CAND Journal最新文献

Intravenous Vitamin C in Cancer Care: Evidence Review and Practical Guidance for Integrative Oncology Practitioners 癌症护理中的静脉注射维生素 C：中西医结合肿瘤医师的证据回顾和实用指南

CAND Journal Pub Date : 2024-03-21 DOI: 10.54434/candj.149

Ellen Conte, Erica Rizzolo, Gillian Flower, M. Legacy, D. Seely

{"title":"Intravenous Vitamin C in Cancer Care: Evidence Review and Practical Guidance for Integrative Oncology Practitioners","authors":"Ellen Conte, Erica Rizzolo, Gillian Flower, M. Legacy, D. Seely","doi":"10.54434/candj.149","DOIUrl":"https://doi.org/10.54434/candj.149","url":null,"abstract":"Intravenous vitamin C (IVC) is a common therapy used by naturopathic doctors and other licensed integrative practitioners. With several proposed mechanisms of action related to cancer care, it is often used in integrative oncology settings. Despite its common use, there are no published evidence-based resources on the efficacy, safety, and procedural considerations for the use of IVC in practice. The objectives of this review are to summarize the evidence on high-dose IVC in supportive cancer care and to provide a resource of practical clinical guidance for IVC application. In cancer care, IVC is most commonly used at doses high enough to achieve a potential cancer cell cytotoxicity. This review focuses on IVC at doses of ≥15 g which we have defined as high-dose. To date, there are 23 published clinical trials evaluating the use of high-dose IVC in cancer support. Based on data from these clinical studies, IVC used concurrently with oxidative therapies, such as chemotherapy and radiotherapy, seems to produce the greatest likelihood for improvements in quality of life and additive anti-tumour effects compared with IVC as monotherapy or with non-oxidative therapies. IVC has shown promise in improving quality of life in patients with breast cancer and advanced pancreatic and ovarian cancers. Limited evidence suggests survival and/or tumour response may be improved with the inclusion of IVC in patients with advanced pancreatic cancer, non-small cell lung cancer, and RAS-mutated colorectal cancer. IVC does not offer curative potential, and further research is needed to explore its effectiveness relevant to mortality outcomes. Practical guidance including assessment, monitoring, dosing, safety, and communication with other healthcare providers is discussed.","PeriodicalId":444026,"journal":{"name":"CAND Journal","volume":"200 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140222579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spring 2024 Editor’s Letter 2024 年春季编辑的信

CAND Journal Pub Date : 2024-03-21 DOI: 10.54434/candj.170

Marianne Trevorrow

引用次数: 0

Cultural Adaptations Addressing Diversity and Health Access in the Mediterranean Diet: A Realist Synthesis 解决地中海饮食多样性和健康获取问题的文化适应性：现实主义综述

CAND Journal Pub Date : 2024-03-21 DOI: 10.54434/candj.146

Nana-Adjoa Bourne, Gursharan K. Gill, Kieran Cooley

{"title":"Cultural Adaptations Addressing Diversity and Health Access in the Mediterranean Diet: A Realist Synthesis","authors":"Nana-Adjoa Bourne, Gursharan K. Gill, Kieran Cooley","doi":"10.54434/candj.146","DOIUrl":"https://doi.org/10.54434/candj.146","url":null,"abstract":"Background: The Mediterranean diet (MD) has been studied for its benefits, including metabolic risk factors, since the 1950s. In recent years, debates around barriers to access within cultural and environmental fields have arisen within non-Eurocentric cultural backgrounds. Using data related to health benefits derived from dietary components, this review will produce a map of MD modifications to match various cultures.\u0000Methods: Foods and constituents of the MD were compared and analyzed to assess benefits for both healthy and metabolic disease states using both empirical and theoretical approaches. Databases (PubMed and Cochrane) were searched using terms for cultural diets and metabolic disease outcomes associated with the MD (e.g., HbA1C, cholesterol, waist circumference, weight, AST and ALT). One multicultural diet database was chosen to identify culturally specific foods that match components of the MD to each cultural affinity.\u0000Results: Cultural alternatives to foods and components of the MD exist. However, there is modest research on the specific health effects of most culturally adapted diets.\u0000Conclusion: While some evidence gaps exist, it is feasible to translate most components of the MD to diets suitable for various cultural affinities. Future research is needed to examine the overall effects of these diets based on MD macronutrient presentation and the barriers associated with cultural–religious dietary practices and access to foods. Healthcare practitioners may benefit from this as a resource and to facilitate inclusivity and cultural competency for a broader range of dietary behaviours.","PeriodicalId":444026,"journal":{"name":"CAND Journal","volume":" 22","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140222088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring the Impact of a 7-Week Heart Rate Variability Biofeedback Protocol on Skin Severity, Quality of Life, and Mental Health in a Proof-of-Concept Pre–Post Trial of Individuals with Psoriasis 在一项针对银屑病患者的概念验证前试验中，探索为期 7 周的心率变异生物反馈方案对皮肤严重程度、生活质量和心理健康的影响

CAND Journal Pub Date : 2024-03-21 DOI: 10.54434/candj.151

S. Park, Devon Fox, Lee Young, Maya Roth, Baljit Khamba

{"title":"Exploring the Impact of a 7-Week Heart Rate Variability Biofeedback Protocol on Skin Severity, Quality of Life, and Mental Health in a Proof-of-Concept Pre–Post Trial of Individuals with Psoriasis","authors":"S. Park, Devon Fox, Lee Young, Maya Roth, Baljit Khamba","doi":"10.54434/candj.151","DOIUrl":"https://doi.org/10.54434/candj.151","url":null,"abstract":"Background: Psoriasis often coexists with psychiatric disorders and decreased quality of life (QoL), with treatments commonly overlooking the psychological impact of the disease. Heart rate variability biofeedback (HRVB) may offer a mind–body solution by providing real-time feedback on autonomic functions, teaching individuals to manage stress via controlled breathing.\u0000Objective: To examine the impact of a 7-week HRVB protocol on skin severity (SS), QoL, and mental health (MH) in individuals with psoriasis and determine the sustainability of any outcomes post-intervention.\u0000Methods: A single-arm, proof-of-concept pre–post trial was conducted at Bastyr University Clinic in San Diego, CA. Five individuals were recruited, screened, and underwent a 7-week HRVB protocol. Assessments included SS through the Psoriasis Area and Severity Index (PASI-P and PASI-C), QoL via the Cardiff Dermatology Life Quality Index (DLQI), and MH using the Generalized Anxiety Disorder-7 (GAD-7) and Patient Health Questionnaire-9 (PHQ-9). Data collection points were baseline, post-protocol, and 1-month follow-up.\u0000Results: Notable improvements were observed between baseline and post-protocol for PASI-P, DLQI, and GAD-7. A significant change remained for GAD-7 between baseline and follow-up. No major differences were identified for PASI-C and PHQ-9 across any timeframe, and other scales remained consistent between post-protocol and follow-up.\u0000Conclusion: HRVB showed promise in enhancing perceived SS, QoL, and anxiety over 7 weeks. Further studies should expand participant numbers and diversify initial scores, comparing HRVB with a control group.\u0000Trial registration: ClinicalTrials.gov NCT05506644, retrospectively registered on 16 August 2022.","PeriodicalId":444026,"journal":{"name":"CAND Journal","volume":"84 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140224125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adjunctive Naturopathic Medicine in the Management of Depression and Anxiety Symptoms: A Retrospective Chart Review 辅助自然疗法治疗抑郁和焦虑症状：病历回顾

CAND Journal Pub Date : 2024-03-21 DOI: 10.54434/candj.157

Joy Dertinger, Monique Aucoin

{"title":"Adjunctive Naturopathic Medicine in the Management of Depression and Anxiety Symptoms: A Retrospective Chart Review","authors":"Joy Dertinger, Monique Aucoin","doi":"10.54434/candj.157","DOIUrl":"https://doi.org/10.54434/candj.157","url":null,"abstract":"Background: Naturopathic medicine uses natural and evidence-based treatments to promote health. The objective of this study was to characterize and evaluate the effectiveness of naturopathic medicine in reducing symptoms of anxiety and depression in patients seeking care from the Mental Health Shift at a Canadian naturopathic teaching clinic.\u0000Methods: Charts of 192 consecutive patients who attended appointments between 1 January 2019 and 6 March 2020 were reviewed. Subjects were included if they screened positive on the General Anxiety Disorder 7 (GAD7) or the Patient Health Questionnaire 9 (PHQ9) and attended follow up at least 4 weeks after initial treatment.\u0000Results: Of the 22 included subjects, a clinically significant decrease of at least 5 points occurred in 76% of individuals with elevated baseline PHQ9 scores and 59% of individuals with elevated GAD7 scores. Mean PHQ9 and GAD7 scores decreased 7.5 (p<0.0001) and 4.6 (p<0.008) points, respectively. Mild adverse events were reported in 9 charts (41%). No serious adverse events were reported. Most subjects were also in the care of a medical doctor and counsellor.\u0000Conclusion: Naturopathic medicine as performed on the Mental Health Shift may be effective in reducing depression and anxiety symptoms as an adjunctive treatment. Further research incorporating comparison groups is warranted.","PeriodicalId":444026,"journal":{"name":"CAND Journal","volume":"103 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140224318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Role of Movement, Exercise, and Breathing in the Prevention and Treatment of COVID-19: An Umbrella Review 运动、锻炼和呼吸在预防和治疗 COVID-19 中的作用：综述

CAND Journal Pub Date : 2023-12-28 DOI: 10.54434/candj.163

Tristan Carter, Carla O’Brien, Titilayo Akinbode, Iva Lloyd

{"title":"The Role of Movement, Exercise, and Breathing in the Prevention and Treatment of COVID-19: An Umbrella Review","authors":"Tristan Carter, Carla O’Brien, Titilayo Akinbode, Iva Lloyd","doi":"10.54434/candj.163","DOIUrl":"https://doi.org/10.54434/candj.163","url":null,"abstract":"Objective: To identify the published review literature regarding movement, exercise, and breathing in the prevention and/ or treatment of the coronavirus 2019 disease (COVID-19) and long COVID, with the goal of describing the literature and identifying areas for further research and clinical application. Movement and exercise incorporate sedentary behaviours, various forms of exercise, breathing and respiratory therapies, and yoga-asanas (postures). Methods: This paper progresses from a live review and incorporates systematic reviews and narrative reviews. A literature search occurred monthly using PubMed and Google Scholar from May 2022 to May 2023. A measurement tool to assess systematic reviews (AMSTAR) scoring assessed systematic review quality, while the scale for the assessment of narrative review articles (SANRA) guidelines were used to evaluate narrative reviews. Only information and data focused on movement and exercise relevant to COVID-19 prevention and/or treatment were extracted from each review. Results: Three narrative reviews and five systematic reviews were included. Sedentary behaviours increased significantly during the pandemic. Decreased physical activity level was associated with risk of hospitalization from COVID-19. Physical activity and breathing exercises, whether conducted face-to-face (F-2-F) or via telerehabilitation were associated with improvement in dyspnea (shortness of breath), exercise capacity, lung function, fatigue, and quality of life (QoL). Extreme exercise is best avoided for at least 2 to 3 weeks after severe COVID-19 symptoms. Conclusion: Sedentary behaviour and lack of regular physical activity is correlated with an increased risk of COVID-19. Various forms of movement, exercise, and breathing may be beneficial in the treatment of COVID-19 and in long COVID. Further research and understanding of the importance of movement, exercise, and breathing as it relates to immune health is warranted.","PeriodicalId":444026,"journal":{"name":"CAND Journal","volume":"53 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139149523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Role of Nutraceuticals in the Prevention and/or Treatment of COVID-19: An Umbrella Review 营养保健品在预防和/或治疗 COVID-19 中的作用：综述

CAND Journal Pub Date : 2023-12-28 DOI: 10.54434/candj.165

Randa Karzon, Andrew Jackson, Iva Lloyd, Alexander Hall, Lauren Lee

{"title":"The Role of Nutraceuticals in the Prevention and/or Treatment of COVID-19: An Umbrella Review","authors":"Randa Karzon, Andrew Jackson, Iva Lloyd, Alexander Hall, Lauren Lee","doi":"10.54434/candj.165","DOIUrl":"https://doi.org/10.54434/candj.165","url":null,"abstract":"Background: To identify the results of published review literature regarding nutraceuticals, including probiotics, melatonin, poly-unsaturated fatty acids (PUFAs), quercetin, N-acetyl cysteine (NAC), and propolis as they relate to the prevention and/ or treatment of COVID-19 (CV) and/or long COVID (long CV) and to outline key areas to consider for clinical application and for further research. Methods: This paper is part of a six-part umbrella review which progresses from a living review. This review incorporates systematic reviews and narrative reviews as they relate to nutraceuticals. A live literature search occurred monthly in PubMed and Google Scholar from May 2022 to May 2023. Assessing the Methodological Quality of Systematic Reviews Version 2 (AMSTAR-2) scoring assessed systematic review quality, while the Scale for the Assessment of Narrative Review Articles (SANRA) guidelines evaluated narrative reviews. Only those studies that were relevant to the nutraceuticals outlined above and that addressed COVID-19 prevention and/or treatment of CV and/or long CV were extracted from each review. Results: Fifteen narrative reviews and 16 systematic reviews were included in this umbrella review. Studies indicate that nutraceuticals may be beneficial in improving the rate of recovery from various COVID-19 symptoms, rate of conversion parameters such as rate or duration of hospital stay and risk of intensive care unit (ICU) admission, and an improvement in various laboratory tests. Conclusion/Summary: The broad antioxidant, anti-inflammatory, antiviral, and immune modulatory characteristics make the nutraceuticals included in this review reasonable choices for further research. Of the nutraceuticals discussed above, probiotics, melatonin, NAC, and quercetin indicate the greatest potential for benefit in the prevention and treatment of COVID-19 and long CV.","PeriodicalId":444026,"journal":{"name":"CAND Journal","volume":"40 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139150402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Role of Minerals in COVID-19: An Umbrella Review 矿物在 COVID-19 中的作用：综述

CAND Journal Pub Date : 2023-12-28 DOI: 10.54434/candj.164

Claudine Van De Venter, Cécile Konn, Monica Doherty, Renée Purdy

{"title":"The Role of Minerals in COVID-19: An Umbrella Review","authors":"Claudine Van De Venter, Cécile Konn, Monica Doherty, Renée Purdy","doi":"10.54434/candj.164","DOIUrl":"https://doi.org/10.54434/candj.164","url":null,"abstract":"Background: This umbrella review aims to synthesize the existing literature on the preventive and therapeutic benefits of minerals zinc, selenium, iron, copper, magnesium, phosphorus, and calcium in the context of COVID-19 prevention and management. The objective is to highlight the clinical applicability and identify avenues of future research. Methods: A systematic search was conducted in PubMed and Google Scholar databases using predefined keywords for each mineral combined with COVID-19–related terms. Narrative and systematic reviews were included, following Cochrane guidelines. AMSTAR scoring was used to assess systematic review quality, while SANRA guidelines were used to evaluate narrative reviews. Data extraction and synthesis were performed, and reference overlap analysis was conducted (see Table S1 in the supplemental material). Results: Narrative reviews highlighted the range of therapeutic properties of minerals including antimicrobial, antiviral, antioxidant, anti-inflammatory, and immune-modulating and the essential role they play in the prevention and treatment of many conditions, including acute respiratory conditions such as COVID-19. The systematic reviews highlighted that deficiency of key minerals such as zinc, selenium, iron, copper, magnesium, phosphorus, and calcium are associated with increased risk of infection and decreased rate of recovery. Iron supplementation may be beneficial as functional anemia is common in those with COVID-19. Zinc supplementation may shorten the duration of olfactory dysfunction. Conclusion/Summary: Deficiency of minerals may increase the risk of infection and decrease the rate of recovery as it relates to COVID-19. Supplementation with and correction of zinc, iron and selenium deficiencies may improve clinical outcomes and immune responses in those with COVID-19.\"","PeriodicalId":444026,"journal":{"name":"CAND Journal","volume":"313 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139149297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Role of Traditional, Complementary, and Integrative Healthcare (TCIH) Therapies and Practices in the Prevention and/or Treatment of COVID-19: An Umbrella Review 传统、补充和综合保健（TCIH）疗法和实践在预防和/或治疗 COVID-19 中的作用：综述

CAND Journal Pub Date : 2023-12-28 DOI: 10.54434/candj.162

Iva Lloyd, Kieran Cooley, Amie Steel

引用次数: 0

Herbal Medicine and COVID-19: An Umbrella Review 草药与 COVID-19：综述

CAND Journal Pub Date : 2023-12-28 DOI: 10.54434/candj.161

Kerrie Oakes, Paul Saunders, Iva Lloyd, Tiffany Turner, Janis Gruska, Belinda Gibbs, Sophie Gleitzman, Caio Fabio Portella, Jamie Friend, Kim Graham, Meagan Leslie

{"title":"Herbal Medicine and COVID-19: An Umbrella Review","authors":"Kerrie Oakes, Paul Saunders, Iva Lloyd, Tiffany Turner, Janis Gruska, Belinda Gibbs, Sophie Gleitzman, Caio Fabio Portella, Jamie Friend, Kim Graham, Meagan Leslie","doi":"10.54434/candj.161","DOIUrl":"https://doi.org/10.54434/candj.161","url":null,"abstract":"Background: Most systems of traditional medicine have been using herbal medicines to prevent and treat acute respiratory conditions and various other conditions for centuries. The aim of this project is to identify and examine the systematic and narrative reviews reporting on the therapeutic use of herbal medicines as it relates to the prevention and treatment of COVID-19 and long COVID. Methods: This paper is part of an umbrella review of studies related to natural health products and natural therapies for the prevention or treatment of COVID-19. It is a follow-up to a live review that was conducted by the World Naturopathic Federation between May 2022 and May 2023. PubMed and Google Scholar were searched for systematic and narrative reviews that met defined quality criteria. Results: Over half of the initial systematic reviews were excluded as they did not meet the inclusion and AMSTAR criteria. The final paper included 25 narrative reviews and 41 systematic reviews (SR), with half of the SRs reporting on the safety of herbal interventions. Various therapeutic properties of over 60 herbal medicines were outlined, some individually and most of them as part of herbal formula (combinations). Conclusion/Summary: Herbal interventions demonstrated statistically significant improved recovery in patients with COVID-19. The most common therapeutic properties identified were immunological properties, anti-inflammatory, anti- microbial, and antioxidant while the most frequently investigated herbs were Glycyrrhiza glabra/uralensis, Tinospora cordifolia, and Curcuma longa. More attention is needed on the regulation of herbal medicines, the quality of research, and the safety of herbal medicines.","PeriodicalId":444026,"journal":{"name":"CAND Journal","volume":"26 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139148120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0