Blockchain in healthcare today最新文献

{"title":"Model Complexity Reduction for ZKML Healthcare Applications: Privacy Protection and Inference Optimization for ZKML Applications-A Reference Implementation With Synthetic ICHOM Dataset.","authors":"Sathya Krishnasamy, Ilangovan Govindarajan","doi":"10.30953/bhty.v7.340","DOIUrl":"10.30953/bhty.v7.340","url":null,"abstract":"<p><p>Web 3.0 represents the next significant evolution of the internet that embodies the underlying decentralized network architectures, distributed ledgers, and advanced AI capabilities. Though the technologies are maturing rapidly, considerable barriers exist to high-scale adoption. The author discusses the barriers and the mitigations through specific technologies maturing to solve those issues in an earlier paper titled Moving Beyond POCs and Pilots, published in 2023 in Blockchain in Healthcare Today. These include privacy-preserving technologies, off-chain and on-chain design optimizations, and the multi-dimensional approach needed in planning and adopting these technologies. As an extension, this paper discusses one such enabler, zero knowledge machine learning (ZKML), which merges two streams of technology in unique ways to address problems in privacy and the cost of inference. Zero-knowledge proofs (ZKP) allow one party to prove the validity of a statement to another party without revealing any additional information about the statement itself. The ZKML combines the cryptographic principle of ZKP with machine learning (ML) techniques. It is still a maturing technology and needs baselines for applications in global healthcare. In this effort, the authors conceptualize the technical and operational feasibility of using ZKML and implement a reference healthcare implementation using the synthetic International Consortium for Health Outcomes Measurement (ICHOM) in the evaluation phase in a global healthcare setting for high-volume data collection, including patient-reported outcomes. Model complexity reduction is researched and reported for the ICHOM diabetes dataset to advance the usage of ML models in global standards of healthcare data collection in network decentralized architectures for increased data protection and efficiencies.</p>","PeriodicalId":72422,"journal":{"name":"Blockchain in healthcare today","volume":"7 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11624495/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142796666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Blockchain's Transformative Potential in Healthcare.","authors":"Geetika Jain, Nishant Kumar, Colin Rigby","doi":"10.30953/bhty.v7.336","DOIUrl":"10.30953/bhty.v7.336","url":null,"abstract":"<p><p>Blockchain's transformative potential, its current applications, and the path forward for its integration into the healthcare ecosystem are all explored in the journal Blockchain in Healthcare Today. The healthcare industry is facing significant challenges and opportunities after COVID-19. As we navigate the complexities of increasing healthcare costs and technological updates for better patient outcomes, innovative technologies are emerging as pivotal tools for healthcare transformation. Healthcare digital platforms have witnessed revolutionizing the dynamics of healthcare systems using disruptive technologies. However, while these technologies have garnered extensive attention for their transformative potential, there remains a critical gap in our understanding of the impact of digital technology on the healthcare industry. Population health management has critical challenges in data protection, sharing, and interoperability, where personalized medicines and wearable devices are highlighted as a concern. Patients and medical personnel need a safe and simple way to record, transmit, or access information through networks without concern for their safety. Using blockchain technology can help address these problems. Blockchain technology enhances medical data security by providing a decentralized, immutable ledger that ensures data integrity, transparency, and privacy. It enables fine-grained access control, improves interoperability, and resists cyber-attacks. Streamlining regulatory compliance allows patients and medical personnel to safely record, transmit, and access sensitive information across networks.</p>","PeriodicalId":72422,"journal":{"name":"Blockchain in healthcare today","volume":"7 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11624497/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142796659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Leveraging Decentralized Clinical Trial Management Systems (dCTMS) to Advance Science: Exploring Challenges Related to the Diffusion of Innovation and Its Execution.","authors":"Rama Krishna Rao","doi":"10.30953/bhty.v7.305","DOIUrl":"10.30953/bhty.v7.305","url":null,"abstract":"<p><p>Decentralized clinical trials (DCTs) recently gained attention in research necessary for drug development. While the COVID-19 pandemic proved to be a challenging time in this arena, drug development was a critical area of emphasis in the rapid advancement of vaccines. The DCTs were necessary to allow research activities to occur across many locations. The use of DCTs can profoundly impact reshaping healthcare by enabling participants to partake in clinical trials remotely; however, implementation challenges must be considered as technology expands. A working group of participants was assembled during an interactive learning exercise at the Conv2X conference (2023) to explore challenges related to the diffusion of innovation among key stakeholders. Pain points experienced with using and implementing technologies were identified, and an innovative solution using a blockchain-anchored option was presented. Participants were divided into three stakeholder groups: patients, payers, and pharmaceutical sponsors. After a time of discussion, the groups reconvened for review. Several themes that can be supported by blockchain technology emerged. These include enhanced efficiencies, patient experience, and demographic diversity, as well as data integrity, privacy, security, and cost-effectiveness. Future research might focus on strategies to facilitate the adoption of the idea across key stakeholder groups.</p>","PeriodicalId":72422,"journal":{"name":"Blockchain in healthcare today","volume":"7 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11073476/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140878046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emerging Trends in Cybersecurity: A Holistic View on Current Threats, Assessing Solutions, and Pioneering New Frontiers.","authors":"Taskeen Zaid, Suman Garai","doi":"10.30953/bhty.v7.302","DOIUrl":"https://doi.org/10.30953/bhty.v7.302","url":null,"abstract":"<p><p>In an era dominated by digital advancements, cybersecurity plays a pivotal role in safeguarding information and systems from evolving threats. The escalating sophistication of cyber threats necessitates a critical examination of the efficacy of contemporary defenses. Recognizing the limitations and gaps in current solutions, this research introduces a pioneering framework aimed at fortifying cyber defenses. Motivated by a comprehensive exploration of research articles, surveys, online media, and practical studies, this study scrutinizes the intricacies of cyber threats and assesses the strengths and weaknesses of existing solutions. The proposed frameworks emerge from a meticulous feasibility and practicality study, leveraging insights garnered from diverse online sources. The \"how\" encompasses a comparative analysis, evaluating the novel framework against established solutions to delineate their respective merits and shortcomings. The impetus behind this research lies in offering valuable insights to researchers, practitioners, and policymakers grappling with the multifaceted challenges of cybersecurity. By navigating through the complexities of existing solutions and introducing innovative frameworks, this paper aims to guide efforts in bolstering cyber defenses. Ultimately, this research envisions a continuous cycle of improvement and evolution in the realm of cybersecurity as stakeholders collectively strive to adapt to the ever-changing digital threat landscape.</p>","PeriodicalId":72422,"journal":{"name":"Blockchain in healthcare today","volume":"7 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11073482/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140878044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-Fungible Tokens for Organoids: Decentralized Biobanking to Empower Patients in Biospecimen Research.","authors":"William Sanchez, Larue Linder, Robert C Miller, Amelia Hood, Marielle S Gross","doi":"10.30953/bhty.v7.303","DOIUrl":"10.30953/bhty.v7.303","url":null,"abstract":"<p><strong>Introduction: </strong>Scientists use donated biospecimens to create organoids, which are miniature copies of patient tumors that are revolutionizing precision medicine and drug discovery. However, biobanking platforms remove donor identifiers to protect privacy, precluding patients from benefiting from their contributions or sharing information that may be relevant to research outcomes. Decentralized biobanking (de-bi) leverages blockchain technology to empower patient engagement in biospecimen research. We describe the creation of the first de-bi prototype for an organoid biobanking use case.</p><p><strong>Methods: </strong>We designed and developed a proof-of-concept non-fungible tokens (NFTs) framework for an organoid research network of patients, physicians, and scientists within a synthetic dataset modeled on a real-world breast cancer organoid ecosystem. Our implementation deployed multiple smart contracts on Ethereum test networks, minting NFTs representing each stakeholder, biospecimen, and organoid. The system architecture was designed to be composable with established biobanking programs.</p><p><strong>Results: </strong>Our de-bi prototype demonstrated how NFTs representing patients, physicians, scientists, and organoids may be united in a privacy-preserving platform that builds upon relationships and transactions of existing biobank research networks. The mobile application simulated key features, enabling patients to track their biospecimens, view organoid images and research updates from scientists, and allow physicians to participate in peer-to-peer communications with basic scientists and patients alike, all while ensuring compliance with de-identification requirements.</p><p><strong>Discussion: </strong>We demonstrate proof-of-concept for a web3 platform engaging patients, physicians, and scientists in a dynamic research community, unlocking value for a model organoid ecosystem. This initial prototype is a critical first step for advancing paradigm-shifting de-bi technology that provides unprecedented transparency and suggests new standards for equity and inclusion in biobanking. Further research must address feasibility and acceptability considering the ethical, legal, economic, and technical complexities of organoid research and clinical translation.</p>","PeriodicalId":72422,"journal":{"name":"Blockchain in healthcare today","volume":"7 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11073479/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140878047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Crypto-Secure Data Management for Healthcare","authors":"Wei Hu","doi":"10.30953/bhty.v7.315","DOIUrl":"https://doi.org/10.30953/bhty.v7.315","url":null,"abstract":"Blockchain is a new technology that has attracted a tremendous amount of interest. However, up to now, blockchain has mainly been used to develop decentralized multi-party applications. This presentation describes breakthrough technology that deeply integrates blockchain into the Oracle database. Since virtually all critical data are stored in databases, this makes it possible to implement blockchain in mainstream healthcare and enterprise applications with minimal changes. We will begin by introducing the threats posed by hackers and compromised insiders. Then we will describe how in-database blockchain can protect data against these threats, comparing this against conventional blockchains. Use cases are shared from customers that have adopted this technology. \u0000Learning Objectives \u0000 \u0000Understand the concepts behind crypto-security and the threats it addresses \u0000Explore the challenges of the adoption of blockchain \u0000Learn how database-integrated blockchain can be used to protect critical data against tampering \u0000What are the advantages and disadvantages of a database-integrated blockchain? \u0000Get an understanding of the types of healthcare data that can be protected using blockchain \u0000","PeriodicalId":72422,"journal":{"name":"Blockchain in healthcare today","volume":"40 23","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140656993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Harnessing Blockchain to Transform Healthcare Data Management","authors":"Horst Treiblmaier, Abderahman Rejeb, Mike Gault, Anjum Khurshid, Alex Norta, Jim Poteet, Suresh Sivagnanam","doi":"10.30953/bhty.v7.301","DOIUrl":"https://doi.org/10.30953/bhty.v7.301","url":null,"abstract":"The proper management of healthcare data is a complex endeavor that needs to balance the requirements and interests of many stakeholders. Previous research has identified and detailed many innovative blockchain-based use cases, but the current state of healthcare data management is still far from perfect. In this paper we present the findings from a panel discussion with healthcare professionals, who elaborate on the current situation in healthcare data management as well as the future role that blockchain can play in this sector. Based on the findings of this panel, we structure the research field of healthcare data management in a comprehensive framework and provide numerous avenues for future research. The outcome is a framework that highlights the important role of patients and their sensitive data, structured into several areas. From a patients’ perspective, we specifically elaborate on trust and privacy as well as the expected benefits. Additionally, four important data properties are identified: integrity, security, sharing and transfer, and interoperability. We outline the importance of the respective areas and derive several timely and important research questions that form the foundation of a future research agenda for blockchain-driven innovation in healthcare data management.","PeriodicalId":72422,"journal":{"name":"Blockchain in healthcare today","volume":"88 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140665207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Blockchain in Health - From Pilots to Mainstream and Implications for AI","authors":"Sathya Krishnasamy, MS, Badri Gopalakrishnan, PhD, Atul Apte, BSc, MODERATOR: Anjum Khurshid, MD, PhD","doi":"10.30953/bhty.v7.309","DOIUrl":"https://doi.org/10.30953/bhty.v7.309","url":null,"abstract":"Speakers delve into and beyond the previously published BHHTY journal article “Moving Beyond Proof of Concept and Pilots to Mainstream: Discovery and Lessons from Blockchain in Healthcare,” located at https://doi.org/10.30953/bhty.v6.280. This continuous enterprise blockchain technology journey extends the framework and solution assemblies including further developments, with cross over into generative AI and ethics. \u0000Objectives \u0000 \u0000Learn specific examples on the economics of blockchain revealing low-hanging fruit for the move from pilots to adoption. Explore concepts such as: \u0000 \u0000 \u0000Data integrity, minimal data, inter-entity streamlining leading to efficiencies, and what is already possible with tech stack developments and economics in efficiency (in millions) from the previously published BHTY article at DOI: https://doi.org/10.30953/bhty.v6.280 \u0000Learn from other verticals to build a framework that is more comprehensive encompassing global perspectives \u0000Future proofing and stair-stepping design for an evolving technology – holistic guidance to find and execute the opportunities \u0000 \u0000 \u0000Obtain a framework for blockchain adoption based on the article. In addition, authors address the academic view of blockchain adoption, and that it is a combination of tech, policy, economics, consumer engagement, and operationalization. \u0000Acquire multi-dimensional discovery and specific blockchain constructs including provenance- consensus, trust maps, convergence, dApp human loops, and future proofing /stair-stepping \u0000Grasp global perspectives on evolving frameworks with in many verticals and the multi-dimensional nature of blockchain transformation, operationalization, blockchain-enterprise landscape, and AI automation. \u0000Gain a better understanding of why is blockchain an essential technology for the future of responsible AI and for scalability of solutions \u0000","PeriodicalId":72422,"journal":{"name":"Blockchain in healthcare today","volume":"107 16","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140678928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EHR Systems and Blockchain: Potentials, Challenges and the Road Ahead","authors":"Jim Poteet, Mike Gault, Anjum Khurshid, MD, PhD, Suresh Sivagnanam, Alex Norta, PhD, Moderator: Horst Treiblmaier, PhD","doi":"10.30953/bhty.v7.312","DOIUrl":"https://doi.org/10.30953/bhty.v7.312","url":null,"abstract":"Panelists discuss blockchain technology use for electronic health records, and specifically delve into the benefits that blockchain brings to EHRs, but also discuss what its pitfalls and limitations are; including presenting perspectives from academia, and examplesfrom practitioners. \u0000Learning Objectives \u0000 \u0000Understand the potential applications of blockchain for electronic health records (EHRs). \u0000Explore the benefits and challenges of implementing blockchain for EHRs, including security, interoperability, privacy, and data integrity. \u0000Identify key use cases and real-world examples of blockchain implementation in healthcare and EHR management. \u0000Analyze the potential impact of blockchain on improving healthcare data exchange, patient consent management, and medical research. \u0000Discuss the regulatory and legal considerations associated with using blockchain in healthcare, such as compliance with data protection laws and standards. \u0000Examine the role of smart contracts and decentralized applications (DApps) in enhancing EHR management and patient control over their health information. \u0000Assess the scalability and performance limitations of blockchain technology in handling large-scale healthcare data and high transaction volumes. \u0000Evaluate potential cost savings and efficiency gains achieved through blockchain implementation in EHRs, considering factors such as data access, auditability, and administrative overhead. \u0000Discuss the future prospects and challenges of integrating blockchain with existing healthcare systems, standards, and infrastructure to achieve widespread adoption and interoperability. \u0000","PeriodicalId":72422,"journal":{"name":"Blockchain in healthcare today","volume":" 21","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140681165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pioneering New Business Models in Value Based Care","authors":"Ahmed Abdulla","doi":"10.30953/bhty.v7.318","DOIUrl":"https://doi.org/10.30953/bhty.v7.318","url":null,"abstract":"\u0000  \u0000 \u0000This session will explore the real-world impact value-based procurement and subsequent contracting, and health technology pricing in the context of value-based care. We will delve into innovative business models that are reshaping the healthcare landscape, promoting cost-effectiveness, and enhancing patient outcomes. Attendees will gain valuable insights into the evolving strategies driving value-based care and its implications for healthcare providers, payers, and patients. \u0000Learning Objectives \u0000 \u0000Understand the concept of value-based care and its significance in the current healthcare environment \u0000Explore the real-world impact of value-based pricing on healthcare delivery and patient outcomes \u0000Examine the role of value-based procurement/contracting in driving cost-effective healthcare solutions \u0000Gain insights into health technology pricing models and their impact on value-based care initiatives \u0000Identify innovative business models that support value-based care and improve patient outcomes \u0000","PeriodicalId":72422,"journal":{"name":"Blockchain in healthcare today","volume":" 1037","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140682312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}