Era's Journal of Medical Research最新文献

{"title":"PROSTATE CANCER AND DIABETES: BIOLOGY OR DETECTION BIAS?","authors":"Afreen Khan, Anu Chandra, A. Mahdi, Syed Tasleem Raza, E. Sarkar","doi":"10.24041/ejmr2022.36","DOIUrl":"https://doi.org/10.24041/ejmr2022.36","url":null,"abstract":"Prostate cancer and diabetes are the two highly prevalent health problems in men worldwide and have a high mortality rates but their association is quite complex and contradictory. This review reported several population based studies which tried to establish a possible association and explains the mechanism by which diabetes exhibits its effect on prostate cancer progression. It also explores the literature around the expression of various receptors and genes which enlightens the possible molecular basis of association and the effect of current antidiabetic drugs like metformin and insulin on the growth and advancement of prostate cancer in diabetic men. Masking of early tumor detection by diabetes might be the possible explanation for the reported inverse association with worse prognosis and shorter survival rate in diabetic prostate cancer patients.","PeriodicalId":368781,"journal":{"name":"Era's Journal of Medical Research","volume":"134 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128553429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MATERNAL HEALTH SITUATION IN UTTAR PRADESH, INDIA","authors":"Samrah Butool Faridi","doi":"10.24041/ejmr2022.37","DOIUrl":"https://doi.org/10.24041/ejmr2022.37","url":null,"abstract":"Health of children and their mothers is a vital aspect of a society's longterm development. Unfortunately, around half of all mothers and over 10 million children die due to preventable causes. Data from a current National Family Health survey (NFHS) was utilized and compared with the previous data of the surveys conducted at national level. The maternal mortality ratio in India has decreased to 113 per 100,000 live births, according to a report released by the WHO. Only 51.6% women reported three or more ANC visits where anaemia is still found among 35.4% women. Although 88% of women delivered in a health facility whereas only 5 7.5 % mothers received postnatal care within two months. The Maternal Mortality Ratio (MMR) in Uttar Pradesh is remains high due to a lack of utilisation of available maternal and child health services, putting the health of mother and children at risk. Hence, to improve the health status, evidence-based policies with grass root level programme planning are required.","PeriodicalId":368781,"journal":{"name":"Era's Journal of Medical Research","volume":"111 6","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114133562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HEMODYNAMICS EFFECT OF BUPIVACAINE AND LEVOBUPIVACAINE IN PAEDIATRIC ABDOMINAL SURGERIES","authors":"Vinod Digraskar, P. Singh, Sukriti Xess, Akansha Jain, Dnyanesh Kashikar","doi":"10.24041/ejmr2022.25","DOIUrl":"https://doi.org/10.24041/ejmr2022.25","url":null,"abstract":"Regional analgesia features a prime role within the multimodal analgesia approach for surgical pain management. currently each day it's common apply of using transverses abdominis plane block (TAP Block) with numerous sorts of native anaesthetics and adjuvants, as a multimodal pain relieving remedy used worldwide for intra and postoperative pain management in several surgeries. However, only a few studies are done wherever hemodyanamics effects when bupivacaine versus levobupivacaine have compared. Aim of this study to examine the consequences of bupivacaine vs levobupivacaine in patients undergoing lower abdominal surgeries and their effects on hemodynamics ( the blood pressure, HR, and SpO2). Method: A randomised double-blind management study conducted when approval from IEC Ref. code-92nd IIB Thesis / P4 . The study has fifty patients, with ASA I – II physical status, as well as each sex and 2-10 years cluster age and who set up for abdominal surgery notably lower abdominal . 25 patients set in every group and every which way allotted: cluster Bupiva and Levobupiva . All patients were well well-read regarding the procedure, drugs, and effects of drugs, and untoward complications. well-read written consent was taken from each patient before involving them within the study. primary objective is to examine the impact of those medicine on Blood pressure, HR, and SPO2 & Secondary objective was to check rescue physiological condition reduction within the surgical period. After the comparison between these 2 clusters, The mean SBP of group Bupiva was found below that of group Levobupiva . and located to be important at fifteen min, one hour, a pair of hr, and four hr and insignificant at baseline zero min, thirty min, half dozen hr (p=0.092), twelve hr, eighteen hr, and twenty four h.differences is insignificant in comparison the DBP at any purpose of your time from baseline to 24 hr. On comparing the center rate, variations were found insignificant from baseline (p = 0.897), 0 min (p = 0.651), 30 min (p = 0.096), 1hr (p = 0.192), 2 hr (p=0.390), four hour (p=0.525), half dozen hr (p=0.469), twelve hr (p=0.443), eighteen hr (p=0.288) to twenty four hr (p=0. 390) except at fifteen min (p=0.010) that was the mean pulse rate of cluster Bupiva is over that of group Levobupiva at one,5 min. On comparison the SPO2differences were insignificant at baseline (p = 0.620), 15 min (p = 0.108), thirty min (p=0.353), 1 hr (p = 0.789), 2 hr (p = 0.364), 4 hr (p = 0.292) and 6 hr (p = 0. 198) however important at 0 min (p = 0.002), 12hr (p = 0.012), 18hr (p = 0.002) and24 hr (p = 0.028) wherever the mean SPO2 of cluster Bupiva was abundant below the group Levobupiva. Stable hemodynamics for a extended period were provided by Levobupivacaine as compared to Bupivacaine.","PeriodicalId":368781,"journal":{"name":"Era's Journal of Medical Research","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116630240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"IMPACT OF OXIDATIVE STRESS IN THE PATHOGENESIS OF CERVICAL CANCER: THERAPEUTIC APPROCHES","authors":"Pushpendra D. Pratap, Syed Tasleem Raza, Ghazala Zaidi, Shipra Kunwar, A. Eba, Muneshwar Rajput","doi":"10.24041/ejmr2022.39","DOIUrl":"https://doi.org/10.24041/ejmr2022.39","url":null,"abstract":"Cervical cancer (CC) is acknowledged as the most ubiquitous carcinoma among females along with the utmost prevalence in developing nations. The major cause of CC is HPV exposure, especially HPV16 and 18. Inflammation is linked to the carcinogenesis of CC in addition to HPV infection. Although the precise cause of CC is yet unknown, using oral contraceptives, being immunosuppressed, and smoking may enhance the risk of the disease. Oxidative stress (OS), in addition to HPV, is linked to cervical cancer. Across several clinical and preclinical research, the dysfunctional redox system and the impact of oxidative stress throughout the aetiology of CC have been examined. Redox homeostasis must therefore be maintained, which calls for both enzymatic and nonenzymatic redox regulators. In this study, we explored the therapeutic strategies used to preserve redox balance, lower cervical cancer mortality, and illustrate the contribution of oxidative stress in the aetiology of the disease.","PeriodicalId":368781,"journal":{"name":"Era's Journal of Medical Research","volume":"50 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130873682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DETERMINATION OF SEX FROM FOOTPRINT DIMENSIONS AMONG NUPE ETHNIC GROUP IN MINNA NIGER STATE","authors":"A. Alabi, Aishat Aniyikaye, Opeyemi Olaoluwa Odunnaike, G. O. Adunmo","doi":"10.24041/ejmr2022.26","DOIUrl":"https://doi.org/10.24041/ejmr2022.26","url":null,"abstract":"Determination of personal identity is a basic and pivotal step in forensic investigations and medico legal practices. In anthropological cases, forensic identification is generally carried out through examination of the body or the remains for prints from the body. Thus, the footprint becomes an invaluable index of identification particularly when the whole body is very badly mutilated. This study was carried out to determine the relationship between footprint dimensions and sex among individuals of Nupe ethnic group of Niger State. Sample size of four hundred and twenty one (421) subjects, two hundred and eighty three (283) males and one hundred and thirty eight (138) females were used in this study. The footprints were gotten by placing the volunteers' foot on the ink pad and it was then transferred on anA4 paper, where the footprint dimensions were later measured with a meter rule. The results of this study show that sex differences were highly significant using toe lengths and breadth (P≤ 0.01) but the footprint indices shows no statistical significance. Footprint dimension is sexually dimorphic. Footprint dimensions can be used to determine sex in addition to or in absence of skeletons such as long bones and skull. It can be applied in forensics for medico legal cases, shoe designing, fashion design and industrial design to optimize products.","PeriodicalId":368781,"journal":{"name":"Era's Journal of Medical Research","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125324125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"BIBLIOMETRIC ANALYSIS OF EMERGENCY MEDICINE","authors":"Derya Can","doi":"10.24041/ejmr2022.28","DOIUrl":"https://doi.org/10.24041/ejmr2022.28","url":null,"abstract":"Emergency medicine is a popular and new medical sub-specialty that provides rapid management of acute critical illness and injuries. In this study, it is aimed to perform bibliometric analysis of the articles about Emergency Medicine using the scientific mapping method. The Web of Science Core Collection (WoS) database was examined within the scope of this study and 3595 articles matching the search criteria were included in the research. For the analysis, the \"bibliometrix 3.0\" program which was developed in the R environment and \"biblioshiny\" web interface provider, which was developed for the use and visualization of this program, were used. It was found that the first article in the field of emergency medicine was published in 1980. It was also found that there was a significant increase in the number of articles after 1995 and peaked in 2021. Academic Emergency Medicine, Annals of Emergency Medicine and Journal of Emergency Medicine are the most influential journals in terms of publication and citation numbers and indexes. Professor Michelle Lin from the University of California, Professor Wendy C Coates from the UCLA Geffen School of Medicine, and Professor Gregory Luke Larkin from the Yale University School of Medicine are the most influential researchers in this field. Emory University, Michigan University, Brown University, which are American universities, are the most competent institutions in the field of emergency medicine. \"Education\" and \"medical education\" keywords are the most frequently used words along with emergency medicine. Recently “leadership”, “internsip” and “malpractice” issues are beginning to emerge. USA, Canada and United Kingdom are the leading countries in total number of publications, single-country and multi-country publications. It is considered that the research is original and its results will contribute to the relevant researchers about the publications in the field of emergency medicine.","PeriodicalId":368781,"journal":{"name":"Era's Journal of Medical Research","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129504893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"BLENDED LEARNING: INNOVATIVE & EFFECTIVE STUDENT CANTERED EDUCATIONAL STRATEGIES IN THE NURSING PROFESSION","authors":"Godhuli Gosh, Subuhi Anwar","doi":"10.24041/ejmr2022.33","DOIUrl":"https://doi.org/10.24041/ejmr2022.33","url":null,"abstract":"Blended learning, a pedagogical approach is nowadays widely accepted as a combination of both “face-to-face” and online learning components. Concerns have grown throughout time regarding an instructional methodology and a teaching and learning strategy. Several studies and reviews all over the world highlighted that Blended Learning is the most effective method of transferring knowledge to the students and implementation of this approach in professional fields like medical, nursing, and paramedical courses will not only improve the teachinglearning environment but also motivate the students in the self-directed learning approach. The term is specifically given to the educational practice of using a combination of traditional classroom teaching and digital learning. National and internationally this method are being used in an educational institution to motivate the students in effective learning. Computers and technology have their own impact on Integrated learning and the teaching-learning process utilizes these impacts to improve the learning methods of the students.","PeriodicalId":368781,"journal":{"name":"Era's Journal of Medical Research","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125851088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"TWO INTERESTING CASES OF FILARIASIS AT UNCOMMON SITES","authors":"A. Fatima, S. Khanduri, Zaara Khan, Danish Ansari, Vibhor Dhingra, Hamza Jamal","doi":"10.24041/ejmr2022.46","DOIUrl":"https://doi.org/10.24041/ejmr2022.46","url":null,"abstract":"Filariasis is a condition resulting from filarial parasites that affects both humans and animals.There are several hundreds of filarial parasites which have been mentioned in medical literature, out of which only eight species are known to cause natural infections in humans. Repeated episodes of inflammation and lymphedema cause lymphatic damage, persistent edema, and elephantiasis of the legs, arms, scrotum, vulva, and breasts. We have reported two cases of filariasis at unusual sites.","PeriodicalId":368781,"journal":{"name":"Era's Journal of Medical Research","volume":"43 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122374371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ROLE OF CIRCULATING miR-21 EXPRESSION PROFILES AND THEIR EMERGENCE AS POTENTIAL BIOMARKERS IN ORAL SQUAMOUS CELL CARCINOMA","authors":"A. Srivastava, J. Misra, R. Ahmad, Subuhi Anwar","doi":"10.24041/ejmr2022.38","DOIUrl":"https://doi.org/10.24041/ejmr2022.38","url":null,"abstract":"Among the widest range of prevalent forms of cancer is oral carcinoma, which can develop anywhere in the mouth or even on the lips. Although there have been many advances in cancer treatment, the expected lifespan for OSCCs have indeed increased marginally. The load of OSCC is anticipated to increase in the near future, yet there is no sign of relief in view. Tumorigenesis is just one of the many physiological processes that can be controlled by microRNAs, a class noncoding endogenous RNAs. Several fibrosis disorders have been linked to miR- 21, and it has been utilised to distinguish oral and tongue cancer from healthy individuals. Studies empirically highlighted the significance of these transcripts as a predictor for prediction and diagnosis in OSCCs. Therefore, the present review summarizes the expression levels of miRNAs in OSCCs and evaluates their functioning in the progression or suppression of cancer. miR-21 can be considered as a prospective candidate for their translational use in OSCCs for early diagnosis prognosis surveillance and tailored treatment which should undergo further validation.","PeriodicalId":368781,"journal":{"name":"Era's Journal of Medical Research","volume":"21 11","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131520219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RUPTURED TUBO-OVARIAN ABSCESS: RARE PRESENTATION OF PELVIC INFLAMMATORY DISEASE - A CASE REPORT","authors":"Preeti Vashistha, F. Khatoon, Saambhavi Saambhavi, Radha Gupta","doi":"10.24041/ejmr2022.43","DOIUrl":"https://doi.org/10.24041/ejmr2022.43","url":null,"abstract":"Background: Infection of the endometrium, fallopian tubes, ovaries, pelvic peritoneam, and adjacent structures is known as Pelvic Inflammatory Disease (PID). Pelvic inflammatory disease and its consequences are still at epidemic levels, Despite the availability of effective broad-spectrum antibiotics. Tubo-ovarian abscess (TAO) may be difficult to identify since the clinical signs are comparable to those of other pelvic and abdominal illnesses. Case Description: Here we are reporting a case, 34 years nulligravida came to emergency department with acute abdomen, she was a known case of chronic PID, Emergency laparotomy was performed, per operatively ruptured tubo-ovarian abscess was present. Conclusion: The clinical diagnosis of PID and TAO is similar, imaging evidence from ultrasonography (US) or magnetic resonance (MR) should be used to supplement the clinical diagnosis. Clinical Significance: To avoid complications and resultant emergency surgeries and their consequences, a vigilant eye must be kept to promptly diagnose, and manage PID at the earliest.","PeriodicalId":368781,"journal":{"name":"Era's Journal of Medical Research","volume":"54 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130490602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}