Maternal-fetal medicine (Wolters Kluwer Health, Inc.)最新文献

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Pregnancy With Wilson's Disease. 妊娠威尔逊氏病
Maternal-fetal medicine (Wolters Kluwer Health, Inc.) Pub Date : 2024-10-04 eCollection Date: 2024-10-01 DOI: 10.1097/FM9.0000000000000246
Meng Jin, Lihong Zhou, Chunfang Lu
{"title":"Pregnancy With Wilson's Disease.","authors":"Meng Jin, Lihong Zhou, Chunfang Lu","doi":"10.1097/FM9.0000000000000246","DOIUrl":"10.1097/FM9.0000000000000246","url":null,"abstract":"","PeriodicalId":74121,"journal":{"name":"Maternal-fetal medicine (Wolters Kluwer Health, Inc.)","volume":"6 4","pages":"265-268"},"PeriodicalIF":0.0,"publicationDate":"2024-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12094332/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144129728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessing Coarctation of the Aorta With Fetal Heart Quantification Technology. 用胎心量化技术评估主动脉缩窄。
Maternal-fetal medicine (Wolters Kluwer Health, Inc.) Pub Date : 2024-07-03 eCollection Date: 2024-07-01 DOI: 10.1097/FM9.0000000000000231
Jiaojiao Yang, Fang Tan, Yuqin Shen, Yuan Zhao, Yan Xia, Sihan Fan, Xueqin Ji
{"title":"Assessing Coarctation of the Aorta With Fetal Heart Quantification Technology.","authors":"Jiaojiao Yang, Fang Tan, Yuqin Shen, Yuan Zhao, Yan Xia, Sihan Fan, Xueqin Ji","doi":"10.1097/FM9.0000000000000231","DOIUrl":"10.1097/FM9.0000000000000231","url":null,"abstract":"<p><strong>Objective: </strong>To use fetal heart quantification (<i>fetal HQ</i>) technology to compare the coarctation of the aorta (CoA) and normal fetal heart structure and systolic function and to assess whether there are abnormalities in the fetal heart structure and systolic function associated with CoA.</p><p><strong>Methods: </strong>This prospective cohort study was conducted from May 2020 to December 2022 and involved 18-40-week-old singleton pregnancies and 30 fetuses diagnosed with CoA using fetal echocardiography at the General Hospital of Ningxia Medical University and Peking University First Hospital Ningxia Women's and Children's Hospital, China. The control group contained 60 normal fetuses. The following parameters were recorded and analyzed statistically: four-chamber view (4CV) end-diastolic long diameter, 4CV epicardial-contralateral epicardial transverse maximum diameter, 4CV global sphericity index (GSI), left ventricular (LV) and right ventricular (RV) 24-segment end-diastolic diameter (EDD), 24-segment sphericity index (SI), LV-fractional area change (LV-FAC), LV-longitudinal strain (LV-LS), RV-fractional area change (RV-FAC), RV-longitudinal strain (RV-LS), and LV and RV 24-segment transverse fractional shortening (FS). Measurement data were compared between the two groups using an independent sample <i>t</i> test, with <i>P</i> < 0.05 indicating statistically significant differences. Moreover, the correlation between gestational age and GSI, LV-FAC, LV-LS, RV-FAC, and RV-LS was assessed.</p><p><strong>Results: </strong>Within and between observer comparisons of the parameters associated with major cardiac function revealed an intragroup correlation coefficient of >0.9, indicating high consistency, and a coefficient of variable of <1%, indicating low variability. Correlation analysis revealed no obvious correlation between gestational age and GSI, LV-FAC, LV-LS, RV-FAC, and RV-LS. A comparison of the four-chamber morphological structural parameters of the hearts in the two groups revealed that when compared with the control group, the 4CV end-diastolic long diameter was shortened in fetuses in the CoA group and the epicardial-contralateral epicardial transverse maximum diameter was wider, while the GSI was lower (<i>P</i> < 0.05). A comparison of the LV and RV morphological structure parameters between the two groups revealed that when compared with the control group, the LV's 24-segment EDD was smaller in the CoA group, the RV's 24-segment EDD was greater in the control group, the SI of the LV's segments 16-24 was greater than in the control group, and the SI of the RV's segments 7-24 was less than in the control group (all <i>P</i> < 0.05). When compared with fetuses in the control group, the LV's segments 16-24 were greater in the CoA group, whereas the RV's segment 6-24 was smaller (<i>P</i> < 0.05). When compared with the control group, LV-FAC, RV-FAC, and LS were lower in the CoA group (<i>P</i> < 0.05). The FS of","PeriodicalId":74121,"journal":{"name":"Maternal-fetal medicine (Wolters Kluwer Health, Inc.)","volume":"6 3","pages":"147-155"},"PeriodicalIF":0.0,"publicationDate":"2024-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12087882/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144129575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An Imperative Role of Fetal Autopsy in Previable Fetuses - Amniotic Deformity Adhesions, Mutilations Complex. 胎儿解剖在可活胎儿中的重要作用-羊膜畸形粘连,残缺复合体。
Maternal-fetal medicine (Wolters Kluwer Health, Inc.) Pub Date : 2024-06-25 eCollection Date: 2024-07-01 DOI: 10.1097/FM9.0000000000000230
Harini Devi Jka, Nidhya Ganesan, Umamaheswari Gurusamy
{"title":"An Imperative Role of Fetal Autopsy in Previable Fetuses - Amniotic Deformity Adhesions, Mutilations Complex.","authors":"Harini Devi Jka, Nidhya Ganesan, Umamaheswari Gurusamy","doi":"10.1097/FM9.0000000000000230","DOIUrl":"10.1097/FM9.0000000000000230","url":null,"abstract":"<p><strong>Objective: </strong>To identify the occurrence of the amniotic deformity adhesions, mutilation (ADAM) complex and imperative role of fetal autopsy in diagnosing this condition.</p><p><strong>Methods: </strong>A retrospective descriptive study spanning nine years, from January 2014 to January 2022, was conducted at the Department of Pathology within a tertiary care hospital in South India. The study focused on analyzing the clinical presentation, prenatal ultrasonogram, and morphological features of fetuses with the ADAM complex, limb body wall complex, or amniotic bands.</p><p><strong>Results: </strong>Among the 438 fetuses assessed during the study period, five fetuses showed features of the ADAM complex (0.01%). The most frequent gestational age observed was 12-18 weeks and most fetuses were female. The common anomaly encountered was limb defects, followed by abdominal and cranial anomalies.</p><p><strong>Conclusion: </strong>The diagnosis of the ADAM complex relies primarily on fetal autopsy to differentiate it from similar conditions like anencephaly or body-stalk anomalies. The pathologist plays a crucial role in understanding the complexities of the ADAM complex. Advanced antenatal imaging and therapies offer potential for prevention through improved counseling.</p>","PeriodicalId":74121,"journal":{"name":"Maternal-fetal medicine (Wolters Kluwer Health, Inc.)","volume":"6 3","pages":"134-140"},"PeriodicalIF":0.0,"publicationDate":"2024-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12087891/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144129561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sudden Collapse of a Newborn Infant Following Delivery Complicated by Shoulder Dystocia. 新生儿分娩后并发肩难产的猝死。
Maternal-fetal medicine (Wolters Kluwer Health, Inc.) Pub Date : 2024-06-25 eCollection Date: 2024-07-01 DOI: 10.1097/FM9.0000000000000229
Shabih Manzar
{"title":"Sudden Collapse of a Newborn Infant Following Delivery Complicated by Shoulder Dystocia.","authors":"Shabih Manzar","doi":"10.1097/FM9.0000000000000229","DOIUrl":"10.1097/FM9.0000000000000229","url":null,"abstract":"","PeriodicalId":74121,"journal":{"name":"Maternal-fetal medicine (Wolters Kluwer Health, Inc.)","volume":"6 3","pages":"201-202"},"PeriodicalIF":0.0,"publicationDate":"2024-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12087896/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144129525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Intrauterine Treatment of Monochorionic Triamniotic Triplet Pregnancy with Twin Reverse Arterial Perfusion Sequence. 单绒毛膜三羊膜三胞胎妊娠双逆动脉灌注序列的宫内治疗。
Maternal-fetal medicine (Wolters Kluwer Health, Inc.) Pub Date : 2024-03-21 eCollection Date: 2024-04-01 DOI: 10.1097/FM9.0000000000000216
Xiaomin Zhao, Yongmei Shen, Liying Yao, Lei Zhang, Shanshan Li, Wen Li, Hong Yu, Ling Chen, Ying Chang
{"title":"Intrauterine Treatment of Monochorionic Triamniotic Triplet Pregnancy with Twin Reverse Arterial Perfusion Sequence.","authors":"Xiaomin Zhao, Yongmei Shen, Liying Yao, Lei Zhang, Shanshan Li, Wen Li, Hong Yu, Ling Chen, Ying Chang","doi":"10.1097/FM9.0000000000000216","DOIUrl":"10.1097/FM9.0000000000000216","url":null,"abstract":"","PeriodicalId":74121,"journal":{"name":"Maternal-fetal medicine (Wolters Kluwer Health, Inc.)","volume":"6 2","pages":"120-123"},"PeriodicalIF":0.0,"publicationDate":"2024-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12094394/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144129401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Maternal Group B Streptococcus Infection Correlates Inversely With Preeclampsia in Pregnant African American Women. 非裔美国孕妇B群链球菌感染与子痫前期呈负相关
Maternal-fetal medicine (Wolters Kluwer Health, Inc.) Pub Date : 2023-11-16 eCollection Date: 2024-01-01 DOI: 10.1097/FM9.0000000000000204
Keun Soo Kwon, Tzu Hsuan Cheng, Simone A Reynolds, Jordan Zhou, Huchong Cai, Sharon Lee, Ivan Velickovic, Mudar Dalloul, David Wlody, Ming Zhang
{"title":"Maternal Group B Streptococcus Infection Correlates Inversely With Preeclampsia in Pregnant African American Women.","authors":"Keun Soo Kwon, Tzu Hsuan Cheng, Simone A Reynolds, Jordan Zhou, Huchong Cai, Sharon Lee, Ivan Velickovic, Mudar Dalloul, David Wlody, Ming Zhang","doi":"10.1097/FM9.0000000000000204","DOIUrl":"10.1097/FM9.0000000000000204","url":null,"abstract":"<p><strong>Objective: </strong>To determine whether an association exists between group B Streptococcus (GBS) colonization and preeclampsia among pregnant Black women.</p><p><strong>Methods: </strong>This retrospective cross-sectional study involved Black women who gave birth at State University of New York Downstate Hospital between January 2010 and December 2017. Data were collected from the Obstetric Department, including delivery date, time, mode of delivery, age of the mother, weeks of gestation at delivery, and antepartum complications. The GBS test results were originally determined using the eSwab transport system. Preeclampsia was defined based on the American College of Obstetricians and Gynecologists criteria for the periods 2010-2012 and 2013-2017. The primary outcome was whether GBS was associated with the outcome of preeclampsia in the population of Black women. Covariates, including smoking status, gestational age, parity, body mass index, maternal age, and presence of herpes simplex virus (HSV) and human immunodeficiency virus (HIV) were examined as potential confounders. Chi-squared test and logistic regression model were used, presenting odds ratios with 95% confidence intervals (<i>P</i> < 0.050), analyzed with SAS on Demand for Academics (SAS Institute, Inc., NY).</p><p><strong>Results: </strong>Among the 8,019 Black women included in this study, GBS-positive women (<i>n</i> = 977) had a 53% reduction in the likelihood of being diagnosed with preeclampsia compared to GBS-negative women (adjusted odds ratio, 0.47; 95% confidence interval, 0.32-0.70). We did not find evidence of differences in the distribution of smoking habits (<i>P</i> = 0.783) or maternal age (<i>P</i> = 0.107) between GBS-positive and GBS-negative women. However, the GBS-positive women tended to be less likely to have a preterm delivery (9.62% (94/977) <i>vs.</i> 24.24% (1707/7042), <i>P</i> < 0.001), less likely to be nulliparous (33.37% (326/977) <i>vs.</i> 37.87% (2667/7042), <i>P</i> = 0.006), and less likely to be obese (51.38% (502/977) <i>vs.</i> 55.30% (3894/7042), <i>P</i> < 0.001) compared with GBS-negative women. In contrast, GBS-positive women were more likely to have a comorbid infection than their counterparts: HSV (5.94% (58/977) <i>vs.</i> 2.63% (185/7042), <i>P</i> < 0.001) and HIV (1.54% (15/977) <i>vs.</i> 0.82% (58/7042), <i>P</i> = 0.028).</p><p><strong>Conclusion: </strong>We found a reduced likelihood of preeclampsia among women who were positive for GBS at delivery. Given the cross-sectional nature of our study, more research is needed to further explore this association.</p>","PeriodicalId":74121,"journal":{"name":"Maternal-fetal medicine (Wolters Kluwer Health, Inc.)","volume":"6 1","pages":"23-28"},"PeriodicalIF":0.0,"publicationDate":"2023-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12094417/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144129361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pregnant Women with Severe Factor VII Deficiency Undergoing Cesarean Section Managed with a Short-Term Regimen of Recombinant Factor VIIa. 重组因子VIIa短期方案治疗严重因子VII缺乏孕妇剖宫产
Maternal-fetal medicine (Wolters Kluwer Health, Inc.) Pub Date : 2023-07-01 Epub Date: 2023-06-16 DOI: 10.1097/FM9.0000000000000194
Nathan Obore, Wan Jin, Qian Huiqin, Qian Wei, Hu Yan, Yu Hong
{"title":"Pregnant Women with Severe Factor VII Deficiency Undergoing Cesarean Section Managed with a Short-Term Regimen of Recombinant Factor VIIa.","authors":"Nathan Obore, Wan Jin, Qian Huiqin, Qian Wei, Hu Yan, Yu Hong","doi":"10.1097/FM9.0000000000000194","DOIUrl":"10.1097/FM9.0000000000000194","url":null,"abstract":"","PeriodicalId":74121,"journal":{"name":"Maternal-fetal medicine (Wolters Kluwer Health, Inc.)","volume":"5 1","pages":"195-198"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12096402/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41809379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ligation or Occlusion of the Internal Iliac Arteries for the Treatment of Placenta Accreta Spectrum: Why Is This Technique Still Performed? 髂内动脉结扎或闭塞治疗胎盘增生谱:为什么这种技术仍在使用?
Maternal-fetal medicine (Wolters Kluwer Health, Inc.) Pub Date : 2023-07-01 Epub Date: 2023-07-21 DOI: 10.1097/FM9.0000000000000195
Albaro José Nieto-Calvache, José M Palacios-Jaraquemada, Rozi Aditya Aryananda, Nicolás Basanta, Juan Manuel Burgos-Luna, Fernando Rodriguez, Carlos Ordoñez, Daniela Sarria-Ortiz, Laura Muñoz-Córdoba, Juan Carlos Quintero, Valentina Galindo-Velasco, Adriana Messa-Bryon
{"title":"Ligation or Occlusion of the Internal Iliac Arteries for the Treatment of Placenta Accreta Spectrum: Why Is This Technique Still Performed?","authors":"Albaro José Nieto-Calvache, José M Palacios-Jaraquemada, Rozi Aditya Aryananda, Nicolás Basanta, Juan Manuel Burgos-Luna, Fernando Rodriguez, Carlos Ordoñez, Daniela Sarria-Ortiz, Laura Muñoz-Córdoba, Juan Carlos Quintero, Valentina Galindo-Velasco, Adriana Messa-Bryon","doi":"10.1097/FM9.0000000000000195","DOIUrl":"10.1097/FM9.0000000000000195","url":null,"abstract":"","PeriodicalId":74121,"journal":{"name":"Maternal-fetal medicine (Wolters Kluwer Health, Inc.)","volume":"5 1","pages":"131-136"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12096400/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41636925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Care Bundles: Enhanced Recovery After Delivery. 护理包:增强产后恢复
Maternal-fetal medicine (Wolters Kluwer Health, Inc.) Pub Date : 2023-07-01 Epub Date: 2023-01-05 DOI: 10.1097/FM9.0000000000000178
Ling-Qun Hu, Plato J Lysandrou, Rebecca Minehart, Jing-Ping Wang, Yun Xia, Yiling Hu, Brett Worly
{"title":"Care Bundles: Enhanced Recovery After Delivery.","authors":"Ling-Qun Hu, Plato J Lysandrou, Rebecca Minehart, Jing-Ping Wang, Yun Xia, Yiling Hu, Brett Worly","doi":"10.1097/FM9.0000000000000178","DOIUrl":"10.1097/FM9.0000000000000178","url":null,"abstract":"<p><p>The care of obstetrics patients has improved dramatically over the past few decades. Unfortunately, rates of cesarean section remain high, and decreasing this rate requires close care and follow-up in the prenatal outpatient setting. Counseling regarding cesarean delivery and vaginal delivery is imperative. Opportunities still exist in helping patients objectively weigh the decision for cesarean delivery versus vaginal delivery. Additional developments have occurred in the intrapartum and the postpartum setting, with an aim to improve patient and neonatal outcomes. Changes have been implemented for patients undergoing cesarean delivery including preoperative and intraoperative treatment of pain, nausea, and vomiting, as well as postoperative care bundles that improve patient outcomes. Innovations have also occurred in the care of postpartum patients after vaginal delivery, again with improvements in patient outcomes. This article summarizes the current evidence, provides care recommendations, and identifies the next steps in improving obstetrics care.</p>","PeriodicalId":74121,"journal":{"name":"Maternal-fetal medicine (Wolters Kluwer Health, Inc.)","volume":"5 1","pages":"155-162"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12096399/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42695755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Conservative Treatment of Fetal Goitrous Hypothyroidism Due to Thyroglobulin Mutations: A Case Report and Literature Review. 甲状腺球蛋白突变致胎儿甲状腺功能减退症的保守治疗1例并文献复习
Maternal-fetal medicine (Wolters Kluwer Health, Inc.) Pub Date : 2023-07-01 Epub Date: 2023-05-18 DOI: 10.1097/FM9.0000000000000191
Shiping Liu, Wei Bai, Ying Gao, Chunyan Shi, Lixin Fan, Junya Chen, Jian Shi, Weijie Sun, Xinlin Hou, Huixia Yang
{"title":"Conservative Treatment of Fetal Goitrous Hypothyroidism Due to Thyroglobulin Mutations: A Case Report and Literature Review.","authors":"Shiping Liu, Wei Bai, Ying Gao, Chunyan Shi, Lixin Fan, Junya Chen, Jian Shi, Weijie Sun, Xinlin Hou, Huixia Yang","doi":"10.1097/FM9.0000000000000191","DOIUrl":"10.1097/FM9.0000000000000191","url":null,"abstract":"<p><p>With the advances in fetal medicine, there will be more cases of congenital hypothyroidism (CH) diagnosed in the fetal period. However, there is no consensus on the management protocol. We present a successful case of conservatively managed fetal goitrous hypothyroidism due to compound heterozygous <i>TG</i> mutations. Goiter was observed in a fetus at 23 weeks of gestation. Because there was no evidence of transplacental passage of antithyroid antibody and drugs, iodine overload, and iodine deficiency, the fetus was highly suspected to have CH. Considering the potential risks of amniocentesis/cordocentesis, and lack of available parenteral levothyroxine in China, the fetus was closely monitored thereafter. A male neonate was delivered vaginally without complications at 39 weeks of gestation. We verified severe hypothyroidism in the infant and immediately initiated levothyroxine therapy. His growth and mental development were normal at the age of 8 month. Whole-exome sequencing showed that the neonate had two compound heterozygous mutations in the <i>TG</i> gene. We also performed a literature review of the prognosis of postnatal treatment of CH due to <i>TG</i> mutations and the result showed that postnatal treatment of CH due to <i>TG</i> mutations has a favorable prognosis. However, further prospective studies are warranted to verify this conclusion.</p>","PeriodicalId":74121,"journal":{"name":"Maternal-fetal medicine (Wolters Kluwer Health, Inc.)","volume":" ","pages":"182-186"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12096404/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43914481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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