medRxiv - Cardiovascular Medicine最新文献_第4页

High levels of IsoDGR-modified fibronectin are associated with higher levels of macrophages and other rupture-prone plaque characteristics in patients undergoing carotid endarterectomy 在接受颈动脉内膜切除术的患者中，高水平的 IsoDGR 修饰纤连蛋白与较高水平的巨噬细胞和其他易破裂斑块特征有关

medRxiv - Cardiovascular Medicine Pub Date : 2024-09-03 DOI: 10.1101/2024.09.02.24312942

Tetiana Motsak, Barend M. Mol, Joost K.R. Hoekstra, Valentina Osorio Zuluaga, Saskia Rumpff-Derksen, Ioanna Paspali-Strik, Sofon Cam Ngan, Gerard Pasterkamp, Gert J. de Borst, Siu Kwan Sze, Dominique P.V. de Kleijn

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Triglyceride/High Density Lipoprotein Cholesterol Index and Future Cardiovascular Events in Diabetic Patients without Known Cardiovascular Disease 未患已知心血管疾病的糖尿病患者的甘油三酯/高密度脂蛋白胆固醇指数与未来心血管事件的关系

medRxiv - Cardiovascular Medicine Pub Date : 2024-09-01 DOI: 10.1101/2024.08.30.24312870

Ryosuke Nakashima, Shota Ikeda, Keisuke Shinohara, Sho Matsumoto, Daisuke Yoshida, Yoshiyasu Ono, Hiroka Nakashima, Ryohei Miyamoto, Shouji Matsushima, Junji Kishimoto, Hiroshi Itoh, Issei Komuro, Hiroyuki Tsutsui, Shintaro Kinugawa, Kohtaro Abe

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Large Language Models in Cardiology: A Systematic Review 心脏病学中的大型语言模型：系统回顾

medRxiv - Cardiovascular Medicine Pub Date : 2024-09-01 DOI: 10.1101/2024.09.01.24312887

Moran Gendler, Girish N Nadkarni, Karin Sudri, Michal Cohen-Shelly, Benjamin S Glicksberg, Orly Efros, Shelly Soffer, Eyal Klang

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Predicting thoracic aortic dissection in a diverse biobank using a polygenic risk score 利用多基因风险评分预测不同生物库中的胸主动脉夹层

medRxiv - Cardiovascular Medicine Pub Date : 2024-09-01 DOI: 10.1101/2024.09.01.24312895

John DePaolo, Siavash Zamirpour, Sarah Abramowitz, Gina Biagetti, Renae Judy, Cameron Beeche, Jeffrey Duda, James Gee, Walter R. Witschey, Julio A. Chirinos, Nicholas J. Goel, Nimesh Desai, Wilson Y. Szeto, Dongchuan Guo, Dianna M. Milewicz, Michael G. Levin, James P. Pirruccello, Scott M. Damrauer

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High Precision ECG Digitization Using Artificial Intelligence 利用人工智能实现高精度心电图数字化

medRxiv - Cardiovascular Medicine Pub Date : 2024-09-01 DOI: 10.1101/2024.08.31.24312876

Anthony Demolder, Viera Kresnakova, Michal Hojcka, Vladimir Boza, Andrej Iring, Adam Rafajdus, Simon Rovder, Timotej Palus, Martin Herman, Felix Bauer, Viktor Jurasek, Robert Hatala, Jozef Bartunek, Boris Vavrik, Robert Herman

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Children and Adolescent Patients with Variants in the ATP1A3-encoded Sodium-Potassium ATPase Alpha-3 Subunit Demonstrate an Impaired QT Response to Bradycardia and Predisposition to Sinus Node Dysfunction ATP1A3编码的钠-钾ATP酶α-3亚基变异的儿童和青少年患者对心动过缓的QT反应受损，容易出现窦房结功能障碍

medRxiv - Cardiovascular Medicine Pub Date : 2024-09-01 DOI: 10.1101/2024.08.31.24312446

Meredith K. Srour, Minu-Tshyeto K. Bidzimou, Padmapriya Muralidharan, Saige M. Mitchell, Mary E. Moya-Mendez, Lauren E. Parker, Gabriela Reyes Valenzuela, Roberto Caraballo, Giacomo Garone, Federico Vigevano, Sarah Weckhuysen, Charissa Millevert, Monica Troncoso, Mario Matamala, Simona Balestrini, Sanjay M. Sisodiya, Josephine Poole, Claudio Zucca, Eleni Panagiotakaki, Maria T. Papadopoulou, Sébile Tchaicha, Matthildi Athina Papathanasiou Terzi, Marta Zawadzka, Maria Mazurkiewicz-Bełdzińska, Carmen Fons, Jennifer Anticona, Elisa De Grandis, Ramona Cordani, Livia Pisciotta, Sergiu Groppa, Sandra Paryjas, Francesca Ragona, Elena Mangia, Tiziana Granata, Andrey Megvinov, Rosaria Vavassori, Mohamad A. Mikati, Andrew P. Landstrom

{"title":"Children and Adolescent Patients with Variants in the ATP1A3-encoded Sodium-Potassium ATPase Alpha-3 Subunit Demonstrate an Impaired QT Response to Bradycardia and Predisposition to Sinus Node Dysfunction","authors":"Meredith K. Srour, Minu-Tshyeto K. Bidzimou, Padmapriya Muralidharan, Saige M. Mitchell, Mary E. Moya-Mendez, Lauren E. Parker, Gabriela Reyes Valenzuela, Roberto Caraballo, Giacomo Garone, Federico Vigevano, Sarah Weckhuysen, Charissa Millevert, Monica Troncoso, Mario Matamala, Simona Balestrini, Sanjay M. Sisodiya, Josephine Poole, Claudio Zucca, Eleni Panagiotakaki, Maria T. Papadopoulou, Sébile Tchaicha, Matthildi Athina Papathanasiou Terzi, Marta Zawadzka, Maria Mazurkiewicz-Bełdzińska, Carmen Fons, Jennifer Anticona, Elisa De Grandis, Ramona Cordani, Livia Pisciotta, Sergiu Groppa, Sandra Paryjas, Francesca Ragona, Elena Mangia, Tiziana Granata, Andrey Megvinov, Rosaria Vavassori, Mohamad A. Mikati, Andrew P. Landstrom","doi":"10.1101/2024.08.31.24312446","DOIUrl":"https://doi.org/10.1101/2024.08.31.24312446","url":null,"abstract":"<strong>Background</strong> Alternating hemiplegia of childhood (AHC) is a rare disorder with both neurologic and cardiac manifestations. The ATP1A3-D801N variant is associated with a pathologically short QT interval and risk of ventricular arrhythmia following bradycardia; however, the mechanism of this remains unknown. We investigated the relationship between heart rate (HR), QT, and QTc, hypothesizing that individuals with ATP1A3-D801N have abnormal, impaired shortening of QT and QTc at lower HR leading to arrhythmia predisposition.","PeriodicalId":501297,"journal":{"name":"medRxiv - Cardiovascular Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142218965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aortic root anatomy and impact on new-onset conduction abnormalities after transcatheter aortic valve implantation 主动脉根部解剖及其对经导管主动脉瓣植入术后新发传导异常的影响

medRxiv - Cardiovascular Medicine Pub Date : 2024-08-31 DOI: 10.1101/2024.08.30.24312869

Habib Layoun, Joseph Kassab, Michel Chedid El Helou, Joseph El Dahdah, Odette Iskandar, Maryam Muhammad Ali Majeed Saidan, Abdelrahman Abushouk, Toshiaki Isogai, Grant Reed, Rishi Puri, Oussama M. Wazni, Amar Krishnaswamy, Serge Harb, Samir Kapadia

引用次数: 0

Exploring associations between estrogen and gene candidates identified by coronary artery disease genome-wide association studies 探索雌激素与冠状动脉疾病全基因组关联研究确定的候选基因之间的关系

medRxiv - Cardiovascular Medicine Pub Date : 2024-08-30 DOI: 10.1101/2024.08.29.24312812

Ava P. Aminbakhsh, Emilie T. Théberge, Elizabeth Burden, Cindy Kalenga Adejumo, Anna Lehman, Tara L. Sedlak

引用次数: 0

Advanced Echocardiographic Assessment in Transthyretin Amyloidosis: Early Phenotype Markers in Mutation Carriers 转甲状腺素淀粉样变性的高级超声心动图评估：突变携带者的早期表型标志物

medRxiv - Cardiovascular Medicine Pub Date : 2024-08-29 DOI: 10.1101/2024.08.27.24311875

Lorena Squassante Capeline, Frederico José Neves Mancuso, Gardênia Silva Lobo Oishi, Marly Uellendahl, Fernando Naylor, Acary Souza Bulle Oliveira, Valdir Ambrósio Moises

引用次数: 0

Comorbidity trajectories before and after the diagnosis of heart failure: a UK Biobank cohort study 心力衰竭诊断前后的合并症轨迹：英国生物库队列研究

medRxiv - Cardiovascular Medicine Pub Date : 2024-08-28 DOI: 10.1101/2024.08.28.24312712

Hugo MacGowan, Oliver Brown, Michael Drozd, Andrew Walker, Marilena Giannoudi, Sam Straw, Maria Paton, John Gierula, Melanie McGinlay, Kathryn Griffin, Klaus Witte, Mark Kearney, Richard Cubbon

{"title":"Comorbidity trajectories before and after the diagnosis of heart failure: a UK Biobank cohort study","authors":"Hugo MacGowan, Oliver Brown, Michael Drozd, Andrew Walker, Marilena Giannoudi, Sam Straw, Maria Paton, John Gierula, Melanie McGinlay, Kathryn Griffin, Klaus Witte, Mark Kearney, Richard Cubbon","doi":"10.1101/2024.08.28.24312712","DOIUrl":"https://doi.org/10.1101/2024.08.28.24312712","url":null,"abstract":"Background: Heart Failure (HF) is frequently associated with multiple comorbidities. We aimed to define their trajectory of accrual to identify opportunities for disease prevention.\u0000Methods: We identified all participants in the UK Biobank cohort study diagnosed with HF prior to enrolment or during follow-up, who had disease occurrence data available from both primary and secondary care records (n=9,824). We established the time between diagnosis of HF and 16 common comorbidities to determine the rate and sequence of comorbidity accrual in relation to HF. Stratified analyses considered associations with sex and age at diagnosis of HF.\u0000Findings: In chronological sequence, HF was the median fourth diagnosis for men and women. As the age at HF diagnosis increased, HF came later in the sequence of diseases (median second in under 50s to fifth in those aged 80-90). In all age strata, comorbidities accumulated for over a decade before HF and this accelerated in the years immediately before HF. The median time between comorbidity and HF diagnoses ranged from depression preceding HF by 10.7 years to dementia proceeding HF by 0.7 years; all comorbidities presented earlier in women. Atrial fibrillation/flutter was the commonest disease to immediately precede HF, followed by hypertension, cancer, myocardial infarction and osteoarthritis.\u0000Interpretation: HF is most often diagnosed in people with established multimorbidity. There is a protracted window of opportunity during which interventions to prevent HF could be applied, often in disease contexts where this is not routine care, such as cancer and osteoarthritis.\u0000Funding: British Heart Foundation (RG/F/22/110076)","PeriodicalId":501297,"journal":{"name":"medRxiv - Cardiovascular Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142218969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0