Journal of Regenerative Biology and Medicine最新文献

{"title":"Hyperbaric Oxygen therapy and anti-aging Practice and Protocols","authors":"Gordon L Slater","doi":"10.37191/mapsci-2582-385x-5(4)-138","DOIUrl":"https://doi.org/10.37191/mapsci-2582-385x-5(4)-138","url":null,"abstract":"In the quest for effective anti-aging solutions, this paper explores the potential of Hyperbaric Oxygen Therapy (HBOT) as a promising, noninvasive approach. HBOT involves exposure to high-pressure oxygen environments and has demonstrated notable effects, including the reduction of senescent cells, promotion of angiogenesis, and improvement in tissue health. Emerging protocols featuring intermittent exposure to hyperbaric conditions have shown promise in increasing length of the telomere, enhancing cognitive function, and rejuvenating various physiological aspects. Despite promising preclinical results, the lack of substantial clinical trial data remains a gap, and concerns about potential adverse effects persist. Standardized protocols, guidelines, and biomarkers are crucial for optimizing the potential benefits of HBOT in anti-aging strategies. Further research is imperative to ascertain ideal treatment parameters and safety profiles, particularly for individuals seeking healthy aging outcomes.","PeriodicalId":489506,"journal":{"name":"Journal of Regenerative Biology and Medicine","volume":"56 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136344709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Probiotic Use in a Randomized Controlled Trial to Prevent Sepsis and/or Necrotizing Enterocolitis in Low-Birth-Weight Infants","authors":"Venugopal Reddy Ι","doi":"10.37191/mapsci-2582-385x-5(2)-130","DOIUrl":"https://doi.org/10.37191/mapsci-2582-385x-5(2)-130","url":null,"abstract":"Neonatal sepsis is a major problem throughout the world. Early detection of neonatal sepsis is difficult because the first signs of this disease may be minimal, especially in preterm infants. The clinical signs are similar to those of non-infectious processes. Definitive blood culture results not being immediately available may prove detrimental. As a result, many babies are evaluated and treated for presumed sepsis with parenteral antibiotics while awaiting microbial isolation. This study was undertaken to evaluate the efficacy of probiotics in prevention of Late onset sepsis and or NEC in low-birth-weight babies.","PeriodicalId":489506,"journal":{"name":"Journal of Regenerative Biology and Medicine","volume":"42 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135886685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effects of Autologous Stem Cells from Bone Marrow and Adipose Tissue on Patients with Knee Osteoarthritis","authors":"Paul Eliot Hughes","doi":"10.37191/mapsci-2582-385x-5(4)-135","DOIUrl":"https://doi.org/10.37191/mapsci-2582-385x-5(4)-135","url":null,"abstract":"Osteoarthritis (OA) of the knee joint, the most common form of knee arthritis, is the gradual degeneration of joint cartilage. A progression of OA is characterized by the degradation and degeneration of the articular cartilage with subchondral bone remodeling, osteophyte formation and inflammation leading to bone-on-bone contact causing pain, stiffness, and functional difficulties and disability. OA affects the patient’s quality of life and creates a significant financial burden on the health care system. This retrospective study collected data from patients who received autologous MSCs injections of bone marrow aspirate concentrate (BMAC) and/or micro-fragmented adipose tissue (MFAT). Data from patient-reported outcomes (PROs) were collected pre-treatment and at post-treatment follow-ups and correspondences. Surveys distributed included Visual Analog Scale (VAS), Knee Injury and Osteoarthritis Outcome Score for Joint Replacement (KOOS, JR), and a patient satisfaction survey. Out of 151 patients that met clinical criteria, 103 patients (159 knees) had appropriate follow up data. Of the 103 patients, 25 patients had knee arthroscopy prior to stem cell injection. 63 patients received platelet-rich plasma (PRP) injections within 12 months and five patients had conversion to Total Knee Arthroplasty (TKA). BMAC, MFAT graft, and BMAC and MFAT graft groups showed significant improvement in both VAS and KOOS, JR between baseline and 3,6,12, and 24 months post-treatment (p<0.00001). Among BMAC only patients, KL grade breakdown showed significant improvement in VAS and KOOS, JR scores within 24 months post-treatment across all grades (2-4).","PeriodicalId":489506,"journal":{"name":"Journal of Regenerative Biology and Medicine","volume":"34 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135886682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HLA Type Variation Across Populations","authors":"Shivani Kaushik","doi":"10.37191/mapsci-2582-385x-5(4)-137","DOIUrl":"https://doi.org/10.37191/mapsci-2582-385x-5(4)-137","url":null,"abstract":"Background: Human Leukocyte Antigen (HLA) is highly polymorphic and it is commonly used as a marker for core population genital aspects such as human migration, predisposition to diseases and in tissue transplantation compatibility. Methodology: For our study authors have taken up sample size of 86 for meta- analysis of high-resolution frequency data of the HLA allele. North Indian patients from tertiary centre were analyzed for identification of HLA-A, B, C, DRB1 and DQB1 alleles by sing serological and molecular typing techniques. A plethora of known alleles were identified at different loci e.g., HLA A 18, HLA B 36, HLA C 5, HLA DRB1 28 and HLA DQB1 8. This study focusing on frequencies of HLA alleles and their homozygosity and heterozygosity have been reported, but HLA data in the North Indian population living in Delhi, Haryana, Uttarakhand , Uttar Pradesh, Punjab and Himachal Pradesh, are reported here characterized. Allele frequencies were analyzed by using the Hardy-Weinberg equilibrium. Results: Allele heterozygosity was observed in 96.51% individuals for locus HLA-A, 97.67% individuals for locus HLA-B and 96.51% for HLA-DRB1,overallheterozygosity for all three loci was 89.5% (77/86 individuals). Among individuals showing homozygosity (9 individuals), two showed homozygosity at two loci. Conclusion: The increased heterozygosity for class 1 and class 2 is associated with selective advantage against infectious diseases. The phenotypic frequency of B*35 alleles (B*35:01, B*35:03 and B*35:08) in our study is 31.39%. Comparable B*35 allele phenotypic frequency (27.5%) was reported in north Indian patients.","PeriodicalId":489506,"journal":{"name":"Journal of Regenerative Biology and Medicine","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135886679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Iron Deficiency: A Risk Factor for Simple Febrile Seizures","authors":"Venugopal Reddy Ι","doi":"10.37191/mapsci-2582-385x-5(3)-132","DOIUrl":"https://doi.org/10.37191/mapsci-2582-385x-5(3)-132","url":null,"abstract":"The most prevalent type of convulsive disorder, occurring in approximately 2 to 5% of children, are febrile seizures. The prognosis for febrile seizures is often very good. A seizure or convulsion is a brief, intermittent alteration in behavior or motor activity brought on by aberrant electrical activity in the brain. In boys, febrile seizures are a little more frequent. In comparison to febrile controls without seizures, the risk variables for a first febrile seizure have been investigated. Higher temperatures, perinatal factors, and low plasma ferritin levels, which indicate poor iron status or iron deficiency, are risk factors. This study's objectives are to ascertain the prevalence of iron deficiency in kids who have simple febrile seizures and the relative risk of iron deficiency as a cause of simple febrile seizures. It was discovered that uncomplicated febrile seizures in children at risk of iron shortage could be avoided with early identification and iron supplementation.","PeriodicalId":489506,"journal":{"name":"Journal of Regenerative Biology and Medicine","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135886681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study of Perinatal Outcome in Premature Babies with Complete and Incomplete Course of Antenatal Corticosteroids","authors":"Rajesh Babu M","doi":"10.37191/mapsci-2582-385x-5(3)-131","DOIUrl":"https://doi.org/10.37191/mapsci-2582-385x-5(3)-131","url":null,"abstract":"The rate of preterm birth sweeps from 5-18% across 184 countries. India has a lofty number of preterm births as well as neonatal deaths due to prematurity. Preterm birth is a risk factor in at least 50% of all neonatal deaths and is the second most common cause of death (after pneumonia) among children under the age of five. In the Indian context, many pregnant women are registered late or are referred to a peripheral center when a preterm delivery is suspected. Many receive an incomplete course (only one dose) of corticosteroids. Therefore, in this proximity of the truncation researcher’s attempt to analyze the efficacy of a single dose, to see whether it is as good as two doses in averting impediment, especially RDS in preterm babies. This study aims to determine the differences in survival and short-term morbidity in neonates receiving an incomplete course (one dose) of steroids in comparison to those receiving a complete course (two doses) and to know the relation between co-morbidity with respect to those receiving a complete course of drug (two doses). The study depicts that RDS more common in premature babies who did not receive ANCS that who did. It also shows that requirement of surfactant and no. of doses of surfactant less in babies who received ANCS than babies who did not.","PeriodicalId":489506,"journal":{"name":"Journal of Regenerative Biology and Medicine","volume":"63 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135886684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation Into the Potential Prospects of Induced Pluripotent Stem Cells","authors":"Ashwin Prabahar A","doi":"10.37191/mapsci-2582-385x-5(4)-136","DOIUrl":"https://doi.org/10.37191/mapsci-2582-385x-5(4)-136","url":null,"abstract":"Cell cultures and stem cell studies have revolutionized the field of biotechnology and regenerative medicine by opening various medicine sectors that were once closed due to lack of information and technology. The potent ability of stem cells has proven to be really significant in the field of medical research for treating degenerative diseases and disorders, thus developing novel therapeutics. Induced pluripotent stem cells are created by reprogramming adult cells to behave like an embryonic-like pluripotent state cell. The reprogramming of cells is done by introducing specific combinations or sets of genes into the cells using viral vectors. This in turn resets the genetic program and reprograms the cells in a way that the cells can differentiate into any type of cell in the human body. Induced pluripotent stem cells have the ability to self-renew and differentiate into all cell types, also including gametes. This type of stem cell can be cultured in lab, and have been proven to renew themselves indefinitely. These cells can be reprogrammed from cells obtained from any healthy person or patient. Stem cells are considered as a valuable resource in the field of medicine but pluripotent stem cells in nature are embryonic stem cells, so their study and isolation posed multiple ethical barriers to be overcome, and inducing pluripotent nature in adult cells has proven to be a solution to overcome those barriers. Induced pluripotent stem cells are considered to be the key for regenerative medicine as their potent ability can be manipulated to replace any diseased or damaged tissues. The authors have discussed the current status of induced pluripotent stem cells and their potential future prospects in this paper. There are also a lot of ethical and legal challenges and opportunities that must be overcome to fully exploit the potential of stem cells. Overall, the aim of this paper is to shed light on the significance of the study and development of stem cells and its research in the field of medicine, and its potential to formulate newer therapies and therapeutics. The authors tend to provide an overview of stem cell research and hope to inspire further research and development in this area to generate significant results in novel and effective stem-cell based therapies.","PeriodicalId":489506,"journal":{"name":"Journal of Regenerative Biology and Medicine","volume":"65 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135886812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Concentrated Alpha-2 Macroglobulin Rich Autologous Plasma Injections for Chronic Pain and Reduction in Opioid Use","authors":"Joel I Osorio","doi":"10.37191/mapsci-2582-385x-5(3)-133","DOIUrl":"https://doi.org/10.37191/mapsci-2582-385x-5(3)-133","url":null,"abstract":"The US Opioid Epidemic has been a serious continuous threat to Americans since the early 2000s. \"More than 932,000 people have died since 1999 from a drug overdose. Nearly 75% of drug overdose deaths in 2020 involved an opioid\" (CDC, 2022). Prescription opioids are highly addictive and are commonly prescribed to treat moderate, severe, or chronic pain. Chronic pain is a multidimensional experience that encompasses both sensory and emotional elements in patients who suffer from it. Opioids are highly effective in treating these symptoms, however chronic opioid use causes many unwanted side effects. Thus, the challenge of providing effective pain treatment while minimizing these unwanted side effects is an ongoing issue with significant clinical and societal impact. Researchers also see that in many situations, medical care providers are more willing to prescribe opioid drugs for chronic pain in clinical settings.","PeriodicalId":489506,"journal":{"name":"Journal of Regenerative Biology and Medicine","volume":"44 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135886680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial Intelligence in the Genomics Era: A Blessing or a Curse?","authors":"Saravanan Sampoornam Pape Reddy","doi":"10.37191/mapsci-2582-385x-5(3)-134","DOIUrl":"https://doi.org/10.37191/mapsci-2582-385x-5(3)-134","url":null,"abstract":"As it offers tremendous potential for genomic advancements and has become an invaluable tool in understanding and harnessing the power of genetic information, artificial intelligence has revolutionised genomics by enabling researchers to analyse complex genomic data, unravel biological insights, and accelerate discoveries in personalised medicine, disease diagnosis, drug development, and gene editing. Artificial intelligence can be considered both a boon and a bane in the field of genomics, depending on how it is applied and its implications. Artificial intelligence has the potential to bring significant benefits to genomics, including improved data analysis, precision medicine, and drug discovery. However, ethical considerations, interpretability challenges, biases, and the need for human expertise must be carefully addressed to fully harness the potential of artificial intelligence in genomics and ensure its responsible and beneficial application. The purpose of this narrative review is to shed light on the various applications of genomics that take advantage of technological advancements in artificial intelligence, and to identify its benefits and limitations.","PeriodicalId":489506,"journal":{"name":"Journal of Regenerative Biology and Medicine","volume":"42 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135886683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}