M. Ja’afaru, Abubakar Gaure, J. U Ewansiha, O. Adeyemo
{"title":"Prevalence of Extended Spectrum β-Lactamases-Producing Escherichia coli Isolated from Clinical Samples and Their Antibiotic Resistance Pattern","authors":"M. Ja’afaru, Abubakar Gaure, J. U Ewansiha, O. Adeyemo","doi":"10.52547/jommid.11.1.34","DOIUrl":"https://doi.org/10.52547/jommid.11.1.34","url":null,"abstract":"ABSTRACT","PeriodicalId":34460,"journal":{"name":"Journal of Medical Microbiology and Infectious Diseases","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82129500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Podophyllotoxin, Deoxypodophyllotoxin and Ursolic Acid as Potential Inhibitors of tcpA, ompW, and ctxB Genes in Vibrio cholerae: An in-Silico Study","authors":"Yasin SarveAhrabi, Ovis Rostamiyan, Sarina Nejati Khoei","doi":"10.52547/jommid.11.1.41","DOIUrl":"https://doi.org/10.52547/jommid.11.1.41","url":null,"abstract":"Introduction: Cholera is a highly contagious disease that causes severe diarrhea and dehydration. This study investigated podophyllotoxin, deoxypodophyllotoxin, and ursolic acid as inhibitors of tcpA , ompW, and ctxB genes in Vibrio cholerae . Methods: We obtained the crystallized structure of podophyllotoxin, deoxypodophyllotoxin, and ursolic acid from the PubChem database for use as a ligand. The mm 2 method in Chem3D v20.1.1.125 was used to optimize the structure of the ligands. We used AutodackVina v.1.2.0 to evaluate the ligands as inhibitors against the active site of the tcpA , ompW , and ctxB proteins. The output results were analyzed and assessed by BIOVIA Discovery Studio 2016 V16.1.0 X64. Results: The reported affinities ranged from -6.8 and -8.7 kcal/mol. The highest diversity of links was found in tcpA and ctxB . Hydrogen bonds were established with Threonine (91, 111), Glycine (113, 114, 94), and Alanine (92) of tcpA , indicating the effectiveness of ligands against tcpA . The ligands podophyllotoxin, deoxypodophyllotoxin, and ursolic acid showed a variety of hydrogen bonds against ompW and ctxB , respectively, with Arginine, Isoleucine, Histidine, Glycine, and Glutamine. These results demonstrate the excellent inhibitory effects of the ligands against Vibrio cholerae . Conclusion: Vibrio cholerae plays a crucial role in causing pandemic cholera in humans. The predicted conformations of the ligands in this study showed that podophyllotoxin and deoxypodophyllotoxin have higher inhibitory potential than ursolic acid. Therefore, podophyllotoxin and deoxypodophyllotoxin can be potential agents for further research in developing Anti-Vibrio cholerae drugs.","PeriodicalId":34460,"journal":{"name":"Journal of Medical Microbiology and Infectious Diseases","volume":"51 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89089683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sameer Abdul Samad, Hafeedha Kallarakkal, N. Basheer
{"title":"Intraventricular Administration of Cefepime for the Treatment of Meningitis due to Pseudomonas aeruginosa","authors":"Sameer Abdul Samad, Hafeedha Kallarakkal, N. Basheer","doi":"10.52547/jommid.11.1.60","DOIUrl":"https://doi.org/10.52547/jommid.11.1.60","url":null,"abstract":"Intraventricular Administration of Cefepime for the Treatment of Meningitis due to Pseudomonas aeruginosa Sameer Abdul Samad , Hafeedha Kallarakkal , Noufal Basheer Department of Infectious Diseases, Aster Malabar Institute of Medical Sciences, Calicut, India; Department of Clinical Pharmacy, Aster Malabar Institute of Medical Sciences, Calicut, India; Department of Neurosurgery, Aster Malabar Institute of Medical Sciences, Calicut, India","PeriodicalId":34460,"journal":{"name":"Journal of Medical Microbiology and Infectious Diseases","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75651975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
T. Ndong Mba, Hilaire Moundounga Kenguele, Ulrick Nzamba, A. B. Pambo-Pambo, Romial Zang Mintsa, P. Mickala
{"title":"Prevalence of Salmonella enterica Subspecies enterica Serovar Typhi (Salmonella typhi) Infection in Febrile Patients at the Sino-Gabonese Friendship Hospital in Franceville: A Two-Year Retrospective Study in South East Gabon","authors":"T. Ndong Mba, Hilaire Moundounga Kenguele, Ulrick Nzamba, A. B. Pambo-Pambo, Romial Zang Mintsa, P. Mickala","doi":"10.52547/jommid.11.1.20","DOIUrl":"https://doi.org/10.52547/jommid.11.1.20","url":null,"abstract":"Introduction","PeriodicalId":34460,"journal":{"name":"Journal of Medical Microbiology and Infectious Diseases","volume":"22 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74924550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sabereh Ahmadzadeh, M. Sedighi, Amin Torkashvand, Pejman Hashemzadeh, F. Shafiei, M. Torkashvand, A. Hasan-Zadeh
{"title":"Pathological Effects of COVID-19 on Body Organs","authors":"Sabereh Ahmadzadeh, M. Sedighi, Amin Torkashvand, Pejman Hashemzadeh, F. Shafiei, M. Torkashvand, A. Hasan-Zadeh","doi":"10.52547/jommid.11.1.1","DOIUrl":"https://doi.org/10.52547/jommid.11.1.1","url":null,"abstract":"ABSTRACT","PeriodicalId":34460,"journal":{"name":"Journal of Medical Microbiology and Infectious Diseases","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88905693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
B. Sreekanth, Amarendra Goviundu, Dhanalakshmi A, Manikonda Rajini
{"title":"A Recent Profile of HIV-Positive Patients Attending an Integrated Testing and Counseling Centre (ICTC) at a Tertiary Care Center in Bangalore, India","authors":"B. Sreekanth, Amarendra Goviundu, Dhanalakshmi A, Manikonda Rajini","doi":"10.52547/jommid.11.1.49","DOIUrl":"https://doi.org/10.52547/jommid.11.1.49","url":null,"abstract":"HIV-positive","PeriodicalId":34460,"journal":{"name":"Journal of Medical Microbiology and Infectious Diseases","volume":"23 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78100311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Arbabi, Aimohammad Bakhshi, Hossein Hooshyar, R. Ghasemikhah, Mahdi Delavari, M. Sehat
{"title":"Prevalence and Morphometric Comparison of Trichostrongylus spp. among Sheep and Goats from Kashan Abattoir, Central Iran","authors":"M. Arbabi, Aimohammad Bakhshi, Hossein Hooshyar, R. Ghasemikhah, Mahdi Delavari, M. Sehat","doi":"10.52547/jommid.11.1.28","DOIUrl":"https://doi.org/10.52547/jommid.11.1.28","url":null,"abstract":"length, were measured in 70 worm isolates. The data were analyzed using the ANOVA test in SPSS 18 software. Results: Of 284 livestock (130 goats and 154 sheep) examined, 26 (9/15%) were infected with Trichostrongylus. The prevalence of infection in goats and sheep was 12.3% and 6.5%, respectively. The most frequent species were Trichostrongylus colubriformis (48.7%), followed by Trichostrongylus vitrinus (25.7%). Trichostrongylus capricula and Trichostrongylus probolurus had an incidence of 12.8%. T. probolurus showed a higher length of spicule and gubernaculum, while T. vitrinus showed a wider copulatory bursa compared to the other species ( P <0.001). Conclusion: The prevalence of Trichostrongylus infection in this region was remarkable. Morphometric and morphological methods are practical tools in differentiating","PeriodicalId":34460,"journal":{"name":"Journal of Medical Microbiology and Infectious Diseases","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82992680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Exacerbation of Activated Latent Tuberculosis Following COVID-19: A Case Report","authors":"Lautika Sonkar, Rampal Singh, Jagdamba Sharan, Deepika Verma","doi":"10.52547/jommid.10.4.204","DOIUrl":"https://doi.org/10.52547/jommid.10.4.204","url":null,"abstract":"","PeriodicalId":34460,"journal":{"name":"Journal of Medical Microbiology and Infectious Diseases","volume":"47 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72544346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shalini Shukla, K. Kamini, B. Gupta, S. Bahadur, S. Kalhan, Madhuvan Gupta
{"title":"Parameters of Coagulation in COVID-19 Patients: A Correlation with Clinical Severity","authors":"Shalini Shukla, K. Kamini, B. Gupta, S. Bahadur, S. Kalhan, Madhuvan Gupta","doi":"10.52547/jommid.10.4.153","DOIUrl":"https://doi.org/10.52547/jommid.10.4.153","url":null,"abstract":"Introduction: COVID-19 infection can be complicated by coagulation derangement and a high risk of thromboembolic episodes. Our study aimedto investigate coagulation parameters in COVID-19 patients and their correlation with clinical severity. Methods: We analyzed coagulation parameters PT, APTT, D-Dimer, and Fibrinogen in 98 RT-PCR-confirmed COVID-19 patients admitted to the Government Institute of Medical Sciences, Gautam Buddha Nagar, Uttar Pradesh, India. Results: This study involved 69 males (70.50%), and 29 (29.5%) were females. The mortality rate was 6.12% (n= 06). Forty-six patients (46.94%) had comorbidities. Thirty-four patients had elevated PT, and 7 had high APTT, whereas D-dimer and fibrinogen levels were raised in 68 and 61 patients, respectively. Among all four parameters, D-Dimer levels were significantly associated with disease severity. Conclusion: Derangement of D-dimer levels is significantly associated with disease severity in COVID-19 infection.","PeriodicalId":34460,"journal":{"name":"Journal of Medical Microbiology and Infectious Diseases","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73871877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}