Virchows Archiv. A, Pathological anatomy and histology最新文献_第2页

Lack of cardiotoxic effect of isoproterenol in streptozotocin diabetic rats. A morphometric study of isoproterenol induced fibrosis. 异丙肾上腺素对链脲佐菌素糖尿病大鼠缺乏心脏毒性作用。异丙肾上腺素诱导纤维化的形态学研究。

Virchows Archiv. A, Pathological anatomy and histology Pub Date : 1982-01-01 DOI: 10.1007/BF00430895

O Gøtzsche

{"title":"Lack of cardiotoxic effect of isoproterenol in streptozotocin diabetic rats. A morphometric study of isoproterenol induced fibrosis.","authors":"O Gøtzsche","doi":"10.1007/BF00430895","DOIUrl":"https://doi.org/10.1007/BF00430895","url":null,"abstract":"The well known cardiotoxic effect of isoproterenol (ISO) was investigated in normal and streptozotocin diabetic rats. Seven days after the subcutaneous injection of ISO (15 mg/kg) the hearts were perfusion fixed and 12 sections from each heart were stained (Masson's trichrome). ISO induced myocardial fibrosis was quantified at the light microscopic level according to established morphometric principles. Pulse rate and ST elevation were recorded by EEC (3 standard leads) before and after the ISO injection. Non-diabetic control animals showed marked fibrosis after ISO, but surprisingly the diabetic animals showed no fibrosis after ISO treatment. These findings were in accordance with an ISO induced ST elevation seen only among control animals although both groups showed the same degree of tachycardia. Insulin treatment prevented the protection against ISO and when streptozotocin was injected 24 h after the ISO a normal quantitative and qualitative appearance of the scar tissue was seen. It thus seems that streptozotocin diabetic rats are protected against the toxic effect of ISO, leaving the haemodynamic response unaffected. Which factor in the diabetic metabolism is responsible for the present phenomenon is not known, but a defect in the signal transmission from the beta-receptor to the adenylcyclase is suggested as a possible explanation.","PeriodicalId":76799,"journal":{"name":"Virchows Archiv. A, Pathological anatomy and histology","volume":"397 1","pages":"83-91"},"PeriodicalIF":0.0,"publicationDate":"1982-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF00430895","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17808398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Experimental diffuse intimal thickening of the femoral arteries in the rabbit. 兔股动脉弥漫性内膜增厚的实验。

Virchows Archiv. A, Pathological anatomy and histology Pub Date : 1982-01-01 DOI: 10.1007/BF00428499

J Gebrane, J Roland, L Orcel

引用次数: 10

Aneurysmal bone cyst, a study of ultrastructure and malignant transformation. 动脉瘤性骨囊肿，超微结构与恶性转化的研究。

Virchows Archiv. A, Pathological anatomy and histology Pub Date : 1982-01-01 DOI: 10.1007/BF00429610

H J Aho, A J Aho, S Einola

引用次数: 40

Stroke-prone spontaneously hypertensive rats as an experimental model of malignant hypertension. A pathological study. 卒中易发自发性高血压大鼠作为恶性高血压的实验模型。病理研究。

Virchows Archiv. A, Pathological anatomy and histology Pub Date : 1982-01-01 DOI: 10.1007/BF00430664

J Ogata, M Fujishima, K Tamaki, Y Nakatomi, T Ishitsuka, T Omae

引用次数: 33

Adenocarcinoma of the Fallopian tube. An ultrastructural study. 输卵管腺癌。超微结构研究。

Virchows Archiv. A, Pathological anatomy and histology Pub Date : 1982-01-01 DOI: 10.1007/BF00496577

T S Talamo, B L Bender, L D Ellis, E A Scioscia

引用次数: 7

Immunohistochemical localisation of keratin in human lung tumours. 人肺肿瘤中角蛋白的免疫组化定位。

Virchows Archiv. A, Pathological anatomy and histology Pub Date : 1982-01-01 DOI: 10.1007/BF00430670

B Gusterson, D Mitchell, M Warburton, J Sloane

引用次数: 2

Virchows Archiv. A, Pathological anatomy and histology Pub Date : 1982-01-01 DOI: 10.1007/BF00496573

M G Ormerod, G Bussolati, J P Sloane, K Steele, P Gugliotta

引用次数: 5

Pituitary adenomas with hyperfunction of TSH. Frequency, histological classification, immunocytochemistry and ultrastructure. 垂体腺瘤伴TSH功能亢进。频率，组织学分类，免疫细胞化学和超微结构。

Virchows Archiv. A, Pathological anatomy and histology Pub Date : 1982-01-01 DOI: 10.1007/BF00430669

W Saeger, D K Lüdecke

{"title":"Pituitary adenomas with hyperfunction of TSH. Frequency, histological classification, immunocytochemistry and ultrastructure.","authors":"W Saeger, D K Lüdecke","doi":"10.1007/BF00430669","DOIUrl":"https://doi.org/10.1007/BF00430669","url":null,"abstract":"In a collection of 564 surgically removed pituitary adenomas, 4 cases werefound to have had elevated TSH plasma levels. One of these tumors )(case 1) could be classified as a highly differentiated mucoid TSH cell adenoma presenting histochemical reactions typical of, as well as electron microscopical features identical to, normal TSH cells. Immunoenzymatic studies failed to dfemonstrate TSH in the tumor cells. Two further adenomas (case 2 and 3) were similarly structured in many areas, but showed regions of poorer differentiation in which distinct pleomorphism, irregular secretory granules, increased numbers of ribosomesand a well developed rough endoplasmic reticulum were present. In 10% of the tumor cells GH could be demonstrated immunoenzymatically, but there was no TSH. The fourth adenoma was an undifferentiated acidophilic adenoma showing pleomorphic cells having slight acidophil and partly mucoid granulations. The ultrastructure showed convoluted nuclei, increased numbers of free ribosomes as well as abundant rough endoplasmic reticulum and secretory granules which were differentin size and number but distinctly of the TSH cell type. Immunoenzymatically, TSH was found in some cells, with GH in more cells. Endocrinologically, elevated levels of GH were measured in cases 2, 3 and 4 with LH being increased in case 1. Clinical and morphological correlations are discussed.","PeriodicalId":76799,"journal":{"name":"Virchows Archiv. A, Pathological anatomy and histology","volume":"394 3","pages":"255-67"},"PeriodicalIF":0.0,"publicationDate":"1982-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF00430669","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17342395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 18

Alpha-1-antitrypsin in malakoplakia. 斑疹病α -1-抗胰蛋白酶。

Virchows Archiv. A, Pathological anatomy and histology Pub Date : 1982-01-01 DOI: 10.1007/BF00443481

F Callea, B Van Damme, V J Desmet

引用次数: 8

Congenital "histiocytoid" cardiomyopathy: evidence suggesting a developmental disorder of the Purkinje cell system of the heart. 先天性“组织细胞样”心肌病:表明心脏浦肯野细胞系统发育障碍的证据。

Virchows Archiv. A, Pathological anatomy and histology Pub Date : 1982-01-01 DOI: 10.1007/BF00431240

A Zimmermann, P Diem, H Cottier

引用次数: 29