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Non-coding RNA investigation最新文献

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Sonic hedgehog-regulated myotome formation relies on the myomiR, miR-133 声波刺猬调节的肌节形成依赖于子宫肌瘤miR-133
Non-coding RNA investigation Pub Date : 2018-06-12 DOI: 10.21037/NCRI.2018.11.08
R. Donato
{"title":"Sonic hedgehog-regulated myotome formation relies on the myomiR, miR-133","authors":"R. Donato","doi":"10.21037/NCRI.2018.11.08","DOIUrl":"https://doi.org/10.21037/NCRI.2018.11.08","url":null,"abstract":"Over the past two decades a great deal of information has been provided concerning myogenesis—the process of skeletal muscle formation. Much is known about the cellular and molecular mechanisms of adult myogenesis—the process through which adult muscle regenerates following acute injury and embryonic myogenesis—the process of skeletal muscle tissue development (1,2); however, the picture of the molecular mechanisms governing myogenesis is far from being complete. A recent paper by Mok et al. (3) adds an important piece of information to the mosaic of molecules/factors driving the ordered sequence of muscle-related events leading to cell fate decisions in developing embryos.","PeriodicalId":74314,"journal":{"name":"Non-coding RNA investigation","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45957229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Emerging role of long noncoding RNAs and circular RNAs in pancreatic β cells 胰腺β细胞中长链非编码RNA和环状RNA的新作用
Non-coding RNA investigation Pub Date : 2018-06-12 DOI: 10.21037/NCRI.2018.11.02
Debojyoti Das, A. Das, A. Panda
{"title":"Emerging role of long noncoding RNAs and circular RNAs in pancreatic β cells","authors":"Debojyoti Das, A. Das, A. Panda","doi":"10.21037/NCRI.2018.11.02","DOIUrl":"https://doi.org/10.21037/NCRI.2018.11.02","url":null,"abstract":"The advent of high-throughput genomic technologies revealed the expression of thousands of long noncoding RNAs (lncRNAs) and circular RNAs (circRNAs) in human. Both classes of RNAs have limited or no protein coding potential. Both lncRNAs and circRNAs regulates gene expression by interacting with target DNA, RNA or proteins. Accumulating studies have demonstrated that lncRNAs and circRNAs play important role in various human diseases, including diabetes. Pancreatic β cell function is at the core of development of diabetes. This review will highlight the present knowledge about the role of lncRNAs and circRNAs in pancreatic β cell function and their association with development of diabetes.","PeriodicalId":74314,"journal":{"name":"Non-coding RNA investigation","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.21037/NCRI.2018.11.02","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45507308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Anastomotic leak: are we closer to eliminating its occurrence? 吻合口漏:我们离消除它的发生更近了吗?
Non-coding RNA investigation Pub Date : 2018-06-08 DOI: 10.21037/ALES.2018.07.07
M. Stamos, Matthew T. Brady
{"title":"Anastomotic leak: are we closer to eliminating its occurrence?","authors":"M. Stamos, Matthew T. Brady","doi":"10.21037/ALES.2018.07.07","DOIUrl":"https://doi.org/10.21037/ALES.2018.07.07","url":null,"abstract":"Anastomotic leak is one of the most fretted complications in colon and rectal surgery and its occurrence carries a significant degree of morbidity and mortality for affected patients. Given the degree of harm this complication causes patients, a significant amount of work has been done in the field to identify factors associated with anastomotic leak in an effort to minimize both its occurrence and associated morbidity.","PeriodicalId":74314,"journal":{"name":"Non-coding RNA investigation","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43598985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 9
Cancer prevention through miRNAs: miR-206 prevents the initiation and progression of hepatocellular carcinoma by attenuating c-MET signaling and cell-cycle progression via cyclin D1 and CDK6. 通过mirna预防癌症:miR-206通过减弱c-MET信号和通过cyclin D1和CDK6的细胞周期进展来阻止肝细胞癌的发生和进展。
Non-coding RNA investigation Pub Date : 2018-06-01 Epub Date: 2018-06-26 DOI: 10.21037/ncri.2018.06.05
Maxine Umeh-Garcia, Colleen Sweeney
{"title":"Cancer prevention through miRNAs: miR-206 prevents the initiation and progression of hepatocellular carcinoma by attenuating c-MET signaling and cell-cycle progression via cyclin D1 and CDK6.","authors":"Maxine Umeh-Garcia, Colleen Sweeney","doi":"10.21037/ncri.2018.06.05","DOIUrl":"https://doi.org/10.21037/ncri.2018.06.05","url":null,"abstract":"","PeriodicalId":74314,"journal":{"name":"Non-coding RNA investigation","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.21037/ncri.2018.06.05","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37536191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Identifying intronic circRNAs: progress and challenges. 识别内含子环状rna:进展与挑战。
Non-coding RNA investigation Pub Date : 2018-06-01 Epub Date: 2018-06-14 DOI: 10.21037/ncri.2018.05.06
Amaresh C Panda, Myriam Gorospe
{"title":"Identifying intronic circRNAs: progress and challenges.","authors":"Amaresh C Panda, Myriam Gorospe","doi":"10.21037/ncri.2018.05.06","DOIUrl":"https://doi.org/10.21037/ncri.2018.05.06","url":null,"abstract":"In an insightful editorial (1), Bogard and colleagues discussed a recent publication from our laboratory describing the method ‘RNase R treatment followed by Polyadenylation and poly(A) + RNA Depletion’ (RPAD) to isolate highly enriched circular RNAs (circRNAs) from heterogeneous total RNA pools (2).","PeriodicalId":74314,"journal":{"name":"Non-coding RNA investigation","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.21037/ncri.2018.05.06","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36430378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
miRNA-211 stops the clock. miRNA-211使时钟停止。
Non-coding RNA investigation Pub Date : 2018-05-01 Epub Date: 2018-05-06 DOI: 10.21037/ncri.2018.04.05
Carmit Levy, Tamar Golan, David E Fisher
{"title":"miRNA-211 stops the clock.","authors":"Carmit Levy, Tamar Golan, David E Fisher","doi":"10.21037/ncri.2018.04.05","DOIUrl":"https://doi.org/10.21037/ncri.2018.04.05","url":null,"abstract":"The endoplasmic reticulum (ER) is an essential mediator of cellular homeostasis and stress responses; it influences secreted protein synthesis, post-translation modification, and peptide folding (1).","PeriodicalId":74314,"journal":{"name":"Non-coding RNA investigation","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.21037/ncri.2018.04.05","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36477162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
A circular RNA regulator quaking: a novel gold mine to be unfolded in doxorubicin-mediated cardiotoxicity. 循环 RNA 调节器颤抖：多柔比星介导的心脏毒性中有待开发的新金矿。
Non-coding RNA investigation Pub Date : 2018-04-01 Epub Date: 2018-04-20 DOI: 10.21037/ncri.2018.04.02
Tatsuya Aonuma, Ahmed S Bayoumi, Yaoliang Tang, Il-Man Kim
{"title":"A circular RNA regulator quaking: a novel gold mine to be unfolded in doxorubicin-mediated cardiotoxicity.","authors":"Tatsuya Aonuma, Ahmed S Bayoumi, Yaoliang Tang, Il-Man Kim","doi":"10.21037/ncri.2018.04.02","DOIUrl":"10.21037/ncri.2018.04.02","url":null,"abstract":"","PeriodicalId":74314,"journal":{"name":"Non-coding RNA investigation","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6108587/pdf/nihms-984835.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36430380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
How T cells go rogue in the absence of Roquins. T细胞是如何在没有Roquins的情况下失控的。
Non-coding RNA investigation Pub Date : 2018-04-01 Epub Date: 2018-04-23 DOI: 10.21037/ncri.2018.03.08
Abdalla Akef, Stefan A Muljo
{"title":"How T cells go rogue in the absence of Roquins.","authors":"Abdalla Akef,&nbsp;Stefan A Muljo","doi":"10.21037/ncri.2018.03.08","DOIUrl":"https://doi.org/10.21037/ncri.2018.03.08","url":null,"abstract":"<p><p>Roquin-1 and Roquin-2 are RNA-binding proteins essential for modulating T cell activity. Indeed, Roquin dysfunction has been linked to autoimmunity in mice. Essig and colleagues (2017) determine their functions in Foxp3<sup>+</sup> T regulatory cells and uncover novel mechanisms of Roquin-mediated regulation of its target mRNAs (1).</p>","PeriodicalId":74314,"journal":{"name":"Non-coding RNA investigation","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.21037/ncri.2018.03.08","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36131123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Circular RNAs: a novel tool in the development of digestive system biomarker 环状rna:开发消化系统生物标志物的新工具
Non-coding RNA investigation Pub Date : 2018-03-12 DOI: 10.21037/ncri.2018.11.06
L. Xia, Meiyi Song, Fei Wang
{"title":"Circular RNAs: a novel tool in the development of digestive system biomarker","authors":"L. Xia, Meiyi Song, Fei Wang","doi":"10.21037/ncri.2018.11.06","DOIUrl":"https://doi.org/10.21037/ncri.2018.11.06","url":null,"abstract":"As a class of endogenous non-coding RNA expressed by regulatory genes, circular RNAs (circRNAs) have attracted widespread attention due to their unique closed-loop structure. CircRNAs can not only exist stably in different tissues and organs, but also widely exist in blood, exocrine, lymph, saliva and other body fluids. They are involved in the regulation of embryonic development, aging and many pathophysiological processes related to various diseases. Recently, the diagnosis and treatment of digestive diseases have made great advances due to the rapid development of fundamental research. However, most diseases are still lack of accurate early diagnosis and miss the best treatment opportunity, the concomitant complications seriously endanger human health and even lead to death. With the circRNAs becoming a hot research spot, the roles of circRNAs in digestive diseases have also been confirmed and recognized. This review mainly introduces the biological characteristics of circRNAs and their association with digestive diseases, expecting to contribute to the future research on digestive diseases and the exploration of circRNAs function.","PeriodicalId":74314,"journal":{"name":"Non-coding RNA investigation","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.21037/ncri.2018.11.06","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47334310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
CELF1 regulates gap junction integrity contributing to dilated cardiomyopathy. CELF1调节缝隙连接完整性，促进扩张性心肌病。
Non-coding RNA investigation Pub Date : 2018-03-01 Epub Date: 2018-03-07 DOI: 10.21037/ncri.2018.02.03
Danielle A Jeffrey, Carmen C Sucharov
{"title":"CELF1 regulates gap junction integrity contributing to dilated cardiomyopathy.","authors":"Danielle A Jeffrey,&nbsp;Carmen C Sucharov","doi":"10.21037/ncri.2018.02.03","DOIUrl":"https://doi.org/10.21037/ncri.2018.02.03","url":null,"abstract":"Cardiovascular disease is a major contributor of adult mortality and accounts for approximately 801,000 deaths annually throughout the United States alone (1).","PeriodicalId":74314,"journal":{"name":"Non-coding RNA investigation","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.21037/ncri.2018.02.03","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36477164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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