Exclusive Real World Evidence Journal最新文献_第6页

An Uncommon Cause of Hemoptysis Presenting Like Hemolytic Anemia 一种罕见的咯血原因，表现为溶血性贫血

Exclusive Real World Evidence Journal Pub Date : 2022-01-20 DOI: 10.54136/erwej-0201-10011

Thasma Santhanakrishnan Arunprasath, P. Ramanan, Susruthan Muralitharan

引用次数: 0

A Case Report on Progressive Supranuclear Palsy 进行性核上性麻痹1例报告

Exclusive Real World Evidence Journal Pub Date : 2022-01-20 DOI: 10.54136/erwej-0201-10013

Venkatesh Yatakarla, Janakraj Deshmukh, Rajesh Patil, D. Ruikar, Amar Limbapure

引用次数: 0

Effectiveness of Luliconazole for the Treatment of Tinea Infections: A Retrospective Study 吕立康唑治疗足癣感染的疗效:回顾性研究

Exclusive Real World Evidence Journal Pub Date : 2022-01-20 DOI: 10.54136/erwej-0201-10017

P. Kumari, Nitin Jain

引用次数: 0

Hemodynamics of Mitral Stenosis 二尖瓣狭窄的血流动力学

Exclusive Real World Evidence Journal Pub Date : 2022-01-20 DOI: 10.54136/erwej-0201-10015

A. Saxena

{"title":"Hemodynamics of Mitral Stenosis","authors":"A. Saxena","doi":"10.54136/erwej-0201-10015","DOIUrl":"https://doi.org/10.54136/erwej-0201-10015","url":null,"abstract":"Hemodynamic is the intravascular pressure and flow that circulate blood throughout the body. In both the venous and arterial compartments, variations in pressure and flow will necessarily affect each other. Flow and pressure within and between the arterial and venous compartments are influenced by hemodynamic on a beat-to-beat basis. Hemodynamic values that are treated in one compartment are dependent on the state of the other compartments. There are several curved proximal isovelocity surface areas as the streamlines of flow approach the stenotic orifice. A stenotic valve's spatial flow velocity profile depends on its anatomy, inlet geometry, and degree of flow acceleration. A patient with Mitral Stenosis (MS) experiences a pressure gradient from the left atrium to the left ventricle that propels the flow abruptly across the stenotic orifice. An arc-shaped flow profile is created, and the atrioventricular valve will therefore have a hemi elliptical velocity profile. At the level of narrowed stenotic orifices, high-velocity jets form in laminar flow when it reaches the vena contracta, the narrowest cross-sectional area downstream from the anatomic orifice, the flow profile in cross-section is relatively flat at the jet's origin and remains flat until the jet reaches the anatomic orifice. Distally from the stenotic region, the blood flow becomes disorganized with multiple velocities and directions. Stenotic mitral valves exhibit thickened leaflets with a reduced excursion. In this review, we will discuss the challenges and changes which occur in hemodynamic of MS.","PeriodicalId":312076,"journal":{"name":"Exclusive Real World Evidence Journal","volume":"39 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125240197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of Combination of Silymarin, Petrowhite and Soy Extract Versus Combination of Arbutin, Octylmethoxycinnamate, and Vitamin E in Melasma Treatment- A Retrospective Study 水飞蓟素、石油白和大豆提取物与熊果苷、辛基甲氧基肉桂酸和维生素E联合治疗黄褐斑的比较回顾性研究

Exclusive Real World Evidence Journal Pub Date : 2022-01-20 DOI: 10.54136/erwej-0201-10018

P. Kumari, Nitin Jain

{"title":"Comparison of Combination of Silymarin, Petrowhite and Soy Extract Versus Combination of Arbutin, Octylmethoxycinnamate, and Vitamin E in Melasma Treatment- A Retrospective Study","authors":"P. Kumari, Nitin Jain","doi":"10.54136/erwej-0201-10018","DOIUrl":"https://doi.org/10.54136/erwej-0201-10018","url":null,"abstract":"Objective: To compare the efficacy and safety of a combination of silymarin, petrowhite and soy extract (Isoflavones) and a combination of arbutin, octylmethoxycinnamate and vitamin E in the treatment and management of melasma in Indian patients. Methods: A retrospective study was carried out on 153 adult patients with melasma. The patients were divided into two treatment groups. Group A (n=102) received topical silymarin, petrowhite and soy extract (Isoflavones) and group B (n=51) received a combination cream of arbutin, octylmethoxycinnamate, and vitamin E. The treatment duration varied from 30 to 180 days depending on the response and the response was evaluated by a change in MASI score from baseline. Treatment-related side effects were monitored. Results: The mean MASI score was significantly reduced after treatment with silymarin, petrowhite and soy extract (Isoflavones) (10.73 ± 8.00 vs 4.74 ± 5.53, p<0.001). Similarly, in the group B, the mean MASI score was significantly reduced after treatment (9.65 ±6.09 Vs. 4.36 ±4.01, p<0.001). It was also observed that patients with side effects had higher mean MASI score in both treatment groups (Group A 9.30 ± 7.69 vs. 3.76± 4.43, p<0.001) (Group B 8.40 ± 4.64 vs. 3.50 ± 3.33, p=0.003) when compared with patients without side effects. Conclusion: Though both treatment modalities seem to be effective in treating melasma, silymarin, petrowhite and soy extract (Isoflavones) seemed to be moderately superior compared to combination cream (considering the differences in the mean values before and after treatment). The drug-related side effects may influence the treatment outcome.","PeriodicalId":312076,"journal":{"name":"Exclusive Real World Evidence Journal","volume":"281 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132186893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy of Bilastine in the Management of Urticaria- A Retrospective Study 比拉斯汀治疗荨麻疹疗效的回顾性研究

Exclusive Real World Evidence Journal Pub Date : 2022-01-20 DOI: 10.54136/erwej-0201-10016

Eshwari L, Pradeep Kumari

{"title":"Efficacy of Bilastine in the Management of Urticaria- A Retrospective Study","authors":"Eshwari L, Pradeep Kumari","doi":"10.54136/erwej-0201-10016","DOIUrl":"https://doi.org/10.54136/erwej-0201-10016","url":null,"abstract":"Background: Urticaria or hives is a common skin condition with a lifetime prevalence of 7.8–22.3%, a point prevalence of 0.5- 1.0%. This study focuses to determine the efficacy of bilastine in combination with other antihistamines or corticosteroids in the treatment and symptomatic relief from Urticaria in Indian patients. Objective: A retrospective study to evaluate the efficacy of bilastine in the management of Urticaria in an Indian population. Methods: A retrospective study was carried out on 99 patients (7 children and 92 adults) with urticaria. Bilastine, 20 mg once daily, was given in patients with other antihistamines such as levocetirizine, fexofenadine, and corticosteroids. The treatment outcome was assessed as recovered, unchanged, worsened, change in therapy, or lost to follow-up. Results: Bilastine was prescribed at 20 mg dose orally either once daily (91 patients) or twice daily (2 patients). About six patients were given bilastine in syrup formulation at a dose of 5 mL (2.5 mg/mL), OD. Out of the 99 patients, most (77/99- 77.78%) reported recovery during the follow-up visit. Seven patients were still on treatment, six patients still had rashes on exposure to the sun, one patient had rashes while swimming, three patients had no recovery, and four were lost to follow-up. Conclusion: Bilastine (20 mg OD), a new generation non-sedating H1-antihistamine, was highly effective in treating urticaria when given in combination with other second-generation antihistamines.","PeriodicalId":312076,"journal":{"name":"Exclusive Real World Evidence Journal","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125017250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of Abnormal Brachial Index with Diabetic Nephropathy as an Independent Risk Factor for Coronary Arterial Disease in Type 2 Diabetic Patients - A Retrospective Single Centre Real-World Evidence Study in Indian Population 臂指数异常与糖尿病肾病作为2型糖尿病患者冠状动脉疾病的独立危险因素的关联——印度人群的回顾性单中心真实世界证据研究

Exclusive Real World Evidence Journal Pub Date : 2021-07-01 DOI: 10.54136/erwej-0101-10002

Siddhant Trehan, R. Chawla, S. Jaggi, A. S., Srivani Palukuri, S. Deka, B. Makkar

{"title":"Association of Abnormal Brachial Index with Diabetic Nephropathy as an Independent Risk Factor for Coronary Arterial Disease in Type 2 Diabetic Patients - A Retrospective Single Centre Real-World Evidence Study in Indian Population","authors":"Siddhant Trehan, R. Chawla, S. Jaggi, A. S., Srivani Palukuri, S. Deka, B. Makkar","doi":"10.54136/erwej-0101-10002","DOIUrl":"https://doi.org/10.54136/erwej-0101-10002","url":null,"abstract":"Objective: To study the association between ankle brachial index (ABI) and microvascular complications in Type 2 diabetes (T2DM) patients with the coronary arterial disease (CAD). Methodology: A retrospective study was carried out on 3,458 T2DM patients reportedly with CAD, G1 (n=33), and without CAD, G2 (n=3125), who had given the ABI test. ABI was defined as normal (1.0 - 1.4) and abnormal (<1.0 and >1.4). The logistic regression analysis was used to identify the determinants of CAD positive outcomes in T2DM patients. Results: Overall, patient percentage-wise CAD 10% (333), abnormal ABI 26% (913), neuropathy 37% (1278), nephropathy, 8% (293), and retinopathy <1% (24). The ABI abnormality and CAD positives were higher in patients with nephropathy (32 and 20%) than in neuropathy (28 and 13%). Age-wise, 52 and 62% of neuropathy and nephropathy patients, respectively, were >60 years and had shown increased ABI abnormality from age 50 years onwards. The logistic model had shown nephropathy patients, [OR-1.8 [1.26-2.58], - p-0.001] in association with abnormal ABI, [OR-1.27 [95% CI, 0.99–1.63], p- 0.057] predicted to have CAD positive outcomes. While neuropathy, OR-0.69, [0.54 - 0.90], and hypertension, OR-0.43 [0.33 - 0.57] were not contributing towards CAD in our study population. Conclusion: Type 2 diabetes patients with abnormal ABI were predicted to have a 27% increased odds ratio of CAD outcome and 80% in the presence of nephropathy. Thus, as part of comprehensive diabetes care, albuminuria screening along with ABI measurement is being suggested.","PeriodicalId":312076,"journal":{"name":"Exclusive Real World Evidence Journal","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125655542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Essential Tremors: A Detailed Review 基本震颤:详细回顾

Exclusive Real World Evidence Journal Pub Date : 2021-07-01 DOI: 10.54136/erwej-0101-10003

H. Garg, Betina Chandolia

{"title":"Essential Tremors: A Detailed Review","authors":"H. Garg, Betina Chandolia","doi":"10.54136/erwej-0101-10003","DOIUrl":"https://doi.org/10.54136/erwej-0101-10003","url":null,"abstract":"Essential tremor (ET) is the most prevalent movement disorder globally and is ten times more prevalent than Parkinson's. It is considered one of the most common movement disorders with various treatment options reported in clinical practice but uncertainty about the most robust one. The International Parkinson and Movement Disorder Society recently reviewed the clinical studies of essential tremors and updated the treatment guidelines. Mild to moderate tremor severity can sometimes be managed with occupational treatment such as speech therapy or adaptation. In contrast, the first-line pharmacological treatments include symptomatic treatment with propranolol, primidone, and topiramate. Botulinum toxin is preferred for selected cases, whereas invasive treatments should be considered a severe essential tremor treatment option. Focused ultrasound thalamotomy is attracting a lot of attention as a new therapy for essential tremors. Misdiagnosis among tremor syndromes is another point of concern and impacts both clinical care and research. A new neurophysiological measure, known as the tremor stability index, is introduced recently to attain diagnostic accuracy between Parkinson's disease tremor and essential tremor. Also, ET-Plus is a newly suggested term for the classification of tremor in the recent Consensus statement, which acknowledges the presence of additional neurological signs in patients with ET. This review includes in detail defining ET, hypothesis about ET, clinical features along with points to consider while differentiating between ET and Parkinson's Disease (PD), evaluation of ET based on laboratory findings, treatment procedures, measures to reduce misdiagnosis between ET and PD, and reality about the new term ET-Plus syndrome.","PeriodicalId":312076,"journal":{"name":"Exclusive Real World Evidence Journal","volume":"42 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115632864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Differing Physician Perceptions of Oxcarbazepine and Levetiracetam for Women of Child- Bearing Age: A Physician Survey Based Study 育龄妇女不同医师对奥卡西平和左乙拉西坦的看法:一项基于医师调查的研究

Exclusive Real World Evidence Journal Pub Date : 2021-07-01 DOI: 10.54136/erwej-0101-10005

Avani Shukla

{"title":"Differing Physician Perceptions of Oxcarbazepine and Levetiracetam for Women of Child- Bearing Age: A Physician Survey Based Study","authors":"Avani Shukla","doi":"10.54136/erwej-0101-10005","DOIUrl":"https://doi.org/10.54136/erwej-0101-10005","url":null,"abstract":"Background: Young women of reproductive age constitute a significant proportion of India's epilepsy patient population. Doctors take several considerations into account while prescribing antiepileptic drugs (AEDs) to young women to balance the risk of seizures with other concerns. Objective: To understand how doctors perceive various AEDs regarding their safety, efficacy, and other attributes for women of childbearing age. Materials and Methods: This study consisted of a survey designed to understand the usage and perception of 12 antiepileptic drugs in the Indian market. The survey respondents of this study were neurologists, neurosurgeons, and psychiatrists from all over India, from private or government setups, and with different experience and patient load levels. Results: In the study, 93% of all survey respondents indicated that they avoid one or more AEDs in women of childbearing age, making it a significant consideration. This consideration is a specialty split for the second- generation AEDs, Oxcarbazepine, and Levetiracetam. Approximately three times more Neurosurgeons avoid Oxcarbazepine as compared to neurologists and psychiatrists who use this drug. In the case of Levetiracetam, mainly only psychiatrists avoid it for women of reproductive age. Apart from the personal experience of doctors, factors other than teratogenic risks, such as changes in reproductive hormone levels, may have contributed to the observed difference in perception. Conclusion: The study highlights doctors ‘differing perceptions for highly used drugs among all specialties emphasizing the need to determine if such differences in perception exist between other AEDs for various types of patient profiles.","PeriodicalId":312076,"journal":{"name":"Exclusive Real World Evidence Journal","volume":"70 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133411646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Thyroid Disorders in Type 2 Diabetics in India: A Real-world Evidence-based Study 印度2型糖尿病患者甲状腺功能障碍:一项真实世界的循证研究

Exclusive Real World Evidence Journal Pub Date : 2021-07-01 DOI: 10.54136/erwej-0101-10004

Akash Garg, A. Dubey

{"title":"Thyroid Disorders in Type 2 Diabetics in India: A Real-world Evidence-based Study","authors":"Akash Garg, A. Dubey","doi":"10.54136/erwej-0101-10004","DOIUrl":"https://doi.org/10.54136/erwej-0101-10004","url":null,"abstract":"Background: In Type 2 diabetes mellitus (T2DM), both hypothyroidism and hyperthyroidism are commonly seen. The circulating thyroid hormones have a significant effect on the metabolism of glucose, lipid, and protein. In the case of T2DM, glycaemic control can worsen due to this effect. In T2DM patients, hyperglycemia can occur due to worsening diabetes mellitus because of hyperthyroidism and thyrotoxicosis and can increase the risk of complications of diabetes. T2DM also affects the levels of thyroid stimulating hormone by reducing it. It also impairs triiodothyronine (T3) conversion from thyroxine (T4) in the peripheral tissues. If T2DM is poorly managed, it can lead to insulin resistance and hyperinsulinemia. It is important to carry out more studies to clarify the relationship between thyroid disorders and T2DM. Objective: To understand the interdependent relationship between TD, T2DM, and hypertension. Material and methods: Retrospective, single-center, observational study conducted on anonymized patient data captured from electronic medical records (EMR). The demographic and clinical profile of T2DM patients were noted along with the thyroid test lab values available for the diabetic patients in the records. Results: A high prevalence of thyroid dysfunction was found in T2DM diabetics than found in the normal population. In the present study, hypothyroidism was found to be more in T2DM patients as compared to hypothyroidism. Conclusion: An increased prevalence of TD is being seen in T2DM patients and can worsen each other's function. A more systematic approach is needed for thyroid testing considering the clinical implications of the coexistence of TD and T2DM.","PeriodicalId":312076,"journal":{"name":"Exclusive Real World Evidence Journal","volume":"31 10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123157248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0