The Open AIDS Journal最新文献_第5页

Fcgbp - A Potential Viral Trap in RV144. RV144中潜在的病毒陷阱Fcgbp。

The Open AIDS Journal Pub Date : 2014-09-08 eCollection Date: 2014-01-01 DOI: 10.2174/1874613601408010021

Jacquelyn L Schwartz

引用次数: 21

Understanding STI Risk and Condom Use Patterns by Partner Type Among Female Sex Workers in Peru. 了解秘鲁女性性工作者中按伴侣类型划分的性传播感染风险和安全套使用模式。

The Open AIDS Journal Pub Date : 2014-05-30 eCollection Date: 2014-01-01 DOI: 10.2174/1874613601408010017

Janni J Kinsler, Magaly M Blas, Alejandra Cabral, Cesar Carcamo, Neal Halsey, Brandon Brown

引用次数: 17

Factors Associated with Uptake of HIV Test Results in a Nationally Representative Population-Based AIDS Indicator Survey. 在一项具有全国代表性的以人群为基础的艾滋病指标调查中，与接受艾滋病毒检测结果相关的因素。

The Open AIDS Journal Pub Date : 2014-03-07 eCollection Date: 2014-01-01 DOI: 10.2174/1874613601408010007

Mary Mwangi, Timothy A Kellogg, Sufia S Dadabhai, Rebecca Bunnell, Godfrey Baltazar, Carol Ngare, George K'opiyo, Margaret Mburu, Andrea A Kim

{"title":"Factors Associated with Uptake of HIV Test Results in a Nationally Representative Population-Based AIDS Indicator Survey.","authors":"Mary Mwangi, Timothy A Kellogg, Sufia S Dadabhai, Rebecca Bunnell, Godfrey Baltazar, Carol Ngare, George K'opiyo, Margaret Mburu, Andrea A Kim","doi":"10.2174/1874613601408010007","DOIUrl":"https://doi.org/10.2174/1874613601408010007","url":null,"abstract":"Population-based surveys with HIV testing in settings with low testing coverage provide opportunities for participants to learn their HIV status. Survey participants (15-64 years) in a 2007 nationally representative population-based HIV serologic survey in Kenya received a voucher to collect HIV test results at health facilities 6 weeks after blood draw. Logistic regression models were fitted to identify predictors of individual and couple collection of results. Of 15,853 adults consenting to blood draw, 7,222 (46.7%) collected HIV test results (46.5% men, 46.8% women). A third (39.5%) of HIV-infected adults who were unaware of their infection and 48.2% of those who had never been tested learned their HIV status during KAIS. Individual collection of HIV results was associated with older age, with the highest odds among adults aged 60-64 years (adjusted odds ratio [AOR], 1.6, 95% confidence interval [CI] 1.2-2.1); rural residence (AOR 1.8, 95%CI 1.2-2.6); and residence outside Nairobi, with the highest odds in the sparsely populated North Eastern province (AOR 8.0, 95%CI 2.9-21.8). Of 2,685 married/cohabiting couples, 18.5% collected results as a couple. Couples in Eastern province and in the second and middle wealth quintiles were more likely to collect results than those in Nairobi (AOR 3.2, 95%CI 1.1-9.4) and the lowest wealth quintile (second AOR 1.5, 95%CI 1.1-2.3; middle AOR 1.6, 95% CI 1.2-2.3, respectively. Many participants including those living with HIV learned their HIV status in KAIS. Future surveys need to address low uptake of results among youth, urban residents, couples and those with undiagnosed HIV infection. ","PeriodicalId":515834,"journal":{"name":"The Open AIDS Journal","volume":"8 ","pages":"7-16"},"PeriodicalIF":0.0,"publicationDate":"2014-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ef/6a/TOAIDJ-8-7.PMC3975632.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32239946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Modulation of Regulatory T-Cell Subsets in Very Long-Term Treated Aviremic HIV(+) Patients and Untreated Viremic Patients. 长期治疗的病毒血症HIV(+)患者和未治疗的病毒血症患者调节性t细胞亚群的调节

The Open AIDS Journal Pub Date : 2014-02-07 eCollection Date: 2014-01-01 DOI: 10.2174/1874613601408010001

Federico Serana, Marco Chiarini, Eugenia Quiros-Roldan, Daria Gotti, Cinzia Zanotti, Alessandra Sottini, Diego Bertoli, Luigi Caimi, Luisa Imberti

{"title":"Modulation of Regulatory T-Cell Subsets in Very Long-Term Treated Aviremic HIV(+) Patients and Untreated Viremic Patients.","authors":"Federico Serana, Marco Chiarini, Eugenia Quiros-Roldan, Daria Gotti, Cinzia Zanotti, Alessandra Sottini, Diego Bertoli, Luigi Caimi, Luisa Imberti","doi":"10.2174/1874613601408010001","DOIUrl":"https://doi.org/10.2174/1874613601408010001","url":null,"abstract":"Naïve, central- and effector-like memory regulatory T cells (Tregs) were evaluated in untreated and long-term antiretroviral-treated HIV(+) patients that showed comparable CD4(+) cell levels, while being, respectively, viremic and aviremic. In the untreated patients, the percentage of naïve-like Tregs was significantly increased to the detriment of central memory regulatory T cells. This redistribution of regulatory Treg subsets may contribute to explain the partially preserved CD4(+) cell counts seen in these patients despite the ongoing viremia. On the contrary, in the long-term treated patients, the percentages of Treg subsets were similar to those of healthy donors, demonstrating a restored Treg homeostasis. The characterization of Treg subsets, rather than an evaluation of the total Treg population, may lead to a deeper understanding of the Treg role in HIV infection and therapy. ","PeriodicalId":515834,"journal":{"name":"The Open AIDS Journal","volume":"8 ","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2014-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/d2/db/TOAIDJ-8-1.PMC3952203.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32173765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Cervical HPV Infection in Female Sex Workers: A Global Perspective. 女性性工作者宫颈HPV感染:全球视角。

The Open AIDS Journal Pub Date : 2013-12-30 eCollection Date: 2013-01-01 DOI: 10.2174/1874613601307010058

Melissa Soohoo, Magaly Blas, Gita Byraiah, Cesar Carcamo, Brandon Brown

{"title":"Cervical HPV Infection in Female Sex Workers: A Global Perspective.","authors":"Melissa Soohoo, Magaly Blas, Gita Byraiah, Cesar Carcamo, Brandon Brown","doi":"10.2174/1874613601307010058","DOIUrl":"https://doi.org/10.2174/1874613601307010058","url":null,"abstract":"Introduction: Approximately 291 million women worldwide are HPV DNA carriers. Studies have indicated that having multiple sexual partners may lead to higher HPV transmission. Thus female sex workers (FSWs) may be at greater risk of infection compared to the general population. Herein we review publications with data on FSW cervical HPV test results. We also examine variations of HPV prevalence and risk behaviors by region. Knowledge of prevalent HPV types in FSWs may lead to improved prevention measures and assist in understanding vaccination in high-risk groups.Methods: We conducted a review of the literature by searching PUBMED using the terms \"prostitution\" or \"female sex workers\", \"human papillomavirus\" or \"HPV\", and \"prevalence\" or \"PCR\" to find articles. We excluded studies without HPV testing or HPV type specific results, or unconventional HPV testing.Results: A total of 35 peer-reviewed publications were included in our review. High risk HPV types 16 and 18 ranged from 1.1-38.9‰ in prevalence. In addition to high-risk HPV types, newer studies reported non-carcinogenic HPV types also of high prevalence. The most prevalent HPV types reported among FSWs included HPV 6 (11.5%), 16 (38.9%), 18 (23.1%), 31 (28.4%), 52 (32.7%), and 58 (26.0%).Conclusions: Female sex workers have an overall high prevalence of HPV infection of high-risk types as evident through various testing methods. FSWs are thought to be at increased risk of cervical cancer because of high HPV exposure. This highlights the need for HPV and cervical prevention campaigns tailored to FSWs.","PeriodicalId":515834,"journal":{"name":"The Open AIDS Journal","volume":"7 ","pages":"58-66"},"PeriodicalIF":0.0,"publicationDate":"2013-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2174/1874613601307010058","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32101875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 54

Older Adults with HIV/AIDS in Rural China. 中国农村老年艾滋病感染者

The Open AIDS Journal Pub Date : 2013-12-27 DOI: 10.2174/1874613601307010051

Yurong Zhang, Esme Fuller-Thomson, Christine Anne Mitchell, Xiulan Zhang

{"title":"Older Adults with HIV/AIDS in Rural China.","authors":"Yurong Zhang, Esme Fuller-Thomson, Christine Anne Mitchell, Xiulan Zhang","doi":"10.2174/1874613601307010051","DOIUrl":"https://doi.org/10.2174/1874613601307010051","url":null,"abstract":"Although the number of older people living with HIV/AIDS (PLWHA) has increased substantially, few studies have focused on older PLWHA in developing countries. Based on a sample of 866 rural PLWHA in Henan, Anhui and Yunnan provinces in China, this study compares the characteristics of PLWHA aged 50 or older (n=185) with younger PLWHA (n=681). Most of the older PLWHA were female (n=112), illiterate, married and at the clinical stage of HIV. Over 90% of older people with HIV/AIDS lived in Henan and Anhui provinces. The severe epidemic in Henan and Anhui provinces was caused by commercial blood and plasma donation. Older PLWHA were less educated, received less social support and were more likely to live alone than younger PLWHA. The results underline the importance of developing programs and policy initiatives targeted at older people infected with HIV/AIDS. The policy and program recommendations include using a gender sensitive strategy, designing specific AIDS education and prevention programs suitable for low-literacy older adults and social support interventions for older PLWHA. ","PeriodicalId":515834,"journal":{"name":"The Open AIDS Journal","volume":"7 ","pages":"51-7"},"PeriodicalIF":0.0,"publicationDate":"2013-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/f2/25/TOAIDJ-7-51.PMC3893720.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32055046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14

The Higher Frequency of Blood Group B in a Brazilian Population with HIV Infection. 巴西HIV感染人群中B型血的频率较高。

The Open AIDS Journal Pub Date : 2013-10-18 eCollection Date: 2013-01-01 DOI: 10.2174/1874613601307010047

Tor Gunnar Hugo Onsten, Sidia Maria Callegari-Jacques, Luciano Zubaran Goldani

{"title":"The Higher Frequency of Blood Group B in a Brazilian Population with HIV Infection.","authors":"Tor Gunnar Hugo Onsten, Sidia Maria Callegari-Jacques, Luciano Zubaran Goldani","doi":"10.2174/1874613601307010047","DOIUrl":"https://doi.org/10.2174/1874613601307010047","url":null,"abstract":"Objective: To analyze the frequency of and odds for and against HIV infection based on ABO blood type in a large sample of blood donors.Background: Coevolution between pathogens and hosts may explain the ABO system of polymorphisms. HIV-infected cells add ABO(H) blood group antigens to the viral envelope. Naturally occurring antibodies against ABO(H) antigens that are present in normal human sera are able to neutralize ABO-expressing HIV in vitro. Blood donors are ideal for studying blood groups and HIV infection in vivo because all donors are routinely typed and tested.Methods: All blood donors who donated blood between 1994 and 2010 were tested for HIV (ELISA antibody tests and Western blot test or immunofluorescence testing) and were ABO typed (direct and reverse grouping tests). HIV infection based on the ABO blood group was analyzed using the chi-square test and game theory.Results: The total number of examined blood donors during this period was 271,410, of whom 389 were infected with HIV. B-group donors were more infected than non-B donors (p= 0.006).Conclusions: A more restricted antigen recognition capacity of anti-Galα1-3Gal in blood groups AB and B and a weaker antigen-binding capacity of anti-A antibodies may contribute to a higher frequency of HIV infection in blood group B.","PeriodicalId":515834,"journal":{"name":"The Open AIDS Journal","volume":"7 ","pages":"47-50"},"PeriodicalIF":0.0,"publicationDate":"2013-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2174/1874613601307010047","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31858317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 19

An Ecological View of Internet Health Information Seeking Behavior Predictors: Findings from the CHAIN Study. 网络健康信息寻求行为预测因子的生态学观点:来自CHAIN研究的发现。

The Open AIDS Journal Pub Date : 2013-10-18 eCollection Date: 2013-01-01 DOI: 10.2174/1874613601307010042

Joshua K Calvert, Angela A Aidala, Josh H West

{"title":"An Ecological View of Internet Health Information Seeking Behavior Predictors: Findings from the CHAIN Study.","authors":"Joshua K Calvert, Angela A Aidala, Josh H West","doi":"10.2174/1874613601307010042","DOIUrl":"https://doi.org/10.2174/1874613601307010042","url":null,"abstract":"Objective: The purpose of the study was to further elucidate proximal and distal demographic and social predictors of Internet Health Information Seeking Behavior (IHISB) among a cohort of HIV+ individuals through an ecological framework.Methods: The Community Health Advisory & Information Network (CHAIN) project is an ongoing prospective study of a representative sample of persons living with HIV/AIDS in New York City and the Tri-County region. The study sample was drawn from a two-stage randomized technique with the clients of 43 medical and social service organizations with 693 HIV+ participants. Bivariate correlations were computed between IHISB and independent demographic variables in ecological blocks. Multivariate hierarchical logistic regression was used to test association between blocks of variables and IHISB.Results: Among the surveyed respondents (n=645) 50.3% indicated that they used the Internet. Being above the poverty line, having less than a high school education, and having fewer neighbors were statistically significant predictors of IHISB related to HIV.Conclusions: The benefits of accessing the Internet may influence health behavior and may be considered a target for interventions that aim to increase access to health related information online. Coupled with increased access, is the need for increased patient education interventions, and creative managed care approaches to ensure that information gleaned from online sources is interpretable and accurate in order to benefit the lives of those living with HIV/AIDS.","PeriodicalId":515834,"journal":{"name":"The Open AIDS Journal","volume":"7 ","pages":"42-6"},"PeriodicalIF":0.0,"publicationDate":"2013-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/e5/40/TOAIDJ-7-42.PMC3821080.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31858316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 16

mHealth for HIV Treatment & Prevention: A Systematic Review of the Literature. 移动医疗用于艾滋病治疗和预防:文献的系统回顾。

The Open AIDS Journal Pub Date : 2013-08-13 eCollection Date: 2013-01-01 DOI: 10.2174/1874613620130812003

Caricia Catalani, William Philbrick, Hamish Fraser, Patricia Mechael, Dennis M Israelski

{"title":"mHealth for HIV Treatment & Prevention: A Systematic Review of the Literature.","authors":"Caricia Catalani, William Philbrick, Hamish Fraser, Patricia Mechael, Dennis M Israelski","doi":"10.2174/1874613620130812003","DOIUrl":"https://doi.org/10.2174/1874613620130812003","url":null,"abstract":"This systematic review assesses the published literature to describe the landscape of mobile health technology (mHealth) for HIV/AIDS and the evidence supporting the use of these tools to address the HIV prevention, care, and treatment cascade. The speed of innovation, broad range of initiatives and tools, and heterogeneity in reporting have made it difficult to uncover and synthesize knowledge on how mHealth tools might be effective in addressing the HIV pandemic. To do address this gap, a team of reviewers collected literature on the use of mobile technology for HIV/AIDS among health, engineering, and social science literature databases and analyzed a final set of 62 articles. Articles were systematically coded, assessed for scientific rigor, and sorted for HIV programmatic relevance. The review revealed evidence that mHealth tools support HIV programmatic priorities, including: linkage to care, retention in care, and adherence to antiretroviral treatment. In terms of technical features, mHealth tools facilitate alerts and reminders, data collection, direct voice communication, educational messaging, information on demand, and more. Studies were mostly descriptive with a growing number of quasi-experimental and experimental designs. There was a lack of evidence around the use of mHealth tools to address the needs of key populations, including pregnant mothers, sex workers, users of injection drugs, and men who have sex with men. The science and practice of mHealth for HIV are evolving rapidly, but still in their early stages. Small-scale efforts, pilot projects, and preliminary descriptive studies are advancing and there is a promising trend toward implementing mHealth innovation that is feasible and acceptable within low-resource settings, positive program outcomes, operational improvements, and rigorous study design. ","PeriodicalId":515834,"journal":{"name":"The Open AIDS Journal","volume":"7 ","pages":"17-41"},"PeriodicalIF":0.0,"publicationDate":"2013-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2174/1874613620130812003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31813496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 223

Delay in Seeking Care for Sexually Transmitted Diseases in Young Men and Women Attending a Public STD Clinic. 在公立性病诊所就诊的年轻男女在寻求性传播疾病治疗方面的延误。

The Open AIDS Journal Pub Date : 2013-06-14 eCollection Date: 2013-01-01 DOI: 10.2174/1874613620130614002

Angela M Malek, Chung-Chou H Chang, Duncan B Clark, Robert L Cook

{"title":"Delay in Seeking Care for Sexually Transmitted Diseases in Young Men and Women Attending a Public STD Clinic.","authors":"Angela M Malek, Chung-Chou H Chang, Duncan B Clark, Robert L Cook","doi":"10.2174/1874613620130614002","DOIUrl":"10.2174/1874613620130614002","url":null,"abstract":"Background: Delay in seeking care for sexually transmitted diseases (STDs) has adverse consequences for both the individual and population. We sought to identify factors associated with delay in seeking care for STDs.Methods: Subjects included 300 young men and women (aged 15-24) attending an urban STD clinic for a new STD-related problem due to symptoms or referral for an STD screening. Subjects completed a structured interview that evaluated STD history, attitudes and beliefs about STDs, depression, substance use, and other factors possibly associated with delay. Delay was defined as waiting > 7 days to seek and obtain care for STDs.Results: Nearly one-third of participants delayed seeking care for > 7 days. Significant predictors for delay included self-referral for symptoms as the reason for visit (OR 5.3, 95% CI: 2.58 - 10.98), and the beliefs \"my partner would blame me if I had an STD\" (OR 2.44, 95% CI: 1.30 - 4.60) and \"it's hard to find time to get checked for STDs\" (OR 3.62, 95% CI: 1.95 - 6.69), after adjusting for age, race, sex, and other factors. Agreeing with the statement \"would use a STD test at home if one were available\" was associated with a decrease in delay (OR 0.24, 95% CI: 0.09 - 0.60).Conclusions: Many young persons delay seeking care for STDs for a number of reasons. Strategies to improve STD care-seeking include encouragement of symptomatic persons to seek medical care more rapidly, reduction of social stigmas, and improved access to testing options.","PeriodicalId":515834,"journal":{"name":"The Open AIDS Journal","volume":"7 ","pages":"7-13"},"PeriodicalIF":0.0,"publicationDate":"2013-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/22/22/TOAIDJ-7-7.PMC3785038.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31769190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0