Textbook of Natural Medicine最新文献_第8页

Angelica Species 当归的物种

Textbook of Natural Medicine Pub Date : 1900-01-01 DOI: 10.1016/b978-0-323-43044-9.00053-4

Michael T. Murray, J. Nowicki

引用次数: 0

Gout 痛风

Textbook of Natural Medicine Pub Date : 1900-01-01 DOI: 10.1016/b978-0-323-43044-9.00174-6

Michael T. Murray, J. Nowicki

引用次数: 0

Boron 硼

Textbook of Natural Medicine Pub Date : 1900-01-01 DOI: 10.1016/b978-0-323-43044-9.00058-3

Joseph E. Pizzorno

引用次数: 0

Aphthous Stomatitis 口疮的性口炎

Textbook of Natural Medicine Pub Date : 1900-01-01 DOI: 10.1016/b978-1-4377-2333-5.00146-2

Michael Traub, Michael T. Murray

引用次数: 0

Parkinson’s Disease 帕金森病

Textbook of Natural Medicine Pub Date : 1900-01-01 DOI: 10.1016/b978-0-323-43044-9.00205-3

R. Kachko, P. Logiudice

引用次数: 0

Phage Therapy 噬菌体疗法

Textbook of Natural Medicine Pub Date : 1900-01-01 DOI: 10.1201/9781420009330.ch44

E. Kutter, N. Hoyle, W. Eisner, S. Kuhl, Z. Alavidze, B. Blasdel

{"title":"Phage Therapy","authors":"E. Kutter, N. Hoyle, W. Eisner, S. Kuhl, Z. Alavidze, B. Blasdel","doi":"10.1201/9781420009330.ch44","DOIUrl":"https://doi.org/10.1201/9781420009330.ch44","url":null,"abstract":"Phage therapy refers to the use of bacteriophages (phages bacterial viruses) as therapeutic agents against infectious bacterial diseases. This therapeutic approach emerged in the beginning of the 20th century but was progressively replaced by the use of antibiotics in most parts of the world after the second world war. More recently however, the alarming rise of multidrug-resistant bacteria and the consequent need for antibiotic alternatives has renewed interest in phages as antimicrobial agents. Several scientific, technological and regulatory advances have supported the credibility of a second revolution in phage therapy. Nevertheless, phage therapy still faces many challenges that include: i) the need to increase phage collections from reference phage banks; ii) the development of efficient phage screening methods for the fast identification of the therapeutic phage(s); iii) the establishment of efficient phage therapy strategies to tackle infectious biofilms; iv) the validation of feasible phage production protocols that assure quality and safety of phage preparations; and (v) the guarantee of stability of phage preparations during manufacturing, storage and transport. Moreover, current maladapted regulatory structures represent a significant hurdle for potential commercialization of phage therapeutics. This article describes the past and current status of phage therapy and presents the most recent advances in this domain. History of Phage Therapy Origins of Phage Therapy In 1915, Frederick Twort, a medically trained bacteriologist from England, reported a bacteriolytic phenomenon and advanced the hypothesis that it may be due to a virus. However, excitement with the possibilities of bacteriophage can be said to have begun six months before when Félix d'Hérelle, a microbiologist at the Pasteur Institute, was sent 50 miles from the Western Front to Maisons-Laffitte to investigate an outbreak of dysentery among 10 French mounted infantrymen. Returning with samples he described a soon eponymous novel bacillus. However, in his investigations of this bacteria over the next 18 months, he found that some seemingly sterile Chamberland filtrates of it were capable of effecting the killing (lysis) of another dysentery bacillus (likely Shigella). In one of the great scientific works of the twentieth century, d'Herelle described in two short pages the experiments that he performed demonstrating that this lytic property could be serially passaged from one culture to the next by transferring 10 dilutions to new cultures fifty times. Any toxin would be too diluted after fifty passages to have a biological effect. Similarly, he showed that no dilution of these lysed cultures would produce partial growth inhibition when added over a lawn of bacteria like an antibacterial toxin would, but instead would display a number of clear glassy holes (called \"plaques\") equal to the concentration that would lyse a liquid culture. From these observations, d'Hérelle radica","PeriodicalId":297383,"journal":{"name":"Textbook of Natural Medicine","volume":" 18","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"113952444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Cystitis and Interstitial Cystitis/Painful Bladder Syndrome 膀胱炎和间质性膀胱炎/膀胱疼痛综合征

Textbook of Natural Medicine Pub Date : 1900-01-01 DOI: 10.1016/B978-1-4377-2333-5.00159-0

G. Espinosa, Michael T. Murray

引用次数: 0

Bacterial Overgrowth of the Small Intestine Breath Test 细菌过度生长的小肠呼吸试验

Textbook of Natural Medicine Pub Date : 1900-01-01 DOI: 10.1016/B978-1-4377-2333-5.00010-9

M. James

引用次数: 0

Porphyrias

Textbook of Natural Medicine Pub Date : 1900-01-01 DOI: 10.1016/b978-0-323-43044-9.00210-7

T. Kruzel

引用次数: 0

Centella asiatica (Gotu Kola)

Textbook of Natural Medicine Pub Date : 1900-01-01 DOI: 10.1016/B978-0-323-43044-9.00064-9

Michael T. Murray, J. Nowicki

引用次数: 0