World Journal of Clinical Cases最新文献

{"title":"Aneurysm rupture in median arcuate ligament syndrome leading to duodenal stenosis: A case report.","authors":"Tomohiro Tanikawa, Keisuke Miyake, Mayuko Kawada, Katsunori Ishii, Takashi Fushimi, Noriyo Urata, Nozomu Wada, Ken Nishino, Mitsuhiko Suehiro, Miwa Kawanaka, Hidenori Shiraha, Ken Haruma, Hiroyasu Fujiwara, Tomoki Yamatsuji, Hirofumi Kawamoto","doi":"10.12998/wjcc.v13.i25.106089","DOIUrl":"10.12998/wjcc.v13.i25.106089","url":null,"abstract":"<p><strong>Background: </strong>A 56-year-old female presented with acute abdominal pain due to a ruptured pseudoaneurysm associated with median arcuate ligament syndrome (MALS), a rare condition caused by the compression of the celiac artery by the median arcuate ligament (MAL), potentially leading to ischemia, aneurysm formation, and rupture.</p><p><strong>Case summary: </strong>Computed tomography revealed a retroperitoneal hematoma, celiac artery stenosis, and two aneurysms in the inferior pancreaticoduodenal artery. Hemostasis was achieved using transcatheter arterial embolization. However, 15 days after embolization, the patient developed duodenal stenosis, manifesting as gastric distension and nausea without abdominal pain. Endoscopy revealed mucosal edema and luminal narrowing of the duodenum. Conservative treatment was ineffective, and the patient underwent MAL transection and gastrojejunostomy. She recovered uneventfully, and follow-up at 4 months showed complete resolution of duodenal stenosis and no recurrence.</p><p><strong>Conclusion: </strong>This case highlights the importance of the early diagnosis and multidisciplinary management of MALS.</p>","PeriodicalId":23912,"journal":{"name":"World Journal of Clinical Cases","volume":"13 25","pages":"106089"},"PeriodicalIF":1.0,"publicationDate":"2025-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12243907/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144971666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical application of radiofrequency technology in the treatment of facial skin wrinkles and laxity.","authors":"Hua Liu, Fei Ke, Cheng-Zhi Li, Shu-Ping Li, Xue-Qin He, Hua Lu","doi":"10.12998/wjcc.v13.i25.97335","DOIUrl":"10.12998/wjcc.v13.i25.97335","url":null,"abstract":"<p><strong>Background: </strong>Aging is an inevitable aspect of human life, characterized by the gradual decline in the function of individual cells and structural components, including bones, muscles, and ligaments.</p><p><strong>Aim: </strong>To evaluate the clinical effects of radiofrequency technology in treating facial skin wrinkles and laxity.</p><p><strong>Methods: </strong>This study included 60 female patients, aged 36-58 years (mean age 47.71 ± 1.56 years), who received focused radiofrequency technology treatment for facial wrinkles and laxity in the Department of Medical Cosmetology at our hospital between January 2021 and June 2022. Each patient underwent three treatment sessions, one every two months. Facial photographs were taken before treatment and one week after the final session. A single physician assessed wrinkle severity using a standardized wrinkle severity scale, and patients completed a satisfaction questionnaire one week after the last treatment.</p><p><strong>Results: </strong>After three consecutive radiofrequency treatments, performed every two months, patients exhibited significantly reduced wrinkles and skin laxity compared to baseline. One week after the third treatment, the mean facial wrinkle severity score had significantly decreased from 3.00 ± 0.79 to 2.71 ± 0.47 (<i>t</i> = 2.58, <i>P</i> < 0.05). Additionally, 88.24% of patients reported noticeable improvements in facial wrinkles and skin laxity. No serious adverse reactions occurred during or following treatment.</p><p><strong>Conclusion: </strong>Radiofrequency technology demonstrates significant clinical efficacy in improving facial skin wrinkles and laxity.</p>","PeriodicalId":23912,"journal":{"name":"World Journal of Clinical Cases","volume":"13 25","pages":"97335"},"PeriodicalIF":1.0,"publicationDate":"2025-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12243918/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144971709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Post-endoscopic retrograde appendicitis therapy stent impaction leading to exacerbation of appendicitis: A case report.","authors":"Tan-Tu Ma, Hao-Run Lyu","doi":"10.12998/wjcc.v13.i25.106587","DOIUrl":"10.12998/wjcc.v13.i25.106587","url":null,"abstract":"<p><strong>Background: </strong>Endoscopic retrograde appendicitis therapy (ERAT) is an emerging technique. However, its efficacy remains uncertain, and postoperative complications often exacerbate inflammation, thereby increasing the difficulty of surgery. The use of ERAT in appendicitis remains contentious, prompting the presentation of this case report.</p><p><strong>Case summary: </strong>We report the case of a 43-year-old female patient presenting with intermittent right lower abdominal pain for one day. The patient had undergone ERAT six months previously. Examination revealed stent impaction in the appendix, leading to exacerbated inflammation. Subsequently, a solo single-incision laparoscopic appendectomy (SSLA) was performed. The ERAT-related complications increased surgical difficulty and prolonged the operation time. Post-SSLA, the patient was hospitalized for one day and showed favorable recovery upon follow-up.</p><p><strong>Conclusion: </strong>This case highlights the risks of ERAT. Thorough preoperative assessment, proper stent placement during surgery and regular postoperative follow-up are crucial in preventing complications, as their occurrence can increase surgical difficulty. Compared to ERAT, SSLA remains more widely used in clinical practice. Both techniques require further clinical data and research to optimize their application.</p>","PeriodicalId":23912,"journal":{"name":"World Journal of Clinical Cases","volume":"13 25","pages":"106587"},"PeriodicalIF":1.0,"publicationDate":"2025-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12243855/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144971699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atypical presentation of a large posterior falx meningioma involving the parafalcine region in a 78-year-female: A case report.","authors":"Nadeem AlSabea, Samar Syeda, Marina Gubran, Viktoriya Gibatova, Rahul Sharma, Anjiya Aswani","doi":"10.12998/wjcc.v13.i25.108429","DOIUrl":"10.12998/wjcc.v13.i25.108429","url":null,"abstract":"<p><strong>Background: </strong>Meningiomas represent the most common primary intracranial tumor in adults. The majority of meningiomas are indolent, benign, and sporadic in nature. The incidence of meningiomas is directly proportional to the age, peaking around 65 years. The presenting symptomatology of intracranial meningiomas is mainly dependent on their anatomical location, as with the majority of brain tumors. Surgical resection and radiation therapy remain the treatment modality for meningiomas of all grades.</p><p><strong>Case summary: </strong>We present a case describing a 78-year-old female who came in following a ground level fall. The primary assessment was notable for a history of similar recurrent falls and subtle left-sided peripheral visual field loss. Further neurological examination was otherwise largely unremarkable. A computed tomography scan of the head revealed a large extra-axial mass located along the posterior aspect of the falx. Follow-up magnetic resonance imaging confirmed a lesion measuring around 6.6 cm × 4.2 cm × 5.5 cm. A partial surgical resection of the right-sided portion of the lesion was performed. Complete resection was limited by insufficient visualization and challenges with hemostatic control of the left parafalcine region. Further histopathological analysis confirmed a fibrous meningioma with focal necrosis, consistent with World Health Organization Grade 2 classification. She was subsequently scheduled for outpatient follow-up to assess the residual tumor management.</p><p><strong>Conclusion: </strong>This case highlights the importance of maintaining a high index of suspicion for intracranial pathology in elderly patients with nonspecific presentation.</p>","PeriodicalId":23912,"journal":{"name":"World Journal of Clinical Cases","volume":"13 25","pages":"108429"},"PeriodicalIF":1.0,"publicationDate":"2025-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12243921/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144971703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Critical presentation of bradycardia, renal failure, atrioventricular nodal blockade, shock, and hyperkalemia syndrome: A case report.","authors":"Nicholas Thales Pavlatos, Pawan Daga, Zyad Smiley, Agastya Belur, Priyanka Bhattacharya, Rafay Khan","doi":"10.12998/wjcc.v13.i25.107948","DOIUrl":"10.12998/wjcc.v13.i25.107948","url":null,"abstract":"<p><strong>Background: </strong>Bradycardia, renal failure, atrioventricular nodal blockade, shock, and hyperkalemia (BRASH) syndrome is an acronym used to describe a constellation of BRASH. It is an underrecognized phenomenon that can be deadly if not appropriately managed in a timely manner. This case highlights the importance of rapid diagnosis and reviews a multitude of treatment options in a uniquely severe case of BRASH syndrome.</p><p><strong>Case summary: </strong>We present a case of a 54-year-old male on a beta-blocker and angiotensin-converting enzyme inhibitor who presented with one day history of nausea, vomiting, and shortness of breath. Upon presentation, he was bradycardic and hypotensive, requiring transcutaneous pacing. Initial electrocardiogram showed atrial fibrillation with ventricular rate in 30's. He was found to have acute kidney injury, hyperkalemia, and metabolic acidosis. He was successfully treated with multiple potassium lowering agents, continuous renal replacement therapy, four pressors, mechanical ventilation, and transvenous pacing with complete recovery prior to discharge.</p><p><strong>Conclusion: </strong>Increased awareness of BRASH syndrome may improve outcomes through timely diagnosis and aggressive intervention.</p>","PeriodicalId":23912,"journal":{"name":"World Journal of Clinical Cases","volume":"13 25","pages":"107948"},"PeriodicalIF":1.0,"publicationDate":"2025-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12243919/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144971722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of herbal medicines containing Paeoniae Radix on patients with restless legs syndrome: A retrospective chart review study.","authors":"Young Seon Lee, Han-Gyul Lee, Seungwon Kwon, Seung-Yeon Cho, Woo-Sang Jung, Seong-Uk Park, Sang-Kwan Moon, Jung-Mi Park, Chang-Nam Ko","doi":"10.12998/wjcc.v13.i25.108244","DOIUrl":"10.12998/wjcc.v13.i25.108244","url":null,"abstract":"<p><strong>Background: </strong>Restless legs syndrome (RLS) is a neurological disorder characterized by an uncontrollable urge to move the legs during rest. Standard treatments may provide short-term relief but are limited by long-term adverse effects. Herbal medicine containing Paeoniae Radix (HCP) has traditionally been used in Korean medicine to treat RLS symptoms.</p><p><strong>Aim: </strong>To investigate the clinical effectiveness and safety of HCP in treating RLS.</p><p><strong>Methods: </strong>This retrospective chart review study included 15 patients with RLS who were treated with HCP between September 2017 and August 2022 at the Kyung Hee University Korean Medicine Hospital. The demographic, disease-related, and treatment-related characteristics, as well as the impressions of each patient, were analyzed. The study also evaluated the changes in the subjective complaints of RLS symptoms, the Korean version of the International Restless Legs Scale (K-IRLS) scores before and after treatment, and the adverse events after HCP administration.</p><p><strong>Results: </strong>Following HCP administration, 14 patients (93.3%) experienced a decrease in the degree of discomfort associated with their symptoms, with an average reduction to 44.7 ± 35.1% compared to their discomfort levels before taking the drug. After treatment, the mean total K-IRLS score decreased significantly from 23.00 ± 9.75 to 13.93 ± 10.9 (<i>P</i> = 0.005). Among the HCP, a significant reduction in the K-IRLS score was observed in the Gyejibokryeonghwan (26.0 ± 9.7 to 10.0 ± 9.4, <i>P</i> = 0.028) and Jakyakgamchotang (23.2 ± 12.6 to 6.6 ± 4.2, <i>P</i> = 0.042) groups. Additionally, no adverse events were reported.</p><p><strong>Conclusion: </strong>HCP improved symptoms in RLS patients. These results suggest that HCP may be an effective and safe alternative for RLS. A randomized controlled trial is required to confirm these findings.</p>","PeriodicalId":23912,"journal":{"name":"World Journal of Clinical Cases","volume":"13 25","pages":"108244"},"PeriodicalIF":1.0,"publicationDate":"2025-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12243905/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144971734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unexpected metastasis of thyroid cartilage involvement from lung adenocarcinoma: A case report.","authors":"Mao-Mao Ai, Tao Lin, Ruo-Yu Guo, Ying-Ying Zhang, Feng Yu","doi":"10.12998/wjcc.v13.i25.107471","DOIUrl":"10.12998/wjcc.v13.i25.107471","url":null,"abstract":"<p><strong>Background: </strong>Thyroid cartilage noncontiguous metastatic involvement is an extremely rare entity due to the absence of vessels within the cartilaginous tissue. A literature review revealed that metastasis from lung cancer is even rarer.</p><p><strong>Case summary: </strong>A 51-year-old male smoker presented with progressive, painful left upper neck lumps for 8 months, accompanied by 10 kg weight loss, poor appetite, and mentation. He had a 30-year history of chronic alcohol use. Following comprehensive imaging studies and pathological examinations, we have identified metastatic lung adenocarcinoma with widespread dissemination to multiple sites including the thyroid cartilage. The final diagnosis is: Lung adenocarcinoma (pT3N3M1c, Stage IVb), epidermal growth factor receptor-mutated (p.E746_S752delinsV). After multidisciplinary team discussion, the patient was initiated on targeted therapy with gefitinib (250 mg/day). At 6-month follow-up, the patient has shown significant clinical improvement with marked reduction in subcutaneous masses in both the cervical and abdominal regions.</p><p><strong>Conclusion: </strong>Monitor for uncommon thyroid cartilage noncontiguous metastases; early detection improves outcomes.</p>","PeriodicalId":23912,"journal":{"name":"World Journal of Clinical Cases","volume":"13 25","pages":"107471"},"PeriodicalIF":1.0,"publicationDate":"2025-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12243910/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144971478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tramadol overdose in total knee arthroplasty: A case report.","authors":"Bushu Harna, Shivali Arya","doi":"10.12998/wjcc.v13.i25.104742","DOIUrl":"10.12998/wjcc.v13.i25.104742","url":null,"abstract":"<p><strong>Background: </strong>Tramadol is a synthetic opioid analgesic commonly employed in postoperative pain control due to its moderate efficacy and comparatively favorable safety profile. Nonetheless, overdose can result in significant adverse effects, notably central nervous system depression. This risk is amplified in individuals with chronic kidney disease (CKD), where reduced renal clearance may potentiate drug accumulation and toxicity. Elderly patients are particularly at risk owing to age-associated alterations in pharmacokinetics and pharmacodynamics. We describe a case of tramadol overdose in a 77-year-old male with stage 3 CKD following total knee arthroplasty.</p><p><strong>Case summary: </strong>A 77-year-old male with diabetes mellitus and CKD stage 3 underwent elective right total knee arthroplasty for grade 4 osteoarthritis under spinal anesthesia. Preoperative evaluation revealed deranged renal function tests but no other significant abnormalities. Postoperative pain was managed with multimodal analgesics, including intravenous tramadol and a buprenorphine skin patch. On postoperative third day, the patient was found unconscious (Glasgow Coma Scale 8/15) with mild respiratory depression. Investigations ruled out stroke, pulmonary embolism, or other cardiopulmonary events. Elevated serum tramadol levels suggested opioid toxicity exacerbated by impaired renal clearance. The buprenorphine patch was removed, and diuresis was initiated. Supportive management, including prophylactic intubation, led to recovery of consciousness within 48 hours, and the patient was extubated and mobilized by postoperative sixth day. Pain control was maintained with oral paracetamol and pregabalin. The patient was discharged on postoperative tenth day in stable condition with improved pain scores and mobility. This case underscores the need for cautious use of tramadol in elderly patients with CKD due to impaired drug clearance and the potential for toxicity. It highlights the importance of close monitoring, judicious analgesic use, and prompt management of complications to ensure favorable postoperative outcomes in high-risk populations.</p><p><strong>Conclusion: </strong>This case underscores the necessity for judicious tramadol administration in elderly patients with CKD, as diminished renal function markedly impairs drug clearance, predisposing to toxicity. Vigilant assessment of renal function and individualized dose adjustments are essential to mitigate the risk of adverse events in this demographic. Clinicians should maintain a heightened awareness of potential opioid toxicity in postoperative patients presenting with unexplained neurological manifestations. Timely identification and initiation of appropriate supportive measures are pivotal in achieving favorable clinical outcomes.</p>","PeriodicalId":23912,"journal":{"name":"World Journal of Clinical Cases","volume":"13 25","pages":"104742"},"PeriodicalIF":1.0,"publicationDate":"2025-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12243904/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144971500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extensive idiopathic mesenteric phlebosclerosis presenting as intestinal pseudo-obstruction: A case report.","authors":"Xiao-Lin Hou, Jie Chen, Mei-Hua Cui, Gui-Bin Yang","doi":"10.12998/wjcc.v13.i25.105028","DOIUrl":"10.12998/wjcc.v13.i25.105028","url":null,"abstract":"<p><strong>Background: </strong>Idiopathic mesenteric phlebosclerosis (IMP) is a rare condition that causes ischaemic colitis, has various clinical manifestations, and may even be asymptomatic, often resulting in clinical misdiagnosis.</p><p><strong>Case summary: </strong>We report the case of a 44-year-old woman with chief complaints of abdominal pain, vomiting and decreased defecation. One year prior, the patient was asymptomatic and therefore misdiagnosed with inflammatory bowel disease based on incidental findings on an abdominal computed tomography (CT) scan. The present abdominal CT scan revealed an intestinal obstruction, diffuse thickening of the entire colon wall and calcification of the mesenteric and colonic veins. Colonoscopy revealed multiple ulcerations and extensive dark purple discolouration of the oedematous mucosa. Colonic transit studies suggested a decrease in colonic motility. IMP was considered the underlying cause of her pseudoileus, which was potentially linked to her consumption of Chinese medicinal teas for more than 30 years. The patient underwent conservative medical treatment, and her symptoms gradually improved. She exhibited no signs of ileus or other significant discomfort at the outpatient follow-up one year after the discontinuation of Chinese herbal tea consumption.</p><p><strong>Conclusion: </strong>IMP can present with symptoms of pseudoileus as initial complication. Clinicians can use CT and colonoscopy for differential diagnoses.</p>","PeriodicalId":23912,"journal":{"name":"World Journal of Clinical Cases","volume":"13 25","pages":"105028"},"PeriodicalIF":1.0,"publicationDate":"2025-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12243906/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144971676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of nitric oxide, prostaglandins, thromboxanes and endothelins in lung cancer: An overview.","authors":"Sadettin Demirel, Ipek Nazli Sinag","doi":"10.12998/wjcc.v13.i25.107907","DOIUrl":"10.12998/wjcc.v13.i25.107907","url":null,"abstract":"<p><p>Lung cancer is the most frequent cause of cancer-related mortality worldwide. Nitric oxide (NO), prostaglandins (PGs), thromboxanes (TXs), and endothelins (ETs) participate in numerous physiological processes. These agents play an important role in lung carcinogenesis by regulating cancer cell proliferation, apoptosis, invasion, and angiogenesis. NO is a gaseous free radical with tumoricidal and tumorigenic activities in lung cancer. Arachidonic acid-derived PGs, including PGD₂, PGE₂, 8-iso-PGF_2α, and PGI₂, are related to the development of lung cancer. PGD₂ and PGI₂ act as tumor suppressors, while PGE₂ and 8-iso-PGF_2α promote tumor progression. TXA₂ catalyzed by cyclooxygenase induces proliferation as well as angiogenesis. Elevated levels of TXB₂, an inactive metabolite of TXA₂, are positively correlated with lung carcinoma stages. ET-1 and ET-2 are 21 amino acid polypeptides; their silencing hinders lung cancer cell proliferation and invasion. ET-2 depletion also triggers apoptotic death. This chapter review aims to provide a comprehensive overview of the role of NO, PGs, TXs, and ETs in lung cancer.</p>","PeriodicalId":23912,"journal":{"name":"World Journal of Clinical Cases","volume":"13 25","pages":"107907"},"PeriodicalIF":1.0,"publicationDate":"2025-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12243923/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144971662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}