International Journal of Diabetes and Metabolism最新文献

{"title":"International Conference of the Gulf Group for the Study of Diabetes, Dubai, UAE, February 13-15, 2005","authors":"H. Nejad","doi":"10.1159/000497572","DOIUrl":"https://doi.org/10.1159/000497572","url":null,"abstract":"","PeriodicalId":405374,"journal":{"name":"International Journal of Diabetes and Metabolism","volume":"32 10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134584879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"7th Annual Workshop on Diabetes Mellitus and its Complications","authors":"","doi":"10.1159/000497524","DOIUrl":"https://doi.org/10.1159/000497524","url":null,"abstract":"","PeriodicalId":405374,"journal":{"name":"International Journal of Diabetes and Metabolism","volume":"96 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114341547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"10th Annual Workshop on Diabetes Mellitus and its Complications Al Ain, United Arab Emirates","authors":"","doi":"10.1159/000497558","DOIUrl":"https://doi.org/10.1159/000497558","url":null,"abstract":"","PeriodicalId":405374,"journal":{"name":"International Journal of Diabetes and Metabolism","volume":"40 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115513585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pancreatic peptides, neuropeptides and neurotransmitters in diabetes mellitus: a review","authors":"Ernest Adeghate E., Abdulsamad Ponery A.","doi":"10.1159/000486885","DOIUrl":"https://doi.org/10.1159/000486885","url":null,"abstract":"Diabetes mellitus is due to defective secretion and/ or function of insulin. It is a common chronic disease affecting up to 6% of the world population. This prevalence increases to about 24% in the island of Nauru and some Middle Eastern countries. Diabetes mellitus is associated with profound changes in the endocrine pancreas. These changes include a significant decrease in the number of beta cells, the cell type that produces and secretes insulin. A decrease in the number of insulin producing cells is more evident in type I diabetes. The decrease in the number of insulin-secreting cells is associated with a concomitant increase in the number of glucagon, somatostatin and pancreatic-polypeptide producing cells. The increase in glucagon producing cells results in hyperglucagonaemia, which further exacerbates the hyperglycaemia induced by lack of insulin. In addition to the changes in the number and plasma levels of pancreatic hormones, the number of calcitonin-generelated peptide- and galanin-positive cells in the islet of Langerhans decreases after the onset of diabetes. Pancreatic amino butyric acid is also decreased in diabetes. These abnormal changes in the pattern of distribution of peptides, neuropeptides and neurotransmitters may contribute to the pathogenesis of diabetes mellitus.","PeriodicalId":405374,"journal":{"name":"International Journal of Diabetes and Metabolism","volume":"36 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121322209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"4th International Symposium on Diabetes Mellitus and its Complications: From Molecular Biology to Clinical Medicine Preston, UK","authors":"","doi":"10.1159/000497557","DOIUrl":"https://doi.org/10.1159/000497557","url":null,"abstract":"","PeriodicalId":405374,"journal":{"name":"International Journal of Diabetes and Metabolism","volume":"43 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114806342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"11th Annual Workshop on Diabetes Mellitus and its Complications Al Ain, United Arab Emirates","authors":"","doi":"10.1159/000497563","DOIUrl":"https://doi.org/10.1159/000497563","url":null,"abstract":"","PeriodicalId":405374,"journal":{"name":"International Journal of Diabetes and Metabolism","volume":"271 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123117494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Insulin Resistance Index and Proatherogenic Lipid Indices in the Offspring of People with Diabetes","authors":"O. Sonuga, F. Abbiyesuku, K. Adedapo, A. Sonuga","doi":"10.1159/000497079","DOIUrl":"https://doi.org/10.1159/000497079","url":null,"abstract":"Background: Diabetes mellitus and cardiovascular diseases significantly contribute to medical morbidity and mortality worldwide, especially in developing countries like Nigeria. Insulin resistance, a characteristic finding of type 2 diabetics and their offspring, is associated with an abnormal lipid metabolism and cardiovascular disease. Aims: This study therefore aims to determine the pattern of lipid biomarkers of atherogenesis and their relationship with insulin resistance index in young people with a family history of diabetes mellitus. Methods: This is a cross-sectional study carried out among 150 apparently healthy young adults between 18 and 25 years of age, including 76 with a family history of diabetes mellitus in first- and/or second-degree relatives (YWFH) and 74 with no family history of diabetes mellitus (YWoFH). Anthropometric characteristics, insulin resistance index, plasma glucose, fasting lipid profile (plasma total cholesterol, triglycerides [TG], high-density lipoprotein cholesterol, low-density lipoprotein cholesterol), and serum levels of insulin, lipoprotein(a) [Lp(a)], apolipoprotein B (ApoB), apolipoprotein A-1 (ApoA-1), and ApoB/ApoA-1 ratios were compared in the 2 groups. Plasma glucose, total cholesterol, high-density cholesterol, and TG were measured using standard methods. The Friedewald equation was used to calculate low-density cholesterol. Serum insulin, Lp(a) levels, ApoB, and ApoA-1 were also measured using standard assays. The insulin resistance index was determined using homeostatic model assessment (HOMA). Statistical analysis was performed using SPSS version 20.0. Comparisons between variables were performed using the Mann-Whitney U test, and correlations between variables were performed using Spearman rank correlation coefficients. The level of significance was set at p < 0.05. Results: Offspring of diabetics (YWFH) had a significantly higher median BMI (p = 0.015), waist-to-hip ratio (WHR; p = 0.002), insulin resistance index (p = 0.038), total cholesterol (p = 0.017), TG (p = 0.004), Lp(a) (p = 0.045), ApoB (p = 0.002), and ApoB/ApoA-1 ratio (p = 0.001) than the age-matched control group with no family history of diabetes mellitus (YWoFH). There was no correlation between the insulin resistance index and each of the lipid biomarkers of atherogenesis except Lp(a), with which it was negatively correlated. Conclusion: This study demonstrates that a positive family history of type 2 diabetes mellitus is associated with a higher insulin resistance index and elevated atherogenic lipid indices; thus, a positive family history of diabetes mellitus in first or second-degree relatives when the index person is not diabetic confirms a significant cardiovascular risk.","PeriodicalId":405374,"journal":{"name":"International Journal of Diabetes and Metabolism","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129182519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Developing and Validating the Educational Materials for a Nurse-Led Self-Management Education in Adults with Type 2 Diabetes","authors":"Golnaz Azami, K. L. Soh, S. Sazlina, Md.Said Salmiah, Sanaz Aazami, M. Mozafari, H. Taghinejad, B. Badakhsh","doi":"10.1159/000495762","DOIUrl":"https://doi.org/10.1159/000495762","url":null,"abstract":"Background: Diabetes education and self-care are the cornerstones of diabetes management. There are few nurse-led structured diabetes management programs available in Iran. Objectives: This paper aims to develop and validate a nurse-led diabetes self-management intervention for patients with type 2 diabetes. Method: The theoretical framework underpinning the intervention was the Bandura’s self-efficacy theory. The seven basic steps of the Taba model were used to develop and validate the study intervention. Results: The preliminary results from this study suggest that the study intervention was carefully contextualized and linked to the existing diabetes care. Overall, the intervention was very well received and appreciated by the respondents. Conclusion: This was the first known validated nurse-led diabetes self-management intervention available in the Persian Language.","PeriodicalId":405374,"journal":{"name":"International Journal of Diabetes and Metabolism","volume":"59 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131161978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Paraoxonase 1 Gene Polymorphisms (Q192R and L55M) Are Associated with Coronary Artery Disease Susceptibility in Asian Indians","authors":"S. Kaur, G. Bhatti, R. Vijayvergiya, Puneetpal Singh, S. Mastana, R. Tewari, J. S. Bhatti","doi":"10.1159/000494508","DOIUrl":"https://doi.org/10.1159/000494508","url":null,"abstract":"Background: Coronary artery disease (CAD) is a complex metabolic disorder in which lifestyle and genetic factors are known to play key roles in pathogenesis. The paraoxonase 1 (PON1) enzyme has a defensive effect against CAD progression, as it safeguards low-density lipoproteins (LDLs) from oxidative modifications. The most extensively studied genetic variants in the PON1 gene are Q192R and L55M, which have been related with LDL antioxidative activity and risk of CAD. Objective: The present case-control study intended to examine the Q192R and L55M polymorphisms and their association with the risk of CAD patients in north Indians. Methods: A total of 872 subjects (412 CAD patients and 460 controls) were recruited from north India. The PON1 gene was amplified and genotypes were studies using PCR-RFLP. χ2 analysis was performed to compare genotype/allele frequencies in patients and controls. Results: The present study indicated abdominal obesity, elevated body mass index, and dyslipidemia with increased levels of total cholesterol and triglycerides as well as reduced high-density lipoprotein cholesterol in CAD subjects compared to healthy controls (p < 0.05). Logistic regression analysis of the data revealed an association of the RR genotype of the Q192R polymorphism with an about 2-fold elevated risk of CAD (OR = 2.23, 95% CI = 1.47–3.37, p = 0.0001). Contrariwise, the L55M polymorphism did not show significant association with CAD (OR = 1.81, 95% CI = 0.66–4.95, p = 0.326). Conclusions: The Q192R polymorphism in the PON1 gene may be a susceptibility gene associated with increased risk of CAD in an Asian Indian population.","PeriodicalId":405374,"journal":{"name":"International Journal of Diabetes and Metabolism","volume":"60 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114183048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of Type 2 Diabetes Mellitus among Hepatitis C Virus-Infected Patients: A Systematic Review and Meta-Analysis","authors":"S. Ambachew, Setegn Eshetie, D. Geremew, A. Endalamaw, M. Melku","doi":"10.1159/000493945","DOIUrl":"https://doi.org/10.1159/000493945","url":null,"abstract":"Background: The ever-increasing global prevalence of hepatitis C infection is fueling the burden of diabetes mellitus, which exacerbates various complications and may be a cause of death of millions of people. Several studies have reported that hepatitis C virus infection is an important risk factor for the development of diabetes mellitus. However, fragmented studies have reported variable and inconsistent findings regarding the prevalence of type 2 diabetes mellitus among hepatitis C virus-infected patients. Therefore, this meta-analysis aimed to estimate the overall prevalence of type 2 diabetes mellitus among patients infected with hepatitis C virus. Methods: This systematic review and meta-analysis includes original articles reporting on cohort and cross-sectional studies. A systematic search was performed in PubMed, ScienceDirect, and Google Scholar. A random-effects meta-analysis model was used to estimate the global pooled prevalence of type 2 diabetes mellitus among hepatitis C-infected patients. A sensitivity analysis was conducted to check the stability of the summary estimate. Heterogeneity was assessed using the I2 statistic. A subgroup analysis was also conducted based on geographical region. Funnel plots were used to spot publication bias. Results: A total of 40 eligible articles reporting data on 14,765 study participants were included in this meta-analysis. The pooled prevalence of type 2 diabetes mellitus among hepatitis C virus-infected patients was 19.67% (95% CI: 17.25, 22.09). The subgroup analysis showed a pooled prevalence of 27.72% (95% CI: 20.79, 34.65) in Africa, 20.73% (95% CI: 17.57, 23.90) in Asia, 16.64% (95% CI: 6.79, 26.49) in North America, and 15.02% (95% CI: 10.66, 19.38) in Europe. Conclusions: The overall prevalence of type 2 diabetes mellitus among hepatitis C virus-infected patients was considerably higher than in the general population in a global perspective. The highest prevalence was noted in Africa and Asia, followed by North America and Europe. Therefore, early intervention is needed (prevention and early treatment of hepatitis C virus infection) to prevent the development of type 2 diabetes mellitus.","PeriodicalId":405374,"journal":{"name":"International Journal of Diabetes and Metabolism","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124158694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}