Expert Review of Ophthalmology最新文献

{"title":"Immunopathogenesis of ocular toxoplasmosis and implications for treatment","authors":"J. Gomez Marin, Alejandra de la Torre, Mónica Vargas-Montes","doi":"10.1080/17469899.2023.2279178","DOIUrl":"https://doi.org/10.1080/17469899.2023.2279178","url":null,"abstract":"","PeriodicalId":39989,"journal":{"name":"Expert Review of Ophthalmology","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2023-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139211688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rod mediated dark adaptation, a functional test for early and intermediate AMD outcomes","authors":"Cynthia Owsley, Thomas A. Swain, Deepayan Kar, C. Curcio","doi":"10.1080/17469899.2023.2287178","DOIUrl":"https://doi.org/10.1080/17469899.2023.2287178","url":null,"abstract":"","PeriodicalId":39989,"journal":{"name":"Expert Review of Ophthalmology","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2023-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139242824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targeting the complement system in geographic atrophy: mechanisms and therapeutics","authors":"Majid Khan, Olawale E. Akinyemi, Maliha Masud, Mathew J. Thomas, Nicholas Martin, A. Khanani","doi":"10.1080/17469899.2023.2286607","DOIUrl":"https://doi.org/10.1080/17469899.2023.2286607","url":null,"abstract":"","PeriodicalId":39989,"journal":{"name":"Expert Review of Ophthalmology","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2023-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139258379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Examining correlation between ocular microbiome and ocular diseases including keratitis","authors":"S. Shivaji","doi":"10.1080/17469899.2023.2284313","DOIUrl":"https://doi.org/10.1080/17469899.2023.2284313","url":null,"abstract":"","PeriodicalId":39989,"journal":{"name":"Expert Review of Ophthalmology","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2023-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139255383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An update of recommendations for follow-up care following unsuccessful cataract surgery","authors":"Manpreet Kaur, Akshaya Balaji, J. Titiyal, Sridevi Nair","doi":"10.1080/17469899.2023.2284881","DOIUrl":"https://doi.org/10.1080/17469899.2023.2284881","url":null,"abstract":"","PeriodicalId":39989,"journal":{"name":"Expert Review of Ophthalmology","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2023-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139267822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lower blepharoplasty; advanced techniques and adjunctive procedures","authors":"Nasser Karimi, Parya Abdolalizadeh, Hossein Ghahvehchian, Mansooreh Jamshidian Tehrani, Christopher J Compton, Jeremy D Clark, Nicole L West, Mohsen Bahmani Kashkouli","doi":"10.1080/17469899.2023.2281442","DOIUrl":"https://doi.org/10.1080/17469899.2023.2281442","url":null,"abstract":"ABSTRACTIntroduction There are two main techniques of lower blepharoplasty: transcutaneous and transconjunctival approaches. Most patients seeking lower eyelid rejuvenation have concomitant involutional changes in the lower eyelid and midface, which would better be addressed concurrently with the lower blepharoplasty procedure to yield better aesthetic and functional outcomes.Areas covered This study aims to review common aging-related changes in the lower eyelid as well as important preoperative considerations, surgical techniques, and various modifications of lower blepharoplasty. A literature search was performed in the PubMed database of English-language journals without restriction on the publication date using selected keywords. The relevant articles were selected by reviewing the titles and abstracts.Expert opinion The lower eyelid and midface should be perceived as a continuum. Currently the fat preservation approach is the mainstream in lower blepharoplasty to prevent postoperative skeletonization of the eye. Fat transposition, via either pedicled fat flaps or free fat grafts, is used to efface tear trough deformity and the eyelid-cheek junction as a primary aim inaesthetic lower eyelid surgeries. Lower blepharoplasty can also be combined with adjuvant procedures to address festoon and droopy midface in selected individuals.KEYWORDS: Lower blepharoplastylower eyelidtear troughtransconjunctival blepharoplastytransconjunctival blepharoplastyorbital fat Article highlights The composite morphology of lower eyelid and mid-face aging is commonly designated as the double convexity deformity.The concept of lower blepharoplasty has shifted from a pure subtractive surgery to fat reposition, conservative skin excision and blending of the eyelid-cheek junction.Releasing the orbicularis retaining ligament is a crucial step in lower blepharoplasty, specifically for patients with an untoward infraorbital hollow.Although pedicled fat flap transposition can effectively efface the infraorbital hollow, this technique has some downsides.Recently it has been demonstrated that the aims of fat redistribution in lower blepharoplasty can be safely achievable by the minced fat graft technique.Most, if not all, cases of lower blepharoplasty would better be complemented with prophylactic canthal anchoring techniques to prevent lower eyelid malposition.Suborbicularis oculi fat elevation is an alternative to lower eyelid fat repositioning, particularly for subjects with negative vectors or hypoplastic malar prominences.Declaration of interestsJD Clark is a professional speaker for Horizon therapeutics. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.Reviewer disclosuresPeer reviewers on this manuscript have no relevant financial or other relationships to disclose.Additio","PeriodicalId":39989,"journal":{"name":"Expert Review of Ophthalmology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135037416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current challenges facing the clinical treatment for HTLV-1 ocular manifestations","authors":"Koju Kamoi","doi":"10.1080/17469899.2023.2281446","DOIUrl":"https://doi.org/10.1080/17469899.2023.2281446","url":null,"abstract":"ABSTRACTIntroduction Human T-lymphotropic virus type 1 (HTLV-1) is a lifelong persistent retrovirus associated with numerous systemic and ocular diseases, presenting significant clinical challenges.Areas covered A detailed overview of HTLV-1 associated ocular diseases is provided, along with the highlighting of recent findings challenging traditional views on transmission routes and the role of proviral load in HTLV-1 disease onset. The focus is on pathogenesis, clinical presentation, diagnostic approaches, current therapeutic strategies, recent advancements, and potential future directions in treatment.Expert opinion Recent discoveries emphasize the crucial role of horizontal transmission in HTLV-1 associated diseases, highlighting the need for heightened global awareness and effective screening practices. It’s revealed that HTLV-1 uveitis onset can be accelerated patients with Graves’ disease, despite a low proviral load and short latency period. Understanding such interplay and the pathogenesis of HTLV-1-associated ocular diseases is important in developing effective treatment strategies. Given the complexities of HTLV-1 ocular diseases, interdisciplinary collaboration is of the essence.KEYWORDS: Human T-lymphotropic virus type 1HTLV-1Horizontal transmissionHTLV-1 uveitisGraves’ diseaseKeratoconjunctivitis SiccaScleritisOptic neuritisAdult T-cell leukemia/lymphomaATLL-related ocular manifestationsOpportunistic infectionsHematopoietic stem cell transplantationDisclaimerAs a service to authors and researchers we are providing this version of an accepted manuscript (AM). Copyediting, typesetting, and review of the resulting proofs will be undertaken on this manuscript before final publication of the Version of Record (VoR). During production and pre-press, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal relate to these versions also. Article highlightsThe Human T-Cell Leukemia Virus-1 (HTLV-1) is associated with a wide range of ocular conditions, including HTLV-1 uveitis, keratoconjunctivitis sicca, interstitial keratitis, optic neuritis, overlap syndrome, and Adult T-cell leukemia/lymphoma (ATLL)-related ocular conditions. Each condition presents unique clinical challenges that necessitate an in-depth understanding and tailored treatment strategies for effective management.Therapeutic strategies for ocular inflammatory diseases related to HTLV-1, including HTLV-1 uveitis, currently focus on suppressing inflammation and controlling symptoms, largely through the use of steroids. This reliance on steroids punctuates the crucial need for new, targeted, and less invasive treatments. While potential solutions such as targeted drugs and biologics offer promising advances, it’s necessary to conduct further research to confirm their effectiveness, assess safety, and validate their use.The growing recognition of horizontal transmission as a significant route for HTLV-1-associated disease could d","PeriodicalId":39989,"journal":{"name":"Expert Review of Ophthalmology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135241102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of genetic testing for microphthalmia, anophthalmia and coloboma: experiences from a translational approach","authors":"Richard Holt","doi":"10.1080/17469899.2023.2281441","DOIUrl":"https://doi.org/10.1080/17469899.2023.2281441","url":null,"abstract":"","PeriodicalId":39989,"journal":{"name":"Expert Review of Ophthalmology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135342138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improving access to eye care in low and middle-income countries – challenges, opportunities, and the way forward","authors":"Srinivas Marmamula, V. K. Yelagondula, Rajashekar Varada, R. Khanna","doi":"10.1080/17469899.2023.2281448","DOIUrl":"https://doi.org/10.1080/17469899.2023.2281448","url":null,"abstract":"ABSTRACT Introduction Vision loss is a public health challenge adversely affecting over a billion people worldwide. Low and middle income countries (LMICs) have a disproportionately higher prevalence of vision loss compared to high-income countries. Over 80% of vision loss can be addressed with either spectacles or cataract surgery. Both of these interventions are low cost and cost effective. Despite this, several barriers prevent individuals from accessing eye care. Areas covered This paper covers various elements of access (approachability, acceptability, affordability, availability and appropriateness) and presents barriers that prevent access to eye care services in LMICs. Disease-specific barriers and various models and strategies that address the accessibility challenges are presented with a special reference to the use of technology to improve access. Expert opinion Strategies such as providing free eye care, lowering direct and indirect costs, improve access to cataract surgery. While access-related challenges related to cataract surgery are well studied, there is inadequate information on access to refraction services for refractive errors and other conditions. Future research can focus on addressing this information gap. This can then help develop strategies to address the burden of uncorrected refractive errors and other causes of vision loss and contribute towards achieving universal eye health coverage. Search strategy used A literature search was carried out to identify the relevant articles reporting barriers to seeking eye care in the Medline, CINHAL and PsycINFO databases between 20 and 27 May 2023. From this search, the relevant articles were shortlisted for data extraction.","PeriodicalId":39989,"journal":{"name":"Expert Review of Ophthalmology","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2023-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139290630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surgical management of macular holes: techniques, outcomes, and treatment of special cases","authors":"Alexis S. Kassotis, Meera Ramakrishnan, T. Tezel","doi":"10.1080/17469899.2023.2281447","DOIUrl":"https://doi.org/10.1080/17469899.2023.2281447","url":null,"abstract":"ABSTRACT Introduction Full-thickness macular hole is a visually significant condition with a very high surgical anatomical closure rate. Areas covered A literature review was performed focusing on surgical techniques for macular holes. What is known about the underlying anatomy and pathophysiology of macular hole formation is applied to surgical techniques that address the mechanisms for hole closure. Expert opinion While anatomic and functional success can be achieved at high rates, much is yet to be learned about the molecular and microstructural changes resulting from surgical manipulation. These insights will help guide novel techniques for complex cases which still suffer from suboptimal surgical outcomes.","PeriodicalId":39989,"journal":{"name":"Expert Review of Ophthalmology","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2023-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139290200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}