Berkala Kedokteran最新文献

{"title":"Hesperidin Interaction with HMG-CoA-Reductase Enzyme in Hypercholesterolemia: A Study in Silico","authors":"Annisa Oktaviani, Veronica Shania Aprillia, E. Suhartono, N. Komari","doi":"10.20527/jbk.v17i2.11692","DOIUrl":"https://doi.org/10.20527/jbk.v17i2.11692","url":null,"abstract":"Abstract: Dyslipidemia is a degenerative disease occurred with increased levels of fat and cholesterol levels in blood. One of the proteins used as anti-cholesterol is an HMG-CoA-Reductase. Hesperidin in orange peel can reduce cholesterol levels by interacting with HMG-CoA-Reductase. To prove this, an in silico method was used by using swissdock.ch (http://swissdock.ch/docking#). The receptor protein in dyslipidemia was obtained from the RCSB Protein Data Bank (https://www.rcsb.org) namely HMG-CoA-reductase receptor with code PDB: 1HW9. The natural ligand, hesperidin, was obtained from PubChem with code: 10621 (https://pubchem.ncbi.nlm.nih.gov/). Protein was prepared by omitting the natural ligand residues present in the protein. Ligand and protein preparations were used by the chimera 1.15. The result of this study indicated that the interaction of hesperidin with several amino acid recidues was predicted to provide inhibitory activity on HMG-CoA reductase as the protein target. Inhibition of HMG-CoA reductase will reduce mevalonate synthesis so that cholesterol levels will decrease.  Keywords: hesperidin, HMG-CoA-Reductase, cholesterol, dyslhahipidemia","PeriodicalId":53378,"journal":{"name":"Berkala Kedokteran","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47608440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Play Therapy as a Method of Trauma Healing in PTSD Children Victims of Flood Disaster in West Martapura, South Kalimantan","authors":"Endang Pertiwiwati, I. Maulana, Fitriani Az Zahra, Ida Yuliana","doi":"10.20527/jbk.v17i2.11673","DOIUrl":"https://doi.org/10.20527/jbk.v17i2.11673","url":null,"abstract":"Abstrat: Banjar Regency was recorded as the area most affected by flooding and the West Martapura District was the sub-district area that suffered the most damage. Children as disaster victims who are prone to PTSD, they need to get serious treatment so that the consequences are not prolonged and hamper their development. One form of intervention that can be applied to restore the psychological condition of children affected by disasters is counseling through play therapy. This study aims to analyze the effectiveness of Play Therapy as a Trauma Healing Method in Children With PTSD Flood Disaster Victims. The research design used a quasi-experimental one pre-post test group research design. The research subjects were 35 children with mild to moderate PTSD based on the PLC C version of the PTSD questionnaire, aged 4-6 years. The study was conducted for 5 weeks with various play therapy media and the intervention was carried out for 3 weeks. The results showed that there was a significant difference between the scores of the pretest and posttest scores on the PTSD questionnaire (p = 0.000) with the Wilcoxon test after trauma healing with the play method was performed. The conclusion of the study was  trauma healing with the play therapy method is effectived for treating pediatric patients with PTSD victims of the post-flood South Kalimantan. Keywords: Trauma Healing, Play Therapy, PTSD, Flood, Children, PTSD Questionnaire","PeriodicalId":53378,"journal":{"name":"Berkala Kedokteran","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42982591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ethanol Extract of Areca Nuts was Able to Improve the Histopathological Features of P. Berghei-Induced Liver Damage in Mice","authors":"Alissa Anna Safira, Ika Fidianingsih, Dwi Nur Ahsani","doi":"10.20527/jbk.v17i2.11664","DOIUrl":"https://doi.org/10.20527/jbk.v17i2.11664","url":null,"abstract":"Abstract: Adequate therapy is necessary to prevent further damage to the liver infected with Plasmodium sp. Areca catechu and curcumin have the potential for malaria therapy, and scientific evidence is required to examine such potential either alone or in combination. This experimental study used a posttest-only group design involving 24 male Swiss mice (Mus musculus) as the subjects divided into 6 groups (@4 mice). P. berghei was injected intraperitoneally in 5 groups, and different types of treatment (4 days, feeding tube) were administered to 4 groups (K1 = chloroquine, K3 = ethanol extract of Areca nuts + curcumin, K4 = ethanol extract of Areca nuts, K5 = curcumin). The doses were 0.012mg/kgBW of chloroquine, 150mg/kgBW of Areca nut ethanol extract, and 30mg/kgBW of curcumin. K2 was the unhealthy group (infected with P. berghei without therapy), while K6 was the normal/healthy group. Parasitemia was examined in 3 days after induction by P. berghei (inclusion criterion: parasitemia >5%, exclusion criterion: parasitemia >15%). The liver was embedded in paraffin blocks and stained with HE. Observations were made to identify the presence of necrosis, portal inflammation, and hemosiderin. The data of histopathological changes in the liver was expressed in percentages. The administration of Areca nut ethanol extract was able to provide better histopathological features than curcumin therapy alone, in combination, or chloroquine therapy (K4, no necrosis; mild portal inflammation = 50%, moderate = 25%; hemosiderin = 25%). Areca nut ethanol extract had yet to show histopathological features that resembled a healthy condition (K6 = normal inflammation, mild, moderate = 50%, 50%, 0%, respectively; hemosiderin = 0%). The ethanol extract of Areca nuts alone was shortly able to improve the histopathological features of P. berghei-induced liver damage in mice. Keywords: Areca nuts, Plasmodium berghei, histopathology of liver","PeriodicalId":53378,"journal":{"name":"Berkala Kedokteran","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43954377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Literature Study of Bligo Fruit Extract (Benincasa hispida (Thunb) Cogn) and Bitter Melon (Momordica charantia L.) Extract on the Minimum Inhibition of Salmonella typhi Bacteria","authors":"Mei Rizqi Putri Afifah, N. K. Indahsari","doi":"10.20527/JBK.V17I2.11679","DOIUrl":"https://doi.org/10.20527/JBK.V17I2.11679","url":null,"abstract":"Abstract: Salmonella typhi is a gram-negative bacteria species that causes typhoid fever. Salmonella typhi is sensitive to antibiotics such as amoxicillin, chloramphenicol, ciprofloxacin, and cotrimoxazole. However, there has been some increase in antibiotic resistance, so there is a need for new antibacterials that do not have a resistance effect to treat infection. Bligo fruit (Benincasa hispida (Thunb) Cogn) and bitter melon (Momordica charantia L.) contain saponins, tannins, flavonoids, alkaloids, and triterpenoids which have antibacterial power. The purpose of this study was to compare the effectiveness of the bligo fruit extract (Benincasa hispida (Thunb) Cogn) and bitter melon extract (Momordica charantia L.) on the minimum inhibition of Salmonella typhi bacteria. The method used is narrative literature review. The results of the journal study showed that the extract of bitter melon (Momordica charantia L.) was more effective in inhibiting Salmonella typhi bacteria than the extract of bligo (Benincasa hispida (Thunb) Cogn) with a minimum inhibitory power at a concentration of 20%, namely 8.5 mm. Keywords: Bligo Fruit (Benincasa hispida (Thunb) Cogn), Bitter Melon (Momordica charantia L.), Salmonella typhi.","PeriodicalId":53378,"journal":{"name":"Berkala Kedokteran","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43163606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation of Vitamin D with Ferritin in Pregnant Mothers Chronic Energy Deficiency of the Second Trimester","authors":"Hendera Henderi, S. Siahaan, Irwin Priyatna Kusumah, Heru Cahjono, F. A. Tannus, Nimas Pristiwanto D S, Helen Octavia","doi":"10.20527/jbk.v17i2.11675","DOIUrl":"https://doi.org/10.20527/jbk.v17i2.11675","url":null,"abstract":"Abstract: Based on the prevalence of the Kediri Health Office in 2013 and 2014, pregnancy in CED in Kediri was 6.6% and 6.7%, which was an increase of 0.1% from the previous year. According to the prevalence of CED pregnancy in Badas Puskesmas in 2013 and 2014, it was 7.8% and 6.1%. Aimed at knowing the differences in vitamin D levels in normal pregnancy with second trimester CED pregnancy; know the difference between ferritin in normal pregnancy and second trimester CED pregnancy; know the correlation between vitamin D and ferritin in normal pregnancy and second trimester CED pregnancy; know the correlation between vitamin D and UAC in normal pregnancy and second trimester CED pregnancy. This study used an analytical test (case-control) with randomization of pregnant and pregnant CED patients in the Sukomanunggal district. The results showed that the difference in Vitamin D (33.5380 ± 5.60498 vs 32.4300 ± 4.40708) p = 0.166, the comparison was not significant. The difference in ferritin (17.4080 ± 10.90625 vs 24.7420 ± 21.79586) p = 0.388 comparison was not significant. The correlation between vitamin D and ferritin (p = 0.030) had a significant relationship. There was no significant correlation between Vitamin D and UAC (p = 0.730). The correlation between ferritin and UAC (p = 0.304) was not significant.  Keywords: Vitamin D, Iron, Ferritin, UAC, CEDAbstract: Based on the prevalence of the Kediri Health Office in 2013 and 2014, pregnancy in CED in Kediri was 6.6% and 6.7%, which was an increase of 0.1% from the previous year. According to the prevalence of CED pregnancy in Badas Puskesmas in 2013 and 2014, it was 7.8% and 6.1%. Aimed at knowing the differences in vitamin D levels in normal pregnancy with second trimester CED pregnancy; know the difference between ferritin in normal pregnancy and second trimester CED pregnancy; know the correlation between vitamin D and ferritin in normal pregnancy and second trimester CED pregnancy; know the correlation between vitamin D and UAC in normal pregnancy and second trimester CED pregnancy. This study used an analytical test (case-control) with randomization of pregnant and pregnant CED patients in the Sukomanunggal district. The results showed that the difference in Vitamin D (33.5380 ± 5.60498 vs 32.4300 ± 4.40708) p = 0.166, the comparison was not significant. The difference in ferritin (17.4080 ± 10.90625 vs 24.7420 ± 21.79586) p = 0.388 comparison was not significant. The correlation between vitamin D and ferritin (p = 0.030) had a significant relationship. There was no significant correlation between Vitamin D and UAC (p = 0.730). The correlation between ferritin and UAC (p = 0.304) was not significant.  Keywords: Vitamin D, Iron, Ferritin, UAC, CED","PeriodicalId":53378,"journal":{"name":"Berkala Kedokteran","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41314062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hand Soap Activity Against the Number oOf Bacterial Colonies from the Housewife's Hand Swab Samples in a Temporary Landfill in Kelurahan Gadang Banjarmasin","authors":"Farida Heriyani, L. Budiarti, Widya Nursantari, Ayu Apriliani","doi":"10.20527/jbk.v17i2.11665","DOIUrl":"https://doi.org/10.20527/jbk.v17i2.11665","url":null,"abstract":"Abstract: Unhygienic waste handling in a temporary landfill, can make the surrounding environment a source of transmission of pathogenic bacteria and colonization of bacterial growth in the hands. The study aims to identify the type of bacteria on the hands and test the activity of hand wash soap in lowering the number of colonies of hand bacteria. The identification of bacteria against 30 hand swab samples derived from the hands of housewives in temporary landfill (TPS) in Kelurahan Gadang Banjarmasin, was carried out in conventional media. Test the activity of hand wash soap in lowering the number of colonies of hand bacteria using 2 different brands.  Bacterial identification is carried out by descriptive method and experimental testing of hand wash soa p activity use pretest-posttest design with control group design. The data was analyzed using shapiro wilk test and  wilcoxon test with 95% confidence level. Identification of hand swab bacterial isolates obtained Staphylococcus aureus (66.6%), Staphylococcus epidermidis (10%) and Escherichia coli (23.33%). Statistical analysis showed significant differences between the two brands of hand wash soap tested (sig. 0.000 >0.05). The conclusion of the type of gram-positive bacteria more widely found in the hands of housewives; Type B hand soap has a higher effectiveness in reducing the number of bacterial colonies on the hands than A-brand. Keywords: hand wash soap, housewife hand swab, number of colonies of hand bacteria.","PeriodicalId":53378,"journal":{"name":"Berkala Kedokteran","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44990961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive Refractive Error Post Congenital and Developmental Cataract Surgery","authors":"E. Imelda, Feti Karfiati, Mayasari Wahyu, Irawati Irfani, Primawita Oktarima, Sesy Caesarya","doi":"10.20527/jbk.v17i2.11702","DOIUrl":"https://doi.org/10.20527/jbk.v17i2.11702","url":null,"abstract":"Abstract: Cataract is one of the leading treatable causes of visual impairment in children. Visual rehabilitation is crucial for the development of good visual function after cataract surgery in children. The research aimd to describe post-operative Predictive Refractive Error (PRE) in congenital and developmental cataracts in Cicendo National Eye Hospital from January 2017 to December 2018. This is a retrospective analytic observational study from medical records. We found 107 eyes of 62 children with congenital and developmental cataracts had had cataract surgery and primary implantation of Intraocular Lens (IOL) in Pediatric Ophthalmology and Strabismus Unit, Cicendo National Eye Hospital. The patients were divided into two groups, with axial length (AXL) of ≤ 24 mm and > 24 mm. The paired t-test was used to compare Predictive Error (PE) in SRK/T, SRK II, and Showa SRK formula. Mean age at surgery was 6.7 ± 4.0 years.  Ninety-five eyes had AXL ≤ 24 mm, and 12 eyes had AXL > 24 mm. Prediction Error from patients with AXL ≤ 24 mm was 0.29 D, and from patients with AXL > 24 mm was 2.40 D in SRK/T formula (P < 0.05). There was no significant difference between PE and Absolute Predictive Error (APE) in SRK/T, SRK II, and Showa SRK in patients with AXL > 24 mm (P > 0.05). SRK/T is the most predictable formula in patients with AXL ≤ 24 mm. There is no significant difference in patients with AXL > 24 mm in all formulas. Keywords: congenital and developmental cataract, axial length, Prediction Error, intraocular lens","PeriodicalId":53378,"journal":{"name":"Berkala Kedokteran","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48626317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PATTERN OF ANTIBIOTICS USE IN ADULT PATIENTS WITH URINARY TRACT INFECTION (UTI)","authors":"Hidayatul Kurniawati, Anisa Auliyanah","doi":"10.20527/JBK.V17I1.10244","DOIUrl":"https://doi.org/10.20527/JBK.V17I1.10244","url":null,"abstract":"Introduction: Urinary tract infection (UTI) is an infectious disease caused by the growth and proliferation of bacteria in the urinary tract, including infections in the bladder to the renal parenchyma with a certain number of bacteria in the urine. The use of antibiotics is therapy that commonly used to treat infectious diseases caused by bacteria. Irrational use of antibiotics can lead to bacterial resistance and toxicity. Objective: To determine the rationality of using antibiotics in adult patients with a urinary tract infection (UTI) in the X Hospital Yogyakarta from January-December 2017.Methods: This study is a non-experimental study with a descriptive observational study design and retrospective data collection. The sample of this study was inpatients with a diagnosis of urinary tract infection (UTI) and was recorded in the Medical Record X Hospital Yogyakarta for the period January-December 2017 which was included in the inclusion criteria. Results: Medical records that were included in the inclusion criteria were 61. The single most widely used antibiotic was ceftriaxone in 25 cases (44.64%) and the most widely used combination antibiotic was ceftazidime + levofloxacin in 2 cases (40%). The use of antibiotics with the right indication was 61 patients (100%), the right type was 61 patients (100%), the correct duration was 54 patients (88.52%), the right dose was 61 patients (100%), the right interval was 60 patients (98.36%) and the right route of administration was 61 patients (100%).","PeriodicalId":53378,"journal":{"name":"Berkala Kedokteran","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41244775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ethylenediaminetetraacetic Acid‑Dependent Pseudothrombocytopenia in Patient Previously Treated as Dengue Fever","authors":"Hendra Nur'amin, M. Prenggono, Wivina Riza Devi","doi":"10.20527/JBK.V17I1.10250","DOIUrl":"https://doi.org/10.20527/JBK.V17I1.10250","url":null,"abstract":"Abstract: One of the most widely used anticoagulants for a complete blood count is ethylenediaminetetraacetic acid (EDTA).  Pseudothrombocytopenia (PTCP) may be caused by EDTA, this condition may lead to inappropriate diagnosis and treatment. We report a 25-year-old female with unspecific headache and joint pain with very low platelet count since 1 month before hospital admission. She was diagnosed with Dengue fever infection and got some platelet transfusion from the previous secondary hospital. She was carried out for a blood test with another anticoagulant (sodium citrate) and bone marrow aspiration. The results showed that she had normal platelet count and bone marrow cellularity. When a patient was identified with thrombocytopenia without any bleeding manifestation, hematology disease, and family history, PTCP should be taken into consideration to prevent unnecessary intervention. Keywords: platelet, pseudothrombocytopenia, ethylenediaminetetraacetic acid, Dengue fever","PeriodicalId":53378,"journal":{"name":"Berkala Kedokteran","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46178237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thoracic Gunshot Wound with Vascular Lesion","authors":"Ahmad Adityawarman, A. Ghozali","doi":"10.20527/JBK.V17I1.10253","DOIUrl":"https://doi.org/10.20527/JBK.V17I1.10253","url":null,"abstract":"Abstract: The thoracic gunshot wounds may cause high morbidity and mortality, especially if accompanied by vascular injuries. Therefore, immediate management and precise decision are needed. A 35-year-old man who was referred from the regional hospital presented with thoracic gunshot wound and a history of hemorrhagic shock. A projectile was found through the chest wall and caused axillary artery rupture. The patient underwent exploratory thoracotomy and axillo-brachial artery bypass using a great saphenous vein graft. The patient's postoperative condition showed improvement in hemodynamic and distal limb perfusion. Keywords: Chest trauma, gunshot wound, axillary artery, vascular injury","PeriodicalId":53378,"journal":{"name":"Berkala Kedokteran","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44085818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}