International Journal of Cancer Care and Delivery最新文献

{"title":"What’s Moral Distress Got to Do With It? How to Avoid Burnout and Optimize Patient Care","authors":"Bowen He, Claudia A Finkelstein, Lynn Symonds, Natalie F Uy, Hannah M Linden","doi":"10.53876/001c.94856","DOIUrl":"https://doi.org/10.53876/001c.94856","url":null,"abstract":"Burnout, estimated to affect between 40-80% of healthcare professionals, is a complex issue encompassing emotional exhaustion, depersonalization, and a decreased sense of personal accomplishment. The Stanford Model of Professional Fulfillment considers both individual and system-level factors with three main elements of efficiency of practice, personal resilience, and culture of wellness. Dr. Finkelstein’s alternate model for burnout reimagines the Stanford Model with three main factors contributing to burnout: inevitable suffering, moral distress, and “extra junk.” In Dr. Finkelstein’s alternate model, inevitable suffering arises from the emotional toll of providing patient care. While interventions like coaching, therapy, and mindfulness are beneficial, they must be offered genuinely, not as profit-driven schemes. “Extra junk” refers to administrative burdens that take away from patient care. Some initiatives aim to alleviate these burdens, but their effectiveness needs critical evaluation. Finally, moral distress occurs when external constraints hinder an individual’s ethical actions. Burnout affects not just individual professionals but also the entire healthcare system, leading to early retirements, lower quality care, and worsening health outcomes. Recognizing this, the US Surgeon General has outlined an approach to address burnout that requires cultural changes at all levels of the healthcare ecosystem. Healthcare professionals are resilient, and part of the solution lies in individual recognition of burnout, work-life balance, and finding joy in work. However, larger cultural shifts towards justice and equity, both within healthcare and broader society, are needed. This includes prioritizing workforce diversity, humane sick and maternity leave policies, and reducing unnecessary administrative burdens. Academic institutions also have a role in promoting mentorship, recognizing the contributions of underrepresented groups, and supporting burnout research. Addressing burnout effectively requires a comprehensive approach that considers individual and system-level factors, advocating for systemic reforms, and prioritizing justice and equity within the healthcare ecosystem.","PeriodicalId":507790,"journal":{"name":"International Journal of Cancer Care and Delivery","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140380068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cell Therapy: Actionable Takeaways from the 2023 Precision Oncology Summit Session","authors":"Hannah Abrams, I. Abuali, Abdul Moiz Khan, Ivy Riano, Greg Allen, Michael A Spinner, Krishna Komanduri","doi":"10.53876/001c.94047","DOIUrl":"https://doi.org/10.53876/001c.94047","url":null,"abstract":"The 2023 Precision Oncology Summit was held in San Francisco on October 7th and 8th, focusing on actionable strategies addressing personalized treatment to improve patient outcomes. This manuscript summarizes the discussion and key learning points from the “Cell Therapy” session.","PeriodicalId":507790,"journal":{"name":"International Journal of Cancer Care and Delivery","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140377779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Revolution in Germline DNA Testing: Actionable Takeaways from the 2023 Precision Oncology Summit","authors":"Inas Abuali, Hannah Abrams, Abdul Moiz Khan, Ivy Riano, Pamela Munster, Siddhartha Yadav, Marianne E Dubard-Gault","doi":"10.53876/001c.94045","DOIUrl":"https://doi.org/10.53876/001c.94045","url":null,"abstract":"The 2023 Precision Oncology Summit was held in San Francisco on October 7th and 8th, focusing on actionable strategies addressing personalized treatment to improve patient outcomes. This manuscript summarizes the discussion and key learning points from “The Revolution in Germline DNA Testing” session.","PeriodicalId":507790,"journal":{"name":"International Journal of Cancer Care and Delivery","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140422694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gastrointestinal Malignancies: Actionable Takeaways from the 2023 Precision Oncology Summit","authors":"Inas Abuali, Ivy Riano, Hannah Abrams, Abdul Moiz Khan, Hanlee P. Ji","doi":"10.53876/001c.94048","DOIUrl":"https://doi.org/10.53876/001c.94048","url":null,"abstract":"The 2023 Precision Oncology Summit was held in San Francisco on October 7th and 8th, focusing on actionable strategies addressing personalized treatment to improve patient outcomes. This manuscript summarizes the discussion and key learning points from the precision medicine clinical science symposium in gastrointestinal (GI) malignancies.","PeriodicalId":507790,"journal":{"name":"International Journal of Cancer Care and Delivery","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140419806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Implementation of Precision Oncology into the Diagnostic and Therapeutic Armamentarium: Actionable Takeaways from the 2023 Precision Oncology Summit","authors":"Ivy Riano, Inas Abuali, Hannah Abrams, Moiz Khan, Manish Kohli, Andrei Iagaru","doi":"10.53876/001c.94061","DOIUrl":"https://doi.org/10.53876/001c.94061","url":null,"abstract":"The 2023 Precision Oncology Summit was held in San Francisco, CA on October 7th and 8th, focusing on actionable strategies addressing personalized treatment to improve patient outcomes. This manuscript summarizes the discussion and key learning points from the precision medicine clinical science symposium in the implementation of Precision Oncology into the diagnostic and therapeutic armamentarium. This topic encompasses the advancement of molecular imaging in precision medicine and machine learning (ML) as a strategy to enhance precision oncology by individualizing patient treatments.","PeriodicalId":507790,"journal":{"name":"International Journal of Cancer Care and Delivery","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140418024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PARP Inhibitors in Prostate Cancer – Understanding the Current Landscape","authors":"Karine Tawagi, M. Schmolze, Brandon Nguyen, Aaron Laviana, Natalie M Reizine","doi":"10.53876/001c.92258","DOIUrl":"https://doi.org/10.53876/001c.92258","url":null,"abstract":"Poly (ADP [adenosine diphosphate]-ribose) polymerase inhibitors (PARPi) are a current standard of care treatment option for patients with metastatic castration resistant prostate cancer (mCRPC), defined as prostate cancers that continue to progress despite treatment with the usual first-line androgen-deprivation therapies. PARPi’s function by targeting faulty homologous recombination repair pathways that result in cytotoxic double strand DNA break (DSB) accumulation in prostate cancer cells. While the efficacy of PARPi’s as a monotherapy option in mCRCP has been demonstrated clinically, the added utility of PARPi’s in combination with other anti-cancer agents is still being explored. This article will review the scientific rationale behind PARP-inhibitors, discuss the germline and somatic mutation testing critical to identifying predictive biomarkers for PARPi efficacy, and present the currently approved PARPi combination therapies and their indications. This review will also examine the incidence and management of PARPi toxicity, summarize ongoing trials, and propose areas of future study.","PeriodicalId":507790,"journal":{"name":"International Journal of Cancer Care and Delivery","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140497274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}