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Brazilian Journal of Oncology最新文献

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Epithelial-mesenchymal transition in uterine carcinosarcoma from a dedifferentiated papillary serous carcinoma to a sarcoma: case report 子宫癌肉瘤由去分化乳头状浆液性癌向肉瘤的上皮-间质转变1例
Brazilian Journal of Oncology Pub Date : 1900-01-01 DOI: 10.5935/2526-8732.20230403
Y. Barbosa, Ana C Lopes, Camila Delfino Chaves, Régis Ponte Conrado, M. L. V. Costa, R. Leal
{"title":"Epithelial-mesenchymal transition in uterine carcinosarcoma from a dedifferentiated papillary serous carcinoma to a sarcoma: case report","authors":"Y. Barbosa, Ana C Lopes, Camila Delfino Chaves, Régis Ponte Conrado, M. L. V. Costa, R. Leal","doi":"10.5935/2526-8732.20230403","DOIUrl":"https://doi.org/10.5935/2526-8732.20230403","url":null,"abstract":"","PeriodicalId":395496,"journal":{"name":"Brazilian Journal of Oncology","volume":"47 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122690387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
How is advanced melanoma treated in the Public Health System in Brazil: a call for change 巴西公共卫生系统如何治疗晚期黑色素瘤:呼吁变革
Brazilian Journal of Oncology Pub Date : 1900-01-01 DOI: 10.5935/2526-8732.20190020
R. Kaliks, Andrew M Santos, T. F. Matos, L. Holtz
{"title":"How is advanced melanoma treated in the Public Health System in Brazil: a call for change","authors":"R. Kaliks, Andrew M Santos, T. F. Matos, L. Holtz","doi":"10.5935/2526-8732.20190020","DOIUrl":"https://doi.org/10.5935/2526-8732.20190020","url":null,"abstract":"Introduction: Treatment of advanced melanoma has been revolutionized in the last decade. The adoption of new treatments is necessary in order to offer significantly longer survival. Objective: To evaluate how patients are being treated for advanced melanoma at the Public Health System in Brazil. Methods: We evaluated the Authorization of Ambulatory Care Procedure (APAC) related to all patients treated for advanced melanoma between January 2015 and December 2017. We grouped treatments according to their reported efficacy as being inadequate, minimally effective, moderately effective or effective treatments. We evaluated treatments given according to the efficacy, variety of treatments in first line and duration of overall treatment. Results: We analyzed 10,843 APACs, related to the treatment of 4,338 patients. Patients were 57% male, 43% female, 72% were older than 50 years of age. The median number of APACs filled per patient was 2 (ranging from 1 to 15). The mean of different types of treatment prescribed to individual patients was 1.22 (1 - 5). We identified 19 different treatment protocols used as first line, of which 11 consisted of single drug and 8 of drug combinations. Over the two-year period, 3,097 (88%) and 281 (8%) patients initiated treatment with a minimally effective or moderately effective regimen, respectively. Only 0.4% of patients initiated their treatment with an effective therapy. The average length on any treatment was six months. Conclusion: More than 98% of patients treated between 2015 and 2017 for advanced melanoma at the Public Health System in Brazil received minimally effective treatments. ABSTRACT","PeriodicalId":395496,"journal":{"name":"Brazilian Journal of Oncology","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127592702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
USE OF DENOSUMAB IN GIANT-CELL TUMOR AT A PUBLIC HOSPITAL IN SOUTHERN BRAZIL: REPORT OF 13 CASES. 在巴西南部一家公立医院使用地诺单抗治疗巨细胞肿瘤:13例报告
Brazilian Journal of Oncology Pub Date : 1900-01-01 DOI: 10.5935/1806-6054.20190009
Tamise da Silva Baptista, L. Lima, A. Lino, G. G. Ganev, P. Kechele, Rita Oliveira
{"title":"USE OF DENOSUMAB IN GIANT-CELL TUMOR AT A PUBLIC HOSPITAL IN SOUTHERN BRAZIL: REPORT OF 13 CASES.","authors":"Tamise da Silva Baptista, L. Lima, A. Lino, G. G. Ganev, P. Kechele, Rita Oliveira","doi":"10.5935/1806-6054.20190009","DOIUrl":"https://doi.org/10.5935/1806-6054.20190009","url":null,"abstract":"Giant-cell tumor is a relatively rare neoplasia, benign but locally aggressive, that causes significant bone destruction with predilection for epiphyseal and metaphyseal regions of long bones and the spine. Definitive treatment is surgical, with complete tumoral resection followed by autograft, homograft, arthrodesis, unconventional endoprostheses or methylmethacrylate. In most cases, surgery is accompanied by high morbidity and variable recurrence rates, depending on the site, size and type of surgical intervention.Denosumab, a RANKL inhibitor, acts by decreasing tumoral osteoclastic activity and is approved by the Food and Drug Administration for treatment of GCT when surgery is not possible or when it is associated with high morbidity. This report of cases is based on the review of medical records from the Ambulatory Service for Adolescents and Young Adults (AYA), aiming to show the experience of the Service with the use of denosumab for neoadjuvant purposes. ABSTRACT","PeriodicalId":395496,"journal":{"name":"Brazilian Journal of Oncology","volume":"29 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132575451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reviewing prognostic factors associated with recurrence in clinically early-stage low-risk endometrial cancer 回顾临床早期低危子宫内膜癌复发相关的预后因素
Brazilian Journal of Oncology Pub Date : 1900-01-01 DOI: 10.5935/2526-8732.20220244
T. Batista, R. P. Santana, C. Augusto, N.A.O.S. Morais, M. L. Ventura, A. L. R. Bezerra
{"title":"Reviewing prognostic factors associated with recurrence in clinically early-stage low-risk endometrial cancer","authors":"T. Batista, R. P. Santana, C. Augusto, N.A.O.S. Morais, M. L. Ventura, A. L. R. Bezerra","doi":"10.5935/2526-8732.20220244","DOIUrl":"https://doi.org/10.5935/2526-8732.20220244","url":null,"abstract":"","PeriodicalId":395496,"journal":{"name":"Brazilian Journal of Oncology","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115038143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Updated Brazilian guidelines for the management of immune-related adverse events associated with checkpoint inhibitors - edition 2.0 新版巴西检查点抑制剂相关免疫相关不良事件管理指南2.0版
Brazilian Journal of Oncology Pub Date : 1900-01-01 DOI: 10.5935/2526-8732.20220305
R. Munhoz, C. Mathias, G. Harada, Renan O Clara, A. Calabrich, A. Wainstein, A. Melo, A. Buzaid, Artur Katz, C. Ferreira, C. H. Anjos, C. Baldotto, E. Gomes, Fernando Moura, Gilberto de Castro Junior, G. Marta, G. Fernandes, L. Faria, M. Laloni, P. Hoff, R. Barroso-Sousa, S. Azevedo, V. C. C. Lima, W. N. William Junior
{"title":"Updated Brazilian guidelines for the management of immune-related adverse events associated with checkpoint inhibitors - edition 2.0","authors":"R. Munhoz, C. Mathias, G. Harada, Renan O Clara, A. Calabrich, A. Wainstein, A. Melo, A. Buzaid, Artur Katz, C. Ferreira, C. H. Anjos, C. Baldotto, E. Gomes, Fernando Moura, Gilberto de Castro Junior, G. Marta, G. Fernandes, L. Faria, M. Laloni, P. Hoff, R. Barroso-Sousa, S. Azevedo, V. C. C. Lima, W. N. William Junior","doi":"10.5935/2526-8732.20220305","DOIUrl":"https://doi.org/10.5935/2526-8732.20220305","url":null,"abstract":"","PeriodicalId":395496,"journal":{"name":"Brazilian Journal of Oncology","volume":"35 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116049504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
PERSEPHONE in Perspective 透视珀尔塞福涅
Brazilian Journal of Oncology Pub Date : 1900-01-01 DOI: 10.5935/1806-6054.20190019
N. Pondé, S.G.G. Sanches
{"title":"PERSEPHONE in Perspective","authors":"N. Pondé, S.G.G. Sanches","doi":"10.5935/1806-6054.20190019","DOIUrl":"https://doi.org/10.5935/1806-6054.20190019","url":null,"abstract":"Braz J Oncol. 2019 1 Breast cancer is one of the most frequent type of cancer among women worldwide, as well as one of the most common causes of cancer-specific death.1 In Brazil, the most recent available data estimates 59.700 new cases of breast cancer in 2018, corresponding to 29,5% of all cancers diagnosed in women.2 Additionally, in 2015, breast cancer led to more than 15.000 deaths in Brazil. Today, due to improving treatment standards most women diagnosed with breast cancer have early disease and receive treatment with a curative intent.3 This improvement has been largely based on a better understanding of the molecular heterogeneity of breast cancer4 and the increasing number of new treatment options which leverage specific molecular targets.","PeriodicalId":395496,"journal":{"name":"Brazilian Journal of Oncology","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121539358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Distal pancreatectomy with celiac axis resection for locally advanced pancreatic carcinoma: case report 远端胰切除术联合腹腔轴切除术治疗局部晚期胰腺癌1例
Brazilian Journal of Oncology Pub Date : 1900-01-01 DOI: 10.5935/2526-8732.20210017
R. Zanatto, P.M.M. Beato, Maurício José Vieira, C. R. Passeri
{"title":"Distal pancreatectomy with celiac axis resection for locally advanced pancreatic carcinoma: case report","authors":"R. Zanatto, P.M.M. Beato, Maurício José Vieira, C. R. Passeri","doi":"10.5935/2526-8732.20210017","DOIUrl":"https://doi.org/10.5935/2526-8732.20210017","url":null,"abstract":"Long-term survival of pancreatic ductal adenocarcinoma after surgery is still rare. One of the main reasons for unresectability is the tumor invasion of the main vessels, such as the celiac axis, common hepatic artery and superior mesenteric artery. The optimal management of these patients is controversial. Despite the challenges on the topic, we present a case of pancreatic ductal adenocarcinoma with invasion of the celiac axis treated with pancreatectomy and vascular resection plus perioperative chemoradiotherapy. After 30 months of follow-up, hepatic and peritoneal recurrence were identified. Palliative chemotherapy was administered until disease progression and death in March 2020. Surgical resection when used in selected patients, proved to be feasible with acceptable morbidity. Besides that, the aggressive surgical approach associated with multimodal schemes provided an improvement in disease-free and overall survival. ABSTRACT A sobrevida a longo prazo do adenocarcinoma ductal pancreático após a cirurgia ainda é rara. Um dos principais motivos da irressecabilidade é a invasão tumoral dos principais vasos, como o eixo celíaco, a artéria hepática comum e a artéria mesentérica superior. O manejo ideal desses pacientes é controverso. Apesar dos desafios no assunto, apresentamos um caso de adenocarcinoma ductal pancreático com invasão do eixo celíaco tratado com pancreatectomia e ressecção vascular associada à quimiorradioterapia perioperatória. Após 30 meses de acompanhamento, foram identificadas recidivas hepática e peritoneal. A quimioterapia paliativa foi administrada até a progressão da doença e óbito em março de 2020. A ressecção cirúrgica, quando utilizada em pacientes selecionados, mostrou-se viável com morbidade aceitável. Além disso, a abordagem cirúrgica agressiva associada a esquemas multimodais proporcionou melhora na sobrevida livre de doença e global.","PeriodicalId":395496,"journal":{"name":"Brazilian Journal of Oncology","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126034233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chondrosarcoma metastasis simulating a primary stomach tumor: a case report 软骨肉瘤转移模拟原发性胃肿瘤:1例报告
Brazilian Journal of Oncology Pub Date : 1900-01-01 DOI: 10.5935/2526-8732.20220361
Kevyn Alisson Nascimento Gurgel, Paulo Henrique Silva Nunes, Davi Teixeira de Macêdo, Clarice Sampaio Torres, M. P. Cunha, Diego Costa de Almeida, R. Leal, M. L. V. Costa
{"title":"Chondrosarcoma metastasis simulating a primary stomach tumor: a case report","authors":"Kevyn Alisson Nascimento Gurgel, Paulo Henrique Silva Nunes, Davi Teixeira de Macêdo, Clarice Sampaio Torres, M. P. Cunha, Diego Costa de Almeida, R. Leal, M. L. V. Costa","doi":"10.5935/2526-8732.20220361","DOIUrl":"https://doi.org/10.5935/2526-8732.20220361","url":null,"abstract":"","PeriodicalId":395496,"journal":{"name":"Brazilian Journal of Oncology","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128686255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Abscess-like postpartum metaplastic breast carcinoma in breastfeeding woman: a case report 母乳喂养妇女产后脓肿样化生性乳腺癌1例报告
Brazilian Journal of Oncology Pub Date : 1900-01-01 DOI: 10.5935/2526-8732.20230390
Bianca Gardini Ferrari, G. F. Silva, Marcela Martins Rodrigues, Rafaela Martins Rodrigues, R. Sá, L. E. Kerche
{"title":"Abscess-like postpartum metaplastic breast carcinoma in breastfeeding woman: a case report","authors":"Bianca Gardini Ferrari, G. F. Silva, Marcela Martins Rodrigues, Rafaela Martins Rodrigues, R. Sá, L. E. Kerche","doi":"10.5935/2526-8732.20230390","DOIUrl":"https://doi.org/10.5935/2526-8732.20230390","url":null,"abstract":"","PeriodicalId":395496,"journal":{"name":"Brazilian Journal of Oncology","volume":"66 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127212094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Delayed and sequencial hemolytic uremic syndrome as a complication of Gemcitabine therapy 延迟和顺序溶血性尿毒症综合征作为吉西他滨治疗的并发症
Brazilian Journal of Oncology Pub Date : 1900-01-01 DOI: 10.5935/2526-8732.20220353
Thais H. S Almeida, R. Bonadio, Rafaela Lopes da Silva Naves, Paulo Henrique Amor-Divino, P. Hoff
{"title":"Delayed and sequencial hemolytic uremic syndrome as a complication of Gemcitabine therapy","authors":"Thais H. S Almeida, R. Bonadio, Rafaela Lopes da Silva Naves, Paulo Henrique Amor-Divino, P. Hoff","doi":"10.5935/2526-8732.20220353","DOIUrl":"https://doi.org/10.5935/2526-8732.20220353","url":null,"abstract":"","PeriodicalId":395496,"journal":{"name":"Brazilian Journal of Oncology","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121483680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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