Journal of Clinical and Experimental Investigations最新文献

{"title":"Post-antibiotic Effect of Various Antibiotics against Achromobacter xylosoxidans Strains Isolated from Patients with Cystic Fibrosis","authors":"Berna Özbek-Çelik, Damla Damar-Çelik, N. Nørskov-Lauritsen","doi":"10.5799/jcei/8294","DOIUrl":"https://doi.org/10.5799/jcei/8294","url":null,"abstract":"Objectives: Achromobacter xylosoxidans is an emerging pathogen in cystic fibrosis (CF) disease, although relatively limited is known about its clinical impact and optimal management. Pharmacodynamics such as post-antibiotic effect (PAE) are increasingly being applied to the design of antibiotic dosing regimens. In the present study, meropenem, doripenem, colistin, levofloxacin, tigecycline, tobramycin, and chloramphenicol were tested for their PAE.\u0000Materials and Methods: The in vitro activities of meropenem, doripenem, colistin, levofloxacin, tigecycline, tobramycin, and chloramphenicol were determined by the microbroth dilution technique. To determine the PAEs, A. xylosoxidans strains in the logarithmic phase of growth were exposed for 1 h to antibiotics. Recovery periods of test cultures were evaluated using viable counting after centrifugation.\u0000Results: The mean values of in vitro PAEs at 1xMIC and 4xMIC concentrations were 3.21 ± 0.66 and 3.58 ± 0.68 hours for colistin, 1.54 ± 0.46 and 2.27 ± 0.41 hours for levofloxacin, 2.34 ± 0.48 and 3.47 ± 0.64 hours for tobramycin, 1.72 ± 0.47 and 2.24 ± 0.41 hours for tigecycline 1.91 ± 0.14 and 2.13 ± 0.13 hours for chloramphenicol, respectively. The carbapenem antibiotics exhibited weak PAEs, as expected.\u0000Conclusions: This study’s findings could have important implications for the timing of doses during antimicrobial therapy with tested antibiotics.","PeriodicalId":53255,"journal":{"name":"Journal of Clinical and Experimental Investigations","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49089877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Postraumatic Torsion of Wandering Spleen in 9-year-old Boy","authors":"T. Zavidić, Dino Lovrinic, M. Bogović, B. Lodeta","doi":"10.5799/jcei/8271","DOIUrl":"https://doi.org/10.5799/jcei/8271","url":null,"abstract":"Post-traumatic torsion of wondering spleen is extremely rare cause of acute abdominal pain in children with only few cases reported. We report a case of a 9-year-old boy with wandering spleen torsion after bike crash and subacute clinical presentation. After a bicycle crash and a period of persistent fever family physician performed an ultrasound of abdomen which showed a round focal lesion of 10 x 12 cm in size, a spleen-like echogenicity in the middle-lower abdominal position and in the small pelvis, which raised suspicion of ectopic (wandering) spleen. The abdominal MSCT confirmed the diagnosis of wandering spleen, Numerous immunologic, hematological, radiological, infectious, endocrinological, chromosomal and cytological tests and markers confirmed a diagnosis of the splenic malformation. A surgeon arranged to perform splenopexy after checking the vaccination status. Laparotomy was initiated. The splenic artery and vein, which was in a triple twist, was released and due to the resulting path, the spleen itself was larger than the CT finding. The spleen was placed under the left ribs and splenopexy was performed. At the fifteen-day and two-month follow ups, the patient felt good, was painless, afebrile and the spleen gradually decreased. Wondering spleen should be considered as a possible cause of acute abdominal pain when the spleen is not seen in its usual position. The treatment of choice is surgery, with the goal of preservation of the organ whenever possible.","PeriodicalId":53255,"journal":{"name":"Journal of Clinical and Experimental Investigations","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48336834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Urgent Needs to Consider and Assess the Transmission of Coronavirus (COVID-19) via Hospital Sewage and Wastewater","authors":"L. Mandi","doi":"10.5799/jcei/8261","DOIUrl":"https://doi.org/10.5799/jcei/8261","url":null,"abstract":"The emergence and spread of SARS-CoV-2 responsible for COVID-19 disease are considered as a major threat to human health since WHO declared COVID-19 outbreak a global pandemic In recent studies, scientists confirmed the presence of SARS-CoV-2 RNA in feces of COVID-19 patients and wastewater In several areas, particularly low-income countries, hospital effluents are not disinfected or pretreated and they are mostly discharged into urban sewerage systems reaching wastewater treatment plants depending if it exists or not, consequently several infectious agents could be developed such as Coronavirus COVID-19 causing significant environmental and health risks Several researchers across the world suggested that wastewater surveillance could be a sensitive tool to monitor the circulation of the virus in the population and may represent a complementary approach to measure the presence and the prevalence of current infectious disease when the capacity for clinical testing is limited Only a few studies were done on the survival of Coronaviruses in wastewater and still there is limited information on its transmission potential through the environment Taking into account the current situation, there is an urgent need to consider and assess the transmission of Coronavirus (COVID-19) via hospital sewage and wastewater Further researches are imperative to fill the knowledge gaps in COVID-19 behavior in hospital and urban sewage, and wastewater treatment plants, identify the safety measures and better manage the pandemic phenomena [ABSTRACT FROM AUTHOR] Copyright of Journal of Clinical & Experimental Investigations / Klinik ve Deneysel Arastirmalar Dergisi is the property of Journal of Clinical & Experimental Investigations and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission However, users may print, download, or email articles for individual use This abstract may be abridged No warranty is given about the accuracy of the copy Users should refer to the original published version of the material for the full abstract (Copyright applies to all Abstracts )","PeriodicalId":53255,"journal":{"name":"Journal of Clinical and Experimental Investigations","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43481488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can Human Transmit COVID-19 to Animal?","authors":"S. E. Baz, B. Imziln","doi":"10.5799/jcei/8262","DOIUrl":"https://doi.org/10.5799/jcei/8262","url":null,"abstract":"Coronavirus (COVID-19) has infected more than three million people worldwide and it's widely believed to have originated in horseshoe bats and passed to humans through other species on sale in a wildlife market in Wuhan First human transmission to dogs has been detected in Hong Kong;which they have caught the novel coronavirus from owners Other reported cases of cats in Belgium tested positive with COVID-19 Researchers reveal that cats are not only susceptible to contracting coronavirus but can transmit it on other cats as well Also, a tiger tested positive for COVID-19 after coming into contact with an asymptomatic caretaker In this report, we provide all cases registered over the world prompting to take a closer look at the human to pet transmission of the virus and to keep measures to prevent exposure Also, increased transmission of COVID-19 from human to animal can affect the global health security owing to its ability to rapidly spread due to movement of animals So, we should reevaluate the probability that this outbreak might also be caused by infected pets' hosts Particular attention must be also paid to the distribution and the evolution of the virus in animals to control the COVID-19 pandemic [ABSTRACT FROM AUTHOR] Copyright of Journal of Clinical & Experimental Investigations / Klinik ve Deneysel Arastirmalar Dergisi is the property of Journal of Clinical & Experimental Investigations and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission However, users may print, download, or email articles for individual use This abstract may be abridged No warranty is given about the accuracy of the copy Users should refer to the original published version of the material for the full abstract (Copyright applies to all Abstracts )","PeriodicalId":53255,"journal":{"name":"Journal of Clinical and Experimental Investigations","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41596550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Forecasting COVID-19 in Morocco","authors":"M. Layelmam, Y. A. Laaziz, S. Benchelha, Yahya Diyer, Sarra Rarhibou","doi":"10.5799/jcei/8264","DOIUrl":"https://doi.org/10.5799/jcei/8264","url":null,"abstract":"The COVID-19 has become a public health emergency of international concern. As of April 26, 2020, this pandemic has caused in Morocco more than 4065 confirmed infections and more than 161 reported deaths. To mitigate this epidemic threat and act quickly, it is very important to monitor and analyze changing trends and predict what might happen in the future. The main objective of this paper is to develop a successful prediction. We used in this study at the end of each week the TBATS model to forecast confirmed cases. This model is calculated on the basis of the daily historical data. From the results obtained we can conclude that the predictions obtained are close to reality and for the peak of this epidemic is not yet identified. The obtained results shows that this epidemics will continue to grow. For our forecast from 04/27/2020 to 05/03/2020 we estimate that the number of affected cases will achieve 4367 cases.","PeriodicalId":53255,"journal":{"name":"Journal of Clinical and Experimental Investigations","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45881832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Climate and the Equator on the Total Coronavirus Cases of the Nine Countries from Africa","authors":"Hanane Bougherara, S. Benramache","doi":"10.5799/jcei/8263","DOIUrl":"https://doi.org/10.5799/jcei/8263","url":null,"abstract":"On the 01 March, 2020, an outbreak of coronavirus disease 2019 (COVID-19) has resulted in 88 585 confirmed cases African countries move from COVID-19 readiness to respond as many confirmed cases The equator differs from the rest of the world in its climate and environment In this work we conducted a comparative study of cases of coronavirus infection and the number of deaths, this study was investigated in nine countries from Africa with the same climate and which belong to the equator, where the results were compared with the relation to the general population and total area From the studied results, we found a zero % of the Deaths for Rwanda, Equatorial Guinea and Uganda The equator countries of Africa have not been affected much by this virus, Climate found in the equator countries helped these countries to obtain a small number of injuries, Air and temperature affected the number of deaths, and the equator countries authorize its climate to help them acquire special immunity [ABSTRACT FROM AUTHOR] Copyright of Journal of Clinical & Experimental Investigations / Klinik ve Deneysel Arastirmalar Dergisi is the property of Journal of Clinical & Experimental Investigations and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission However, users may print, download, or email articles for individual use This abstract may be abridged No warranty is given about the accuracy of the copy Users should refer to the original published version of the material for the full abstract (Copyright applies to all Abstracts )","PeriodicalId":53255,"journal":{"name":"Journal of Clinical and Experimental Investigations","volume":"11 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2020-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45482458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Coronavirus 2019 (COVID-19) Outbreak in India: A Perspective so far","authors":"P. Gupta, P. Bhaskar, S. Maheshwari","doi":"10.5799/jcei/8220","DOIUrl":"https://doi.org/10.5799/jcei/8220","url":null,"abstract":"There is a new public health emergency victimization the world with the emergence and spread of COVID-19 However, India has performed very well to tackle this emergency of public health so far but at the time of writing the manuscript (as on 06 04 2020), India is on the stage to increase the lockdown period in the current situation because of peak rise in the confirmed cases of COVID-19 The present study aims to review the decisions of the Indian government that are being implemented so far to hold the situation of COVID-19 along with the challenges faced so far However, only time will tell that the decisions taken so far are sufficiently strong to protect the majority of Indian during on-going COVID-19 pandemic At last, special considerations highlight on major footsteps and challenges so far in India due to COVID-19 [ABSTRACT FROM AUTHOR] Copyright of Journal of Clinical & Experimental Investigations is the property of Modestum Publications and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission However, users may print, download, or email articles for individual use This abstract may be abridged No warranty is given about the accuracy of the copy Users should refer to the original published version of the material for the full abstract (Copyright applies to all Abstracts )","PeriodicalId":53255,"journal":{"name":"Journal of Clinical and Experimental Investigations","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46698277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COVID-19 Pandemic in North Cyprus","authors":"Ayşen Berberoğlu","doi":"10.5799/jcei/8213","DOIUrl":"https://doi.org/10.5799/jcei/8213","url":null,"abstract":"When COVID -19, the novel coronavirus leading to severe acute respiratory syndrome, first identified in Wuhan China during December 2019, Northern Cyprus community would never imagine the virus could make its way to the less populated and mostly isolated part of the island During the first week of March 2020, the uneasiness was in the minds of people and suspected coronavirus cases started to surface However, until 10th of March 2020, the suspected cases were found COVID-19 negative On 10th of March 2020, the first positive case of COVID -19 was reported who was a German woman tourist, arrived with a charter flight two days before By 12th of April, North Cyprus had a total of 99 positive COVID -19 cases, 3 deaths and 57 recovered [ABSTRACT FROM AUTHOR] Copyright of Journal of Clinical & Experimental Investigations is the property of Modestum Publications and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission However, users may print, download, or email articles for individual use This abstract may be abridged No warranty is given about the accuracy of the copy Users should refer to the original published version of the material for the full abstract (Copyright applies to all Abstracts )","PeriodicalId":53255,"journal":{"name":"Journal of Clinical and Experimental Investigations","volume":"11 1","pages":"1-3"},"PeriodicalIF":0.0,"publicationDate":"2020-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43137946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Coronavirus Disease 2019 (COVID‐19): Morocco Interrupting the Transmission by Ethics, Logistics, and Therapeutics Efforts","authors":"S. E. Baz, B. Imziln","doi":"10.5799/jcei/8214","DOIUrl":"https://doi.org/10.5799/jcei/8214","url":null,"abstract":"Since the first case of 2019 novel coronavirus (COVID-19) identified on 02 March 2020 in Morocco, the number of cases rapidly increased, resulting in 3046 cases including 143 deaths as of 20 April 2020 Morocco used every possibility (socio-economic and medical) to control and to limit the spread of COVID-19 and support the implementation of social distancing measures to quickly control the outbreak The percentage of death was 4 7% as of 20 April 2020, and increases with older age The median age of the deaths was 65 years Moroccan government noted that 80% of the death had health problems, 15% of positive COVID-19 cases show no symptoms and only 11 5% of patients were recovered This report examines the impact of the ongoing pandemic of COVID-19 in Morocco The Moroccan government has considered being more effective in responding to the pandemic Persistent efforts have been made to limit the transmission of COVID-19, and many strategies to protect people against COVID-19 is running well to keep the spread of coronavirus under control in comparison with other countries in Europe or Africa (especially North Africa) In this report, in contrast, the situation demonstrates the need of rapid and accurate detection and identification methods that can be used in hospitals bearing the burden of identifying and treating patients Also, this paper demonstrate that the different measures adapted by Morocco can be a good example for other developing countries and used to fight COVID-19 before it reaches the poorest countries of the world [ABSTRACT FROM AUTHOR] Copyright of Journal of Clinical & Experimental Investigations is the property of Modestum Publications and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission However, users may print, download, or email articles for individual use This abstract may be abridged No warranty is given about the accuracy of the copy Users should refer to the original published version of the material for the full abstract (Copyright applies to all Abstracts )","PeriodicalId":53255,"journal":{"name":"Journal of Clinical and Experimental Investigations","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41826760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sexuality and Fertility in the Time of COVID-19","authors":"Rachid Ait Addi, A. Benksim, M. Cherkaoui","doi":"10.5799/jcei/8211","DOIUrl":"https://doi.org/10.5799/jcei/8211","url":null,"abstract":"COVID-19 is an acute respiratory disease caused by novel coronavirus SARS-CoV-2 or 2019- nCoV Recently, on March 11, 2020, COVID-19 was declared by the WHO as a virus pandemic disease Many measures were conducted to tackle COVID-19 outbreak The important one is social isolation that have been adopted all over the world which are the first one done as widely as that in modern history Such measures have wide reaching consequences as reducing significantly the opportunity for casual sexual meetings, and increasing sexual intercourse for couples with stable sexual relationships, especially married ones This leads us to the conclusion that within 9 months there will be an increase in births This means that the global fertility will increase, especially in the developing countries whom have the highest rate of fertility [ABSTRACT FROM AUTHOR] Copyright of Journal of Clinical & Experimental Investigations is the property of Modestum Publications and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission However, users may print, download, or email articles for individual use This abstract may be abridged No warranty is given about the accuracy of the copy Users should refer to the original published version of the material for the full abstract (Copyright applies to all Abstracts )","PeriodicalId":53255,"journal":{"name":"Journal of Clinical and Experimental Investigations","volume":"11 1","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2020-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42281822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}