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Acta Leidensia最新文献

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Malaria research and control. 疟疾研究和控制。
Acta Leidensia Pub Date : 1991-01-01
E B Doberstyn
{"title":"Malaria research and control.","authors":"E B Doberstyn","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":7108,"journal":{"name":"Acta Leidensia","volume":"60 1","pages":"9-11"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12982956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Genetic relatedness between different clones from a single Plasmodium falciparum isolate. 单一恶性疟原虫分离株不同克隆间的遗传亲缘关系。
Acta Leidensia Pub Date : 1991-01-01
C Gentil, J Patarapotikul, S Mellouk, G Langsley, P Druilhe
{"title":"Genetic relatedness between different clones from a single Plasmodium falciparum isolate.","authors":"C Gentil, J Patarapotikul, S Mellouk, G Langsley, P Druilhe","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":7108,"journal":{"name":"Acta Leidensia","volume":"60 1","pages":"131-3"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12983770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Drug use and design in the nineties. 九十年代的药物使用和设计。
Acta Leidensia Pub Date : 1991-01-01
P I Trigg
{"title":"Drug use and design in the nineties.","authors":"P I Trigg","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":7108,"journal":{"name":"Acta Leidensia","volume":"60 1","pages":"147-56"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12983773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The value of isolating and studying temperature sensitive mutants of Plasmodium falciparum. 恶性疟原虫温敏突变体的分离与研究价值。
Acta Leidensia Pub Date : 1991-01-01
J Inselburg
{"title":"The value of isolating and studying temperature sensitive mutants of Plasmodium falciparum.","authors":"J Inselburg","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":7108,"journal":{"name":"Acta Leidensia","volume":"60 1","pages":"177-9"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12983776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The 235 kD rhoptry protein of Plasmodium yoelii. 约氏疟原虫的235kd状体蛋白。
Acta Leidensia Pub Date : 1991-01-01
A A Holder, J K Keen, K A Sinha, K N Brown
{"title":"The 235 kD rhoptry protein of Plasmodium yoelii.","authors":"A A Holder,&nbsp;J K Keen,&nbsp;K A Sinha,&nbsp;K N Brown","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A 235 kD rhoptry protein produced by the malaria parasite, Plasmodium yoelii is the target of antibodies that protect mice against blood-stage challenge with the virulent YM strain. In the protected animals the parasites are confined to reticulocytes and the course of parasitaemia is reminiscent of an avirulent 17X strain infection. The DNA coding for the rhoptry protein has been identified as a multigene family containing at least four members. Sequence analysis of short DNA clones has identified the C-terminus of the protein; a preliminary analysis of longer clones confirms that the genes are polymorphic. The possible implications of these findings for the biology of the parasite are discussed.</p>","PeriodicalId":7108,"journal":{"name":"Acta Leidensia","volume":"60 1","pages":"101-6"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12982454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Selection of genetic variants from Plasmodium clones. 疟原虫克隆遗传变异的选择。
Acta Leidensia Pub Date : 1991-01-01
S A Dolan, L H Miller, T E Wellems
{"title":"Selection of genetic variants from Plasmodium clones.","authors":"S A Dolan,&nbsp;L H Miller,&nbsp;T E Wellems","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Clones of Plasmodium alter their antigenic profile or invasion phenotype when presented with specific challenges. Two examples are reviewed which may represent different genetic mechanisms of adaptation to selection pressures. In one series of experiments, rhesus monkeys were vaccinated with a 143,000/140,000 Mr P. knowlesi merozoite surface protein and then infected with a parasite clone expressing this protein. Primary parasitemia was controlled, but subsequent waves of parasitemia developed from populations of parasites harboring mutations in the 143,000/140,000 Mr gene. Mutations in this gene may be occurring at a continual low rate in the population (as with any normal gene) and particular mutations may have been selected in the vaccinated monkeys. In other experiments, P. falciparum parasite lines were selected from a clone (Dd2) that initially exhibited low rates of invasion into erythrocytes made sialic-acid deficient by neuraminidase treatment. After several growth cycles in neuraminidase-treated erythrocytes, a switch was observed and parasite lines were recovered that invaded neuraminidase-treated and normal erythrocytes at the same rate. The switch mechanism in invasion may represent another aspect of genetic variation, i.e. a programmed response in which certain genes are activated or rearranged. Vaccine trials in the future should include studies on the selection of mutations in the target antigen. Where switching mechanisms exist, knowledge of the genetic mechanisms that produce these adaptive responses will advance analysis of prospective vaccine candidates and contribute to our understanding of parasite biology.</p>","PeriodicalId":7108,"journal":{"name":"Acta Leidensia","volume":"60 1","pages":"93-9"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12982957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Genome organization and genetics of Plasmodium. 疟原虫的基因组组织与遗传学。
Acta Leidensia Pub Date : 1991-01-01
C Frontali, D Walliker, B Mons
{"title":"Genome organization and genetics of Plasmodium.","authors":"C Frontali,&nbsp;D Walliker,&nbsp;B Mons","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":7108,"journal":{"name":"Acta Leidensia","volume":"60 1","pages":"13-7"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12983769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The relative evolution of Plasmodium. 疟原虫的相对进化。
Acta Leidensia Pub Date : 1991-01-01
A P Waters, D G Higgins, T F McCutchan
{"title":"The relative evolution of Plasmodium.","authors":"A P Waters,&nbsp;D G Higgins,&nbsp;T F McCutchan","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":7108,"journal":{"name":"Acta Leidensia","volume":"60 1","pages":"37-41"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12983780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Minisatellite-like repeat sequences in the genome of rodent malaria parasites. 啮齿动物疟疾寄生虫基因组中的小卫星样重复序列。
Acta Leidensia Pub Date : 1991-01-01
A van Belkum, G Trommelen, A Uitterlinden
{"title":"Minisatellite-like repeat sequences in the genome of rodent malaria parasites.","authors":"A van Belkum,&nbsp;G Trommelen,&nbsp;A Uitterlinden","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Using minisatellite DNA probes and various Southern blots containing DNA samples from rodent malaria parasites it was shown that minisatellite-like sequences occur in the genome of these Plasmodium species. In contrast to the high copy number as observed in higher eukaryotes, the use of fingerprinting techniques on DNA from these parasites reveals that minisatellite sequences are only present at a small number of loci. When parasite lines which differ in biological parameters are compared, no frequent restriction fragment length polymorphism (RFLP) is observed. Screening data banks revealed the presence of repeated copies of one of the probes, which has the monomer sequence CAGGTGG, in the DNA encoding the immunodominant peptide repeat region of the circumsporozoite (CS) protein from a Plasmodium cynomolgi strain. Comparing the sequences for the CS protein from a number of strains of P. cynomolgi revealed that the core region of the repeats, though subject to limited variation, shares homology to the bacterial recombination signal sequence Chi (GCTGGTGG). The implications of the above findings for genetic variation in malaria parasites and evolution of minisatellite sequences will be discussed.</p>","PeriodicalId":7108,"journal":{"name":"Acta Leidensia","volume":"60 1","pages":"83-91"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12982955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Variation in karyotype and gametocyte production during asexual multiplication of Plasmodium berghei. 柏氏疟原虫无性繁殖过程中核型和配子体产生的变异。
Acta Leidensia Pub Date : 1991-01-01
C J Janse, M Ponzi, T Pace, E Dore, B Mons
{"title":"Variation in karyotype and gametocyte production during asexual multiplication of Plasmodium berghei.","authors":"C J Janse,&nbsp;M Ponzi,&nbsp;T Pace,&nbsp;E Dore,&nbsp;B Mons","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":7108,"journal":{"name":"Acta Leidensia","volume":"60 1","pages":"43-8"},"PeriodicalIF":0.0,"publicationDate":"1991-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12983781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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