Ural Medical Journal最新文献

{"title":"Development of a method for the quantitative determination of ritonavir and lopinavir in blood plasma","authors":"P. M. Manakov, O. P. Kolesov, I. L. Tikhonova, M. Piterskiy","doi":"10.52420/2071-5943-2023-22-6-50-58","DOIUrl":"https://doi.org/10.52420/2071-5943-2023-22-6-50-58","url":null,"abstract":"","PeriodicalId":247511,"journal":{"name":"Ural Medical Journal","volume":"50 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139165459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing changes in the pattern of healthcare-associated infectious agents in intensive care units during a novel coronavirus infection pandemic (COVID-19)","authors":"O. G. Malkova, O. G. Mashaeva, G. V. Sobetova, A. V. Orlov, R. T. Rakhimov, G. V. Vtyurina, M. V. Kistankina, O. A. Markina, A. V. Dzhapakova, I. S. Yuryeva, A. V. Pervushin","doi":"10.52420/2071-5943-2023-22-6-31-42","DOIUrl":"https://doi.org/10.52420/2071-5943-2023-22-6-31-42","url":null,"abstract":"Introduction. The novel coronavirus infection (COVID-19) pandemic has been a major challenge to the global healthcare system, affecting more than 32 million patients worldwide. Unprecedented anti-epidemic measures carried out in hospitals allowed clinicians to hope for a decrease of hospital infection, however, the pandemic exacerbated the problem of the spread and circulation of multidrug-resistant bacteria in hospitals.   The goal of study to conduct a comparative assessment of changes in the microbial landscape and the level of antibiotic resistance of the main pathogens of lower respiratory tract infections in ICU patients who were in different epidemiological conditions during the COVID-19 pandemic in comparison with the “pre-Covid” period.   Materials and methods. A multicenter retrospective observational cohort study was conducted, which included the ICU of 4 hospitals in Yekaterinburg, which were in different epidemiological situations during the COVID-19 pandemic, as well as a comparative analysis of the length of stay of patients in the ICU, the frequency and duration of mechanical ventilation, the resuscitation mortality rate, and also the results of microbiological examination of sputum with an assessment of the structure of pathogens and the level of their antibiotic resistance.   Results. The structure of pathogens in sputum in ICU patients of the “green zone” has not fundamentally changed. In the “red zone” there was an increase in the number of documented infections of the lower respiratory tract and blood flow, while hospitals showed differences in changes in the microbial landscape. The microbiological situation in the ICU of the “red zone” was characterized by a decrease in the number of isolated strains of Enterobacterales and non-fermenting Gram-negative bacteria by the end of the pandemic, as well as a significant increase fungi in sputum. In hospitals, where there was an alternation of periods of work in the “red” and “green” zones, there was a decrease of Enterobacterales, an increase in non-fermenting Gram-negative bacteria and a fungi. Among the microflora isolated by bacteriological methods in patients with COVID-19, gram-negative bacteria and fungi predominated, mainly Klebsiella pneumonia, Acinetobacter baumanii and fungi of the Candida spp. A significant increase in the proportion of fungi in sputum was noted in ICU patients in infectious diseases hospitals during the pandemic period. An increase in the level of antibiotic resistance of the main pathogens of lower respiratory tract infections was revealed with the appearance of multi-resistant and extremely resistant strains of Klebsiella pneumoniae and Acinetobacter baumanii. Discussion. Changes in the microbial landscape may indirectly reflect the features of immune damage in patients with a new coronavirus infection COVID-19, which, combined with the severity of the disease and the characteristics of its therapy, led to an increase in complications in the form of ","PeriodicalId":247511,"journal":{"name":"Ural Medical Journal","volume":"45 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139164401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic efficacy of S-adenosylmethionine in chronic uranium intoxication in rats","authors":"K. Sivak, K. Stosman, T. N. Savateeva-Lyubimova, E. Y. Kalinina, T. Rassokha","doi":"10.52420/2071-5943-2023-22-6-68-76","DOIUrl":"https://doi.org/10.52420/2071-5943-2023-22-6-68-76","url":null,"abstract":"Introduction. Chronic exposure to uranium compounds causes adverse cytotoxic and immunopathological effects in the body.   The aim of the work was to evaluate the therapeutic efficacy of S-adenosylmethionine when administered intragastrically with respect to hepato-, nephro- and immunotoxic effects in chronic intoxicationwith uranyl acetate dihydrate (UAD).   Materials and methods. Chronic intoxication was modeled by injecting 85 male rats with UAD solution (5.0 mg/kg/day by element) for one month. S-adenosylmethionine was administered to animals at a dose of 72.7 mg/kg for 21 days.   Results. In chronic poisoning with UAD, 65% lethality, decrease of liver mass ratios (MR) and increase of renal MR were observed. Decrease in alkaline phosphatase activity, glucose level, lactic acid, number of CD4+ T-lymphocytes, increase in lactate dehydrogenase activity and creatinine level, number of CD8+ T-lymphocytes and apoptotic cell death, formation of catabolic pool of low and medium molecular weight substances (LMSMS) of blood plasma were registered. The results of urine analysis revealed the development of hyposthenuria, signs of glucosuria, hematosuria, proteinuria and leukocyturia, appearance of bilirubin in the urine. S-adenosylmethionine contributed to the decrease in the degree of target organ damage (reduction of fibroplastic and dystrophic changes in the liver and kidneys), normalization of immune system parameters (increase in CD4+ T-cells, decrease in CD8+ T-cells and frequency of apoptotic death of lymphocytes in immunocompromised animals) and endotoxicosis (decrease in the level of LMSMS from the catabolic pool area).   Discussion. According to the totality of all revealed pathological changes, UAD poisoning led to the development of tubulointerstitial nephritis, metabolic disorders of detoxification functions of the liver. The causes of animal death during the first week of the experiment were acute kidney damage or confluent pneumonia. The appearance of bilirubin in the urine was associated with porphyrin metabolism disorders. In the remote period of intoxication an imbalance of the T-cell link of the immune system developed, as well as, probably, a decrease in nonspecific resistance, which led to the development of pneumonia in rats.   Conclusion. S-adenosylmethionine therapy of hepato-, nephro- and immunotoxic effects in chronic UAD intoxication contributed to a decrease in the degree of damage to target organs, normalization of immune system parameters and endogenous intoxication.","PeriodicalId":247511,"journal":{"name":"Ural Medical Journal","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139165178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antitoxic activity of spruce cone extract in acute lead acetate poisoning in experiment","authors":"D. K. Guljaev, G. A. Terehin, D. O. Semakin, V. D. Belonogova","doi":"10.52420/2071-5943-2023-22-6-43-49","DOIUrl":"https://doi.org/10.52420/2071-5943-2023-22-6-43-49","url":null,"abstract":"Introduction. Lead contamination is continuing worldwide. The development of new effective drugs for lead poisoning is an urgent task.   The aim of the work is to evaluate the effectiveness of dry aqueous extract of spruce cones in lead poisoning.   Materials and methods. The experiment was carried out on 24 white mongrel rats of both sexes. Animals of the studied groups were administered aqueous solution of lead acetate. The animals of the third group were treated with the extract of cones of common spruce (extract) by intragastric administration 3 times a week for a month. Animals of the fourth group were treated with polypheman by intragastric administration 3 times a week for a month. The elemental composition of tissue samples of animals of the studied groups was determined on energy dispersive X-ray fluorescence spectrometer QUANT’X. The free radical reaction with 2,2-diphenyl-1-picrylhydrazyl was used to determine the antioxidant activity of the extract.   Results. In groups of animals injected with lead acetate solution and treated with the extract and the comparison preparation polyphepan, a decrease in lead content in bones and brain tissues was observed compared to the content in animals injected with lead acetate solution without treatment. No effect of the extract on the motor function of the intestine was revealed. When determining the antiradical activity, it was found that the extract showed a pronounced ability to bind free radicals, comparable to the known antioxidant rutin.   Discussion. The use of the extract allows effective excretion of lead and prevents its deposition in bone tissue. Due to the ability of procyanidins to penetrate the blood-brain barrier, the extract is effective in brain damage caused by lead. The extract will also be effective in relieving oxidative stress resulting from lead poisoning.   Conclusion. The dry aqueous extract of cones of common spruce shows the ability to reduce the lead content in bones and brain tissues in comparison with the group that did not receive treatment for lead acetate poisoning. The extract is able not only to effectively reduce the lead content in the body, but also to fight the consequences of poisoning, due to its pronounced antiradical activity.","PeriodicalId":247511,"journal":{"name":"Ural Medical Journal","volume":"74 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139165964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predicting the need for pre-transport adjustments in neonatal intensive care depending on the level of initial medical organization","authors":"R. Mukhametshin, O. P. Kovtun, N. S. Davydova, A. A. Kurganski","doi":"10.52420/2071-5943-2023-22-6-20-30","DOIUrl":"https://doi.org/10.52420/2071-5943-2023-22-6-20-30","url":null,"abstract":"Introduction. The need for intensive care adjustments to be made by the transport team at the originating medical organization remains an important element of pre-transport preparation, being an indirect indicator that the level of care does not match the needs of the patient.   The aim of the study is to identify factors associated with the need for therapy adjustments depending on the level of initial medical organization.   Materials and methods. The one-stage, cross-sectional study included the data of visits of the neonatal transport team of the resuscitation and consultative centre of the Regional Children’s Clinical Hospital (Ekaterinburg) in the period 01. 07. 2014–31. 12. 2018 (n = 2029). The sample was divided into groups: the first group – patients from level 1 organizations (22.8 %, n = 462), the second group – patients from level 2 organizations without paediatric intensive care units (34.9 %, n = 709), the third group – patients from level 2 organizations with paediatric intensive care units (32.5 %, n = 659), the fourth group – patients from level 3 institutions (9.8 %, n = 199).   Results. The need for therapy adjustment at baseline was dependent on the level of the institution, with a maximum in level 1 organizations and a minimum in level 3 organizations. The odds ratio of need for therapy correction for level 1 organizations compared to level 2 organizations with paediatric intensive care units was 1.4, 95 % CI [1.2–1.7], p = 0.002, and compared to level 3 organizations was 1.6, 95 % CI [1.2–2.3], p = 0.003. Multivariate analysis identified the following factors associated with the need to adjust therapy at the original facility: for level 1 facilities, respiratory support, dopamine administration; for level 2 facilities without paediatric intensive care units, respiratory support, dopamine and epinephrine infusion, sedation; for level 2 facilities with paediatric intensive care units, respiratory support, dopamine infusion; for level 2 facilities with paediatric intensive care units, respiratory support, dopamine infusion; for level 2 facilities with paediatric intensive care units, respiratory support, dopamine infusion; for level 2 facilities with paediatric intensive care units, respiratory support, dopamine infusion; for level 2 facilities with paediatric intensive care units, respiratory support, dopamine infusion; and for level 3 facilities with paediatric intensive care units, respiratory support, dopamine infusion.   Discussion. The need for respiratory support and administration of catecholamines are indicators of the severity of the patient’s condition. Patients in low-acuity healthcare organizations require an increased level of care, regardless of the birth weight and gestational age of the newborn.   Conclusion. Logistic regression analysis revealed factors associated with the need for therapy correction in patients in the initial medical organizations depending on their level. The following factors played a stati","PeriodicalId":247511,"journal":{"name":"Ural Medical Journal","volume":"3 3‐4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139167589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Possibility of using non-invasive modes of respiratory support at the stages of interhospital transportation of newborns","authors":"R. Mukhametshin, O. P. Kovtun, N. S. Davydova, M. A. Stupin","doi":"10.52420/2071-5943-2023-22-6-10-19","DOIUrl":"https://doi.org/10.52420/2071-5943-2023-22-6-10-19","url":null,"abstract":"Introduction. Respiratory support remains the most common procedure performed by neonatal transport team specialists. Non-invasive ventilation is a very common method of respiratory support for newborns, reducing the incidence of chronic lung disease. However, the safety and efficacy of this type of support during transportation remain controversial.   The aim of the work is to determine the current state of the problem of non-invasive respiratory support in newborns in the initial medical organization, at the stage of pre-transport preparation and during transportation.   Materials and methods. Literature sources were searched and selected in PubMed and eLibrary. The following queries were used for the search: nasal continuous positive airway pressure, non invasive ventilation, neonate, newborn, patient transportation, transport, transfer. Types of studies considered: retrospective observational studies, prospective studies (randomized, quasi-randomized, non-randomized), systematic reviews, meta-analyses, clinical protocols. Depth of search − 20 years. The total number of publications included in the review was 61, including 29 studies directly related to the use of noninvasive ventilation in interhospital neonatal transport.   Results and discussion. Non-invasive respiratory support is one of the priority and actively used methods of therapy of respiratory disorders of various genesis in neonatology. Nasal CPAP is used both independently and in conjunction with various methods of surfactant administration, reducing the risk of a combined outcome “death or chronic lung disease”. It is recommended both as a method of starting respiratory support and as an intermediate option to increase the probability of successful extubation. There is limited experience with non-invasive respiratory support during interhospital transport of neonates. The available studies suggest that when patients are selected rationally and reasonable criteria are applied to administer nCPAP en route, this method of respiratory support is safe, effective, maintains the benefits of spontaneous breathing, and reduces the duration of intensive care. The small number and poor design quality of studies in this direction do not allow at this stage to form evidence-based recommendations.   Conclusion. Medical evacuation of newborns from 1−2 level institutions to level 3 organization with nCPAP is safe and has a number of potential benefits. Existing recommendations are empirical, and there are exceptionally few studies evaluating the validity of such recommendations.","PeriodicalId":247511,"journal":{"name":"Ural Medical Journal","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139166911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of the toxic effects of fluoroquinolones in laboratory rabbit models","authors":"N. Izmozherova, V. Bazarnyi, V. Bakhtin, L. Polushina, A. Maksimova","doi":"10.52420/2071-5943-2023-22-4-61-68","DOIUrl":"https://doi.org/10.52420/2071-5943-2023-22-4-61-68","url":null,"abstract":"Introduction. Fluoroquinolones are antibacterials for which the development of cardiotoxicity, hepatotoxicity, nephrotoxicity and connective tissue damage has been noted. The likely mechanism for the development of these reactions is magnesium metabolism disorder. An available method to detect fluoroquinolones toxicity in animal experiments is a blood biochemical test.The aim of the work was to identify the biochemical signs of the toxic effects of fluoroquinolones in laboratory rabbit models.Materials and methods. Twenty male rabbits randomised into three groups were included in the study: 6 control animals; 7 rabbits treated with ciprofloxacin 150 mg/kg 14 days; 7 rabbits treated with levofloxacin 150 mg/kg 14 days. Serum levels of albumin, alanine aminotransferase (liver damage marker), creatinine (nephrotoxicity marker), creatine kinase MB (cardiotoxicity marker), matrix metalloproteinase 9 (connective tissue damage marker), serum and plasma magnesium content were studied in this work. Data are presented as mean (standard deviation).Results. Serum levels of albumin, alanine aminotransferase and creatinine did not change during the experiment. Rabbits treated with levofloxacin had 2.0–2.5 times lower values of CF creatine kinase activity than control animals. There was double increase of serum concentration of matrix metalloproteinase 9 in ciprofloxacin group in comparison with control (70,17 (20,88) and 38,10 (16,04) ng/ ml, p = 0,019). Magnesium content was unchanged with both fluoroquinolones.Discussion. The absence of signs of hepatotoxicity and nephrotoxicity is consistent with their low frequency of detection in clinical and experimental studies. A decrease in the activity of creatine kinase MB in animals treated with levofloxacin has not been described in the literature. An increase in the concentration of metalloproteinase 9 is evidence of destruction of connective tissue structures. The absence of changes in serum and plasma concentrations of magnesium is explained by the functioning of the systems maintaining the constancy of its content in blood.Conclusion. No biochemical evidence of hepato-, nephro- and cardiotoxic effects of ciprofloxacin and levofloxacin at the doses of 150 mg/kg for 14 days was shown in rabbits; no magnesium metabolism disorders were shown, and the ability of ciprofloxacin to increase the serum content of matrix metalloproteinase type 9 was demonstrated. The proposed model can be used to investigate ways to prevent the toxic effects of fluoroquinolones on connective tissue structures.","PeriodicalId":247511,"journal":{"name":"Ural Medical Journal","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114306617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perioperational management of elderly and senile patients based on a comprehensive geriatric assessment for endoprosthetics of large joint","authors":"Хуршед Камарович Хисомов, Вячеслав Судер-оолович Ондар, Хуршед Камарович Хисомов","doi":"10.52420/2071-5943-2023-22-4-92-101","DOIUrl":"https://doi.org/10.52420/2071-5943-2023-22-4-92-101","url":null,"abstract":"Introduction. Due to the changing age structure of the world’s population, an increase in the number of geriatric patients undergoing endoprosthetics of large joints is to be expected in the future. Age-related frailty and existing comorbidities pose problems for the entire treatment team.The aim of the study was to determine the effectiveness of comprehensive geriatric management of elderly and senile patients before and after endoprosthetic of the hip and knee joints.Materials and methods. An analysis of publications on the use of comprehensive in endoprosthetic of large joints in elderly and senile patients with osteoarthritis was performed. Searched in the electronic databases and libraries Web of Science, Conchrane library, PubMed, eLibrary using the search words: comprehensive geriatric assessment.Results and discussion. There is an increasing incidence of large joints endoprosthetic in orthogeriatric patients with osteoarthritis. Anaesthesia and arthroplasty in this group of patients is an important issue, as well as ensuring immediate postoperative mobilization of the patient. An individualized patient preparation plan for surgical intervention and postoperative management, aimed at preventing the development of transient cognitive impairment and other complications associated with geriatric status, in particular falls, is a necessary organizational element of treatment.Conclusion. A comprehensive geriatric assessment plays a crucial role in the perioperative introduction of geriatric patients for endoprosthetic of large joints. Timely identification of geriatric patients during the preoperative phase eliminates risk factors.","PeriodicalId":247511,"journal":{"name":"Ural Medical Journal","volume":"97 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121573499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Macroscopic evaluation of nasal mucosal regeneration after trauma (experimental study)","authors":"I. Y. Berest","doi":"10.52420/2071-5943-2023-22-4-69-76","DOIUrl":"https://doi.org/10.52420/2071-5943-2023-22-4-69-76","url":null,"abstract":"Introduction. Adhesions as a manifestation of pathological regeneration in the nasal cavity after surgical interventions is a rather pressing problem of modern medicine.The aim of the study. was to evaluate the effectiveness of regenerative treatment regimens for nasal mucosal trauma under experimental conditions.Materials and methods. A randomized experimental study was carried out on 480 male white rats, divided into six treatment-dependent groups. At control times (2, 5, 10, 14, 21, 30, 42, 60 days), 10 animals were each removed from the experiment.Results. After nasal musocal trauma on the 2−5th day the processes of alteration prevailed, which were more pronounced in the group that did not receive anti-inflammatory treatment. In the group treated with a combination of the antioxidant “Demiphosphon” and the reparant “Derinat”, already from the 10th day there there was noted a restoration of the integrity of the mucous membrane of the wound edges, by the 60th day in all 10 (100 %) animals there was a complete closure of the defect. The incidence of adhesions in the group without treatment was 11.3 % with the use of reparative agents in the groups a statistically significant reduction of the adhesion process was observed.Discussion. Other authors have described the effects of various drugs on wound healing and adhesions. The effectiveness of hyaluronic acid remains controversial; in the study presented, no nasal adhesions were detected when sodium hyaluronate (“Olifrin”) was used.Conclusion. The best result was observed in the groups where the combination of the antioxidant “Demiphosphon” and the reparative agent “Derinat” was used: in addition to the absence of adhesions, earlier closure of the defect was noted. The inclusion of reparative agents in the treatment regimens increases the effectiveness of treatment by correcting the effects on reparative regeneration processes.","PeriodicalId":247511,"journal":{"name":"Ural Medical Journal","volume":"715 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125368221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute coronary syndrome in women. Are there any special features?","authors":"Татьяна Олеговна Бродовская, Эдуард Васильевич Аребьев, Ирина Федоровна Гришина, Мария Ивановна Петровских, Аэропорт Кольцово","doi":"10.52420/2071-5943-2023-22-4-128-139","DOIUrl":"https://doi.org/10.52420/2071-5943-2023-22-4-128-139","url":null,"abstract":"Introduction. The increasing incidence of coronary heart disease, including acute coronary syndrome, among women, the lack of public awareness of the cardiovascular risks in women and the late presentation of these patients for medical care necessitates a review of the existing literature on the problem.Purpose of the work was to systematize data on acute coronary syndrome in women and to characterize its distinctive features.Materials and methods. A literature search was conducted for the period from 2011 to 2022 in PubMed, Cochrane Library, Embase, Google Scholar using the search terms: cardiovascular diseases in women, ischemic heart disease in women, acute coronary syndrome in women and acute myocardial infarction in women. Inclusion criteria: evidence of sex differences in acute coronary syndrome. The preferred languages were Russian and English.Results and discussion. The risk factors of acute coronary syndrome in women are characterized and the data on the peculiarities of the clinic of this pathology are summarized. Data on the problem of a differentiated approach and on the determination of management tactics for patients with acute coronary syndrome are presented.Conclusion. Despite the increasing awareness of cardiovascular disease as a major cause of disability and mortality in both sexes, the attention of specialists to the problem of a differentiated approach to the management of women with ACS remains insufficient, which determines the need for in-depth research on this problem.","PeriodicalId":247511,"journal":{"name":"Ural Medical Journal","volume":"99 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131299648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}