Вісник Одеського національного університету最新文献

{"title":"DETERMINATION OF THE IONIZATION CONSTANT OF FAVIPIRAVIR API","authors":"Yu. V. Scrypynets, G. O. Fedosenko, G. V. Maltsev, I. I. Chebotars'ka, D. I. Aleksandrova, S. N. Kashutskуy, A. V. Yegorova","doi":"10.18524/2304-0947.2023.2(85).286603","DOIUrl":"https://doi.org/10.18524/2304-0947.2023.2(85).286603","url":null,"abstract":"One of the aspects of studying the physical and chemical properties of compounds is the establishment of their ionization constants. These indicators are extremely important from both a theoretical and a practical point of view. Theoretical analysis of proteolytic equilibria and potentiometric titration of an aqueous solution of an oral antiviral drug approved for the treatment of influenza in Japan, AFI favipiravir, were carried out in the paper. The presence of a hydroxy group in the third position of the pyrazine cycle in the molecule determines the ability of favipiravir to exhibit acid-base properties. According to acid-base titration, the ionization constant of Favipiravir API was determined: pKa = 5.05 ± 0.02. On the basis of the found pK value, the degree of formation of protolytic forms was calculated depending on the pH of the solution. It was established that favipiravir API in solutions exists in two protonated (non-ionized), tautomeric forms A1H and A2H and one deprotonated (ionized) form A-. Based on the calculations, the following conclusions can be drawn: - at a pH value of the solution from 0 to 3.5, approximately 100% of the substance will be in two protonated (non-ionized), tautomeric forms A1H and A2H; - at pH = 5, approximately 50% of the substance will be in two protonated (non-ionized), tautomeric forms, A1H and A2H; - at a pH value > 6.5, approximately 100% of the substance will be in one deprotonated (ionized) form of A-. This is confirmed by the nature of the electronic absorption spectra of aqueous solutions of favipiravir. In the spectrum of favipiravir in a 0.1 M hydrochloric acid solution, there are two bands at the wavelengths of 322 nm and 365 nm, which correspond to the two tautomeric forms A1H and A2H. In the spectrum of favipiravir in 0.1 M sodium hydroxide solution, there is one band at a wavelength of 364 nm, which corresponds to one ionized form of A-. At the stage of pharmaceutical development, these data on the acid-base properties of the Favipiravir API can be used in the development of production technology, the creation of quality control methods and their validation, as well as in the study of the solubility of the API and the dissolution profiles of the finished medicinal product.","PeriodicalId":491501,"journal":{"name":"Вісник Одеського національного університету","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135935631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HYBRID ORGANIC–INORGANIC ASSEMBLIES BASED ON COORDINATION METAL–LIGAND FRAGMENTS: SYNTHESIS, PROPERTIES, APPLICATION IN CHROMATOGRAPHY","authors":"O. E. Martsynko, K. K. Tsymbalyuk","doi":"10.18524/2304-0947.2023.2(85).286598","DOIUrl":"https://doi.org/10.18524/2304-0947.2023.2(85).286598","url":null,"abstract":"The data on the synthetic methods of metal-organic frameworks (MOF) based on the coordination compounds of metals, including germanium, with the polydentate aromatic acids, their properties and applications are systemised in the paper. The prospect of using such types of MOFs to determine the highly toxic organic pollutants such as polycyclic aromatic hydrocarbons (PAHs) has been identified. Due to their unique properties, including large surface area, uniformly structured nanoscale cavities, tunable pore sizes and thermal stability MOFs are promising materials for use in analytical chemistry. They have been used in air sampling, as a stationary phase in chromatography, and as sorbents for solid-phase extraction, solid-phase microextraction, and magnetic solid-phase extraction. Depending on the structure of the ligands, MOFs can provide molecular recognition through different types of interactions of a wide range of compounds, such as polycyclic aromatic hydrocarbons (PAHs), polychlorinated biphenyls (PCBs), pyrethroids, nitrosamines and parabens, that are immunosuppressors, endocrine disruptors and cancerogenic compounds. For example, MOFs adsorb hydrophobic organic compounds (e.g., PAHs, PCBs) due to π-π stacking and hydrophobic interactions with organic linkers. Whereas the extraction of organic compounds with hydrophilic groups (for example, nitrosamines) occurs due to electrostatic interaction and hydrogen bonds. The most effective methods of synthesis of the considered type MOF are hydro(solvo)thermal synthesis and mechanochemical methods modified by adding a small amount of solvents. The slow diffusion methods are advisable to use to obtain crystals suitable for single-crystal X-ray diffraction.","PeriodicalId":491501,"journal":{"name":"Вісник Одеського національного університету","volume":"66 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135935446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"LUMINESCENT DETERMINATION OF EUROPIUM AND CERIUM IN THE JOINT PRESENCE IN SOLUTIONS – MELTS OF EQUIMOLAR MIXTURES NaCl–KCl","authors":"O. I. Teslyuk, N. A. Chivireva, V. F. Zinchenko, P. G. Doga","doi":"10.18524/2304-0947.2023.2(85).286607","DOIUrl":"https://doi.org/10.18524/2304-0947.2023.2(85).286607","url":null,"abstract":"Europium and Cerium belong to lanthanides of variable valency and have similar chemical properties. Luminescent method was proposed for the analytical determination of Eu(III) and Ce(III) with the simultaneous presence in the sample of [EuF3–CeF3 (1:1)]–[NaCl–KCl] (2:8), which is a promising material for detecting UV-solar radiation. Determination of Eu(III) was carried out by the method of sensitized 4f-4f luminescence in a complex with nalidixic acid at an emission wavelength of 613 nm, λex =351 nm. During complexation, a standard ratio of Stark components to Europium is observed in the luminescence spectra, in contrast to the spectrum of the sample solution without the reagent. This fact indicates that the formation of complexes not only increases the intensity of Eu(III) luminescence, but also reduces the effect of Cerium present in the solution. To determine Ce(III), its own luminescence caused by 5d-4f electronic transitions was used at an emission wavelength of 351 nm, λex =263 nm. The presence of Europium ions in the solution does not affect the nature of the luminescence excitation spectra and Ce(III) luminescence spectra. For the quantitative determination of these lanthanides, the additive method was used, which allows to level the mutual influence of ions, as well as the influence of Ce(IV) on the determination of Ce(III). It was found that the content of Eu(III) in the melt is 2.44–2.53% weight, which is in good agreement with the data obtained earlier when studying the EuF3 – [NaCl–KCl](1:9) system. Compared to EuF3, the solubility of CeF3 ((0.028–0.032)% weight) is significantly lower than that predicted by previous thermodynamic calculations. The obtained data allow us to conclude that the solubility of fluoride systems containing Eu in the NaCl–KCl melt is almost the same, and the presence of Ce(III) does not significantly affect the EuF3 dissolution process, and therefore does not affect the properties of the systems [EuF3 – CeF3] – [NaCl–KCl] as detectors of ultraviolet solar radiation.","PeriodicalId":491501,"journal":{"name":"Вісник Одеського національного університету","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135935449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CONTRIBUTION OF THE ASSOCIATION OF NATURAL HIGH-MOLECULAR COMPOUNDS IN IMPROVING THE EFFICIENCY OF FLOCCULATION PROCESSES","authors":"A. F. Tymchuk, O. O. Streltsova, A. D. Purich","doi":"10.18524/2304-0947.2023.2(85).286608","DOIUrl":"https://doi.org/10.18524/2304-0947.2023.2(85).286608","url":null,"abstract":"Natural flocculants as chitosan and sodium alginate has a complex of environmental and physic-chemical properties: biodegradability, playback of the raw material base, reaction and complexing ability. Researches had shown that natural polymers can be used for flocculation of suspensions. Association has a specific role in the flocculation process. Association determined by the nature and charge density of the flocculants. It is necessary to understand the mechanism of processes in these systems in order to select an effective flocculants. The mechanism of action of compositions natural flocculants is different from synthetic. The state of biopolymers depends on the pH of the solution. The aim of our researches was to study the flocculation ability of the compositions natural flocculants. It was studied sedimentation stability of suspensions containing macromolecular substances (flocculants) of different nature. We used an aqueous suspension of kaolin and bentonite. Kaolin and bentonite were dried to constant weight. The concentration of the dispersed phase in suspensions was 1–3%. It was shown that the sedimentation stability defines as flocculants characteristics such as molecular weight, concentration, nature of flocculants, polyelectrolyte’s charge density and nature of the suspensions. It was found that compositions of natural flocculants chitosan and sodium alginate are more effective of individual flocculants. The degree of separation suspensions reaches 90–98%. The findings suggest that the studied natural flocculants have significant potential for use, thanks to a number of advantages: the efficiency of their actions, low reagent consumption, environmental safety.","PeriodicalId":491501,"journal":{"name":"Вісник Одеського національного університету","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135935444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CITRIC ACID–SODIUM CITRATE–WATER SOLUTIONS ACID-BASE AND ELECTROCHEMICAL BEHAVIOR","authors":"R. E. Khoma, T. S. Bіenkovska, L. T. Osadchiy, Yu. V. Ishkov","doi":"10.18524/2304-0947.2023.2(85).286600","DOIUrl":"https://doi.org/10.18524/2304-0947.2023.2(85).286600","url":null,"abstract":"The protolytic equilibria in the system citric acid (H3Cit)–sodium citrate (Na3Cit)–water at a total content of citrates forms (citric acid, dihydrocitrate (H2Cit-), hydrocitrate (HCit2-) and citrate (Cit3-) anions) 1.0 mol/l have been studied by pH- and conductometric methods in the temperature range 293 ÷ 313 K. The first concentration ranges at which pH – lg(νH3Cit/νNa3Cit) and κ – CNa+/Ccit functions are linear correspond to the H3Cit/H2Cit- buffer system; the second ones – to H3Cit/H2Cit- and H2Cit-/HCit2-; the third ones to – HCit2-/Cit3- buffer system. The investigated solutions ion-molecular composition and ionic strength (m, mol/l) have been calculated using the mathematical model taking into account the law of mass action, material balance for citrates and electrical neutrality principle. The ionic strength concentration dependences have a complex character due to the ion-molecular composition multicomponent nature for the studied solutions. The ionic strength values are directly proportional to the ratio [Na+]/CCit in the concentration intervals 0 ≤ [Na+]/CCit ≤ 1.0 and 2.0 ≤ [Na+]/CCit ≤ 3.0. In the concentration range 1.0 ≤ [Na+]/CCit ≤ 2.0, the values of m = 1.15 ± 0.27 mol/l) weakly depend on the [Na+]/CCit ratio and practically do not depend on temperature. Citric acid concentration and thermodynamic constants for the first, second, and third dissociation stages have been determined. The obtained data on the acid-base and electrochemical characteristics of the solutions HOC3H4(COOH)3 – HOC3H4(COONa)3 – H2O(СCit = 1.0 mol/l; СNa+ = 0 ÷ 1.0 mol/l) can be used in chemical analysis, microbiological and biochemical studies, and the acidity data of the solutions studied can simulate chemisorption of acidic (SO2) and/or basic (NH3) gases.","PeriodicalId":491501,"journal":{"name":"Вісник Одеського національного університету","volume":"46 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135935445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ISOTHERMAL SECTION OF THE ZrO2–HfO2–Eu2O3 SYSTEM PHASE DIAGRAM AT 1100 °C","authors":"Yu. V. Yurchenko, O. A. Korniienko, S. F. Korychev, S. V. Yushkevych","doi":"10.18524/2304-0947.2023.2(85).286605","DOIUrl":"https://doi.org/10.18524/2304-0947.2023.2(85).286605","url":null,"abstract":"Phase equilibria and structural transformations in the ternary ZrO2–HfO2–Eu2O3 system at 1100 °C were studied by X-ray diffraction over the entire composition range. The samples of different compositions have been prepared from nitrate acid solutions by evaporation, drying, and calcinations at 1100 °C. Fields of solid solutions based on the cubic (F) modification with fluorite-type structure and tetragonal (T) and monoclinic (M) modifications of ZrO2 (HfO2), cubic (C) modification of Eu2O3, and an ordered intermediate phase with pyrochlore-type structure, Ln2Zr2O7 (Ln2Hf2O7)(Py), were established to exist in the system. The solubility of Eu2O3 in M-HfO2(ZrO2) is pretty low and approximately less than 1 mol%, which is confirmed by XRD. The boundaries of phase fields and lattice parameters of the phases were determined. The lattice parameters for F phase vary from а = 0.5305 nm in two-phase sample (C+F) containing 6.75 mol% ZrO2–8.25 mol% HfO2–85 mol% Eu2O3 to а = 0.5283 nm for sample containing 27 mol% ZrO2–33 mol% HfO2–40 mol% Eu2O3 and to а = 0.5275 nm in two-phase sample (Py+F) containing 29.25 mol% ZrO2–35.75 mol% HfO2–35 mol% Eu2O3, and from а = 0.5232 nm in two-phase sample (Py+F), containing 32.625 mol% ZrO2–39.875 mol% HfO2–27.5 mol% Eu2O3 to а = 0.5218 nm sample containing 33.75 mol% ZrO2–41.25 mol% HfO2–25 mol% Eu2O3 and to а = 0.5176 nm in two-phase sample (F+M) containing 40.5 mol% ZrO2–49.5 mol% HfO2–10 mol% Eu2O3 along the section Eu2O3–(55 mol% HfO2–45 mol% ZrO2). The fluorite-type structure (F) is in equilibrium with all phases that exist in the ternary ZrO2–HfO3–Eu2O3 system at 1100 °C and forms substitutional solid solutions with phases of the binary systems. In the ZrO2–HfO2–Eu2O3 system, an infinite series of solid solutions form from the Ln2Zr2O7 (Ln2Hf2O7) (Py) phase. The isothermal section of the ZrO2–HfO2–Eu2O3 phase diagram at 1100 °C contains one three-phase regions (T + M + F) and six two-phase regions (F + C, two-F + Py, F + M, F + T, T + M). No new phases were found in the ZrO2–HfO2–Eu2O3 system at 1100 °C and the nature of phase equilibria was determined by the constitution of the boundary binary systems.","PeriodicalId":491501,"journal":{"name":"Вісник Одеського національного університету","volume":"29 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135935447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SYNERGETIC EFFECTS OF PALLADIUM(II) AND COPPER(II) COMPOUNDS FIXED ON MODIFIED PHLOGOPITE IN THE REACTION WITH SULFUR DIOXIDE","authors":"T. O. Kiose, A. P. Nazar, T. L. Rakyts’ka","doi":"10.18524/2304-0947.2023.2(85).286599","DOIUrl":"https://doi.org/10.18524/2304-0947.2023.2(85).286599","url":null,"abstract":"Palladium(II) and cuprum(II) compounds are the basic components of the Wacker-type heterogeneous catalyst for the low-temperature oxidation of carbon monoxide with oxygen. Al2O3, activated carbon and carbon fiber materials are most commonly used as a carrier. In search of new potential natural media, layered aluminosilicate – phlogopite as part of natural phlogopite concentrate was investigated and it was proved that copper-palladium catalysts are formed on acid-modified samples of phlogopite, which provide a high degree of conversion of carbon monoxide, which meets the sanitary and chemical norm of CO in the working area, namely CKCO ≤ 20 mg/m3. Regardless of the nature of the carrier, it was found that the catalytic effect is achieved due to the synergism of palladium(II) and copper(II). A typical situation is when carbon monoxide and sulfur dioxide are simultaneously present in the waste gases of industrial enterprises. In this regard, research on the polyfunctionality of the Pd(II)-Cu(II)/S̅ nanocatalyst is relevant. The kinetics of the interaction of sulfur dioxide with mono- and bimetallic compositions based on compounds of palladium(II), copper(II) and acid-modified natural (Phl) and thermally swollen (TS-Phl) phlogopite were studied. It was established that monometallic compositions М(ІІ)-KBr/X̅Н-TC-Phl-1, М(ІІ) = Cu(ІІ), Pd(ІІ) fixed on acid-modified samples of swollen phlogopite, except for 6Н-TS-Phl-1, do not show protective properties against sulfur dioxide. It has been proven that the bimetallic compositions Pd(II)-Cu(II)-KBr/S̅ (S̅ = 6H-Phl-1; X̅H-TS-Phl-1, X̅ = 1, 2, 3, 6 M HNO3) in the reaction with SO2 reveal a synergistic effect with a coefficient of КS >> 1, which leads to an increase in the time of the protective action of the samples and the amount of absorbed sulfur dioxide. The synergism constant depends on the conditions of acid modification of the carrier and has a maximum value in the case of the bimetallic composition fixed on the carrier 2Н-ТS-Phl-1.","PeriodicalId":491501,"journal":{"name":"Вісник Одеського національного університету","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135935448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"TEMPERATURE-DEPENDENT KINETICS OF ANTHOCYANINS EXTRACTION FROM RED ROSE PETALS","authors":"L. M. Soldatkina, V. E. Litvinova","doi":"10.18524/2304-0947.2023.2(85).286604","DOIUrl":"https://doi.org/10.18524/2304-0947.2023.2(85).286604","url":null,"abstract":"The red rose is one of the perspective natural resources of anthocyanins, however kinetic study for anthocyanins extraction of red rose petals is not yet elucidated. Red rose petals were dried at 303 K and ground (particle size ~ 5 mm). The petals were extracted by aqueous acid solutions using conventional solid-liquid extraction. The efficiency of 0.1 M aqueous solutions of acids as extractants towards red rose anthocyanins was studied and it can be arranged in the following row: citric acid < acetic acid < hydrochloric acid. Kinetic investigations focusing on the temperature effect on solid-liquid extraction of anthocyanins from petals of red rose were performed at three temperatures (293, 313, and 333 K). Kinetic curves were obtained using an aqueous solution of hydrochloric acid. It was found that the rate of extraction of anthocyanins was very fast at the beginning, but it began to slow down after 60 minutes for all temperatures. The experimental kinetic curves of the extraction of anthocyanins at different temperatures were obtained and analyzed using common empirical kinetic models (the first-order, second-order kinetic models, the Peleg model, and the power-law model). The second-order kinetic model provided the best agreement with the experimental results in terms of statistical parameters (coefficient of determination (R2) and average relative error (ARE)) than other studied models. As temperature increases, the second-order rate constant values and the initial extraction rate values also increased. The second-order rate constants were used to evaluate the activation energy of extraction. The calculated activation energy of the anthocyanin extraction is 39.3 kJ/mol, which is an indication of an endothermic process. Obtained data can be used to predict the extraction of anthocyanins from red rose petals.","PeriodicalId":491501,"journal":{"name":"Вісник Одеського національного університету","volume":"2015 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135935443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SYNTHESIS AND PROPERTIES OF NEW 1-HYDRAZINOCARBONYLMETHYL-7-BROMO-5-PHENYL-3-ARYLYDENE-1,2-DIHYDRO-3H-1,4-BENZODIAZEPIN-2-ONES","authors":"S. Yu. Bachinsky, N. O. Burenkova, S. A. Andronati, Yu. V. Ishkov","doi":"10.18524/2304-0947.2023.2(85).286601","DOIUrl":"https://doi.org/10.18524/2304-0947.2023.2(85).286601","url":null,"abstract":"It is known that 1,4-benzodiazepines have neurotropic properties. Previously, we synthesized a series of 3-arylidene-1,2-dihydro-3H-1,4-benzdiazepin-2-ones 11-18 and showed that they exhibit significant analgesic activity. They also show significant affinity for central benzodiazepine receptors and TSPO receptors CNS. With this in mind, we have previously modified the series of 3-arylidene-1,2-dihydro-3H-1,4-benzodiazepin-2-ones by alkylation of 3-arylidene-1,2-dihydro-3H-1,4-benzodiazepin-2-ones with monobromoacetic acid methyl ester to the first position of the 1,4-diazepine ring to obtain 1-methoxycarbonylmethyl-7-bromo-5-phenyl-3-arylidene-1,2-dihydro-3H-1,4-benzodiazepin-2-ones 19-26, which showed pronounced analgesic activity. The aim of this work is to synthesize and study the affinity for CBR and TSPO receptors 1-hydrazinocarbonylmethyl-7-bromo-5-phenyl-3-arylidene-1,2-dihydro-3H-1,4-benzodiazepin-2-ones 27-31, which have not been previously described in the literature. Compounds 27-31 were synthesized as a result of the reaction of 1-methoxycarbonylmethyl-7-bromo-5-phenyl-3-arylidene-1,2-dihydro-3H-1,4-benzodiazepin-2-ones 19-26 with hydrazine hydrate while stirring the components in ethanol. The yields of the reaction products were 65-92%. It was shown that the hydrazinolysis technique used provides high yields of the target compounds. The structure of the synthesized compounds was confirmed by mass spectrometry and 1H NMR spectroscopy. The affinity of the synthesized compounds to the central benzodiazepine receptors CNS (CBR) and TSPO receptors CNS was studied. The affinity of compounds 27-31 was determined in vitro by radioligand analysis by their ability to displace the commercial radioligands [3H] flumazenil and [3H]PK11195 from their specific binding sites in the GABAA receptor complex and TSPO receptors of the synaptic and the mitochondrial fractions of the rat brain membranes, respectively. Compound 27 displaces the commercial [3H]flumazenil radioligand from its specific binding sites in the GABAA receptor complex by 80.1%, and simultaneously exhibits a very low affinity for TSPO receptors. Derivative 27 is the most potent CBR ligand among the investigated compounds and it is a promising compound for pharmacological research. It has been established that in the synthesized series of 3-fluorobenzylidene derivatives, varying the position of the fluorine atom in the benzylidene fragment leads to change affinity for TSPO receptors. It has been established that the para- position of the fluorine atom in the 3-benzylidene radical of the 1,4-benzodiazepin-2-one molecule is the most important descriptor that determines their affinity for the TSPO receptors. These data agree with the data available in the literature on the effect of the position of chlorine and bromine atoms in the 3-benzylidene radical of the 1,4-benzodiazepin-2-one molecule on the affinity for the TSPO receptors. It was found that the main structural fragment that deter","PeriodicalId":491501,"journal":{"name":"Вісник Одеського національного університету","volume":"67 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135935630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SORPTION OF SCANDUIUM AND YTTRIUM COMPOUNDS BY ZIRCONIA-SILICA NANOSORBENT","authors":"O. V. Perlova, A. O. Ovcharenko, A. O. Shуrykalova","doi":"10.18524/2304-0947.2023.2(85).286606","DOIUrl":"https://doi.org/10.18524/2304-0947.2023.2(85).286606","url":null,"abstract":"Physical and chemical regularities of sorption extraction of scandium and yttrium compounds from (0.1–2.5)∙10-4 M aqueous solutions by zirconium-silica nanosorbent with specific surface area of 900-1000 m2/g, pore radius of 3.5-7, 6 nm and with a ZrO2 content of 29% have been established. It is shown that the studied sorbent efficiently (&gt;99%) removes scandium and yttrium at pH 8 – 10 (Sc) and pH 9 – 10.5 (Y) and at sorbent consumption of 0.4 g/dm3. The time to reach sorption equilibrium is 240 min (Sc) and 210 min (Y). Modeling of scandium and yttrium sorption kinetics by Boyd’s external diffusion and internal diffusion models shows that sorption takes place in a mixed diffusion mode. The values of sorption rate constants (0.018 min-1 Sc, 0.033 min-1 Y), external mass transfer constants (4.74 ∙ 10-8 m/min Sc, 8.51 ∙ 10-8 m/min Y) and internal diffusion rate constants (0.0099 min-1 Sc, 0.0093 min-1 Y) have been calculated. It is established that the kinetics of sorption follows the pseudo-second-order model. It is shown that the sorption isotherms of both investigated metals are described by Freundlich, Frumkin-Fowler-Guggenheim and Dubinin-Radushkevich models. The constants of sorption isotherm models, characteristic energy of sorption (10.79 kJ/mol Sc, 9.58 kJ/mol Y), ΔG0 of sorption (-32.82 kJ/mol Sc, -30.77 kJ/mol Y) are calculated. The results of calculations indicate a significant affinity of scandium and yttrium compounds for this sorbent, spontaneous nature of the process and mixed nature of sorption with a predominance of chemisorption, a significant contribution of ion exchange to the sorption mechanism.","PeriodicalId":491501,"journal":{"name":"Вісник Одеського національного університету","volume":"1088 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135935442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}