Era's Journal of Medical Research最新文献

{"title":"EFFICACY AND SAFETY OF PRIMARY CLOSURE OF COMMON BILE DUCT FOLLOWING LAPAROSCOPIC CHOLEDOCHOLITHOTOMY","authors":"","doi":"10.24041/ejmr2023.6","DOIUrl":"https://doi.org/10.24041/ejmr2023.6","url":null,"abstract":"Following surgical intervention for symptomatic cholelithiasis, approximately 10 to 15 percent of patients are diagnosed with choledocholithiasis, characterized by the presence of stones in CBD. Several surgeons perform open CBD exploration with primary duct closure. However, few surgeons perform duct closure laparoscopically due to technical difficulties and concerns about missed stones and postoperative complications. Thus, we evaluated the efficacy and safety of the primary closure of the common bile duct following laparoscopic choledocholithotomy. In this prospective observational study, 62 patients with CBD stones were confirmed pre-operatively by abdominal ultrasonography and/or magnetic resonance cholangiopancreatography (MRCP). CBD radiological findings and demographics were noted. Details on the intraoperative technique, overall operating time, and post-operative complications were observed. Patients were followed for one month, and post-operative data were collected and analysed. Most of the enrolled patients were female (69.35%), aged 41-50 (37.10%), and had abdominal pain (82.25%). 64.52% had multiple stones in the CBD of the calibre of 8–10 millimetres (40.32%). 94.52±21.58 mins was the mean operative time. CBD clearance was noted in 96.77% of cases. In most cases, intraoperative bleeding was 51–100 ml. Laparoscopic primary closure was performed in 96.77% of patients. On days 3 and 7, 9.68% and 6.45% of patients had bile leakage, respectively. The removal of abdominal drains varied significantly between cases. During the follow-up, two patients with bile leaks and jaundice after surgery were found to have retained stones and underwent post-operative ERCP without additional complications. The primary closure after LCBDE is considered a safe and effective alternative to T-tube drainage with an acceptable short-term outcome.","PeriodicalId":368781,"journal":{"name":"Era's Journal of Medical Research","volume":"os-26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127771415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ENDOBRONCHIAL TUBERCULOSIS MASQUERADING AS ASTHMA","authors":"R. Kacker, J. Manchanda, Harshita Rani, K. Gupta, Urooj Roohani","doi":"10.24041/ejmr2023.26","DOIUrl":"https://doi.org/10.24041/ejmr2023.26","url":null,"abstract":"The contagion of the tracheobronchial tree by Mycobacterium Tuberculosis is known as Endobronchial Tuberculosis (EBTB). It is known to be the outcome of a spread from parenchymal lesions or bronchial invasion from mediastinal tubercular lymphadenitis. A young female with cough, breathlessness and fever is a case in point. Initially, she was treated as a patient of bronchial asthma, which later turned out to be endobronchial tuberculosis confirmed on bronchoscopy","PeriodicalId":368781,"journal":{"name":"Era's Journal of Medical Research","volume":"40 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123228893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"KI-67 LABELLING INDEX IN UROTHELIAL NEOPLASM","authors":"Ravneet Kaur, P. Gupta, V. Agarwal, Anee Mathur","doi":"10.24041/ejmr2023.2","DOIUrl":"https://doi.org/10.24041/ejmr2023.2","url":null,"abstract":"Urothelial neoplasms can be classified as non-invasive & invasive lesions. The major prognostic factors are degree of differentiation and depth of invasion in urothelial tumors. Ki-67 is a non- histone nuclear protein marker of cell proliferation which is encoded by MKi-67 gene in humans. This study evaluates and correlate immunohistochemical Ki-67 expression in Non-invasive & Invasive urothelial neoplasm. This retrospective study is done in the Department of Pathology of L.N. Medical College and J.K. Hospital, Bhopal. Urothelial Neoplasm cases diagnosed from January 2019 to January 2022 were included, & relevant clinico-pathological data and their Ki-67 Labelling Index was evaluated & correlated. Total 60 cases were studied, 30 had invasive carcinoma whereas, 30 had non-invasive neoplasm. Ki-67 expression (>13%) was seen maximum in invasive cancers i.e 40% cases, whereas (<13%) was seen maximum in non-invasive neoplasms i.e 38.3%. A statistically significant expression of Mean Ki-67 Labelling Index was observed that increased from papilloma to PUNLMP, Non- Invasive urothelial neoplasm Low grade & High grade in non-invasive urothelial neoplasm (p<0.001), and from lamina propria invasive to muscle invasive urothelial cancers (p=0.013). A Higher tumor proliferation of greater than 13% was significantly related to greater tumor size (p=0.04). Ki-67 labelling index being a measure of tumor proliferation is related to tumor histological grade. Large urothelial tumor size was associated to high Ki-67 LI and was not strongly associated with age and gender. Therefore Ki-67 expression can be used as Diagnostic & Prognostic marker in urothelial tumors.","PeriodicalId":368781,"journal":{"name":"Era's Journal of Medical Research","volume":"2007 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130633634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DELTA-9 TETRAHYDROCANNABINOID AND GEMSITABIN COMBINATION ON NON-SMALL CELL (SQUAMOUS CELL, SK-MES-1) LUNG CANCER CELL LINE","authors":"F. Kalkan, M. Özler","doi":"10.24041/ejmr2023.1","DOIUrl":"https://doi.org/10.24041/ejmr2023.1","url":null,"abstract":"Squamous cell carcinoma falls within the category of non-small cell lung cancers, presenting a considerable challenge in terms of treatment management. There has been growing interest in the potential anti-cancer properties of Delta-9 tetrahydrocannabinol. Gemcitabine, a nucleoside analog, has shown effectiveness against diverse cancer types. This study aimed to assess the combined efficacy of Delta-9 tetrahydrocannabinol and Gemcitabine in treating cancer. The squamous lung cancer cell line required for our study was provided by the stem cell unit. The doses were determined as 5µm/L and 10µm/L for Delta-9 tetrahydrocannabinol, 20 and 40 µm/Lfor Gemcitabine by performing a literature review. In our study, CellViabilityAnalysis by MTT, Xcelligence Real-Time Cell Analysis, Annexin V Apoptosis Flow Cytometry Analysis, Total Oxidant, Antioxidant Status, and Caspase-3 Detection Analysis was performed. Upon evaluating the rates of apoptotic cell death, it was observed that the THC 5 and THC 10 treatment groups exhibited a 30% and 60% increase, respectively, compared to the alcohol group. A significant difference in cytotoxic effect, as determined by MTT, was found between the control group and the Gemsitabin 20, Delta-9 Tetrahydrocannabinol 5µm/L, and Gemsitabin 20+Delta-9 Tetrahydrocannabinol 5µm/L groups (p<0.001). There was a statistically significant difference between the groups regarding TOS (p<0.001). All experimental groups exhibited a higher level of caspase 3 activations, in comparison to the control group. We observed a significant cytotoxic effect of Gemcitabine on squamous cell lung cancer cells. Delta-9 tetrahydrocannabinol, when used alone, exhibited a relatively low cytotoxic effect. However, no significant difference was observed in the groups where Delta-9 tetrahydrocannabinolwas combined with Gemcitabine.","PeriodicalId":368781,"journal":{"name":"Era's Journal of Medical Research","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114091853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EXOSOME’ EMERGING FUNCTION IN CARCINOGENESIS AND CANCER CHEMOTHERAPY RESISTANCE","authors":"Raushan Kumar, Sharique Ahmad","doi":"10.24041/ejmr2023.18","DOIUrl":"https://doi.org/10.24041/ejmr2023.18","url":null,"abstract":"Globally, cancer and related disorders are major health issues. The scientific community has many obstacles in tackling this problem and creating a streamlined therapy and drug administration plan. Chemotherapy is necessary for cancer treatment, however many individuals acquire drug resistance due to recurrent medication delivery. Chemotherapy resistance hinders cancer treatment. Exosomes are vesicles their size range from 40 to 160 nm (the average being 100 nm). Exosomes can include DNA, RNA, fatty acid, metabolites as well cytosol, and cell surface proteins. Since exosome formation's physiological purpose is unknown, more research is needed. Exosomes regulate intercellular communication and help cancer cells develop chemoresistance. Exosomes can reveal physiological and pathological information about their parent cells. Liquid biopsies assess cancer chemosensitivity using exosomes. Because exosomes are stable and sensitive. This review covers exosome-mediated cancer chemoresistance. We also studied tumor-related processes, exosome biogenesis, and their current and potential roles in cancer diagnosis and treatment, drug delivery systems, and chemoresistance.","PeriodicalId":368781,"journal":{"name":"Era's Journal of Medical Research","volume":"100 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127569066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PREVALENCE AND ANTIMICROBIAL SUSCEPTIBILITY PATTERN OF PSEUDOMONAS AERUGINOSA ISOLATED FROM VARIOUS CLINICAL SAMPLES AT ELMC&H","authors":"Nighat Parveen, V. Khare, S. Hassan, Syed Abid Asghar","doi":"10.24041/ejmr2023.4","DOIUrl":"https://doi.org/10.24041/ejmr2023.4","url":null,"abstract":"To identify P. aeruginosa prevalence in different clinical samples along with to. Evaluate its antibiotic sensitivity method isolated from variety of clinical. Over the course of the six- month trial period, 1200 samples in total were analyzed. To identify and isolate P. aeruginosa, each of them underwent direct microscopy and culture. In this study 63 P. aeruginosa were isolated and identified out of 1200 clinical samples. Pus and urine were where the majority of P. aeruginosa were isolated from specimens. There found sensitivity to Piperacilin- tazobactam (10µg) 35% and Gentamycin (10µg) 38% respectively by kirbey-Bauer disc diffusion method. As an opportunistic organism with a high prevalence that is growing more common due to antimicrobial agent resistance, P. aeruginosa may pose a risk to health.","PeriodicalId":368781,"journal":{"name":"Era's Journal of Medical Research","volume":"41 1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134244015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"THERAPEUTIC POTENTIAL AND BIOEVALUATION OF (CHRYSOPOGON ZIZANIOIDES): A NARRATIVE REVIEW","authors":"I. Singh, Ajay Mahaputra Kumar","doi":"10.24041/ejmr2023.15","DOIUrl":"https://doi.org/10.24041/ejmr2023.15","url":null,"abstract":"Vetiver (Chrysopogon zizanioides ) is a plant that has been utilized in various fields such as medicine, aroma, commerce, environmental protection, and agriculture, owing to its traditional significance and versatile properties. Vetiver has a diverse historical background in traditional medicinal practices; however, only a limited number of research articles have documented its efficacy in disease treatment. The objective of this review was to collate current data about the phytochemistry, pharmacology, and customary applications of Chrysopogon zizanioides (C. zizanioides). The primary objective of the manuscript is to integrate pertinent, genuine, and current information. Relevant articles were also extracted from online databases, including PubMed, Scopus, and Science Direct. The findings of the compilation process indicate that the efficacy of vetiver's traditional uses has been confirmed through the testing of different extracts of this plant part against disease-based pharmacological models. Nevertheless, further comprehensive research is required to substantiate the extraction of bioactive compounds and elucidate their mode of operation. The process of extracting oil necessitates the implementation of distinctive and resilient methodologies, the advancement of which may expedite the identification of biologically advantageous utilities.","PeriodicalId":368781,"journal":{"name":"Era's Journal of Medical Research","volume":"109 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124676788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ANTHROPOMETRIC STUDY OF HANDGRIP STRENGTH IN HANDRELATED AND NON-HAND-RELATED ATHLETES IN KWARA, NIGERIA","authors":"A. Alabi, Opeyemi Olaoluwa Odunnaike, Temidayo Samuel Adeleye, Ezekiel Babatunde Dare","doi":"10.24041/ejmr2023.5","DOIUrl":"https://doi.org/10.24041/ejmr2023.5","url":null,"abstract":"Handgrip strength (HGS) is considered an essential marker of an individual's physical strength throughout life, especially of the upper limb and fine motor function. HGS is influenced by basic anthropometric determinants such as age, stature, and gender. The information about the differences in these anthropometric parameters in athletes as compared to non-athletes and the consequent influence on HGS is scarce. Investigations of the association between involvement in hand-related and non-hand-related sporting activities among different age groups of both sexes with HGS, particularly in a developing nation like Nigeria are scarce. This study aimed to investigate how anthropometric parameters of age, height, weight, and body mass index (BMI), affect handgrip strength and their association with sport-related parameters. A crosssectional study was conducted on 370 healthy Nigerians aged 17-40 years, from sports centres in Kwara state. Subjects were grouped into hand-athletes, non-hand-athletes, and a control group of non-athletes. A questionnaire was administered to get their biodata, while measurements of HGS(lbs); using a dynamometer, height(m), weight(kg), and BMI(kg/m2) were taken. HGS of hand-related athletes was significantly greater than the non-hand athletes and non-athletes. No significant difference was observed between the non-hand athletes and non-athletes. HGS of the non-sportsmen was significantly correlated with age, height, weight, and BMI, however, there were no significant correlations for non-sportswomen. HGS of the non-hand-sportsmen was significantly correlated with age, weight, and BMI, but not with height, while only BMI was significantly correlated for non-hand-sportswomen. HGS of both hand-sportsmen and hand sportswomen were significantly correlated with weight and BMI, however, age and height showed no significant correlation. A strong positive correlation exists between HGS and anthropometric parameters of weight and BMI in relation to hand-related sporting activities in both sexes, but not with age and height.","PeriodicalId":368781,"journal":{"name":"Era's Journal of Medical Research","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127374537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MUSIC AND ITS THERAPEUTIC EFFECTS ON THE HEALTH OF THE HEART","authors":"Emmanuel Ayobami Adeyemo","doi":"10.24041/ejmr2023.19","DOIUrl":"https://doi.org/10.24041/ejmr2023.19","url":null,"abstract":"Music has been a therapeutic tool for many centuries. Still, it was only with the development of modern scientific medicine in the late 19th and early 20th centuries that its use in therapy began to be based on more solid scientific evidence. Today, we know that music can have a powerful effect on the heart, and research has shown that certain types of music can help improve heart function. This review explores the latest scientific findings on how music affects the heart and the different music types that may benefit heart health.","PeriodicalId":368781,"journal":{"name":"Era's Journal of Medical Research","volume":"48 8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126688039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"THE RELATIONSHIP BETWEEN MARITAL ADJUSTMENT AND SEXUAL QUALITY OF LIFE OF WOMEN OF REPRODUCTIVE AGE: EFFECT OF USE FAMILY PLANNING METHODS","authors":"N. Tugut, Z. Golbasi, Dr.Didem Kaya","doi":"10.24041/ejmr2023.8","DOIUrl":"https://doi.org/10.24041/ejmr2023.8","url":null,"abstract":"The aim of this study is to determine the relationship between women's marital adjustment and sexual quality of life, and their use of family planning methods. This is a descriptive study. The sample size was calculated as 349 women. Data were collected using the personal information form, the Dyadic Adjustment Scale, and the Sexual Quality of Life Questionnaire-Female. The data obtained were analyzed using the SPSS 23.0 software by creating the database. The stat൴st൴cal s൴gn൴f൴cance level was set at 0.05. The mean scores the participants obtained from the Dyadic Adjustment Scale and Sexual Quality of Life Questionnaire-Female were 106.27±22.21 and 77.46±21.85 respectively. Of the participating women, 36.7% used an intrauterine device for birth control, 27.8% used condoms, 13.8% used hormonal drugs. No statistically significant differences were determined between the mean scores obtained from the Dyadic Adjustment Scale and between the mean scores obtained from the Sexual Quality of Life Questionnaire-Female in terms of the family planning methods the participants used (p>0.05). However, differences between the mean scores the participants obtained from the affectional expression subscale of Dyadic Adjustment Scale were found to be statistically significant in terms of the family planning methods they used (p<0.05). While the marital adjustment was high among the participating women their quality of life level was moderate. It was determined that the sexual quality of life increased as the marital adjustment increased. It was also determined that family planning methods the participants preferred affected not their sexual quality of life and marital adjustment but the affectional expression subscale. Family planning methods the participating women used did not affect their marital adjustment and sexual quality, but hormonal drugs and intra uterin device affected their scores for the affectional expression subscale of the DyadicAdjustment Scale.","PeriodicalId":368781,"journal":{"name":"Era's Journal of Medical Research","volume":"58 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130389814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}