Sanamed Pub Date : 2022-01-01 DOI: 10.5937/sanamed0-40164

Karatas Savas, Hacıoğlu Burcu, Kalaycı Gökhan

{"title":"Phenotypes of polycystic ovary syndrome and accompanying hormonal disturbances","authors":"Karatas Savas, Hacıoğlu Burcu, Kalaycı Gökhan","doi":"10.5937/sanamed0-40164","DOIUrl":"https://doi.org/10.5937/sanamed0-40164","url":null,"abstract":"Objective: PCOS, which is known as a symptom complex including menstrual dysfunction (OD) and or hirsutism/androgen excess (HA), and/or polycystic ovaries (PCOM), induces women's health damage beyond this classical criteria. Subphenotypes of PCOS have different clinical properties and criteria, and the metabolical differences between these phenotypes have not been elucidated properly. Therefore, we aimed to investigate the metabolic and endocrinological differences between these sub-phenotypes. Materials and Methods: 63 patients with PCOS followed by Istanbul Research and Education Hospital Endocrinology and Metabolism Department were included in the study. Patients were classified into subgroups according to phenotypes. The phenotype groups were compared according to blood glucose, lipid parameters, and serum hormone levels. MetS ratios between groups were also compared. Results: Androgen excess/hirsutism was the most prominent character with a 95.2% (n=60) rate in this study group, and ovulatory dysfunction was the least prominent one. (n=43, 68.2%) PCOM has been detected in 50 patients (80.8%). Patients were grouped according to PCOS phenotypes. Phenotype C was the most common type, and about 65% of the patients were in this group. Triglyceride levels were statistically significantly higher in the Phenotype A group than in the Phenotype B group (p=0.03). MetS was the highest in the Phenotype A group (45.4%) and the lowest in the Phenotype C group (34.7%). Conclusions: Phenotype C has the highest prevalence in Turkish patients with PCOS, MetS was the highest in Phenotype A, and TG and LDL cholesterol levels were higher in Phenotype A. More studies are needed to explain these differences and their lifetime consequences.","PeriodicalId":53269,"journal":{"name":"Sanamed","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71045616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Theoretical basis of perinatology therapy in pregnant women with diabetes mellitus 妊娠期糖尿病围产儿治疗的理论基础

Sanamed Pub Date : 2022-01-01 DOI: 10.5937/sanamed0-40167

S. Dugalić, J. Todorović, Maja Macura, B. Gutic, Miloš Milinčić, Dragana D Božić, Milica Stojiljković, I. Pantić, M. Perović, M. Gojnić

引用次数: 0

The cornea and methods for measuring intraocular pressure 角膜及测量眼压的方法

Sanamed Pub Date : 2022-01-01 DOI: 10.5937/sanamed0-41040

E. Jordanova, P. Hentova-Senćanić, I. Marjanović, Ivan Senčanin, Ivana Stefanović, M. Baralić

{"title":"The cornea and methods for measuring intraocular pressure","authors":"E. Jordanova, P. Hentova-Senćanić, I. Marjanović, Ivan Senčanin, Ivana Stefanović, M. Baralić","doi":"10.5937/sanamed0-41040","DOIUrl":"https://doi.org/10.5937/sanamed0-41040","url":null,"abstract":"Introduction: The study aimed to assert the relationship between central corneal thickness (CCT) and intraocular pressure (IOP) measured by: Goldmann applanation tonometry (GAT) and Dynamic contour tonometry (DCT). Materials and Methods: The study included 150 patients with a mean age of 59.39 ± 13.12 years. Patients were divided into three groups: 50 primary open-angle glaucoma (POAG) patients, 50 ocular hypertension (OHT) patients, and 50 normal tension glaucoma (NTG) patients. IOP was determined using GAT and DCT. CCT was measured by ultrasound pachymetry. Results: IOP measured with DCT was higher than IOP measured with GAT (19.80 ± 3.67 mmHg vs 17.71 ± 3.35 mmHg). A significant positive association between IOP measured with GAT and IOP measured with DCT was found in all patients (r = 0.867, p < 0.01). A significantly positive association between IOP measured with GAT and IOP measured with DCT in POAG (r = 0.855, p <0.01), OHT (r = 0.826, p < 0.01), and NTG patients (r = 0.832, p < 0.01) were found. A significant positive correlation between CCT and IOP measured with GAT (r = 0.198, p < 0.01), as well as a significant positive correlation between CCT and IOP measured with DCT was found (r = 0.198, p < 0.01) in all patients. There was no correlation between CCT and IOP measured neither with GAT nor with DCT separately in three patient groups (p > 0.05). Conclusion: CCT-influenced IOP was measured by both methods, GAT and DCT. DCT can not replace GAT, but it is very useful, especially in cases where errors are in the IOP GAT measurement.","PeriodicalId":53269,"journal":{"name":"Sanamed","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71046741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Oropharyngeal dysphagia in elderly persons: Etiology, pathophysiology and symptomatology 老年人口咽吞咽困难:病因、病理生理学和症状学

Sanamed Pub Date : 2022-01-01 DOI: 10.5937/sanamed0-40913

Mirjana Petrović-Lazić, S. Babac, Ivana Ilić-Savić

{"title":"Oropharyngeal dysphagia in elderly persons: Etiology, pathophysiology and symptomatology","authors":"Mirjana Petrović-Lazić, S. Babac, Ivana Ilić-Savić","doi":"10.5937/sanamed0-40913","DOIUrl":"https://doi.org/10.5937/sanamed0-40913","url":null,"abstract":"Swallowing disorders can occur at any age, although they occur more often in old age when the physiology of swallowing changes due to aging. Oropharyngeal dysphagia is a very common clinical condition affecting 13% of the total population over 65 years of age and 51% of institutionalized older people. Given that oropharyngeal dysphagia can lead to increased morbidity and mortality in the elderly, it is necessary to prevent the occurrence of dysphagia in this population group as much as possible. In relation to this, the paper aims to provide insight into contemporary research into the etiology, pathophysiology, and symptomatology of oropharyngeal dysphagia in the elderly. In this review study, the electronic databases of Google Scholar Advanced Search and the Consortium of Serbian Libraries for Unified Procurement - KoBSON were searched. The following keywords and phrases were used in the search: swallowing, dysphagia, oropharyngeal dysphagia, aging, age and dysphagia, etiology of oropharyngeal dysphagia, the clinical picture of oropharyngeal dysphagia, pathophysiology of oropharyngeal dysphagia. This systematic review and meta-analysis of papers showed significant progress in the effective diagnostic approach of oropharyngeal dysphagia during the last years but also a significant lack of knowledge about adequate modifications of drugs applied during the treatment of patients with dysphagia. A good understanding of the etiology, pathophysiology, and symptomatology of oropharyngeal dysphagia would eliminate the harmful effects of pharmacological substances on the function of swallowing, given that the elderly, on the advice of a doctor, use them daily.","PeriodicalId":53269,"journal":{"name":"Sanamed","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71046695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Newborn treated with continuous renal replacement therapy for citrulinemia-type 1 新生儿持续肾替代治疗瓜氨酸血症1型

Sanamed Pub Date : 2022-01-01 DOI: 10.5937/sanamed0-40473

D. Tosun, N. Akçay, Emin Menentoğlu, E. Şevketoğlu, Ozgul Salihoğlu

{"title":"Newborn treated with continuous renal replacement therapy for citrulinemia-type 1","authors":"D. Tosun, N. Akçay, Emin Menentoğlu, E. Şevketoğlu, Ozgul Salihoğlu","doi":"10.5937/sanamed0-40473","DOIUrl":"https://doi.org/10.5937/sanamed0-40473","url":null,"abstract":"Introduction: Hyperammonemia occurs as a result of the inability to convert ammonia, a metabolic toxin, into urea due to a block in the urea cycle, and there resulting neurotoxicity is responsible for the pathogenesis. Case Presentation: Our patient was 7 days old when followed up in an external center for 3 days with a preliminary diagnosis of neonatal sepsis. Lethargy, vomiting, tachypnea, and convulsions, which are frequently seen in the first neonatal forms of urea cycle disorders, were also present in our patient. He was referred to us as a result of high ammonia levels when he was examined in terms of congenital metabolic diseases. He was intubated due to the rapid development of respiratory failure. When he was admitted to our intensive care unit with hyperammonemia, light reflex could not be obtained, and widespread cutis marmaratus was developed. Continuous renal replacement therapy was started in our patient and administered intermittently for 120 hours. The glucose infusion rate was followed by high fluid. When it orally tolerated, it is supported with sodium benzoate and sodium stearyl fumarate to reduce ammonia. Nutrition was limited to protein with Basic P. Conclusion: After staying in the intensive care unit for 30 days, our patient was discharged with the recommendation of outpatient follow-up by the pediatric metabolism physician. When our patient came for his check up after two months, there was no nystagmus and no seizures.","PeriodicalId":53269,"journal":{"name":"Sanamed","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71046057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Differences in inflammatory markers in COVID-19 mortality in patients aged 18-65, 65-80 and 80 years and older 炎症标志物在18-65岁、65-80岁和80岁及以上患者COVID-19死亡率中的差异

Sanamed Pub Date : 2022-01-01 DOI: 10.5937/sanamed0-40546

Aslan Nuray, Necip Gokhan, Durmus Ensar, Guneysu Fatih, Yurumez Yusuf

{"title":"Differences in inflammatory markers in COVID-19 mortality in patients aged 18-65, 65-80 and 80 years and older","authors":"Aslan Nuray, Necip Gokhan, Durmus Ensar, Guneysu Fatih, Yurumez Yusuf","doi":"10.5937/sanamed0-40546","DOIUrl":"https://doi.org/10.5937/sanamed0-40546","url":null,"abstract":"Background: Since its emergence, coronavirus disease 2019 (COVID-19) has been a challenge to manage and has resulted in high mortality rates. Aim: This study aimed to reveal the differences in the parameters at the time during the first admission, according to age groups in patients who applied due to Covid-19 and died in the hospital. Methods: This was a retrospective, cross-sectional, and descriptive study covering the period from March 16 to May 9, 2021. The study population (1169 patients) included patients with COVID-19 who presented to the emergency department and died in the hospital. The data required for this study were obtained from the electronic medical records of the patients in the information system of our hospital. The patients were divided into three groups and analyzed. Results: It was determined that the highest mortality rate was 547 (46.8%) in the 65-80 age group. In terms of comorbidities, there was a statistically significant difference between the three groups only in the incidence of asthma (p = 0.037). When the laboratory parameters and patient age groups were compared; a statistically significant difference was found in D-dimer, ferritin, WBC, platelet, and neutrophil values (respectively: p=0.001, p=0.020, p=0.005, p=0.029, p=0.037). Conclusion: The highest death rate in Covid 19 patients is seen in the 65-80 age group. In patients over 80 years of age, the presence of asthma and the increase in D-dimer and ferritin levels among laboratory parameters can be used to predict mortality.","PeriodicalId":53269,"journal":{"name":"Sanamed","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71046194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

"Six Sigma" standard as a level of quality of biochemical laboratories “六西格玛”标准作为生化实验室的质量水平

Sanamed Pub Date : 2022-01-01 DOI: 10.5937/sanamed0-40408

Aleksandra Pašić, Emir Šeherčehajić

{"title":"\"Six Sigma\" standard as a level of quality of biochemical laboratories","authors":"Aleksandra Pašić, Emir Šeherčehajić","doi":"10.5937/sanamed0-40408","DOIUrl":"https://doi.org/10.5937/sanamed0-40408","url":null,"abstract":"The principal role of biochemical laboratories is responsibility for reliable, reproducible, accurate, timely, and accurately interpreted analysis results that help in making clinical decisions, while ensuring the desired clinical outcomes. To achieve this goal, the laboratory should introduce and maintain quality control in all phases of work. The importance of applying the Six SIGMA quality model has been analyzed in a large number of scientific studies. The purpose of this review is to highlight the importance of using six SIGMA metrics in biochemical laboratories and the current application of six SIGMA metrics in all laboratory work procedures. It has been shown that the six SIGMA model can be very useful in improving all phases of laboratory work, as well as that a detailed assessment of all procedures of the phases of work and improvement of the laboratory's quality control system is crucial for the laboratory to have the highest level of six SIGMA. Clinical laboratories should use SIGMA metrics to monitor their performance, as it makes it easier to identify gaps in their performance, thereby improving their efficiency and patient safety. Medical laboratory quality managers should provide a systematic methodology for analyzing and correcting quality assurance systems to achieve Six SIGMA quality-level standards.","PeriodicalId":53269,"journal":{"name":"Sanamed","volume":"29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71045971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metastasis of submandibular Adenoid cystic carcinoma to the femur bone causing pathological fracture: A case report 颌下腺样囊性癌转移至股骨引起病理性骨折1例

Sanamed Pub Date : 2022-01-01 DOI: 10.5937/sanamed0-40661

Onur Karaca, Kamil Balaban, Y. Yıldız

引用次数: 0

Prenatal monitoring of pregnancies complicated by diabetes mellitus 妊娠合并糖尿病的产前监测

Sanamed Pub Date : 2022-01-01 DOI: 10.5937/sanamed0-40168

Maja Macura, S. Dugalić, J. Todorović, B. Gutic, Miloš Milinčić, Dragana D Božić, Milica Stojiljković, J. Micic, M. Gojnić

引用次数: 0

Nutrition in pregnancy with diabetes mellitus 妊娠期糖尿病患者的营养

Sanamed Pub Date : 2022-01-01 DOI: 10.5937/sanamed0-40169

J. Todorović, S. Dugalić, Maja Macura, B. Gutic, Miloš Milinčić, Dragana D Božić, Milica Stojiljković, Olivera Sbutega-Filipović, M. Gojnić

引用次数: 0

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