Archiv EuroMedica最新文献

{"title":"DYNAMICS OF MORPHOLOGICAL CHANGES IN CELLS OF THE CEREBELLUM IN ACUTE POISONING WITH CLOZAPINE IN COMBINATION WITH ALCOHOL","authors":"I. Telipov, D. Sundukov, A. Golubev","doi":"10.35630/2022/12/6.10","DOIUrl":"https://doi.org/10.35630/2022/12/6.10","url":null,"abstract":"According to most researchers, the central mechanism of clozapine poisoning in combination with alcohol is their cholinolytic effect. A life-threatening condition with clozapine occurs as a result of an unintentional overdose of the prescribed drug, suicidal behaviour, or criminal behaviour. Despite the urgency of the problem of clozapine poisoning in combination with alcohol, the pathogenesis of these conditions and the resulting morphological changes in the brain have not been sufficiently investigated. In this connection, the purpose of our experimental research is the study of the dynamics of changes in Purkinje cells of the cerebellum in the early period of acute poisoning with clozapine in combination with alcohol. In sections of the cerebellum of the control group, reversible changes in Purkinje cells (15–20%) predominated in the form of primary irritation and acute swelling. Irreversible damage to Purkinje cells (2-5%). 3 hours after poisoning with clozapine in combination with ethanol, Purkinje cells showed irreversible damage to cerebellar cells with signs of severe changes, neuronophagia, and pericellular edema, with the following ratio: reversible 25-30% and irreversible 60-70%. 24 hours after the combined poisoning with clozapine in combination with alcohol, in percentage terms, the ratio of the changes was the following: reversible 25-30% and irreversible 60-70%. The study revealed the dynamics of reversible and irreversible changes in Purkinje cells with a predominance of irreversible damage was established, especially after 24 hours from the start of the experiment.","PeriodicalId":51770,"journal":{"name":"Archiv EuroMedica","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2022-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46530210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"BEHAVIORAL ACTIVITY IN EXPERIMENTAL METABOLIC SYNDROME AND DURING TREATMENT WITH COMPLEX PHYTOADAPTOGENS","authors":"Z. Dzampaeva, F. Datieva, E. Takoeva, M. Nartikoeva","doi":"10.35630/2022/12/6.5","DOIUrl":"https://doi.org/10.35630/2022/12/6.5","url":null,"abstract":"The aim of the study was to evaluate behavioral disorders in experimental metabolic syndrome and the possibility of treatment with complex phytoadaptogens (CPhA). The experiment was carried out on 30 male Wistar rats randomly divided into 3 groups: control (Group 1), metabolic syndrome (MS, Group 2), and treatment of metabolic syndrome with CPhA (Group 3). In Groups 2 and 3, the animals were on a diet high in carbohydrates and fats for 16 weeks. Group 3 animals received CPhA for 14 days with drinking water after 16 weeks of the diet. CPhA consist of standard tinctures of Glycyrrhiza glabra, Rhodiola rosea, Acantopanax senticosus in a ratio of 1:2:1. Behavior was analyzed in the open field test (OFT) and the elevated plus maze (EPM), using Realtimer software (OpenScience, Russia). Data were analyzed using GrafPadPrism 8.03 software (USA). The experiment demonstrated that metabolic syndrome is associated with increased anxiety (decrease in horizontal (p=0.017) and vertical (p=0.017) locomotor activity) and fear (increase in immobility time (p=0.011)) in the OFT. Increased anxiety of animals (decreased open arm time (p=0.012) and increased closed arm time (p=0.043)) and emotional stress (increased frequency of defecation (0.017)) relative to control are also confirmed by EPM data. The data obtained in the treatment group (no significant differences with the control), i.e., a decrease in the manifestations of fear and anxiety (increased orientation and exploratory activity), indicate that the complex phytoadaptogens are an effective anxiolytic. The mechanisms that led to this result remain to be explored, highlighting the role of the autonomic nervous system, leptin and ghrelin in behavior and the effect of the complex phytoadaptogens on them.","PeriodicalId":51770,"journal":{"name":"Archiv EuroMedica","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2022-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49071105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"STRESS RESISTANCE AND COPING STRATEGIES IN FIRST YEAR MEDICAL RESIDENTS","authors":"Karim Usmanov, K. Idrisova, M. Shapovalova, A. Abdullaeva","doi":"10.35630/2022/12/6.2","DOIUrl":"https://doi.org/10.35630/2022/12/6.2","url":null,"abstract":"The article presents the results of an empirical study of the level of stress resistance and coping strategies in first-year medical residents in surgical and pediatric specialties. The problem of adaptation of a young specialist during the period of training in residency to medical practice is relevant, since during this period the correctness of the chosen medical specialty and the career path of a specialist are assessed. As a result of our study, data were obtained on a high level of stress and low adaptation in the residents. Among surgical residents, stress levels are significantly higher. Preferred coping strategies among surgical residents are decision-making and positive reappraisal. Pediatric residents have predominance of escape-avoidance and decision-making coping strategies. The obtained data on the psychological status of medical residents at the initial stage of their career path enabled us to develop a program of psychological support, including diagnosis and training aimed at reducing stress and developing effective behavioral strategies.","PeriodicalId":51770,"journal":{"name":"Archiv EuroMedica","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2022-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47789121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ANTIBIOTIC RESISTANCE OF E. COLI IN CLINICAL PRACTICE","authors":"A. Morozov, S. Mgebrishvili, Anastasia Dorenskaya, K.K. Aleksanyan, K.M. Salmanova, Tatiana Sorokovikova, E. Penyaz', L. Pototskaya","doi":"10.35630/2022/12/6.12","DOIUrl":"https://doi.org/10.35630/2022/12/6.12","url":null,"abstract":"Background: Antibiotic-resistance is one of the most important problems in modern medicine. The overuse and misuse of antibiotics caused the development of drug-resistant pathogens. It is the reason for more difficult treatment for patients. Objective: To monitor E.coli sensitivity to antibiotics and to evaluate its antibiotic resistance in a multidisciplinary hospital setting. Methods: The study is presented by a statistical analysis of the results of microbiological examination of materials obtained from patients infected with E.Coli, treated in different departments of Tver Clinical Emergency Hospital (Russia) in 2018-2020. A total of 142 results of microbiological examination of urogenital tract, abdominal cavity and wound surfaces were processed. Results: The number of antibiotics to which the Gram-negative Escherichia Coli is resistant also increases with the age of the patients. Among the investigated antibacterial drugs in terms of the total number of microorganisms with resistance to them, the lowest clinical efficacy was observed in the drugs of the cephalosporin series. Among the most frequent diseases caused by the studied strains of E.coli are intestinal infections and urinary tract infections. In addition, infections caused by persistence of E. coli as a background disease can significantly complicate the underlying disease. Conclusion: The results present a rapid spread of resistance genes in the studied E.coli strains. It is the imperative for the improvement of antibiotic resistance monitoring using various laboratory methods. Based on the results of microbiological research it is necessary to create a database that will allow to select the optimal strategy for the drug treatment of patients according to its resistance profile.","PeriodicalId":51770,"journal":{"name":"Archiv EuroMedica","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2022-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47972193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"THE SIGNIFICANCE OF PLATELET-DERIVED GROWTH FACTOR CONCENTRATIONS IN ENDOTHELIOTROPIC NATURAL FOCI INFECTIONS","authors":"Vera V. Vasilkova, B. Kantemirova, A. Zhidovinov","doi":"10.35630/2022/12/6.13","DOIUrl":"https://doi.org/10.35630/2022/12/6.13","url":null,"abstract":"In recent years, the clinical symptomatology of Astrakhan spotted fever and coxiellosis has worsened. The pathogenesis of these two natural focal, endothelium-dependent infections is rather complicated, multifactorial and not properly studied. The current clinical symptomatology is characterized by severe intoxication syndrome, frequently signs of multiple organ failure, development of hemocoagulation and vascular complications [3, 4, 5]. To date, no early markers of endothelial vascular damage have been proposed for use in practical health care, which enable accurately assessing the severity degree and predicting the further course of the rickettsiae and coxiellosis. Platelet-derived growth factor (PDGF), which is widely used in the diagnosis and prognosis of cardiovascular diseases, various injuries and diabetes mellitus, may become such a marker.","PeriodicalId":51770,"journal":{"name":"Archiv EuroMedica","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2022-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48659451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"OVERCOMING MALE FACTOR INFERTILITY AMONG MEN WITH VARICOCELE","authors":"M. Faniev, A. Strachuk, E. Korovyakova, N. Sergeeva, Tatiana Ovchinnikova, O. Kosilo, N. Karaseva, S. Pashin, N. Druzhinina, E. Dolgov","doi":"10.35630/2022/12/6.18","DOIUrl":"https://doi.org/10.35630/2022/12/6.18","url":null,"abstract":"Varicocele is a disease that often occurs in infertile men. The prolonged existence of venous reflux in the pampiniform plexus of the scrotum contributes to the progress of the deterioration of the ejaculate, up to the total absence of germ cells in it. Aim: To assess the effect of varicocele on male infertility. Methods: All men (n=72) with varicocele and azoospermia included in the study were divided into two groups. In the first group (n=31), surgical treatment of varicocele was not performed and testicular biopsy was performed immediately. The men of the second group first underwent the microscopic subinguinal varicocelectomy, and after 6 months, according to indications, microTESE was performed. As a result, in the first group of patients, spermatozoa extraction was successful in 1/3 of men, and in the second group - in 2/3 (p<0.01). Conclusion: In patients with azoospermia, surgical treatment of varicocele helps to restore spermatogenesis in 16.6%. Also, the operation according to the microscopic subinguinal varicocelectomy improves the effectiveness of testicular biopsy by 26.3%.","PeriodicalId":51770,"journal":{"name":"Archiv EuroMedica","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2022-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47550892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CRYSTALLOSCOPIC ANALYSIS OF METABOLIC EFFECTS OF SINGLET OXYGEN: IN VITRO STUDY","authors":"A. Martusevich, A. Fedotova, Elena Stepanova, R. Kornev, I. Minenko, V. Nazarov, Mikhail Artamonov","doi":"10.35630/2022/12/6.8","DOIUrl":"https://doi.org/10.35630/2022/12/6.8","url":null,"abstract":"The aim of the study was to assess the effect of reactive oxygen species on the nature of dehydration structuring of blood plasma. The study was performed on 10 whole blood samples of practically healthy volunteers, divided into 3 equal portions. The first one (control) was not manipulated, the second was treated with an ozone-oxygen mixture (ozone concentration – 500 mcg/l), and the third - with a flow from a singlet oxygen generator “Airnergy” (power – 100%). The crystallogenic activity of blood serum was studied by classical crystalloscopy using a system of semi-quantitative indicators. It was stated that the considered reactive oxygen species (ozone and singlet oxygen intermediates) increase the crystallogenic properties of blood plasma, and this effect is more pronounced with respect to the flow from the singlet oxygen generator.","PeriodicalId":51770,"journal":{"name":"Archiv EuroMedica","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2022-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44027690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HEART RATE VARIABILITY AND BASIC HEMODYNAMIC PARAMETERS IN MEDICAL STUDENTS IN SEASONS WITH DIFFERENT PHOTOPERIOD","authors":"V. Belyayeva","doi":"10.35630/2022/12/6.14","DOIUrl":"https://doi.org/10.35630/2022/12/6.14","url":null,"abstract":"One of the main external factors that contributes to the seasonal functional reorganization of the organism in the process of adaptation is seasonal photoperiodic variability. Day length is affecting not only visual function, but also all physiological and behavioural processes controlled by the circadian rhythm system. The person's ability to adapt to changes in external factors is especially important for medical students who experience significant mental overload in the process of studying at a university. The study goal was to investigate the features of the main hemodynamic parameters and heart rate variability in medical students in the spring and autumn periods, with taking into account gender differences. Materials and methods: A cross-sectional study of 304 students of the North-Ossetian State Medical Academy (Russia) comprising 233 female and 71 male subjects was performed during periods of elongation (spring) and shortening (autumn) of the photoperiod. Blood pressure (BP), pulse rate (HR), parameters of heart rate variability (HRV) were measured. Results: The students showed an increase in DBP and MBP rates within the normal range in autumn. Hemodynamic parameters of SBP, DBP, PBP, MBP in males were significantly higher than in females group, regardless of the season. Interseasonal differences in HRV parameters (LF, THF, PHF, PLF, LF/HF, IC) were revealed. From spring to autumn period, LF decreases from 980.22 (590.30; 1445.83) to 690.68 (438.81; 1170.15) ms2 against the background of a decrease in the dominant period of the high-frequency component of the spectrum (THF) from 5.40 (3 .77; 6.10) to 3.71 (3.08; 5.54) s. The contribution of the high-frequency component (PHF) to the total power of HRV fluctuations increases by 10.4%, and the low-frequency component (PLF) decreases by 6.45% as the photoperiod shortens. The centralization index (IC) also declines from 2.58 (1.42; 3.90) to 1.61 (0.97; 2.98); p=0.0076. Parameters of Mean, Mo, RMSSD, pNN50, SDNN, TP, HF, PHF in spring are lower in males in comparison with females, while parameters of HR, SI, PLF, LF/HF, VLF/HF, IC, PARS are higher in males. Conclusions: It was indicated that the change in the photoperiod trend is an important mediator of heart rate variability in the annual cycle. The lengthening of the photoperiod in the spring season is accompanied by a shift in the vegetative balance of students towards an increase in the tonus of the sympathetic division of the autonomic nervous system (ANS) together with the involvement of the central circuit of the heart rhythm regulation. In autumn, on the background of shorter daylight duration hours, parasympathetic influences are intensified and autonomic regulation circuit is most active. In the common trend of increased sympathetic activity of the ANS and activation of the central regulatory circuit in the spring, in young males these changes are indicated at greater extent.","PeriodicalId":51770,"journal":{"name":"Archiv EuroMedica","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2022-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42703343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"THE EFFECT OF CONNECTIVE TISSUE DYSPLASIA ON THE FORMATION OF COMORBID PATHOLOGY IN YOUNG PEOPLE","authors":"V. Murga, I. Ivanova, Valentin Panteleev, Vadim E. Belyaev","doi":"10.35630/2022/12/6.25","DOIUrl":"https://doi.org/10.35630/2022/12/6.25","url":null,"abstract":"Deviations in the development of organs and connective tissue dysplasia (CTD) still remain an urgent interdisciplinary problem. The aim of this study was to study clinical and morphological changes of the maxillofacial system, skeletal deformities and blood parameters in 164 young people. Twice as much as in the control group, orthopedic pathology (68.4% and 32.9%) and manifestations of anemia were found in every fifth (21.5%) of the examined patient. The revealed multi-organ changes identified the need to select individual rehabilitation programs in patients with CTD.","PeriodicalId":51770,"journal":{"name":"Archiv EuroMedica","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2022-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49168483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EVOLUTION OF FIBROSIS, INFLAMMATION, STEATOSIS AND STEATOHEPATITIS IN HCV INFECTED PATIENTS AFTER TREATMENT WITH DIRECT- ACTING ANTIVIRAL THERAPY (A FIBROMAX® ANALYSIS)","authors":"G. Popescu, Razvan Rababoc, A. Mercan-Stanciu, M. Dodot, T. Isac, L. Toma, A. Zgura, A. Trifan, A. Șerbănică, L. Micu, L. Iliescu","doi":"10.35630/2022/12/6.16","DOIUrl":"https://doi.org/10.35630/2022/12/6.16","url":null,"abstract":"Aim: The aim of this study is to assess the evolution of Fibromax® parameters (fibrosis, inflammation, steatosis, steatohepatitis) in patients with chronic HCV hepatitis at one year after sustained virologic response (SVR) achieved by direct acting antiviral agents (DAA). Methods: This is a retrospective observational trial including 73 patients with chronic HCV hepatitis, who obtained sustained virologic response under ombitasvir/paritaprevir/ritonavir and dasabuvir, ledipasvir/sofosbuvir or sofosbuvir/velpatasvir. All the patients were evaluated by Fibromax before the initiation of therapy and at 12 months after SVR. Results and Conclusion: The study included 42 women (57.53%) and 31 men (42.46%), without significant difference in mean age or BMI. We found a higher prevalence of patients with minimal or moderate fibrosis (F1, F2), compared to patients with advanced fibrosis (F3) (63.01% versus 10.95%). At one year follow-up, we found an increased number of patients in the lower levels of fibrosis, inflammation and NASH, with a relatively constant distribution of patients regarding steatosis. Necro-inflammatory activity was significantly diminished, with 58 patients in the no to minimal activity, compared to 37 patients before antiviral therapy. More patients presented N0 and N1 degree of NASH at follow-up than before therapy (63 patients versus 42 patients, p= 0.02). The mean values of Fibrotest (p= 0.03), ActiTest (p<0.01) and NashTest (p=0.02) decreased significantly. The mean value of Steatotest also decreased, but without statistical significance (p=0.12).","PeriodicalId":51770,"journal":{"name":"Archiv EuroMedica","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2022-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48846590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}