Acta physiologica Scandinavica最新文献_第3页

Differential titin isoform expression in human skeletal muscle. 人骨骼肌中titin异构体的差异表达。

Acta physiologica Scandinavica Pub Date : 1995-05-01 DOI: 10.1249/00005768-199505001-00545

A. Fry, R. Staron, C. James, R. S. Hikida, F. Hagerman

{"title":"Differential titin isoform expression in human skeletal muscle.","authors":"A. Fry, R. Staron, C. James, R. S. Hikida, F. Hagerman","doi":"10.1249/00005768-199505001-00545","DOIUrl":"https://doi.org/10.1249/00005768-199505001-00545","url":null,"abstract":"Mammalian skeletal muscle expresses at least two isoforms of the cytoskeletal protein titin (connectin; MW approximately 3000 kDa). These isoforms are associated with different passive force curves, and thus may affect physical performance. To study the distribution of titin and its possible influence on performance in humans, muscle biopsies were obtained from 15 males (mean +/- SE; age = 25.4 +/- 2.9 years, height = 177.7 +/- 1.8 cm, weight = 76.5 +/- 2.2 kg). Two biopsies were obtained on separate occasions from both the right and left vastus lateralis, and one biopsy each from the lateral head of the right gastrocnemius and the right soleus, with all biopsies handled identically. Fibre type analyses were performed via mATPase histochemistry. Expression of titin and myosin heavy chain isoforms were determined by SDS-PAGE. Titin bands in the resulting gels were highly repeatable and were verified by migration patterns, as well as Western blot analysis. Two groups of subjects were identified: group 1 (n = 10) expressed only one titin isoform (titin-1) in all biopsies, and group 2 (n = 5) expressed two titin isoforms (titin-1 and titin-2) in all biopsies. No significant differences (P > 0.05) between groups were observed for percentage fibre types, percentage fibre type areas, fibre type cross-sectional areas, and percentage myosin heavy chain expression when comparing individual muscles, sampling times or bilateral comparisons. This is the first report of differential titin isoform expression in healthy, mature human skeletal muscle, but it is not clear why this occurs or what influence this may have on performance.","PeriodicalId":7160,"journal":{"name":"Acta physiologica Scandinavica","volume":"6 1","pages":"473-9"},"PeriodicalIF":0.0,"publicationDate":"1995-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84745517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

The rights of humans and other animals. 人类和其他动物的权利。

Acta physiologica Scandinavica Pub Date : 1986-01-01 DOI: 10.4324/9781315244426-49

T. Regan

引用次数: 4

Application of knowledge of metabolic integration to the problem of metabolic limitations in middle distance and marathon running. 代谢综合知识在中长跑和马拉松中代谢限制问题中的应用。

Acta physiologica Scandinavica Pub Date : 1986-01-01 DOI: 10.1159/000416276

Newsholme Ea

引用次数: 18

On the mechanism of barbiturate action on potassium channels in the nerve membrane. 巴比妥酸盐作用于神经膜钾通道的机制。

Acta physiologica Scandinavica Pub Date : 1985-03-01

P Arhem, H Kristbjarnarson

引用次数: 0

Morphology of the brachial biceps muscle and elbow flexion in man. 人肱二头肌形态与肘关节屈曲。

Acta physiologica Scandinavica Pub Date : 1983-01-01 DOI: 10.1249/00005768-198101320-00098

E. Nygaard, M. Houston, Y. Suzuki, K. Jørgensen, B. Saltin

{"title":"Morphology of the brachial biceps muscle and elbow flexion in man.","authors":"E. Nygaard, M. Houston, Y. Suzuki, K. Jørgensen, B. Saltin","doi":"10.1249/00005768-198101320-00098","DOIUrl":"https://doi.org/10.1249/00005768-198101320-00098","url":null,"abstract":"This study was undertaken to determine whether skeletal muscle fibre characteristics could be demonstrated to be of significance for muscle function in voluntary contraction in man. 4 male and 4 female adult subjects were studied. During elbow flexion force and velocity was measured at the hand with the forearm in a 100 degree position. A motor-driven heavy flywheel guaranteed a constant velocity or movement at the time of measurement. Force was registered by a straingauge dynamometer, and velocity by two sets of photocells. Cross-sectional area of the brachial biceps muscle was determined by computerized tomography scanning. Muscle fibre composition and fibre cross-sectional areas were assessed histochemically on needle biopsy samples obtained superficially from the brachial biceps muscle, the more superficial of the two large elbow flexor muscles. At contraction velocities from 2 to 7 radians per second (rad/s) a close relationship existed between the relative force output and the relative area of fast-twitch fibers (p less than 0.01). Maximal voluntary isometric contraction force averaged 189 N (120 to 309 N), and showed a close relationship with total cross-sectional area of the brachial biceps muscle. The specific tension (maximal isometric tension) of the muscle averaged 33 N/cm2 with no demonstrable difference between subjects of widely different fibre compositions, suggesting that maximal tetanic tension is similar in fast- and slow-twitch fibres in man.","PeriodicalId":7160,"journal":{"name":"Acta physiologica Scandinavica","volume":"56 1","pages":"287-92"},"PeriodicalIF":0.0,"publicationDate":"1983-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75541394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 43

Neutrino masses, neutrino oscillations, and cosmological implications 中微子质量、中微子振荡和宇宙学意义

Acta physiologica Scandinavica Pub Date : 1982-03-01 DOI: 10.1007/978-3-7091-4031-4_8

F. Stecker

引用次数: 1

Influence of high dose fentanyl on cerebral blood flow and metabolism. 大剂量芬太尼对脑血流和脑代谢的影响。

Acta physiologica Scandinavica Pub Date : 1981-10-01 DOI: 10.1097/00132586-198210000-00011

C. Carlsson, M. Keykhah, Deborah S. Smith, J. Harp

引用次数: 3

Abstracts from the Scandinavian Physiological Society meeting in Oslo 2-3 November 1979. 1979年11月2日至3日在奥斯陆举行的斯堪的纳维亚生理学会会议摘要。

Acta physiologica Scandinavica Pub Date : 1980-02-01

引用次数: 0