Endocrine development最新文献

Transitions in Care from Pediatric to Adult Health Care Providers: Ongoing Challenges and Opportunities for Young Persons with Diabetes. 从儿科到成人医疗保健提供者的护理转变:对年轻糖尿病患者的持续挑战和机遇。

Endocrine development Pub Date : 2018-01-01 Epub Date: 2018-06-08 DOI: 10.1159/000487866

Katharine Garvey, Lori Laffel

{"title":"Transitions in Care from Pediatric to Adult Health Care Providers: Ongoing Challenges and Opportunities for Young Persons with Diabetes.","authors":"Katharine Garvey, Lori Laffel","doi":"10.1159/000487866","DOIUrl":"https://doi.org/10.1159/000487866","url":null,"abstract":"Adolescence and young adulthood are times of multiple developmental changes, including physiological, social, emotional, cognitive, and behavioral transformations. The adolescent or young adult living with type 1 or type 2 diabetes must navigate the vicissitudes of these developmental stages while managing the rigors and self-care demands of these conditions. Diabetes in children is managed by adults, mainly by parents. As the child matures, diabetes management tasks transition from parents to the developing teen. This transition in care is a process that generally begins in early adolescence and culminates when the older teen successfully accepts and manages diabetes self-care tasks. Along with the transitions in diabetes management tasks, older teens and young adults must be prepared for transfer from the pediatric diabetes care team to an adult-focused health care team. Numerous publications have described the challenges associated with both the process of transition and the act of transfer. Lack of preparation during transition followed by unsuccessful transfer often results in gaps in diabetes care exceeding 6 months, deterioration in glycemic control, increase in emergency room use and hospitalization, and emergence of diabetes complications among older teens and young adults. There is need for ongoing research internationally to address these deficiencies in order to improve the short- and long-term health of young persons with diabetes.","PeriodicalId":72906,"journal":{"name":"Endocrine development","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000487866","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36209341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Transition of Care from Childhood to Adulthood: Turner Syndrome. 从童年到成年的照顾过渡:特纳综合症。

Endocrine development Pub Date : 2018-01-01 Epub Date: 2018-06-08 DOI: 10.1159/000487524

Gerard Conway

引用次数: 2

Transition of Care from Childhood to Adulthood: Congenital Hypogonadotropic Hypogonadism. 从儿童期到成年期护理的过渡:先天性促性腺功能减退症。

Endocrine development Pub Date : 2018-01-01 Epub Date: 2018-06-08 DOI: 10.1159/000487527

Andrew A Dwyer, Nelly Pitteloud

{"title":"Transition of Care from Childhood to Adulthood: Congenital Hypogonadotropic Hypogonadism.","authors":"Andrew A Dwyer, Nelly Pitteloud","doi":"10.1159/000487527","DOIUrl":"https://doi.org/10.1159/000487527","url":null,"abstract":"Passage from childhood to adult life involves biological changes culminating in full reproductive capacity as well as psychosocial development. For patients with congenital hypogonadotropic hypogonadism (CHH), this can be an emotionally challenging time as their pubertal failure results in striking physical differences from their peers. CHH is difficult to differentiate from common disorders of puberty such as constitutional delay of growth and puberty. As such, delays in diagnosis are frequent, and it is a common source of stress and frustration for these adolescents. While effective treatments are available for inducing puberty and attaining fertility is possible in most cases, patients may find it difficult to cope with living with CHH. A critical issue for adolescents with CHH is the risk for being lost to follow-up during the transition from pediatric-centered care to adult care. This article will review the state of the art in diagnosis and treatment of patients with CHH with a particular focus on supporting an effective transition from pediatric-centered care to adult-oriented endocrine services. A synthesis of best practices is offered to help guide clinicians in supporting patients and families during this challenging period of care.","PeriodicalId":72906,"journal":{"name":"Endocrine development","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000487527","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36208806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

"Child-Adult" Transition - Adolescence: When Illness Appears…. “儿童-成人”过渡-青春期:当疾病出现....

Endocrine development Pub Date : 2018-01-01 Epub Date: 2018-06-08 DOI: 10.1159/000487522

Sabine Malivoir, Karinne Gueniche

引用次数: 1

Transition in Pediatric and Adolescent Hypogonadal Girls: Gynecological Aspects, Estrogen Replacement Therapy, and Contraception. 儿童和青春期性腺功能低下女孩的转变:妇科方面，雌激素替代疗法和避孕。

Endocrine development Pub Date : 2018-01-01 Epub Date: 2018-06-12 DOI: 10.1159/000487529

Anette Tønnes Pedersen, Line Cleemann, Katharina M Main, Anders Juul

{"title":"Transition in Pediatric and Adolescent Hypogonadal Girls: Gynecological Aspects, Estrogen Replacement Therapy, and Contraception.","authors":"Anette Tønnes Pedersen, Line Cleemann, Katharina M Main, Anders Juul","doi":"10.1159/000487529","DOIUrl":"https://doi.org/10.1159/000487529","url":null,"abstract":"Hypogonadism may be suspected if puberty is delayed. Pubertal delay may be caused by a normal physiological variant, by primary ovarian insufficiency (Turner syndrome), or reflect congenital hypogonadotropic hypogonadism (HH; genetic) or acquired HH (brain lesions). Any underlying chronic disease like inflammatory bowel disease, celiac disease, malnutrition (anorexia or orthorexia), or excessive physical activity may also result in functional HH. Thus, girls with delayed puberty should be evaluated for an underlying pathology before any treatment, including oral contraception, is initiated. Estrogen replacement is important and natural 17β-estradiol, preferably transdermally, is the preferred choice, whereas the oral route can be used as an alternative depending on patient preference and compliance. Sexual activity is often delayed in the hypogonadal adolescent girl. In the adolescent hypogonadal girl, hormone replacement therapy (HRT) most likely has been initiated at the time she becomes sexually active. If a risk of unwanted pregnancy cannot be ruled out, there is a need to consider contraception. This consideration does not contradict the principles of HRT but can be included as a part of the substitution, e.g. oral contraceptives containing 17β-estradiol or a progestogen intrauterine device combined with continuous 17β-estradiol (transdermal or oral).","PeriodicalId":72906,"journal":{"name":"Endocrine development","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000487529","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36215684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Fertility Preservation in Endocrine Disorders during Transition for Girls. 女孩过渡期内分泌失调的生育能力保存。

Endocrine development Pub Date : 2018-01-01 Epub Date: 2018-06-08 DOI: 10.1159/000487530

Julie Bénard, Nathalie Sermondade, Michaël Grynberg

引用次数: 2

Transition of Care from Childhood to Adulthood: Congenital Adrenal Hyperplasia. 从童年到成年护理的过渡:先天性肾上腺增生。

Endocrine development Pub Date : 2018-01-01 Epub Date: 2018-06-08 DOI: 10.1159/000487523

Anne Bachelot

{"title":"Transition of Care from Childhood to Adulthood: Congenital Adrenal Hyperplasia.","authors":"Anne Bachelot","doi":"10.1159/000487523","DOIUrl":"https://doi.org/10.1159/000487523","url":null,"abstract":"Deficiency of the 21-hydroxylase enzyme is the most common form of congenital adrenal hyperplasia (CAH), accounting for more than 95% of the cases. With the advent of newborn screening and hormone replacement therapy, most children with CAH survive into adulthood. Adolescents and adults with CAH experience a number of complications, including short stature, obesity, infertility, impaired bone mineral density, and reduced quality of life. Transition from pediatric to adult care and management of long-term complications are challenging for both patients and practitioners. In adulthood, the aims of the medical treatment are to substitute cortisol and, when necessary, aldosterone deficiency, to ensure normal fertility, and to avoid the long-term consequences of glucocorticoid use on bone, metabolism, and cardiovascular risk. Recent data suggest that poor health status is likely to begin in adolescence and persist into adulthood, highlighting the importance of this time period in a patient's endocrine care. During transition from pediatric to adult specific care, a shift in treatment goals is thus needed. Successful transition from pediatric to adult health care requires a regular follow-up of patients by a multidisciplinary team including pediatric endocrinologists, urologists, gynecologists, psychiatrists, and adult endocrinologists. All of this could be included in a specific therapeutic education program regarding transition and/or CAH.","PeriodicalId":72906,"journal":{"name":"Endocrine development","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000487523","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36209418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14

Fertility Preservation in Klinefelter Syndrome Patients during the Transition Period. Klinefelter综合征患者过渡期生育能力的保存。

Endocrine development Pub Date : 2018-01-01 Epub Date: 2018-06-08 DOI: 10.1159/000487531

Nathalie Rives, Aurélie Rives, Christine Rondanino, Mireille Castanet, Ariane Cuny, Louis Sibert

{"title":"Fertility Preservation in Klinefelter Syndrome Patients during the Transition Period.","authors":"Nathalie Rives, Aurélie Rives, Christine Rondanino, Mireille Castanet, Ariane Cuny, Louis Sibert","doi":"10.1159/000487531","DOIUrl":"https://doi.org/10.1159/000487531","url":null,"abstract":"Spermatozoa have occasionally been identified in ejaculate of adult Klinefelter syndrome (KS) patients but very exceptionally in KS adolescents. Spermatozoa can also be retrieved in testicular tissue of KS adolescents. The testis may also harbor spermatogonia and noncompletely differentiated germ cells. Neither clinical features nor hormonal parameters could predict germ cell recovery in KS adults or adolescents. No predictive factors can actually demonstrate that early diagnosis of KS would allow increasing the chance of sperm retrieval even if it has been suggested that semen quality may decline with age in KS patients. Leydig cell dysfunction may also be another factor that might affect the spermatogenesis process in XXY adolescents. Fertility preservation might be preferentially proposed in KS adolescents when semen sampling is possible, when the patient is able to consider alternative options to become a father, and to accept germ cell retrieval failure. However, precocious diagnosis of KS has also to be considered because it might not solely improve the possibility of fertility preservation after the onset of puberty, but also the medical care and the quality of life of these patients.","PeriodicalId":72906,"journal":{"name":"Endocrine development","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000487531","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36209415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Challenges of the Transition from Pediatric Care to Care of Adults: "Say Goodbye, Say Hello". 从儿科护理过渡到成人护理的挑战:“说再见，说你好”。

Endocrine development Pub Date : 2018-01-01 Epub Date: 2018-06-08 DOI: 10.1159/000487521

Philippe Touraine, Michel Polak

引用次数: 7

Growth Hormone Deficiency in the Transition Age. 过渡年龄的生长激素缺乏。

Endocrine development Pub Date : 2018-01-01 Epub Date: 2018-06-08 DOI: 10.1159/000487525

Sandro Loche, Natascia Di Iorgi, Giuseppa Patti, Serena Noli, Marta Giaccardi, Irene Olivieri, Anastasia Ibba, Mohamad Maghnie

{"title":"Growth Hormone Deficiency in the Transition Age.","authors":"Sandro Loche, Natascia Di Iorgi, Giuseppa Patti, Serena Noli, Marta Giaccardi, Irene Olivieri, Anastasia Ibba, Mohamad Maghnie","doi":"10.1159/000487525","DOIUrl":"https://doi.org/10.1159/000487525","url":null,"abstract":"Growth hormone (GH) is essential not only for normal growth during childhood, but also for the acquisition of bone mass and muscle strength in both sexes. This process is completed after the achievement of adult height in the phase of transition from adolescence to adulthood. Adolescents with childhood onset GH deficiency (GHD) show reduction of bone mineral density, decrease in lean body mass, increase in fat mass, and deterioration of the lipid profile. For this reason, continuation of GH replacement therapy in the transition age is recommended in all patients with a confirmed diagnosis of GHD. To confirm the diagnosis of GHD, GH treatment should be discontinued for at least 1 month after the attainment of adult height, and the patient should be re-evaluated for GH secretion. Current guidelines indicate that retesting is not required for those with a transcription factor mutation, more than 3 pituitary hormone deficits, or isolated GHD associated with an identified mutation. The key predictors of persistent GHD are its severity, the presence of additional pituitary hormone deficits, low insulin-like growth factor I (IGF-I) concentration, and the presence of structural hypothalamic-pituitary abnormalities Treatment should be initiated with a low dose (0.2-0.5 mg/day s.c.) and then adjusted according to IGF-I concentrations.","PeriodicalId":72906,"journal":{"name":"Endocrine development","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000487525","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36209413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11