Российская оториноларингология最新文献

{"title":"Use of intraoperative navigation in endoscopic endonasal surgery for paranasal mucocele","authors":"V. A. Doronina, E. V. Shelesko, A. I. Batalov, Yu. V. Strunina, N. A. Chernikova, D. N. Zinkevich, I. N. Pronin","doi":"10.18692/1810-4800-2023-3-40-50","DOIUrl":"https://doi.org/10.18692/1810-4800-2023-3-40-50","url":null,"abstract":"Objective. Evaluation of the effectiveness, safety, and benefit of the use of electromagnetic computer navigation in endoscopic endonasal surgery of paranasal mucocele. Materials and methods. At the Burdenko National Medical Research Center, from 2019 to 2022, 30 endoscopic endonasal removal of paranasal mucocele were performed: 10 operations were performed under CT-guided navigation, 12 with CT-MRI navigation, and 8 without navigation. The clinical findings of the disease, the history of life of patients, the data of endoscopic examination of the nasal cavity, olfactometry, intraoperative parameters, recurrence rate of the mucocele were analyzed. Results. Localization of the mucocele in the frontal sinus was significantly more common in the groups using navigation (p = 0.044). According to olfactometry before surgery, anosmia on the side of the pathology was more often detected in patients in groups using navigation (p = 0.005). According to endoscopy before surgery, scarring in the nasal cavity was found only in groups using navigation. There were no intraoperative complications in the three groups. The average intraoperative blood loss in the three groups did not differ significantly. The duration of the operation was slightly longer in the groups using navigation. The median navigation setup time in the CT navigation group was 8.5 [7.3; 9.8] min, in the CT-MRI navigation group it was 7.5 [7.0; 8.3] min. The median error in each group was 0 mm. According to the operating surgeon, computer navigation was necessary and the most beneficial in 100% of cases. The median long-term follow-up was 746 [478.3; 1133.0] days in the non-navigation group, 673 [176.0; 791.0] days in the CT-navigation group, and 274 [195.5; 371.0] days in the CT-MRI navigation group. Conclusion. The use of intraoperative navigation is justified in endoscopic debridement of mucocele with destruction of the walls of the orbit and the base of the skull, with scarring in the nasal cavity. The use of CT-MRI navigation is useful in a case of scarring in the nasal cavity and deformation of the orbit walls in the case of a fronto-orbital mucocele as well as while removing a sinonasal neoplasm bordering on the mucocele.","PeriodicalId":485440,"journal":{"name":"Российская оториноларингология","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135212396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Features of sensorineural hearing loss and otitis media with effusion in patients with different variants of coronavirus","authors":"S. L. Kovalenko, S. A. Azamatova, L. A. Lazareva, M. D. Kovalenko, I. R. Azamatov","doi":"10.18692/1810-4800-2023-4-20-31","DOIUrl":"https://doi.org/10.18692/1810-4800-2023-4-20-31","url":null,"abstract":"Objective. To improve the efficiency of diagnosis and treatment of hearing impairment in patients who recovered from COVID-19. Material and methods. The study involved 121 patients with a laboratory-confirmed diagnosis of coronavirus infection caused by the SARS-CoV-2 virus. The patients were divided into groups depending on the strain of coronavirus they had, the severity of the disease, age, the nature of the disturbances in the auditory analyzer, and the timing of seeking medical help. All participants in the study before and after treatment underwent a comprehensive audiological examination, which included tone threshold audiometry, tympanometry, acoustic reflexometry, and registration of otoacoustic emissions. Results and Discussion. After the transferred omicron strain, bilateral sensorineural, mixed or conductive hearing loss of I and II degrees prevailed. An analysis of the results of examinations of patients who recovered from various strains of coronavirus (with the exception of omicron) demonstrated predominantly unilateral severe manifestations of sensorineural hearing loss (SHL), less often bilateral progressive SHL in older patients. After the transferred Omicron strain, bilateral sensorineural, mixed, or conductive hearing loss of I and II degrees prevailed. Hearing dysfunction in children was detected only in cases of infection with the omicron strain. The effectiveness of treatment depended on the transferred strain of SARS-CoV-2 and the timing of contacting an audiologist. Conclusion. The damaging effect of the SARSCoV-2 virus on the auditory analyzer revealed during the study proves the need for an audiological examination of patients.","PeriodicalId":485440,"journal":{"name":"Российская оториноларингология","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135709731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cranioplasty of skull bone defects in experiment","authors":"D. D. Pozharskaya, S. G. Vakhrushev, L. A. Toropova, V. A. Khorzhevskii, A. V. Fedorov, D. V. Evstropova, A. A. Kolchina, T. I. Skobelina, L. A. Umanskaya, D. S. Khotov, D. E. Shirochenko","doi":"10.18692/1810-4800-2023-4-48-56","DOIUrl":"https://doi.org/10.18692/1810-4800-2023-4-48-56","url":null,"abstract":"Objective. To evaluate the effectiveness of using platelet-rich plasma to stimulate bone tissue regeneration during bone cavity with autogenous bone grafting in an experiment on rabbits. Materials and methods. The object of the experimental study is male rabbits in the amount of 36 individuals, divided into 3 groups depending on removal terms after surgery (in 1, 3, and 6 months). With the help of bur, 7 blind holes were formed in the frontal bones of rabbits, each of which was filled with a certain plastic material. Results. The use of bone chips, liquid platelet-rich plasma, and plasmogel for grafting of bone defects, according to visual examination, morphological examination, and computed tomography (CT), promotes rapid regeneration of bone tissue. 6 months after the operation, the holes filled with these materials had the highest bone density in Hounsfield units according to CT data due to the predominance of the bone component. According to the results of the morphological study, pronounced phenomena of bone tissue remodeling with the expansion of bone beams and a decrease in the volume of fibrous tissue were noted. Conclusion. Platelet-rich plasma has a positive effect on the processes of bone regeneration. The use of bone chips contributes to a more active restoration of bone tissue in comparison with bone pâté. The technique can be used in patients with chronic suppurative otitis media with cholesteatoma during the reconstructive surgery for mastoid obliteration.","PeriodicalId":485440,"journal":{"name":"Российская оториноларингология","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135710983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bacteriophages in therapy of bacterial rhinosinusitis","authors":"P. V. Nacharov, A. A. Krivopalov, N. N. Khamgushkeeva","doi":"10.18692/1810-4800-2023-3-69-74","DOIUrl":"https://doi.org/10.18692/1810-4800-2023-3-69-74","url":null,"abstract":"Inflammatory diseases of the paranasal sinuses are among the most common human diseases, and this problem is becoming more and more urgent every year. Patients with rhinosinusitis undergo complex therapy, including the use of systemic antibacterial drugs, to which resistance develops in pathogenic and opportunistic bacteria over time. At the same time, the choice and prescription of antibacterial drugs, as a rule, are empirical in nature and are based on information about typical pathogens and their presumed sensitivity to antibiotics. In addition, antibacterial drugs have a detrimental effect on the microbiome of the mucous membrane of the paranasal sinuses and intestines. The association of pathogenic bacteria in biofilms increases their resistance to antibacterial drugs and contributes to the chronicity of the inflammatory process. The results of a number of studies show that bacteriophages not only lyse antibiotic-resistant pathogenic bacteria but also destroy biofilms in inflammation foci in the paranasal sinuses. Bacteriophages compare favorably with antibacterial drugs in that they do not have an ototoxic effect, do not cause allergic reactions, and do not inhibit the normal intestinal microflora. Bacteriophage preparations are indicated for a wider range of patients.","PeriodicalId":485440,"journal":{"name":"Российская оториноларингология","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134980836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative analysis of methods of diagnostic ultrasound of peritonsillar abscess","authors":"A. N. Chechko, T. Yu. Vladimirova, K. V. Sapozhnikov","doi":"10.18692/1810-4800-2023-3-56-61","DOIUrl":"https://doi.org/10.18692/1810-4800-2023-3-56-61","url":null,"abstract":"In the daily clinical practice of an otorhinolaryngologist, purulent-inflammatory diseases of the pharynx are often encountered. Peritonsillar abscess occupies one of the leading positions among them. Computed tomography and diagnostic ultrasound are proposed as auxiliary instrumental research methods in modern clinical guidelines. The first, with its high sensitivity, has a number of disadvantages: the high cost of the study and low availability. Ultrasound examination has a number of advantages, such as high availability, the ability to detect specific changes characteristic of an abscess, depending on the methods used. This article is devoted to the study of the effectiveness of various methods of diagnostic ultrasound of peritonsillar abscess.","PeriodicalId":485440,"journal":{"name":"Российская оториноларингология","volume":"259 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135211345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of age on relative contribution of sensory systems to control of vertical stance in healthy subjects","authors":"E. N. Kravtsova, A. Yu. Meigal, E. D. Kul’gova, V. V. Dvoryanchikov","doi":"10.18692/1810-4800-2023-4-8-12","DOIUrl":"https://doi.org/10.18692/1810-4800-2023-4-8-12","url":null,"abstract":"The influence of the age factor on the contribution of the vestibular, visual, and proprioceptive sensory systems to the function of spatial orientation was assessed using the stabilometry method (ST-150, Mera, Moscow, Russia) during the vertical stance of a healthy person (N = 69, from 20 to 83 years old, of which 42 women and 27 men). Three age groups of subjects were examined: I (young, 20–25 years old, n = 37), II (middle-aged, 44–64 years old, n = 17 people), and III (elderly and old, 65–83 years old, n = 15). The subjects performed the Romberg test (stand with closed eyes) and postural stability (standing on a hard and soft surface) and a combined test (Romberg test + postural stability). This made it possible to compare the stabilometric parameters (the length and speed of the trajectory and the area of movement of the common center of pressure (COP)) under four conditions: 1) standing with eyes open on a stable surface (SS – EO), 2) eyes closed on a stable surface (SS – EC), 3) standing with eyes open on a thick layer of unstable surface (foam) (US – EO), and 4) eyes closed on a thick layer of unstable surface (foam) (US – EC). To calculate the contribution of sensory systems to the function of maintaining balance in a vertical stance, a formula was used. An increase in the length of the COP trajectory with increasing age was revealed. At the same time, only an insignificant change in the relative contribution of sensory systems to the parameters of the stabilogram was noted in middle-aged and older people compared to young people.","PeriodicalId":485440,"journal":{"name":"Российская оториноларингология","volume":"34 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135317280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostics of chlamydia infection in perennial allergic rhinitis using medical expert systems","authors":"E. G. Portenko, G. B. Burdo, V. S. Kuznetsova, N. A. Vashnevskaya","doi":"10.18692/1810-4800-2023-4-57-67","DOIUrl":"https://doi.org/10.18692/1810-4800-2023-4-57-67","url":null,"abstract":"Increasing the reliability of diagnosing otorhinolaryngological diseases is a rather urgent scientific task. Therefore, the purpose of this work was to create a methodology for diagnosing the presence of chlamydial infection in perennial allergic rhinitis, suitable for its use as a knowledge base in a medical expert system. Based on the results of management of patients with confirmed perennial allergic rhinitis, who, according to the results of basic treatment, had an unstable remission, symptoms of chlamydial infection were established, and a method for determining its presence was developed. All symptomatic data were divided into four groups of signs, a total of 23 indicators were proposed, some of which are mandatory for establishing a diagnosis, and some are alternative. The forecasting technique is based on the analysis of the ratio of mandatory and alternative features and was presented in the form of clear rules suitable for implementation in the MATLAB computing environment. A feature of the methodology is a targeted increase in the reliability of the forecast, which eliminates the redundancy of surveys. The task of creating a knowledge base for medical expert systems was solved. The practical value of the results of the work is to increase the reliability of diagnosing perennial allergic rhinitis caused by chlamydial infection. It was found that the identified 23 diagnostic indicators provide a fairly reliable prediction of the presence of chlamydial infection.","PeriodicalId":485440,"journal":{"name":"Российская оториноларингология","volume":"72 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135711004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of targeted therapy for cystic fibrosis on course of pediatric chronic rhinosinusitis: first russian experience","authors":"D. P. Polyakov, A. A. Pogodina, E. I. Kondrat’eva, A. Yu. Voronkova, A. S. Petrov","doi":"10.18692/1810-4800-2023-3-86-92","DOIUrl":"https://doi.org/10.18692/1810-4800-2023-3-86-92","url":null,"abstract":"Cystic fibrosis is the most common hereditary disease characterized by multiple organ damage to the exocrine glands, one of the manifestations of which is chronic rhinosinusitis (CRS), often polyposis-purulent. A part of patients with this disease require multiple surgical interventions on the paranasal sinuses. With the arrival of targeted therapy, which intracellularly corrects the structure and function of the mutant protein and is directed primarily at treating manifestations of the lungs and pancreas, a positive effect on the course of CRS was also noted. The review of stages of development of this direction of treatment of cystic fibrosis is provided in the article, and also one of the Russia’s first similar clinical observations is given.","PeriodicalId":485440,"journal":{"name":"Российская оториноларингология","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134980675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of MRI in diagnosis of Meniere’s disease","authors":"M. L. Blinova, V. S. Mikhailov, M. V. Morozova","doi":"10.18692/1810-4800-2023-3-20-25","DOIUrl":"https://doi.org/10.18692/1810-4800-2023-3-20-25","url":null,"abstract":"The article deals with the methods of visualization of the structures of the inner ear. An analysis of studies aimed at determining the possibilities of using MRI in the diagnosis of Meniere’s disease was carried out. We examined 13 patients with significant Meniere’s disease. The patients were intravenously injected with a gadolinium-based contrast agent. After 4 hours, an MRI of the brain was performed on a Philips Ingenia magnetic resonance imaging scanner with a magnetic field strength of 1.5 Tesla using the 3D-FLAIR sequence. The diagnosis of Meniere’s disease was confirmed in 11 patients.","PeriodicalId":485440,"journal":{"name":"Российская оториноларингология","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135157689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolomics studies in chronic rhinosinusitis: review of clinical prospects","authors":"V. V. Dvoryanchikov, O. V. Kokorina, R. R. Achba, A. A. Samoilov, V. V. Turieva","doi":"10.18692/1810-4800-2023-3-62-68","DOIUrl":"https://doi.org/10.18692/1810-4800-2023-3-62-68","url":null,"abstract":"Chronic rhinosinusitis (CRS) is one of the most common otorhinolaryngological diseases, which significantly reduces the quality of life of patients. The etiopathogenesis of CRS has not been fully studied to date, it is problematic to predict the effectiveness of the therapy and the possible period of remission. To solve such issues in modern medicine, metabolomic studies are carried out that study various low-molecular metabolites, cell components in biological material taken from a person: in a cell, tissue, fluid, exhaled air, saliva, bronchial lavage, etc. Metabolomic studies allow identifying possible disease markers and also quantifying them. As a result, a set of individual molecular parameters is compiled that form the patient’s metabolic profile. Metabolomic studies define a new level of clinical prediction in a wide range of complex human diseases, including cardiovascular, oncological diseases, asthma, diabetes, etc. Today, it is typical to use a multiomics approach that combines various molecular omics technologies (genomics, proteomics, transcriptomics, lipidomics, etc.). Based on the identified quantitatively measured biomolecules, it becomes possible to compare genetic variability with complex phenotypic features. Publications on metabolomic studies in CRS are not extensive; however, they report the identified differences in various forms of rhinosinusitis. Metabolomic studies in CRS allow determining the diagnostically significant molecular markers of various forms of chronic sinusitis as well as creating a personal omics profile of the patient and providing an opportunity to control the effectiveness of the therapy. Together with complete data on the patient’s lifestyle and health status, the patient’s personal ohmic profile may be the basis of personalized medicine.","PeriodicalId":485440,"journal":{"name":"Российская оториноларингология","volume":"70 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135212620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}