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Emerging β-Amyloid Therapies for the Treatment of Alzheimer's Disease 新出现的β-淀粉样蛋白疗法治疗阿尔茨海默病
Frontiers in Medicinal Chemistry - Online Pub Date : 2003-01-31 DOI: 10.2174/1567204043396514
K. Conway, E. W. Baxter, K. Felsenstein, A. Reitz
{"title":"Emerging β-Amyloid Therapies for the Treatment of Alzheimer's Disease","authors":"K. Conway, E. W. Baxter, K. Felsenstein, A. Reitz","doi":"10.2174/1567204043396514","DOIUrl":"https://doi.org/10.2174/1567204043396514","url":null,"abstract":"Alzheimers Disease (AD) is a progressive neurodegenerative disorder marked by loss of memory, cognition, and behavioral stability. AD is defined pathologically by extracellular neuritic plaques comprised of fibrillar deposits of β-amyloid peptide (Aβ) and neurofibrillary tangles comprised of paired helical filaments of hyperphosphorylated tau. Current therapies for AD, such as cholinesterase inhibitors, treat the symptoms but do not modify the progression of the disease. The etiology of AD is unclear. However, data from familial AD mutations (FAD) strongly support the “amyloid cascade hypothesis” of AD, i.e. that neurodegeneration in AD is initiated by the formation of neurotoxic β-amyloid (Aβ) aggregates, all FAD mutations increase levels of Aβ peptide or density of Aβ deposits. The likely link between Aβ aggregation and AD pathology emphasizes the need for a better understanding of the mechanisms of Aβ production. This review summarizes current therapeutic strategies directed at lowering Aβ levels and decreasing levels of toxic Aβ aggregates through (1) inhibition of the processing of amyloid precursor protein (APP) to Aβ peptide, (2) inhibition, reversal or clearance of Aβ aggregation, (3) cholesterol reduction and (4) Aβ immunization.","PeriodicalId":286890,"journal":{"name":"Frontiers in Medicinal Chemistry - Online","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2003-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116468102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 33
Theoretical Property Predictions 理论性质预测
Frontiers in Medicinal Chemistry - Online Pub Date : 1900-01-01 DOI: 10.2174/1567204052930916
D. Livingstone
{"title":"Theoretical Property Predictions","authors":"D. Livingstone","doi":"10.2174/1567204052930916","DOIUrl":"https://doi.org/10.2174/1567204052930916","url":null,"abstract":"","PeriodicalId":286890,"journal":{"name":"Frontiers in Medicinal Chemistry - Online","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124485125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Potential New Targets for Antithrombotic Therapy 抗血栓治疗的潜在新靶点
Frontiers in Medicinal Chemistry - Online Pub Date : 1900-01-01 DOI: 10.2174/1567204052931078
A. Gruber, S. Hanson
{"title":"Potential New Targets for Antithrombotic Therapy","authors":"A. Gruber, S. Hanson","doi":"10.2174/1567204052931078","DOIUrl":"https://doi.org/10.2174/1567204052931078","url":null,"abstract":"","PeriodicalId":286890,"journal":{"name":"Frontiers in Medicinal Chemistry - Online","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127307004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Macrolide Antibiotics: Binding Site, Mechanism of Action, Resistance 大环内酯类抗生素:结合部位、作用机制、耐药性
Frontiers in Medicinal Chemistry - Online Pub Date : 1900-01-01 DOI: 10.2174/1567204052931113
Marne Gaynor, A. Mankin
{"title":"Macrolide Antibiotics: Binding Site, Mechanism of Action, Resistance","authors":"Marne Gaynor, A. Mankin","doi":"10.2174/1567204052931113","DOIUrl":"https://doi.org/10.2174/1567204052931113","url":null,"abstract":"","PeriodicalId":286890,"journal":{"name":"Frontiers in Medicinal Chemistry - Online","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126792242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 13
Inhibitors of Farnesyltransferase and Geranylgeranyltransferase-I for Antitumor Therapy: Substrate-Based Design, Conformational Constraint and Biological Activity 用于抗肿瘤治疗的法尼基转移酶和香叶基转移酶抑制剂:基于底物的设计、构象约束和生物活性
Frontiers in Medicinal Chemistry - Online Pub Date : 1900-01-01 DOI: 10.2174/1567204052931023
C. Dinsmore, I. M. Bell
{"title":"Inhibitors of Farnesyltransferase and Geranylgeranyltransferase-I for Antitumor Therapy: Substrate-Based Design, Conformational Constraint and Biological Activity","authors":"C. Dinsmore, I. M. Bell","doi":"10.2174/1567204052931023","DOIUrl":"https://doi.org/10.2174/1567204052931023","url":null,"abstract":"","PeriodicalId":286890,"journal":{"name":"Frontiers in Medicinal Chemistry - Online","volume":"C-31 2","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132502754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Targeting Protein Kinases for Bone Disease: Discovery and Development of Src Inhibitors 骨疾病靶向蛋白激酶:Src抑制剂的发现和发展
Frontiers in Medicinal Chemistry - Online Pub Date : 1900-01-01 DOI: 10.2174/1567204043396451
C. Metcalf, M. V. Schravendijk, D. Dalgarno, T. Sawyer
{"title":"Targeting Protein Kinases for Bone Disease: Discovery and Development of Src Inhibitors","authors":"C. Metcalf, M. V. Schravendijk, D. Dalgarno, T. Sawyer","doi":"10.2174/1567204043396451","DOIUrl":"https://doi.org/10.2174/1567204043396451","url":null,"abstract":"","PeriodicalId":286890,"journal":{"name":"Frontiers in Medicinal Chemistry - Online","volume":"64 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132531238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Current Therapies and Emerging Targets for the Treatment of Diabetes 当前治疗糖尿病的方法和新靶点
Frontiers in Medicinal Chemistry - Online Pub Date : 1900-01-01 DOI: 10.2174/1567204043396389
A. Wagman, J. Nuss
{"title":"Current Therapies and Emerging Targets for the Treatment of Diabetes","authors":"A. Wagman, J. Nuss","doi":"10.2174/1567204043396389","DOIUrl":"https://doi.org/10.2174/1567204043396389","url":null,"abstract":"","PeriodicalId":286890,"journal":{"name":"Frontiers in Medicinal Chemistry - Online","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133797612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 60
New Paradigms in Drug Design and Discovery 药物设计和发现的新范式
Frontiers in Medicinal Chemistry - Online Pub Date : 1900-01-01 DOI: 10.2174/1567204043396398
J. Barchi, N. Neamati
{"title":"New Paradigms in Drug Design and Discovery","authors":"J. Barchi, N. Neamati","doi":"10.2174/1567204043396398","DOIUrl":"https://doi.org/10.2174/1567204043396398","url":null,"abstract":"","PeriodicalId":286890,"journal":{"name":"Frontiers in Medicinal Chemistry - Online","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129693223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 13
Histone Deacetylase Inhibitors: From Chromatin Remodelling to Experimental Cancer Therapeutics 组蛋白去乙酰化酶抑制剂:从染色质重塑到实验性癌症治疗
Frontiers in Medicinal Chemistry - Online Pub Date : 1900-01-01 DOI: 10.2174/1567204052931122
J. Arts, S. D. Schepper, K. V. Emelen
{"title":"Histone Deacetylase Inhibitors: From Chromatin Remodelling to Experimental Cancer Therapeutics","authors":"J. Arts, S. D. Schepper, K. V. Emelen","doi":"10.2174/1567204052931122","DOIUrl":"https://doi.org/10.2174/1567204052931122","url":null,"abstract":"","PeriodicalId":286890,"journal":{"name":"Frontiers in Medicinal Chemistry - Online","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121930187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 20
Nitric Oxide Therapies in Vascular Diseases 一氧化氮治疗血管疾病
Frontiers in Medicinal Chemistry - Online Pub Date : 1900-01-01 DOI: 10.2174/1567204043396299
E. Kurowska
{"title":"Nitric Oxide Therapies in Vascular Diseases","authors":"E. Kurowska","doi":"10.2174/1567204043396299","DOIUrl":"https://doi.org/10.2174/1567204043396299","url":null,"abstract":"","PeriodicalId":286890,"journal":{"name":"Frontiers in Medicinal Chemistry - Online","volume":"64 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116958919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 19
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