Ural Medical Journal最新文献

{"title":"Correction of the Inflammatory Reaction in the Discrete Model of Acute Post-manipulation Pancreatitis","authors":"M. Rantsev, P. Sarapultsev, O. N. Chupakhin","doi":"10.52420/2071-5943-2024-23-1-69-76","DOIUrl":"https://doi.org/10.52420/2071-5943-2024-23-1-69-76","url":null,"abstract":"Introduction. Acute post-manipulation pancreatitis (APP) is a common complication of endoscopic interventions on the major duodenal papilla of the duodenum. Moderate acute pancreatitis develops more often than severe acute pancreatitis.The purpose of the work is to determine the effect of compound L-17 of the group of substituted thiadiazines on the severity of the inflammatory reaction in moderate severity APP.Materials and methods. The severity of the inflammatory reaction in experimental APP after surgery in rats using the compound L-17 was studied. During this study, laboratory indicators of the severity of the inflammatory reaction were assessed, including the leukocyte count and the level of increase in the concentration of the major interleukins. Furthermore, morphological data was analyzed to allow an assessment of the dynamics of the cellular composition of the inflammatory infiltrate of the pancreas in the APP in the experiment.Results. A decrease in the severity of the inflammatory reaction was shown according to leukocyte count, cytokine concentration, and a morphological study of the inflammatory infiltrate of the pancreas.Discussion. The effectiveness of the proposed surgical technique for the formation of APP has been proven by the development of acute pancreatitis in all animals operated. Most experimental methods for acute pancreatitis have no such effectiveness. The data obtained confirm the opinion of numerous authors that interventions on the major duodenal papilla are a risk factor for the development of APP. The study used the compound L-17, which is a representative of a new group of organic compounds, substituted thiadiazines, which have a disaggregant and anticoagulant effect. The effect of compound L-17 on the hemocoagulation parameters of blood is associated with the anti-inflammatory mechanism of action of compound L-17.Conclusion. Administration of compound L-17 in moderate-severity experimental APP can reduce the severity of the inflammatory reaction.","PeriodicalId":247511,"journal":{"name":"Ural Medical Journal","volume":"25 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140262205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Promising Role of Oncomarkers CA 19-9 and CA 125 in the Diagnosis of Progressive Pulmonary Fibrosis","authors":"E. Shchepikhin, E. I. Shmelev, A. Ergeshov","doi":"10.52420/2071-5943-2024-23-1-37-45","DOIUrl":"https://doi.org/10.52420/2071-5943-2024-23-1-37-45","url":null,"abstract":"Purpose of the study to study the role of serum glycoproteins CA 19–9 and CA 125 as a potential non-invasive biomarker of progressive fibrosis in interstitial lung diseases.Materials and methods. The study included 77 patients with interstitial diseases. Based on the presence/absence of signs of progression over the previous 6 months, patients were divided into 2 groups. All patients underwent forced spirometry, body plethysmography, diffusion test, computed tomography of the chest, and a study of serum concentrations of CA 19-9 and CA 125.Results. In the group of patients with a progressive fibrotic phenotype of interstitial lung diseases (ILD), higher levels of CA 19-9 and CA 125 were detected. A correlation of the studied level of tumor markers with parameters of pulmonary function and the severity of interstitial changes in lung changes according to computed tomography of the chest was shown (Warrick test).Conclusion. The data obtained demonstrate the capabilities of non-invasive diagnosis of PF-ILD and require further research and prospective observation to assess the diagnostic and prognostic role of the studied biomarkers, as well as determine their place in clinical practice.","PeriodicalId":247511,"journal":{"name":"Ural Medical Journal","volume":"25 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140262042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Analysis of Osseodensification and Standard Implant Site Preparation Techniques in Low Density Bone","authors":"E. A. Levonian, V. A. Badalyan","doi":"10.52420/2071-5943-2024-23-1-12-23","DOIUrl":"https://doi.org/10.52420/2071-5943-2024-23-1-12-23","url":null,"abstract":"Introduction. Dental implantation is getting more popular with patients who require total dental rehabilitation. Patients note that possibility of immediate loading based on dental implants is more favorable treatment option due to active social life. Low bone density, often occurred in the maxilla, frequently presents challenges for clinicians to achieve successful implant primary stability for predictable immediate loading.The aim of our study was to increase the efficiency of treatment of patients who require dental implantation in the maxilla.Materials and methods. Twenty-seven patients aged from 27 to 66 years with missing teeth in the alveolar process of maxilla were treated. All patients in this randomized clinical trial were divided into two groups. We used two methods for implant site preparation: the standard technique according to manufacturer’s recommendations in the first group (n = 13) and the Osseodensification technique via Densah drills (n = 14) in the second. All patients were treated by Astra Tech dental implants with the same dimensions (diameter 4 mm, length 9 mm). Immediately after implant placement the data of the frequency-resonance analysis of the implant stability and insertion torque were installed and obtained. Furthermore, a comparison of the operation time was carried out. Clinical evaluation and patient appreciation of pain, edema and hyperemia of the mucosa were evaluated using a questionnaire at 1, 3, 5 and 7 days after surgery. The measurement of the values of the stability quotient of the implants was repeated and carried out after six months.Results. Higher values of implant primary stability (insertion torque and implant stability quotient during surgery) were showed in the osseodensification group (IT — (45,0±5,8), ISQ — (71,8±2,9)) in comparison with standard technique (IT — (27,7±3,8), ISQ — (62,8±3,2)); p < 0,05.Discussion. Osseodensification technique promotes compaction of a low density bone in direct contact with the implant, which leads to higher implant primary stability due to the physical interaction between bone and implant.Conclusion. The obtained results allow us to consider that the osseodensification method is progressive for improving the effectiveness of implantological treatment on maxilla.","PeriodicalId":247511,"journal":{"name":"Ural Medical Journal","volume":"27 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140262705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Scientific and methodological basis for ensuring the quality of forensic medical examination of mechanical injury","authors":"O. B. Dolgova, P. Romodanovsky","doi":"10.52420/2071-5943-2023-22-6-136-150","DOIUrl":"https://doi.org/10.52420/2071-5943-2023-22-6-136-150","url":null,"abstract":"Introduction. Mechanical injury is the most common cause of violent death in the world, including in Russia.   The purpose of the study is to analyze scientific, methodological literature and regulatory documents to assess the possibility of using them in substantiating the expert’s conclusions.   Materials and methods. 85 sources were selected for the scientific review over a period of 26 years, bibliographic databases PubMed, ResearchGate, Elibrary were used. Results and discussion. The patterns of formation and experience of injuries do not change, this allows us to use the results of scientific, methodological and practical activities in forensic traumatology at the present time: methods for describing injuries to the integumentary tissues of a corpse and clothing, rules for the formulation of a forensic medical diagnosis, algorithms for drawing expert conclusions, a comprehensive assessment of biomechanics and characteristics of the main morphological substrates of traumatic brain injury, established patterns of destruction of skeletal bones under various types of mechanical impact, the results of a study of the pathomorphology of internal organs, classification and features of human injury by predatory animals, provisions on the interaction of sharp objects with various tissues from the point of view of injury biomechanics and substantiation of morphological manifestations of injury mechanisms, methodology for solving expert issues of gunshot wounds and explosive trauma, scientifically based morphological criteria for direct causes of death and features of thanatogenesis in mechanical injury, medical essence of qualifying signs of harm to health and threatening the lives of states at different time intervals after causing damage. The prospect of CT studies as one of the types of long-lasting objective physical evidence has been determined for forensic medical examination.   Conclusion. The study shows that the use of scientific data and methodological works makes it possible in each case of fatal mechanical injury to qualitatively substantiate and argue forensic expert conclusions. The results of clinical diagnostics are evidence in criminal and civil cases, can be preserved for any time period, which determines the prospect of scientific research on the use of clinical diagnostic methods for forensic medical examination.","PeriodicalId":247511,"journal":{"name":"Ural Medical Journal","volume":"1983 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139160361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Febrile seizures in pediatric practice: Risk factors, clinical manifestations, and intensive therapy","authors":"Yu. V. Bykov, A. N. Obedin, V. V. Fischer, E. V. Volkov, I. Yatsuk","doi":"10.52420/2071-5943-2023-22-6-113-123","DOIUrl":"https://doi.org/10.52420/2071-5943-2023-22-6-113-123","url":null,"abstract":"Introduction. Febrile seizures (FS) is the most common type of epileptic seizure experienced by young children. Study of methods of intensive treatment (IT) of FS represents a vital area of research in today’s pediatric science.   The aim of this work: to assess the current approaches to risk factors, clinical manifestations and emergency care for patients with FS in pediatric practice. Materials and methods. The authors performed an analysis of publications that were found in the Cochrane Library, PubMed, eLibrary.ru, and Medscape databases using the following search terms: febrile seizures, children and adolescents, intensive treatment, anticonvulsants. A total of 64 published sources were chosen for review.   Results and Discussion. The risk factors for FS may be numerous, with the main etiological causes in children being genetic susceptibility, viral infections and vaccination. The clinical presentation of FS is characterized by the development of a generalized tonic-clonic seizure in the setting of a high body temperature (≥39°C). FS are subdivided into three main clinical types: simple, complex and febrile status epilepticus (FSE). History taking and physical examination represent the main diagnostic means for determining the type of FS and discovering the cause of infection. Laboratory tests, electroencephalography, neuroimaging studies and lumbar puncture are used on a limited basis, mainly in children with complicated FS accompanied by a brain infection. Hospitalization for IT is necessary if the child has prolonged febrile seizures or FSE. The drugs of choice for relieving FS are benzodiazepines. Barbituric acid derivatives and valproic acid also possess therapeutic efficacy against FS. Antipyretic agents are effective only in relieving the toxic syndrome, but have no effect on the severity of FS and do not prevent relapses. The main antipyretic medications used for treatment of FS in pediatric practice are paracetamol, ibuprofen and nimesulide. Besides benzodiazepines, IT of FSE involves the use of intravenous fosphenytoin, phenobarbital or levetiracetam.   Conclusion. Improvement of the quality of IT in pediatric practice may improve the therapeutic prognosis in patients with FS and bring down complication and mortality rates.","PeriodicalId":247511,"journal":{"name":"Ural Medical Journal","volume":"307 1‐2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139160718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Results of evaluation of neurometabolic and rehabilitation therapy for vincristine polyneuropathy in children with acute lymphoblastic leukemia","authors":"O. Koryakina, O. P. Kovtun, L. Fechina, V. V. Bazarny, A. V. Rezaikin","doi":"10.52420/2071-5943-2023-22-6-124-135","DOIUrl":"https://doi.org/10.52420/2071-5943-2023-22-6-124-135","url":null,"abstract":"Introduction. Vincristine-induced peripheral neuropathies (VIPN) is a current problem in the management of pediatric acute lymphoblastic leukemia (ALL). There are no effective therapeutic strategies for VIPN.   The aim of the study to present the results of evaluation of neurometabolic therapy in the acute period of VIPN in children with ALL and the method of virtual rehabilitation in the recovery period.   Materials and methods. The single-center prospective comparative pilot study involved 69 children with VIPN who were treated in the acute period with the following drugs: group 1 - pyridoxine, group 2 - thioktovic acid, group 3 - inosine + nicotinamide + riboflavin + succinic acid. Clinical and electrophysiological parameters before and after drug treatment were analyzed. Among 10 children with motor deficits in the lower extremities in the recovery period of VIPN, rehabilitation with immersive virtual reality was performed, and the clinical parameters before and after the course were compared.   Results. A positive effect of the studied drugs on the clinical condition of patients by the 30th day of therapy was revealed. In groups 1 and 3 the total score on the NIS-LL scale correlated with mild polyneuropathy - 4 [2÷8] and 2 [2÷6] points, respectively. Neurologic impairment in each of these groups persisted for 19 [14÷25] and 19 [13÷30] days, which was less in contrast to the duration of symptoms in group 2 (p1-2 = 0.021 and p2-3 = 0.046). In the VIPN recovery period before and after virtual rehabilitation: muscle strength in the lower limbs increased (p = 0.025); the severity of polyneuropathy decreased according to the NIS-LL scale (p = 0.003); balance improved according to the Berg scale (p = 0.017); and patients’ mobility increased according to the Functional Walking Category test (p = 0.025) and walking speed according to the time-recorded walking test (p = 0.008).   Discussion. Improvement of clinical parameters with neurometabolic therapy and virtual rehabilitation in children with VIPN has been shown.   Conclusion. Preliminary results of the effectiveness of pyridoxine and inosine + nicotinamide + riboflavin + succinic acid in the acute period of VIPN in children with ALL and the method of virtual rehabilitation in the recovery period were obtained.","PeriodicalId":247511,"journal":{"name":"Ural Medical Journal","volume":"2019 41","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139159799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The influence of alcohol dependence on the course of chronic heart failure in patients with HIV infection","authors":"O. G. Goryacheva, N. A. Terekhina, G. A. Terehin","doi":"10.52420/2071-5943-2023-22-6-104-112","DOIUrl":"https://doi.org/10.52420/2071-5943-2023-22-6-104-112","url":null,"abstract":"Introduction. Alcohol dependence is a condition, the consequences of which are severe in persons with cardiovascular diseases and immunodeficiency.   The purpose of the study is to evaluate the influence of alcohol dependence on the course of chronic heart failure (CHF) in persons infected with human immunodeficiency virus (HIV).   Materials and methods. A clinical study including 240 HIV-infected patients, 160 of them were diagnosed with CHF, 72 had alcohol dependence. AUDIIT scale was used for diagnostics of alcohol dependence. All patients underwent echocardiography, NT-proBNP concentration was determined in blood plasma, serum - content of SRB, transferrin, ferritin, iron, potassium, sodium, bilirubin, creatinine, urea, uric acid, AST, ALT, GGTP activity. Statistical calculations: Kolmogorov-Smirnov, Mann-Whitney methods, odds ratios and risks.   Results. Congestion, lower heart rate prevailed in the group of patients with alcohol dependence. On the background of alcohol dependence in blood serum there was a decrease in the level of total cholesterol, transferrin, potassium, an increase in total bilirubin and GGTP activity, a decrease in the number of platelets. Increase in NT-proBNP concentration was found in blood plasma.   Discussion. Alcohol is characterized by cardiotoxic effect, and regular ethanol consumption is associated with the development of non-ischemic dilated cardiomyopathy and CHF. Echocardiographic findings suggest a predominance of right atrial and left ventricular dilatation in the group of patients with alcohol dependence among all patients with CHF infected with HIV due to the formation of cardiomyopathy.   Conclusion. Alcohol dependence is a condition aggravating the course of CHF in HIV-infected patients, which is manifested by higher values of blood plasma NT-proBNP, with CHF more often acquiring a congestive character. The course of CHF in HIV-infected patients against the background of alcohol dependence is accompanied by liver dysfunction - 3.5 times increase the chance of cholestasis development, 2.5 times increase the chances of death within 2 months after admission to hospital.","PeriodicalId":247511,"journal":{"name":"Ural Medical Journal","volume":"1986 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139160538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanisms of development of postoperative pain syndrome in gynecological patients","authors":"M. O. Popov, S. Kinzhalova, N. S. Davydova, A. Sidenkova","doi":"10.52420/2071-5943-2023-22-6-94-103","DOIUrl":"https://doi.org/10.52420/2071-5943-2023-22-6-94-103","url":null,"abstract":"Introduction. Despite all the advances in anesthesiology, postoperative pain syndrome remains a serious problem. The lowest satisfaction with postoperative pain relief was found among gynecological patients. For adequate anesthesia and relief of postoperative pain syndrome in gynecological patients, a clear understanding of the features of pain development is necessary.   The purpose of the study: identification of mechanisms of development of postoperative pain syndrome in gynecological patients.   Materials and methods. The search and analysis of literature sources in the databases Scholar Google, Cyberleninka, PubMed, by keywords: physiology of pain, postoperative pain in gynecology, pain syndrome after uterine surgery. Criteria for the inclusion of articles: compliance with the subject of the review and the relevance of the data. The search depth was 33 years. The review includes 59 literary sources.   Results. The development of pain syndrome is influenced by pathophysiological mechanisms, such as: the formation of hyperalgesia zones, changes in estrogen levels, damage to nerve fibers and genetic factors. To assess the level of pain, specialized scales are used, such as YOURS, CRH, DN4 scale. Psychological factors have a great influence on the formation of postoperative pain. Namely, the level of anxiety and depression, the level of catastrophization of pain, coping strategies used, psychological stability.   Conclusion. Postoperative pain syndrome in gynecological patients is associated not only with the physiological mechanisms of pain development, but also with psychoemotional factors. A multidisciplinary approach is needed to alleviate pain in gynecological patients, including not only adequate multimodal anesthesia and analgesia in the perioperative period, but also collaboration with clinical psychologists, psychotherapists, to evaluate and possible selection of psycho-social therapy.","PeriodicalId":247511,"journal":{"name":"Ural Medical Journal","volume":"15 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139162307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Liver macrophages as the key regulators of tissue homeostasis in organ","authors":"K. V. Sokolova, I. Danilova","doi":"10.52420/2071-5943-2023-22-6-85-93","DOIUrl":"https://doi.org/10.52420/2071-5943-2023-22-6-85-93","url":null,"abstract":"Introduction. View about hepatic macrophages as key regulators of tissue homeostasis, acting via innate and adaptive immune reactions, stimulated by exogenous and/or endogenous alarm signals of tissue injury or cell stress is substantiated in the review. From one hand, environmental signals determine macrophage polarization and production, but, on the other hand, macrophages affect tissue microenvironment and cells and tissue function at whole.   The review was aimed to provide recent evidence of macrophage role in maintenance of tissue homeostasis in liver.   Materials and Methods. Review is based on the 67 scientific articles, devoted to the study and analysis of macrophage role in the maintenance of tissue homeostasis in liver, found in PubMed database. Most of the analyzed articles (40 from 67) were published in 2017-2023.   Results and Discussion. Information of origin and morpho-functional heterogeneity of hepatic macrophages was summarized in the review.   Conclusion. The information presented in the review allow to conclude that macrophages are key regulators of homeostasis in the liver due to their ability to perceive many endogenous and exogenous signals in tissues and quickly respond to them in the direction of stabilizing the tissue microenvironment.","PeriodicalId":247511,"journal":{"name":"Ural Medical Journal","volume":"12 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139161583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative analysis of the effect of Reamberin and Methadoxyl on the course of acute severe ethanol poisoning","authors":"T. N. Savateeva-Lyubimova, A. G. Aleksandrov, S. B. Kazakova, K. Stosman","doi":"10.52420/2071-5943-2023-22-6-59-67","DOIUrl":"https://doi.org/10.52420/2071-5943-2023-22-6-59-67","url":null,"abstract":"Introduction. One of the ways to improve the quality of intensive therapy in severe forms of acute alcohol poisoning is the inclusion in the complex of measures of means capable of reducing the manifestations of oxidative stress.   The aim of the work was a comparative evaluation of the effectiveness of drugs Reamberin and Methadoxyl in acute severe ethanol poisoning on rats.   Materials and methods. Acute severe alcohol poisoning was modeled in Wistar rats by 40 % ethanol solution at a dose 8,6 g/kg. The studied drugs were administered infusively in the volume of 20 ml/kg for 60 min at an average rate of 0.33 ml/min/kg. The comparative efficacy of infusion therapy was evaluated according to the severity of coma and its duration.   Results. Ethanol caused coma of different severity in animals. At the end of infusion therapy, the death of some animals was observed. The life expectancy of dead animals receiving Reamberin was 4 times higher than that of animals of the control group and animals receiving Metadoxyl. The most significant decrease in the severity of coma and its duration was observed in rats receiving Reamberin. Minimal differences in the frequency of respiratory movements from the background at the end of infusion occurred in the same animals. Discussion Established in acute ethanol poisoning the presence of supportive therapy with Reamberin of neurological status and external respiratory function during infusion is a justification for the inclusion of the drug in the complex of intensive care in this critical condition.   Conclusions. It was experimentally shown that Reamberin, unlike Methadoxyl, significantly reduced the severity of alcohol coma at the end of infusion administration. Reamberin increased the life expectancy of dead animals compared to the control and rats receiving Methadoxyl, and also caused minimal differences in respiratory rate relative to the background at the end of infusion, which had the character of a trend. Reamberin demonstrated greater efficacy with respect to the course of acute severe ethanol poisoning than Methadoxyl.","PeriodicalId":247511,"journal":{"name":"Ural Medical Journal","volume":"178 S439","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139165692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}