in contact with artificial surfaces, may produce a protective glue-like matrix or biofilm. The authors demonstrated that rifampin alone among 35 antibiotics penetrated the biofilm within a 24 hr exposure producing a major but incomplete killing. Antibiotics of the cell-wall active class (including vancomycin) were synergistic with rifampin, completing the bactericidal action. The addition of these antibiotics to a rifampin-vancomycin combination did not alter the synergy. Other antibiotics (including aminoglycosides) antagonized rifampin activity. This antagonism of rifampin was maintained when the antibiotics were added to the rifampin-vancomycin synergistic combination. These results may have implications for the choice of optimal therapeutic regimens in the management of implant-associated infection.</p>","PeriodicalId":77493,"journal":{"name":"ASAIO transactions","volume":"37 3","pages":"M158-60"},"PeriodicalIF":0.0,"publicationDate":"1991-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12913947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Easy access for a left ventricular assist system without thoracotomy. 无需开胸即可轻松获得左心室辅助系统。
ASAIO transactions Pub Date : 1991-07-01
E Sasaki, T Nakatani, Y Taenaka, H Noda, E Tatsumi, H Akagi, T Masuzawa, M Goto, M Sakaki, Y Matsuo
{"title":"Easy access for a left ventricular assist system without thoracotomy.","authors":"E Sasaki,&nbsp;T Nakatani,&nbsp;Y Taenaka,&nbsp;H Noda,&nbsp;E Tatsumi,&nbsp;H Akagi,&nbsp;T Masuzawa,&nbsp;M Goto,&nbsp;M Sakaki,&nbsp;Y Matsuo","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In a previous article, a left ventricular assist system (LVAS) with a percutaneous transseptal cannulation technique for easy application was described. This system was safe and efficient (maximum output greater than 3 L/min) and fitted between the intraaortic balloon pumping and LVAS with thoracotomy. But technical skill for placement was slightly complicated. The cannulation system has been improved. In the new system, the inlet cannula is initially used as a sheath introducer and is quickly inserted into the left atrium after transseptal puncture. The new inlet cannula is made of polyvinyl chloride (TM100, Toyobo, Co., Ltd., Osaka, Japan), which has excellent antithrombogenicity and low friction using a polyester plasticizer. The distal part is designed to be flexible with a spiral wire for easy manipulation. A sealing hub was installed to prevent bleeding at the proximal The simplicity and safety of the new system were examined in chronic animal experiments. The inlet cannula was placed into the left atrium within a few seconds after transseptal puncture. During 20 days of activation, there were no episodes of systemic or pulmonary embolism, although no anticoagulant was used. Under fluoroscopy, there was no thrombus formation around the cannula at removal. On the 14th day after removal, the puncture site of the septum had healed. This system is ready for clinical use and shows promise of satisfactory safety and manageability.</p>","PeriodicalId":77493,"journal":{"name":"ASAIO transactions","volume":"37 3","pages":"M280-1"},"PeriodicalIF":0.0,"publicationDate":"1991-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12913949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A protamine-mediated heparin sensing device. 一种蛋白蛋白介导的肝素传感装置。
ASAIO transactions Pub Date : 1991-07-01
V C Yang, W Chen
{"title":"A protamine-mediated heparin sensing device.","authors":"V C Yang,&nbsp;W Chen","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A convenient, protamine mediated strip assay for heparin was developed. The assay is established on the specific interaction between heparin and protamine, and the metachromatic color change of methylene blue dye from blue to purple in the presence of heparin. The device consists of a fibrin cup fabricated with a cellulose paper strip containing immobilized protamine. To analyze plasma heparin levels, a fixed volume of the test sample is placed in the fibrin cup and allowed to migrate through the strip in a descending manner until exhaustion. The region to which heparin binds is then visualized as purple in color by spraying methylene blue dye onto the strip. The heparin level in the sample is estimated from the length of the purple region using a preconstructed standard curve. This device proved to be capable of detecting and differentiating heparin in clinically relevant concentrations.</p>","PeriodicalId":77493,"journal":{"name":"ASAIO transactions","volume":"37 3","pages":"M292-4"},"PeriodicalIF":0.0,"publicationDate":"1991-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12913956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Vascular access for extracorporeal circulation. Resistance in double lumen cannulas. 体外循环的血管通路。双腔插管阻力。
ASAIO transactions Pub Date : 1991-07-01
C C Stroud, S L Meyer, M C Bawkon, H G Smith, M D Klein
{"title":"Vascular access for extracorporeal circulation. Resistance in double lumen cannulas.","authors":"C C Stroud,&nbsp;S L Meyer,&nbsp;M C Bawkon,&nbsp;H G Smith,&nbsp;M D Klein","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Double lumen catheters (DLCs) currently are being used for vascular access with extracorporeal circulation. Blood flow studies were done on various DLCs connected to a circuit made of polyvinyl chloride tubing. Sheep's blood was used with all catheters at flows of 200 and 400 ml/min. The inlet and outlet pressures were measured and resistances calculated. Modified versions of the Shiley and Kendall catheters, also were tested. In both catheters, resistance was reduced with the use of perfusion adaptors. Flow through catheters, with a diameter that exceeded the Luer fitting dimension, was compromised. The modified Shiley and unmodified Kendall catheters had the lowest resistance to flow, and they thus are best suited for extracorporeal circulation.</p>","PeriodicalId":77493,"journal":{"name":"ASAIO transactions","volume":"37 3","pages":"M418-9"},"PeriodicalIF":0.0,"publicationDate":"1991-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12913957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Laser welding and irradiation in alcohol preserved homografts. 酒精保存同种接枝的激光焊接与辐照。
ASAIO transactions Pub Date : 1991-07-01
S Wang, M Gennaro, C Marini, F G Baumann, S Jonnalagadda, J N Cunningham, I J Jacobowitz
{"title":"Laser welding and irradiation in alcohol preserved homografts.","authors":"S Wang,&nbsp;M Gennaro,&nbsp;C Marini,&nbsp;F G Baumann,&nbsp;S Jonnalagadda,&nbsp;J N Cunningham,&nbsp;I J Jacobowitz","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>This experiment examined the effect of laser welding and irradiation on the patency rate of microvascular anastomoses done with alcohol preserved homografts. The carotid arteries from Sprague-Dawley rats were freshly harvested and preserved in 70% ethyl alcohol for at least 3 weeks. The homografts were interposed into the carotid arteries with one of the following techniques: Group I, grafts were anastomosed with three stay sutures and laser welding (carbon dioxide laser, 90 mW); Group II, anastomoses were completed with eight to nine interrupted sutures (10-0 nylon); or Group III, the same technique used in Group II, but followed by laser irradiation (90 mW for 1 min) of the grafts. These results showed that patency at 2 weeks was 73% in Group I, 71% in Group II, and 82% in Group III, respectively. The patency at 12 weeks was 67% in Group I and unchanged in Groups II and III. In conclusion, laser irradiation and laser welding did not increase the patency rate of microvascular anastomoses done with alcohol preserved homografts. Thrombotic occlusion in microvascular homografts usually occurs before the second week postoperatively.</p>","PeriodicalId":77493,"journal":{"name":"ASAIO transactions","volume":"37 3","pages":"M268-9"},"PeriodicalIF":0.0,"publicationDate":"1991-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12913990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Miniature membrane oxygenator for use in neonatal ECMO. 微型膜式氧合器在新生儿ECMO中的应用。
ASAIO transactions Pub Date : 1991-07-01
M Katayama, K Miyasaka, I Hirose, M Shimada, R Mimura, H Akasu
{"title":"Miniature membrane oxygenator for use in neonatal ECMO.","authors":"M Katayama,&nbsp;K Miyasaka,&nbsp;I Hirose,&nbsp;M Shimada,&nbsp;R Mimura,&nbsp;H Akasu","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A new miniature membrane oxygenator (Kuraray KMO, size, 0.3 m2, with a priming volume of 47 ml, compliance of less than 0.1 ml/100 mmHg, and pressure loss of 45 mmHg) with improved gas transfer and mechanical durability was developed and tested. The membrane material is a hollow fiber double layer polyolefin. The testing procedures determined by the AAMI were followed, and the results showed improved O2 and CO2 transfer (70 ml/min and 55 ml/min, respectively). Hemolysis was within acceptable limits, and plasma leakage was undetectable after 7 days of perfusion. Clinical study demonstrated satisfactory performance.</p>","PeriodicalId":77493,"journal":{"name":"ASAIO transactions","volume":"37 3","pages":"M407-8"},"PeriodicalIF":0.0,"publicationDate":"1991-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12913998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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