Medical Laboratory Technology Journal最新文献_第4页

Effect of Diabetes Mellitus on Hypogonadism in Chronic Renal Failure 糖尿病对慢性肾功能衰竭患者性腺功能减退的影响

Medical Laboratory Technology Journal Pub Date : 2022-09-30 DOI: 10.31964/mltj.v8i1.467

Savaş Karataş, Şennur Kose

{"title":"Effect of Diabetes Mellitus on Hypogonadism in Chronic Renal Failure","authors":"Savaş Karataş, Şennur Kose","doi":"10.31964/mltj.v8i1.467","DOIUrl":"https://doi.org/10.31964/mltj.v8i1.467","url":null,"abstract":"Hypogonadism in male patients with chronic renal failure and diabetes mellitus has been known separately; up to now, the effect of these two diseases together on testosterone deficiency and the impact of testosterone deficiency on metabolic values have not been known precisely, therefore in this study we aimed to investigate testosterone deficiency in patients with diabetes mellitus and chronic renal failure. Eighty-seven chronic renal failure patients and 45 control patients who were followed at endocrinology and nephrology clinics were included in the study. After exclusion criteria, the patients were divided into two groups according to diabetes mellitus status. Groups were compared according to testosterone levels. Testosterone deficiency and good groups were compared to blood glucose, Hba1c, and lipid profile levels. The mean age of 87 CRF patients and 45 people in the control group were similar (59.85 ± 9.99 and 56.67 ± 8.56, respectively, p= 0.16). Testosterone deficiency was 24.1% (21/87) in CRF group and 8.8% (4/45) in control group (p= 0.04). The total testosterone levels were notably lower in the diabetic-CRF patients, 3.44 ± 1.3 vs. 4.26 ± 1.46 mg/dl (p= 0.02). The testosterone deficient CRF group had higher blood glucose and HbA1c according to the testosterone sufficient group. (161.20 ± 61.24 mg/dl vs 133.25 ± 59.87 mg/dl blood glucose, p= 0.04 and 7.54 ± 1.46 vs 6.79 ± 1.14 % HbA1c, p= 0.04). Serum triglyceride and LDL levels did not significantly change between groups (p= 0.20 and 0.76, respectively). Testosterone deficiency in male CRF patients is not uncommon. Male patients with both T2DM and CRF have more common testosterone deficiency. In testosterone-sufficient patients, blood glucose regulation was better. Therefore, in these patients, it may be helpful not to neglect testosterone deficiency, which affects gonadal function, body metabolism, and cardiac and skeletal health.","PeriodicalId":32131,"journal":{"name":"Medical Laboratory Technology Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46931235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Potential Benefit of Flavonoid in Papaya Leave Gel in Neutrophil, Angiogenesis, and Wound size in Rattus Norvegicus 木瓜叶凝胶中黄酮类化合物对褐家鼠中性粒细胞、血管生成和伤口大小的潜在益处

Medical Laboratory Technology Journal Pub Date : 2022-09-28 DOI: 10.31964/mltj.v8i1.464

S. Nurhidayah, I. Marlinawati, S. Winarsih, T. Nurseta

{"title":"Potential Benefit of Flavonoid in Papaya Leave Gel in Neutrophil, Angiogenesis, and Wound size in Rattus Norvegicus","authors":"S. Nurhidayah, I. Marlinawati, S. Winarsih, T. Nurseta","doi":"10.31964/mltj.v8i1.464","DOIUrl":"https://doi.org/10.31964/mltj.v8i1.464","url":null,"abstract":"An incision wound is the destruction of several cells in the skin area that has experienced an incision. Several factors influencing wound healing are neutrophils as causative agents of inflammation, angiogenesis, and wound closure. These three factors should undergo physiologically to obtain the optimal healing process. Currently, herbal products are preferred because they have lower side effects than synthetic ones. Papaya leaves contain flavonoids with various functions, including wound closure and anti-inflammatory and antioxidant effects. Topical intervention, especially gel, is good for healing because it can keep the wound moist. This research aimed to determine the effect of the administration of papaya leaf gel on wound closure, neutrophil, and angiogenesis. Thirty white rats were used as the model animals in a randomized experimental study divided into five groups comprising negative control (0,9% NaCl), positive control (10% Povidone-iodine), and three intervention groups treated with gel of Carica papaya leaves at a dosage 10%, 20%, and 30%. All groups were topically administered treatment once a day on the dorsal surface for seven days. Carica papaya leaves contain flavonoids, saponin, tannin, and alkaloids qualitatively and 7,734 mg/kg of the flavonoid quantitatively. There were no significant differences in wound size in all three groups on three days, but Carica papaya leave gel had a superior effect compared to 10% PI and 0,9% NaCl in the wound closure process. There were significant differences in all groups in neutrophil and angiogenesis. Nevertheless, 20% papaya leave gel showed the lowest number of neutrophils and had a superior effect on improving the new blood vessels significantly compared to negative and positive groups.","PeriodicalId":32131,"journal":{"name":"Medical Laboratory Technology Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45062535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Blood Profile of Rattus Nurvegicus Exposed to HgCl2 and Received Combination of IR Bagendit Rice Leaves-Infused Water and Young Coconut Water HgCl2暴露和IR巴根地水稻叶浸种水和椰子水联合作用下褐家鼠的血液特征

Medical Laboratory Technology Journal Pub Date : 2022-09-21 DOI: 10.31964/mltj.v8i1.472

B. Santosa

{"title":"Blood Profile of Rattus Nurvegicus Exposed to HgCl2 and Received Combination of IR Bagendit Rice Leaves-Infused Water and Young Coconut Water","authors":"B. Santosa","doi":"10.31964/mltj.v8i1.472","DOIUrl":"https://doi.org/10.31964/mltj.v8i1.472","url":null,"abstract":"Mercury chloride (HgCl2) is widely used in industries; in fact, this chemical substance is deadly for health and causes various health problems, such as liver damage, kidney damage, and hematopoietic disorders, especially in erythropoiesis. This study aims to determine the blood profile in Rattus nurvegicus exposed to HgCl2 by combining IR Bagendit rice leaves-infused water and young coconut water. This study employed an experimental method to examine the positive control group exposed to HgCl2 and the negative control group receiving a placebo. Meanwhile, the treatment groups received a combination of IR Bagendit rice leaves-infused water in stratified compositions and young coconut water. The hematologic profile was examined using a hematologic analyzer, while the reticulocyte count was examined using wet and dry methods. The mean value of each group was tested using ANOVA. This study has successively obtained average levels of Hb (C+ 12,0;C- 14,2;T1 12,5;T2 12,9;T3 12,8), the erythrocyte count (C+ 6,52;C- 7,80;T1 1,44;T2 1,07;T3 7,32), levels of Ht (C+ 35,5;C- 42,9;T1 37,8;T2 37,9;T3 38,2), MCV (C+ 73,7;C- 79,9;T1 80,4;T2 78,7;T3 79,6), MCH (C+ 27,3;C- 29,9;T1 29,5;T2 28,5;T3 29,1), and MCHC (C+ 31,1;C- 34,2;T1 31,9;T2 33,3;T3 32,1), and the reticulocyte count (C+ 2,0;C- 1,2;T1 1,3;T2 1,1;T3 1,3). The significant differences in the groups are found in levels of Hb, Ht, MCV, and MCHC (p-value 0,00; 0,00; 0,03; 0,01). This study concludes that combining IR Bagendit rice leaves-infused water and coconut water could prevent blood profile exposure to HgCl2. Suggestions for further research to increase the intervention time and measure oxygen levels.","PeriodicalId":32131,"journal":{"name":"Medical Laboratory Technology Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47188142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transcriptome Analysis May Be Beneficial for Identification of Specific Pathways in Host Cell-Leishmania major Interactions(letter to editor) 转录组分析可能有助于鉴定宿主细胞-利什曼原虫主要相互作用的特定途径(致编辑)

Medical Laboratory Technology Journal Pub Date : 2022-09-01 DOI: 10.52547/mlj.16.5.1

K. Kalavi, M. Faghihi, O. Jorjani, Z. Tatari

引用次数: 0

Mycotic Keratitis in the Middle East: A Systematic Review and Meta-Analysis 中东地区真菌性角膜炎:系统回顾和荟萃分析

Medical Laboratory Technology Journal Pub Date : 2022-09-01 DOI: 10.52547/mlj.16.5.43

mahmoud Karimizadeh Esfahani, M. Najjari, S. Hosseini Teshnizi, S. Dolatabadi, M. Najafzadeh

{"title":"Mycotic Keratitis in the Middle East: A Systematic Review and Meta-Analysis","authors":"mahmoud Karimizadeh Esfahani, M. Najjari, S. Hosseini Teshnizi, S. Dolatabadi, M. Najafzadeh","doi":"10.52547/mlj.16.5.43","DOIUrl":"https://doi.org/10.52547/mlj.16.5.43","url":null,"abstract":"Background and objectives: Mycotic keratitis is a fungal infection of the cornea that can cause blindness. Its incidence, risk factors, and the etiological agents vary worldwide and nationwide. Therefore, proper documentation of these data is essential for better disease management. In this review, we aimed to make a clear picture of this infection in the Middle East. Methods: Data on fungal keratitis from 1986 to 2018 in the Middle East were systematically collected from five English databases (PubMed, Scopus, Science Direct, Web of Science, and Google Scholar) and four Persian databases (Magiran, Scientific Information Database, IranMedex, and Irandoc). A total of 35 studies were included in the review. Result: The pooled prevalence of fungal keratitis in the Middle East was estimated at 26% (95% confidence interval: 19-32%; I 2 = 98.88%, 𝑝 < 0.001) using random-effect model, with considerable variation among the countries. The prevalence of fungal keratitis was highest in Egypt (36%) and Iran (34%) and lowest in Oman (9%). Aspergillus and Fusarium spp. were the most common causative agents (28%) among filamentous fungi, and Candida (13%) was the predominant yeast species causing fungal keratitis. Based on the data, fungal keratitis was more prevalent in males (39%) than in females (23%). Conclusion: Our study is the first systematic review on mycotic keratitis among the Middle Eastern countries. These epidemiological estimates can be used by policy makers to improve treatment strategies, especially in this part of the world.","PeriodicalId":32131,"journal":{"name":"Medical Laboratory Technology Journal","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88848895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of Nanochitin on Serum Concentration of Iron and Calcium in Wistar Rats 纳米几丁质对Wistar大鼠血清铁、钙浓度的影响

Medical Laboratory Technology Journal Pub Date : 2022-09-01 DOI: 10.52547/mlj.16.5.26

Negin Valizadeh KeshmeshTapeh, Somayeh Namroodi, Shohreh Taziki

{"title":"Impact of Nanochitin on Serum Concentration of Iron and Calcium in Wistar Rats","authors":"Negin Valizadeh KeshmeshTapeh, Somayeh Namroodi, Shohreh Taziki","doi":"10.52547/mlj.16.5.26","DOIUrl":"https://doi.org/10.52547/mlj.16.5.26","url":null,"abstract":"Background and objectives : Considering the increasing use of nanochitin for the removal of heavy metals from aqueous solutions, examining the biological effects of this substance on the level of essential metals for humans and animals is crucial. Therefore, this study investigated impact of oral administration of nanochitin on serum levels of iron (Fe) and calcium (Ca) in Wistar rats. Methods : Twenty male Wistar rats were randomly divided into four treatment groups and one control group. Two groups were fed with nanochitin at doses of 1.6 and 2.6 μg/g for 6 weeks, and the other two groups received the mentioned doses for 10 weeks. Serum concentrations of Fe and Ca were measured using atomic absorption spectroscopy. Results : Oral administration of 2.6 μg/g nanochitin for 10 weeks caused a significant decrease in serum Ca and Fe concentrations ( p <0.05). Oral administration of 1.6 and 2.6 μg/g nanochitin for 6 weeks caused a non-significant reduction in serum Fe and Ca concentrations ( p >0.05). However, nanochitin consumption for 10 weeks resulted in a significant decrease in serum Fe concentration but not Ca. Conclusion : The limited reduction of serum Fe and Ca concentrations after oral consumption of nanochitin at a low dose and for a limited duration indicates that the controlled use of nanochitin could be safe for animals. However, complementary studies are needed to determine the exact effects of nanochitin on the animals’ bodies. On the other hand, it is recommended to use Fe and Ca supplements after consuming high doses of nanochitin for longer periods.","PeriodicalId":32131,"journal":{"name":"Medical Laboratory Technology Journal","volume":"58 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88291215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In Vitro Synergistic Effects of Ciprofloxacin, Vitamin E, And Low Power Laser on Human Dermal Fibroblasts 环丙沙星、维生素E和低功率激光对人皮肤成纤维细胞的体外协同作用

Medical Laboratory Technology Journal Pub Date : 2022-09-01 DOI: 10.52547/mlj.16.5.9

Nakisa Zarrabi Ahrabi, Hedyeh Ghadiripour, Seyed Mehdi Tabaie

{"title":"In Vitro Synergistic Effects of Ciprofloxacin, Vitamin E, And Low Power Laser on Human Dermal Fibroblasts","authors":"Nakisa Zarrabi Ahrabi, Hedyeh Ghadiripour, Seyed Mehdi Tabaie","doi":"10.52547/mlj.16.5.9","DOIUrl":"https://doi.org/10.52547/mlj.16.5.9","url":null,"abstract":"Background and objectives: Human Dermal Fibroblasts (HDF) are involved in the production of the extracellular matrix, formation of the connective tissue, and wound healing. Considering the role of ciprofloxacin in the treatment of skin infections and the subsequent oxidative stress as well as the protective effects of vitamin E and low power laser against inflammation and oxidative stress, we evaluated combined effects of low power laser and vitamin E on inflammation and oxidative stress in HDF cells treated with ciprofloxacin. Methods: Morphology of the cells was studied using an inverted microscope. Viability of the cells was assessed using the MTT assay, and the concentration of reactive oxygen species was determined after exposure of the cells to ciprofloxacin (5, 25, 50, 75, and 100 μg/ml), vitamin E (1 mg/ml), and low power laser (660 nm; power density: 30 mW.cm −2 ). Results: The survival rate of the cells increased significantly after the treatment with ciprofloxacin, vitamin E, and low power laser compared with the cells treated with ciprofloxacin and vitamin E ( p <0.001). The amount of reactive oxygen species increased in the treated cells when compared with those only treated with ciprofloxacin and vitamin E. Conclusion: The low power laser treatment has favorable effects on the growth of HDF cells, which can be beneficial for wound healing, even in the presence of ciprofloxacin.","PeriodicalId":32131,"journal":{"name":"Medical Laboratory Technology Journal","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78611727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

High Dose of 3, 7-Dimethyl-1-Propargylxanthine Induces Cell Death in YM-1 and KYSE30 Cancer Cell Lines 高剂量3,7 -二甲基-1-丙基黄嘌呤诱导YM-1和KYSE30癌细胞死亡

Medical Laboratory Technology Journal Pub Date : 2022-09-01 DOI: 10.52547/mlj.16.5.37

Parisa Zeinali, marie saghaeian, J. Asadi, S. Jafari

{"title":"High Dose of 3, 7-Dimethyl-1-Propargylxanthine Induces Cell Death in YM-1 and KYSE30 Cancer Cell Lines","authors":"Parisa Zeinali, marie saghaeian, J. Asadi, S. Jafari","doi":"10.52547/mlj.16.5.37","DOIUrl":"https://doi.org/10.52547/mlj.16.5.37","url":null,"abstract":"Background and objectives: Activation of adenosine A2a receptor has been shown to induce the growth and metastasis of cancer cells. The role of this receptor in esophageal cancer has not yet been determined. The present study aimed to investigate effects of an adenosine A2a receptor antagonist (3, 7-dimethyl-1-propargylxanthine) on growth of esophageal cancer cells. Methods: Real-time polymerase chain reaction was performed to evaluate mRNA expression of the A2a adenosine receptor in KYSE-30 and YM-1 esophageal cancer cell lines. Effects of the antagonist on viability of the cells were evaluated by MTT assay. Results: At low concentrations, the antagonist had no effect on cell viability. However, at concentrations ≥200 μM, the antagonist significantly reduced viability of both cell lines ( p <0.05). Conclusion: The results of this study indicate that the adenosine A2a receptor antagonist exerts inhibitory effects on KYSE30 and YM-1 cancer cells in a dose-dependent manner. Therefore, the use of this antagonist can be exploited as a therapeutic target for the treatment of esophageal cancer. at 60 °C. The obtained cycle thresholds were calculated by using the 2 -(ΔCT) method. Relative gene expression levels were calculated by defining a ratio between the amount of gene expression and the endogenous control. An analysis of the melting curve (60 °C to 95 °C increments of 0.3°C) was also performed to determine the melting temperature of specific amplicons and primer dimmers. All tests were performed in triplicate. Cells (10 4 cells per well) were seeded in 96-well plates. After 24 hours, the cells were treated with 20 µl of 3, 7-dimethyl-1-propargylxanthine (DMPX, Sigma, USA) as","PeriodicalId":32131,"journal":{"name":"Medical Laboratory Technology Journal","volume":"128 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88159843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Effects of a Selected Training Program on Motor Performance and Serum Levels of IL-4 and IL-6 in Elite Water Polo Players 选择性训练方案对优秀水球运动员运动表现和血清IL-4和IL-6水平的影响

Medical Laboratory Technology Journal Pub Date : 2022-09-01 DOI: 10.52547/mlj.16.5.31

S. Hosseini, Ameneh Barjaste Yazdi, Rambod Khajeie, A. Rashidlamir

{"title":"Effects of a Selected Training Program on Motor Performance \u0000and Serum Levels of IL-4 and IL-6 in Elite Water Polo Players","authors":"S. Hosseini, Ameneh Barjaste Yazdi, Rambod Khajeie, A. Rashidlamir","doi":"10.52547/mlj.16.5.31","DOIUrl":"https://doi.org/10.52547/mlj.16.5.31","url":null,"abstract":"Background and objectives: In recent years, exercise immunology studies have focused on key components of immune function, such as immune cells, immunoglobulins, and messenger molecules, as well as the effects of environmental and exercise factors. The aim of this study was to evaluate effects of 8 weeks of selected training on serum levels of interleukin (IL)-4, IL-6, and motor performance in elite water polo players. Methods: For this purpose, 20 male water polo players (mean age: 23 years) were randomly divided into an experimental group (n=10, selected water polo training) and a control group (n=10, traditional water polo training). The selected water polo training was performed for 8 weeks, 6 sessions per week. The intensity of training was controlled using maximum heart rate (80-100%) and increased by 5% every week. Water polo performance tests included a record of 50 meters swimming, 100 meters high swimming, 200 meters’ breaststroke, 6 ×50 meters swimming, and 400 meters swimming. To evaluate the serum levels of IL-6 and IL-4, venous blood (5 ml) was taken in the pretest and posttest stages. The serum levels of IL-4 and IL-6 were measured by sandwich enzyme-linked immunosorbent assay. Mean values were compared using the t-test, at significant level of 0.05. Results: The selected water polo training significantly changed IL-4 levels in elite water polo players ( p <0.05). However, IL-6 levels and performance of the subjects did not change significantly. Conclusion: The selected swimming exercises could relatively improve swimming stagnation of water polo players. However, due to the limited knowledge in this regard, there is a need for further research.","PeriodicalId":32131,"journal":{"name":"Medical Laboratory Technology Journal","volume":"36 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78671235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hypoadiponectinemia, Type 2 Diabetes, Ethnicity, and Exercise Training: A Meta-Analysis of Iranian Randomized Controlled Clinical Trials 低脂联素血症、2型糖尿病、种族和运动训练:伊朗随机对照临床试验的荟萃分析

Medical Laboratory Technology Journal Pub Date : 2022-09-01 DOI: 10.52547/mlj.16.5.16

M. Ghafari, E. Banitalebi, A. Nabipur

{"title":"Hypoadiponectinemia, Type 2 Diabetes, Ethnicity, and Exercise Training: A Meta-Analysis of Iranian Randomized Controlled Clinical Trials","authors":"M. Ghafari, E. Banitalebi, A. Nabipur","doi":"10.52547/mlj.16.5.16","DOIUrl":"https://doi.org/10.52547/mlj.16.5.16","url":null,"abstract":"Background and objectives: Considering racial/ethnic differences is necessary when recommending lifestyle modifications for patients with diabetes. Racial/ethnic diversity may affect hypoadiponectinemia responses to exercise training among individuals with type 2 diabetes. This systematic review and meta-analysis is the first to investigate effects of exercise training on circulating adiponectin concentrations in Iranians with type 2 diabetes. Methods: Literature searches of the Cochrane Central Register of Controlled Trials were carried out using the following search strategy: [exercise OR training OR physical activity OR Training] AND diabetes AND adiponectin. Next, RCTs were included and compared with each type of supervised exercise (aerobic training, resistance training, or combined training). Pooled intervention effects were evaluated and reported as standardized mean difference (MD) and 95% confidence intervals using a random effects model. Subgroup and sensitivity analysis was performed for study heterogeneity and following primary screening full text of the articles was evaluated. Results: Fourteen studies with 444 individuals (236 men and 128 women) were included in the analysis. The age of the participants ranged between 18 and 60 years. The number of exercise sessions per week ranged between 3 and 5. The duration of interventions ranged between 6 and 12 weeks. The meta-analysis showed that adiponectin levels increased significantly in diabetic subjects after physical activity (MD: 0.72 ng/dl, p <0.001,), but the heterogeneity of the study remained significant (I 2 = 89%). Conclusion: Overall, physical exercise, particularly aerobic exercise, increases adiponectin levels in Iranians with diabetes. However, this effect of exercise may be influenced by race/ethnic differences, type of training, frequency, type of adiponectin measurement, and complex and heterogeneous exercise responses of individual with diabetes.","PeriodicalId":32131,"journal":{"name":"Medical Laboratory Technology Journal","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88671136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0