The Egyptian Journal of Internal Medicine最新文献_第3页

Assessing the expression of differentiation antagonizing non-protein coding RNA (DANCR) in newly diagnosed Egyptian acute myeloid leukemia patients 评估分化拮抗非蛋白编码RNA (DANCR)在新诊断的埃及急性髓性白血病患者中的表达

The Egyptian Journal of Internal Medicine Pub Date : 2023-09-18 DOI: 10.1186/s43162-023-00251-y

Nour Mohammed Rasheed, Howaida Attia Nounou, Soad Mohamed Eltabakh, Nahla A. M. Hamed, Ayman Ahmed Darwish

{"title":"Assessing the expression of differentiation antagonizing non-protein coding RNA (DANCR) in newly diagnosed Egyptian acute myeloid leukemia patients","authors":"Nour Mohammed Rasheed, Howaida Attia Nounou, Soad Mohamed Eltabakh, Nahla A. M. Hamed, Ayman Ahmed Darwish","doi":"10.1186/s43162-023-00251-y","DOIUrl":"https://doi.org/10.1186/s43162-023-00251-y","url":null,"abstract":"Abstract Background Role of Long non-coding RNAs in cancer research in the recent years have been highlighted with evidence to their involvement in cancer disease pathogenesis and progression. One of these emerging long non-coding RNAs is differentiation antagonizing non-protein coding RNA (DANCR). DANCR distinct expression in different cancers and implication in tumor signaling pathways made it a promising therapeutic target for cancer. The purpose of this study was to evaluate DANCR expression in de novo acute myeloid leukemia (AML) patients and to assess DANCR expression in relation to cytogenetics and French American British (FAB) AML classification as well as correlate DANCR expression with patients’ response to treatment. The present study included 60 newly diagnosed AML patients and 30 healthy subjects as controls. Relative DANCR expression was done using real time qPCR method. Results DANCR was significantly downregulated in AML patients compared to controls ( p = 0.038). In addition, DANCR showed significantly lower expression in M4 and M5 compared to M0, M1, and M2 groups ( p < 0.001). Furthermore, DANCR expression was significantly downregulated in cytogenetically normal AML patients compared to the controls ( p = 0.011). Conclusion Significant downregulation of DANCR in AML suggests a potential tumor suppressor role and variable expression of DANCR among AML subtypes suggests that DANCR action may be different among AML subtypes. Also, M1 subtype patients with higher DANCR expression were less refractory to treatment and therefore less resistant to cytarabine.","PeriodicalId":22465,"journal":{"name":"The Egyptian Journal of Internal Medicine","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135152311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of metformin on fibroblast growth factor 21 in patients with type 2 diabetes mellitus: faraway but so close 二甲双胍对2型糖尿病患者成纤维细胞生长因子21的影响:远而近

The Egyptian Journal of Internal Medicine Pub Date : 2023-09-13 DOI: 10.1186/s43162-023-00238-9

Hayder M. Al-kuraishy, Ali I. Al-Gareeb, Majid S. Jabir, Salim Albukhaty

{"title":"Effects of metformin on fibroblast growth factor 21 in patients with type 2 diabetes mellitus: faraway but so close","authors":"Hayder M. Al-kuraishy, Ali I. Al-Gareeb, Majid S. Jabir, Salim Albukhaty","doi":"10.1186/s43162-023-00238-9","DOIUrl":"https://doi.org/10.1186/s43162-023-00238-9","url":null,"abstract":"Abstract Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by insulin resistance (IR) and hyperglycemia. The development of inflammatory disorders in T2DM triggers the activation of different growth factors as a compensatory mechanism to reduce IR and adipose tissue dysfunction in T2DM. Fibroblast growth factor 21 (FGF21) which is involved in the regulation of glucose homeostasis is attractive to be a novel therapeutic target in the management of T2DM. FGF21 has poor pharmacokinetic profile as it rapidly degraded; therefore, FGF21 analogs which are more stable can be used in T2DM patients. However, FGF21 analogs are tested pre-clinically but not approved in clinical settings. Therefore, searching for anti-diabetic agents who enhance FGF21 expression is mandatory. It has been shown that metformin which used as a first-line in the management of T2DM can positively affect the expression of FGF21, though the underlying mechanisms for metformin-induced FGF21 expression are not fully elucidated. Therefore, this review from published studies aimed to find how metformin improves insulin sensitivity through FGF21-dependent pathway in T2DM. In conclusion, metformin improves FGF21 signaling in T2DM, and this could be a novel mechanism for metformin in the amelioration of glucose homeostasis and metabolic disorders in T2DM patients.","PeriodicalId":22465,"journal":{"name":"The Egyptian Journal of Internal Medicine","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135735859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The utility of estimation of glomerular filtration rate by serum cystatin C as a predictor of diabetic kidney disease in both type I and type II diabetic patients: a single center study 通过血清胱抑素C估计肾小球滤过率作为1型和2型糖尿病患者糖尿病肾病预测因子的效用:一项单中心研究

The Egyptian Journal of Internal Medicine Pub Date : 2023-09-11 DOI: 10.1186/s43162-023-00243-y

Ahmed E. Mansour, Rasha O. Abdelmoniem, Ayman M. Elbadawy, Walaa M. Ibrahim

{"title":"The utility of estimation of glomerular filtration rate by serum cystatin C as a predictor of diabetic kidney disease in both type I and type II diabetic patients: a single center study","authors":"Ahmed E. Mansour, Rasha O. Abdelmoniem, Ayman M. Elbadawy, Walaa M. Ibrahim","doi":"10.1186/s43162-023-00243-y","DOIUrl":"https://doi.org/10.1186/s43162-023-00243-y","url":null,"abstract":"Abstract Background Diabetic kidney disease is a major microvascular complication of diabetes mellitus and is the leading cause of end-stage renal disease all over the world. The general recommendation for the subjects with DM is to perform kidney function as screening: in T1DM, 5 years after diagnosis, and in type 2, at the time of diagnosis. The early diagnosis of diabetic kidney disease depends on the albumin excretion ratio; however, the albumin excretion ratio (AER) does not correlate with the severity and progression of the disease. Methods The subjects in this study included thirty patients with type 1 diabetes mellitus and thirty patients with type 2 diabetes mellitus who were recruited from the outpatient clinic and inpatient in the Internal Medicine Department at Benha University Hospitals in the endocrinology unit from January 2022 to January 2023 as cases who were subground according to albuminuria into two groups (normoalbuminuria less than 30 mg/24 h urinary collection) and albuminuric group more than 30 mg/24 h urinary collection; all patients were subjected to thorough history including baseline characteristics, examination, and related laboratory investigations. Results Serum cystatin C level at a cutoff value of 82 was associated with sensitivity (81.4) and specificity (82.4), and it was negatively significantly correlated with BMI, duration of diabetes mellitus, albuminuria, blood urea, and serum creatinine, and it was positively significantly correlated with e-GFR creatinine. Conclusion Serum cystatin C can be used as an early marker of diabetic kidney disease in both type I and type II diabetic patients better than AER and serum creatinine.","PeriodicalId":22465,"journal":{"name":"The Egyptian Journal of Internal Medicine","volume":"51 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135979641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Meningococcal meningitis, a life-threatening disease with a dangerous skin rash: two case reports 脑膜炎球菌性脑膜炎，一种危及生命的疾病，伴有危险的皮疹:两例报告

The Egyptian Journal of Internal Medicine Pub Date : 2023-09-11 DOI: 10.1186/s43162-023-00249-6

Hamdy Ibrahim, Safwat Abdel Maksod, Magdy Khorshed, Ahmed Alsisi, Nasser Fouad, Hanan Rady, Alaaa Al Amir, Adel Mohamed, Mohamed Hosny

引用次数: 0

Uncovering the link between celiac disease and hypopituitarism: a case report and review of literature 揭示乳糜泻与垂体功能减退之间的联系：一例报告和文献综述

The Egyptian Journal of Internal Medicine Pub Date : 2023-08-29 DOI: 10.1186/s43162-023-00246-9

Hameed Haidar Khan, Imran Ullah, Javeria Rufaq, Qaiser Wadood, Imad Majeed, Salman Khan

引用次数: 0

Paraspinal myositis in a patient with COVID-19 infection: a case report COVID-19感染患者脊柱旁肌炎1例报告

The Egyptian Journal of Internal Medicine Pub Date : 2023-08-28 DOI: 10.1186/s43162-023-00248-7

W. Pangkanon, N. Leelaviwat, S. Saowapa, En-Dien Liao, J. Payne

引用次数: 0

Agranulocytosis: a rare complication of the thionamides 粒细胞缺乏症:一种罕见的并发症的硫胺

The Egyptian Journal of Internal Medicine Pub Date : 2023-08-18 DOI: 10.1186/s43162-023-00245-w

H. El-Shareif

引用次数: 0

Evaluating the relation between serum apolipoprotein B (apo B), apolipoprotein A (apo A) and apo B/apo A ratio with diabetic retinopathy in a sample of type 2 Egyptian diabetic patient 评价2型埃及糖尿病患者血清载脂蛋白B (apo B)、载脂蛋白A (apo A)和载脂蛋白B/载脂蛋白A比值与糖尿病视网膜病变的关系

The Egyptian Journal of Internal Medicine Pub Date : 2023-08-18 DOI: 10.1186/s43162-023-00241-0

S. Hosny, M. Nasr, Moataz M. W. Abd Elfattah, Samar Helmy Abdel Dayem, R. Ibrahim

引用次数: 0

A step in the right direction: exploring the effects of aerobic exercise on HbA1c reduction 朝着正确的方向迈出了一步:探索有氧运动对降低HbA1c的影响

The Egyptian Journal of Internal Medicine Pub Date : 2023-08-17 DOI: 10.1186/s43162-023-00247-8

Bhupinder Singh, Yogitha Chowdary Koneru, Holden Zimmerman, Sai Gautham Kanagala, Indigo Milne, Anirudh Sethi, Rohit Jain

引用次数: 0

Characterization, treatment preferences, and outcomes of 390 Egyptian Graves’ disease patients: a retrospective study 390名埃及Graves病患者的特征、治疗选择和结局:一项回顾性研究

The Egyptian Journal of Internal Medicine Pub Date : 2023-08-12 DOI: 10.1186/s43162-023-00244-x

T. Elsherbiny

引用次数: 0