C98. HOST RESPONSE TO LUNG INFECTIONS: INSIGHTS INTO NEW MECHANISMS最新文献

NLRP10 Regulates IL-17A/G-CSF Axis to Dampen Pulmonary Host Defense in MRSA Pneumonia NLRP10调控IL-17A/G-CSF轴抑制MRSA肺炎肺宿主防御

C98. HOST RESPONSE TO LUNG INFECTIONS: INSIGHTS INTO NEW MECHANISMS Pub Date : 2019-05-01 DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a5594

Sagar Paudel, Laxman Ghimire, L. Jin, S. Cai, S. Jeyaseelan

引用次数: 0

Dynamic Alveolar Macrophages Responses to Pneumococcal Pneumonia 肺泡巨噬细胞对肺炎球菌肺炎的动态反应

C98. HOST RESPONSE TO LUNG INFECTIONS: INSIGHTS INTO NEW MECHANISMS Pub Date : 2019-05-01 DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a5593

E. Arafa, A. Shenoy, A. Guillon, I. Martin, K. Barker, C. L. D. Ana, A. Wooten, Matthew R. Jones, L. Quinton, J. Mizgerd

引用次数: 0

Streptococcus Pneumoniae Pneumonia Induces Mitochondrial Biogenesis and Antioxidant Responses in Mice 肺炎链球菌肺炎诱导小鼠线粒体生物发生和抗氧化反应

C98. HOST RESPONSE TO LUNG INFECTIONS: INSIGHTS INTO NEW MECHANISMS Pub Date : 2019-05-01 DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a5595

Ashley Losier, Lokesh Sharma, Yi Zhang, Wei Liu, P. Lee, C. D. Cruz

引用次数: 0

Interferon Lambda Inhibits Bacterial Clearance During Influenza, MRSA Super-infection 干扰素Lambda抑制流感，MRSA超级感染期间的细菌清除

C98. HOST RESPONSE TO LUNG INFECTIONS: INSIGHTS INTO NEW MECHANISMS Pub Date : 2019-05-01 DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a5599

Helen E Rich, C. McCourt, W. Q. Zheng, Kevin J. McHugh

引用次数: 0

The Development of Klebsiella Pneumoniae Vaccine Strategy via Eliciting the Serotype-Independent Immunity in the Lung 通过诱导肺部血清型非依赖性免疫的肺炎克雷伯菌疫苗策略的发展

C98. HOST RESPONSE TO LUNG INFECTIONS: INSIGHTS INTO NEW MECHANISMS Pub Date : 2019-05-01 DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a5600

N. Iwanaga, I. Sandquist, K. Chen, E. Norton, J. Moreno, J. Kolls

{"title":"The Development of Klebsiella Pneumoniae Vaccine Strategy via Eliciting the Serotype-Independent Immunity in the Lung","authors":"N. Iwanaga, I. Sandquist, K. Chen, E. Norton, J. Moreno, J. Kolls","doi":"10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a5600","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a5600","url":null,"abstract":"\u0000 \u0000 \u0000 Multidrug-resistant of Klebsiella pneumoniae (K. pneumoniae) has emerged as a global threat. Vaccination for at high-risk populations could be a promising strategy to prevent and control the disease.\u0000 \u0000 \u0000 \u0000 Mice were vaccinated via intranasal with a monovalent vaccine encoding Kp serotype 2 OMPx or a quadrivalent vaccine encoding OmpC, OmpW, Omplolb, and Omp36k, adjuvanted with heat-labile enterotoxin A1 domain (LTA1). Protective immunity was assessed by performing a pulmonary challenge with a heterologous mucoid serotype K1 strain of K. pneumoniae. Lung T-cell responses were evaluated mainly by FACS, ELISPOT, and LUMINEX. We also examined inflammatory cell changes by hematoxylin-eosin stain and immunofluorescence.\u0000 \u0000 \u0000 \u0000 Flow cytometry and ELISPOT analysis revealed that CD4+ T cells were significantly increased in the lungs of the monovalent or quadrivalent vaccinated mice and that a considerable fraction of them produced IL17A. And the supernatant of these cells also showed the significant production of IL-17A. Importantly, vaccinated mice showed a significant decrease in CFU in the lung and spleen, compared with mock-vaccinated mice. Finally, we observed that only lungs of intranasally vaccinated mice had lymphocytic structures around bronchi and vessels. Characterization of these structures by immunofluorescence confirmed the presence of inducible bronchus-associated lymphoid tissue (iBALT) – a structure that can not only support local induction of protective immunity but provide a long-term niche for vaccine-induced lymphocytes.\u0000 \u0000 \u0000 \u0000 These data support the therapeutic value of intranasal vaccination strategies to prevent K. pneumoniae infections.\u0000","PeriodicalId":333244,"journal":{"name":"C98. HOST RESPONSE TO LUNG INFECTIONS: INSIGHTS INTO NEW MECHANISMS","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131813678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synergistic Gene and Protein Expression Analyses Reveal Roles of NFkB and JUN in Inducible Epithelial Resistance Against Infection 协同基因和蛋白表达分析揭示NFkB和JUN在诱导上皮抗感染中的作用

C98. HOST RESPONSE TO LUNG INFECTIONS: INSIGHTS INTO NEW MECHANISMS Pub Date : 2019-05-01 DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a5597

J. Pantaléon-García, V. Kulkarni, Yongxing Wang, S. Evans

引用次数: 0

Eosinophils and Macrophages Direct Allergic Host Responses During Synergistic Viral-Bacterial Infections 嗜酸性粒细胞和巨噬细胞在病毒-细菌协同感染中直接过敏宿主反应

C98. HOST RESPONSE TO LUNG INFECTIONS: INSIGHTS INTO NEW MECHANISMS Pub Date : 2019-05-01 DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a5598

A. Samarasinghe, Kim S. LeMessurier, Meenakshi Tiwary, Heather S. Smallwood

引用次数: 0

Induction of Lower Airway Dysbiosis with Oral Commensals Leads to a Time-Dependent and Persistent Th17 Inflammatory Profile in the Lower Airways of Mice Independent of Cage Effect 口服共生剂诱导下气道失调导致小鼠下气道中独立于笼效应的时间依赖性和持久性Th17炎症谱

C98. HOST RESPONSE TO LUNG INFECTIONS: INSIGHTS INTO NEW MECHANISMS Pub Date : 2019-05-01 DOI: 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a5596

B. Franca, Benjamin G. Wu, Jun-Chieh J. Tsay, L. Perez, Yonghua Li, E. Olsen, I. Sulaiman, A. Gonzalez, K. Yie, S. Ma, Anastasia-Maria Zavitsanou, E. Ivanova, Sergei B Koralov, L. Segal

引用次数: 0