{"title":"Identification for a Large-volume Food-borne Bacteria on a Fully Integrated Portable Centrifugal Disc","authors":"Hau Van Nguyen, V. D. Nguyen, E. Lee, T. Seo","doi":"10.5220/0007690401140118","DOIUrl":"https://doi.org/10.5220/0007690401140118","url":null,"abstract":"Herein, we present a fully integrated portable centrifugal microsystem for multiplex detection of food poisoning bacteria with a large volume of sample up to 1 mL. The microsystem consists of a portable rotary genetic analyzer and a fully integrated lab-on-a-disc device. The portable rotary genetic analyzer is equipped with a couple of heating blocks, a motor and a UV-Vis optical detector. The device was designed with two units: a 3D printed solution-loading cartridge and a centrifugal microfluidic disc. All the essential solutions for the LAMP reaction (a sample, a washing, an elution and a LAMP cocktail solution) are stored inside the cartridge, and orderly released into centrifugal microdevice by a rotation program. Each unit of the device was designed with 20 reaction chambers for simultaneously detecting 19 kinds of food poisoning bacteria in one test. To increase the amount of a sample to 1 mL, we incorporated the super absorbent polymer (SAP) in the waste chamber to absorb the sample and washing solution during the device operation. The whole process was automatically conducted from bead-based DNA extraction to isothermal DNA amplification by LAMP reaction to colorimetric and UV-vis detection of amplicons in 60 min to identify three kinds of bacteria (Escherichia coli O157:H7, Salmonella Typhimurium, and Vibrio parahaemolyticus).","PeriodicalId":357085,"journal":{"name":"International Conference on Biomedical Electronics and Devices","volume":"146 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133767743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Magneto-division of Vesicle: Theory and Possible Experiments","authors":"Yao-Gen Shu, Z. Ou-Yang","doi":"10.5220/0007347001490153","DOIUrl":"https://doi.org/10.5220/0007347001490153","url":null,"abstract":"Our theory has revealed the possibility that the vesicle, which is self-assembled by the diamagnetic amphiphilic block-copolymers, can be manipulated into division by external magnetic field. For the case of the constraint of constant surface area, the passive division can successively take place for 10 times in the situation of Δp = −15 mV; and only 4.5% solution that is contained by the original vesicle with a radius of 4 µm can been retained by 512 vesicles that each contains about 2.31×107 nm3. Thus, if the water channels are embedded in the membrane of vesicle, this method can not only concentrate the solution, but also produce a large number of nanoreactors, which is beneficial to yield an ensemble conclusion of chemical reaction in a very short times. Another case of the constraint of constant volume can also be easy realized by enough supply of the diamagnetic amphiphilic block-copolymers in the progress of division. The latter case is also important for reaction statistics because the original solution can be in equal volume divided into hundreds nanoreactors. This nanoreactor can be used to mimic the reaction of some organelles in vitro. We hope experimenters will try them in future experiments.","PeriodicalId":357085,"journal":{"name":"International Conference on Biomedical Electronics and Devices","volume":"41 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129831824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Catarina Santos, Ana Ferreira, C. Quaresma, Carla Quintão
{"title":"Rehabvisual: Validation of an Application to Stimulate Visuomotor Skills in Preterm Babies with Developmental Alterations","authors":"Catarina Santos, Ana Ferreira, C. Quaresma, Carla Quintão","doi":"10.5220/0007567102480255","DOIUrl":"https://doi.org/10.5220/0007567102480255","url":null,"abstract":"The methods of evaluation and intervention related to the visuomotor skills, for children under the age of 18 months with neurological dysfunctions are not systematic and individualized. Hence, the RehabVisual platform was developed. The aim of this article is to present the usability tests applied to the platform validation, as well as describing the application of the platform in the therapy sessions of a baby with a clinical diagnosis of prematurity. The study concludes that the application of the platform allows the treatment to be more individualized and specific to the baby needs through a common method to all service. Through usability tests, it was possible to ascertain that at the level of occupational therapy, this is a useful tool adapted to the needs of its users.","PeriodicalId":357085,"journal":{"name":"International Conference on Biomedical Electronics and Devices","volume":"29 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134422972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ahmad Anwar Zainuddin, A. Nordin, M. Asri, R. A. Rahim, C. Guines, M. Chatras, A. Pothier, W. Mak
{"title":"Development of Integrated Electrochemical-Quartz Crystal Microbalance Biosensor Arrays: Towards Ultrasensitive, Multiplexed and Rapid Point-of-Care Dengue Detection","authors":"Ahmad Anwar Zainuddin, A. Nordin, M. Asri, R. A. Rahim, C. Guines, M. Chatras, A. Pothier, W. Mak","doi":"10.5220/0007523802200227","DOIUrl":"https://doi.org/10.5220/0007523802200227","url":null,"abstract":"Dengue is an infectious mosquito-borne viral disease that affects approximately 50 million people annually \u0000worldwide and is prevalent mostly in the tropics. Severe cases of dengue can be fatal, making early detection \u0000and fast diagnosis crucial towards improving patient care and survival rates. Currently, early detection can be \u0000achieved through detection of NS1 protein, using ELISA technique. Unfortunately, ELISA is an expensive \u0000method, making it unsuitable as a screening technique, especially in low-resource settings. In this work, we \u0000present a prototype device and its early validation studies, of an integrated electrochemical and mass-sensor \u0000for dengue NS1 antigen. The sensor is connected to open source mass-sensing software and hardware, \u0000OpenQCM which makes it easily portable. Having dual-measurement capabilities (mass and impedance) \u0000increases the sensitivity of the sensor. Preliminary studies suggest that the prototype could achieve ultralow \u0000limit of detection as low as 10 ng mL-1, dual-sensing cross-validation capability, portable size, sample-toanalysis time of less than 30 minutes, and parallelization of multiple assays. This work could lead to early \u0000and accurate dengue detection in routine point-of-care settings.","PeriodicalId":357085,"journal":{"name":"International Conference on Biomedical Electronics and Devices","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125130416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Heterogeneous Earliest Finish Time based Scheduling for Digital Microfluidic Biochips","authors":"Rajesh Kolluri, J. Kumar, Sumanta Pyne","doi":"10.5220/0007367101750182","DOIUrl":"https://doi.org/10.5220/0007367101750182","url":null,"abstract":"One of the recent emerging technology in biochemical analysis field is Lab-on-chip (LOC) technology which uses digital microfluidics property to manipulate droplets discretely. LOC efficiently carries out all biochemical operations we do in traditional laboratories on a single reconfigurable chip called as Digital Microfluidic Biochip (DMFB). DMFBs helps to achieve parallelism and miniaturization compared to traditional laboratory methods in terms of samples and equipment used. One of the important problem in DMFB synthesis is scheduling. We present a simple method called as Heterogeneous Earliest Finish Time for digital microfluidics (DMHEFT) for scheduling DMFB. It is a greedy heuristic based list scheduling. HEFT is previously used for task scheduling where multiple heterogeneous processors are available for solving inter-dependent tasks depicted as DAG. In this paper, it is applied to Microfluidic biochips. DMHEFT uses Upward rank value to prioritize the tasks or operations and earliest finish time to assign tasks to different modules like mixers, heaters and detectors etc. Simulation results show that it produces better assay lengths and run time compared to existing algorithms.","PeriodicalId":357085,"journal":{"name":"International Conference on Biomedical Electronics and Devices","volume":"259 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122257496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Morozov, Abhishek Vaish, A. F. Polupanov, V. E. Antciperov, Igor I. Lychkov, A. N. Alfimtsev, V. Deviatkov
{"title":"Development of Concurrent Object-oriented Logic Programming System to Intelligent Monitoring of Anomalous Human Activities","authors":"A. Morozov, Abhishek Vaish, A. F. Polupanov, V. E. Antciperov, Igor I. Lychkov, A. N. Alfimtsev, V. Deviatkov","doi":"10.5220/0004929400530062","DOIUrl":"https://doi.org/10.5220/0004929400530062","url":null,"abstract":"A logic programming approach to the intelligent monitoring of anomalous human activity is considered. The main idea of this approach is in using of a first order logic for describing abstract concepts of anomalous human activity, i.e. brawls, sudden attack, armed attack, leaving object, loitering, pickpocketing, personal theft, immobile person, etc. We use the Actor Prolog concurrent object-oriented logic language and a state-of-the-art Prolog-to-Java translator for efficient implementation of logical inference on video scenes. A logical rules generation methodology is considered in relation to the analysis of anomalous human behaviour. The problem of creation of special built-in classes of Actor Prolog for the low-level video processing is discussed.","PeriodicalId":357085,"journal":{"name":"International Conference on Biomedical Electronics and Devices","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115684391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
António Silva, P. Amorim, M. Quintas, L. Mourão, J. Gabriel
{"title":"Digital Laryngoscope - A New Force Measuring Laryngoscope","authors":"António Silva, P. Amorim, M. Quintas, L. Mourão, J. Gabriel","doi":"10.5220/0003794303680371","DOIUrl":"https://doi.org/10.5220/0003794303680371","url":null,"abstract":"A laryngoscope is a medical device commonly used in most hospitals worldwide and used to conduct an oral or endotracheal intubation which leads to changes in the patient parameters (heart rate, blood pressure, etc.) due to the force applied on the tongue and other soft-tissues. However, these parameters are being monitored continuously, and provide guidance for anaesthetists to control the drugs which may lead to an inadequate dosage. This work aims to develop a laryngoscope capable of measuring the force applied during a laryngoscopy. To measure the applied force, several solutions, based on different sensors, were analysed and tested. The traditional laryngoscope xenon lighting lamp was replaced by a high bright LED which result in a clear illumination and lower batteries consumption. A Bluetooth® communication module was also include to allow a real-time force acquisition and display.","PeriodicalId":357085,"journal":{"name":"International Conference on Biomedical Electronics and Devices","volume":"119 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116614135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
I. Ivascu, R. Zeggari, C. Pieralli, B. Wacogne, C. Roux
{"title":"Measuring the Refractive Index of Oocytes by Means of an Optical Microsystem - A Non Invasive Technique to Estimate the Evolution of Oocytes Maturity","authors":"I. Ivascu, R. Zeggari, C. Pieralli, B. Wacogne, C. Roux","doi":"10.5220/0002756201270132","DOIUrl":"https://doi.org/10.5220/0002756201270132","url":null,"abstract":"In this paper, we present an optical microsystem used to measure the refractive index of oocytes. The technique relies on oocytes refraction properties and on the optical coupling between optical fibers. A theoretical model of the system is established by means of matrix optics. A numerical fitting allows calculating the refractive index of the oocytes. In a first time we considered the oocytes like homogeneous spheres. In a second time, we considered that the oocytes consist of a shell (the zona pellucida) and a core (the cell). Experimental results showed that the refractive index of the oocytes increases during the maturation process. In this position paper, we also discuss the temporal evolution of the oocytes maturity and we point out that the maturation should not only be estimated visually but in a more continuous manner. The device we propose could be a solution for such non invasive measurements.","PeriodicalId":357085,"journal":{"name":"International Conference on Biomedical Electronics and Devices","volume":"43 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124898240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
V. Naranjo, R. Lloréns, M. A. Raya, B. Rey, S. Albalat, J. Fayos, I. Morales
{"title":"MIRACLE: A CAD/CAM System for the Manufacture of Dental Surgical Splints","authors":"V. Naranjo, R. Lloréns, M. A. Raya, B. Rey, S. Albalat, J. Fayos, I. Morales","doi":"10.5220/0002766202350239","DOIUrl":"https://doi.org/10.5220/0002766202350239","url":null,"abstract":"Nowadays, design and manufacturing process of dental prostheses is very handmade, time consuming and has a raised economic cost. Besides that, there is no objective methodology for the fulfillment of its functional design specifications. This paper presents an overview of MIRACLE project whose objective is the development and validation of an intelligent system for the design, simulation and flexible manufacture of implant-supported dental prostheses. The developed system in MIRACLE is a CAD/CAM system which allows to test the functional characteristics of dental prostheses considering mandible-maxilla interaction (called occlusion) using virtual models, contrary to most commercial solutions where this test is performed using expensive anatomical replicas tested with mechanical articulators and evaluated with patients. Another objective of MIRACLE is to develop a parametric finite elements model (FEM) of the whole prosthesis in order to analyze the failure risk of dental implants and prostheses before its surgical implantation enabling a re-design process. This paper is focused on the CAD/CAM subsystem developed in order to automatize the process of manufacturing surgical guides using several 3D models of the patient dental anatomy. A summarized version of the image processing step will be also presented. The CAD/CAM subsystem has been clinically validated achieving mean errors less than 5 degrees in the placement of the prosthetic crowns.","PeriodicalId":357085,"journal":{"name":"International Conference on Biomedical Electronics and Devices","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132522228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Screen-Printed Sensor for Chloride Quantification in Sweat for Early Determination of Cystic Fibrosis","authors":"J. Gonzalo-Ruiz, Roser Mas, F. Muñoz, R. Camero","doi":"10.5220/0001047601030106","DOIUrl":"https://doi.org/10.5220/0001047601030106","url":null,"abstract":"One-use screen-printed sensor capable to generate sweat and measure the chloride concentration is presented. Sweat is induced by iontophoresis, pilocarpine is forced to get into de skin and stimulate the sweat glands. Chloride concentration is measured by potentiometry. The performance of the devices has been tested by means of reproducibility studies. Finally, the application of these sensors in several volunteers has been carried out. Errors less than 10% have been obtained in real samples.","PeriodicalId":357085,"journal":{"name":"International Conference on Biomedical Electronics and Devices","volume":"38 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125441624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}