Jurnal Ilmiah Farmako Bahari最新文献

EVALUASI PENGGUNAAN OBAT ARB DAN DIURETIK PADA PASIEN RAWAT INAP DENGAN DIAGNOSIS GAGAL JANTUNG DI RUMAH SAKIT KECAMATAN BALEENDAH PROVINSI JAWA BARAT 对西爪哇省巴伦达地区医院确诊为心力衰竭的住院病人使用arb和利尿药的评估

Jurnal Ilmiah Farmako Bahari Pub Date : 2024-01-31 DOI: 10.52434/jifb.v15i1.2544

Vina Septiani, Eni Margayani, Linda P Suherman, Meira Meicareena

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UJI EVALUASI FISIK DAN AKTIVITAS ANTI JAMUR SEDIAAN OVULA EKSTRAK BAWANG PUTIH TERHADAP CANDIDA ALBICANS 大蒜提取物胚珠制剂对白色念珠菌的物理评估试验和抗真菌活性

Jurnal Ilmiah Farmako Bahari Pub Date : 2024-01-31 DOI: 10.52434/jifb.v15i1.2671

Lusi Nurdianti, Aidil Adhani, Taufik Hidayat, FajarDedy Setiawan, Ade Yeni Aprillia, Lilis Tuslinah, Ardianes Firmansya

{"title":"UJI EVALUASI FISIK DAN AKTIVITAS ANTI JAMUR SEDIAAN OVULA EKSTRAK BAWANG PUTIH TERHADAP CANDIDA ALBICANS","authors":"Lusi Nurdianti, Aidil Adhani, Taufik Hidayat, FajarDedy Setiawan, Ade Yeni Aprillia, Lilis Tuslinah, Ardianes Firmansya","doi":"10.52434/jifb.v15i1.2671","DOIUrl":"https://doi.org/10.52434/jifb.v15i1.2671","url":null,"abstract":"Kandidiasis vulvovagina merupakan penyakit umum di kalangan wanita yang membutuhkan penanganan cepat. Kandidiasis vagina dapat diakibatkan oleh infeksi jamur, terutama Candida albicans menyebabkan gejala seperti gatal-gatal, keputihan, kemerahan vagina, dan ketidaknyamanan saat berhubungan seksual serta buang air kecil. Bawang putih (Allium sativum L.), khususnya senyawa allicin memiliki potensi sebagai antibakteri dan antijamur. Selain itu, bawang putih juga mengandung saponin dan flavonoid. Penelitian ini bertujuan untuk mengevaluasi potensi ekstrak etanol Allium sativum L sebagai antijamur terhadap Candida albicans dan untuk mengembangkan sediaan ovula berbasis gelatin dengan konsentrasi ekstrak 20%, 25%, dan 30%. Pengujian daya hambat ovula ekstrak Allium sativum L dilakukan dengan metode sumuran menggunakan Cylinder cup. Hasil penelitian menunjukkan bahwa ovula ekstrak Allium sativum L dengan konsentrasi 20%, 25%, dan 30% memiliki daya hambat rata-rata masing-masing 6,1±0,290 mm, 8,06±0,750 mm dan 11,33±0,460 mm. Analisis ANOVA dilanjutkan dengan uji Least Significant Difference (LSD) menunjukkan perbedaan signifikan dalam kemampuan ovula menghambat pertumbuhan Candida albicans. Oleh karena itu, disimpulkan bahwa ovula ekstrak Allium sativum L memiliki potensi sebagai antijamur yang efektif.","PeriodicalId":197039,"journal":{"name":"Jurnal Ilmiah Farmako Bahari","volume":"216 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140473612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Jurnal Ilmiah Farmako Bahari Pub Date : 2024-01-31 DOI: 10.52434/jifb.v15i1.3243

Rickha Octavia, Seftika Sari, Fitriatun Nisa'

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PRODUKSI ASAM LAKTAT OLEH LACTOBACILLUS ACIDOPHILUS DALAM MEDIA FERMENTASI KOMBINASI LIMBAH CAIR TAHU DAN MANGGA (Mangifera indica l.) 驴粪和芒果（Mangifera indica l.）废弃物混合发酵培养基中的乳酸杆菌（LACTOBACILLUS ACIDOPHILUS）产生乳酸的情况

Jurnal Ilmiah Farmako Bahari Pub Date : 2024-01-31 DOI: 10.52434/jifb.v15i1.2918

Mellova Amir, Neng Sopiatunnisa, Inherni Marti Abna

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REVIEW OF THE PHYTOTHERAPY FOR NEPHROLITHIASIS 肾炎植物疗法综述

Jurnal Ilmiah Farmako Bahari Pub Date : 2024-01-31 DOI: 10.52434/jifb.v15i1.2877

Hanna Salwa Ridwan, S. Megantara, J. Levita

{"title":"REVIEW OF THE PHYTOTHERAPY FOR NEPHROLITHIASIS","authors":"Hanna Salwa Ridwan, S. Megantara, J. Levita","doi":"10.52434/jifb.v15i1.2877","DOIUrl":"https://doi.org/10.52434/jifb.v15i1.2877","url":null,"abstract":"Nephrolithiasis (kidney stone) cases have a prevalence ranging from 1% to 13%. The disease not only hampers kidney function but also elevates the risk of chronic kidney diseases. The pathophysiology of nephrolithiasis is closely linked to elevated concentrations of calcium, oxalate, and/or uric acid in the urine. Pharmacotherapy to manage nephrolithiasis includes thiazide diuretics, allopurinol, citrate supplements, and alpha-blockers that have been prescribed to relieve symptoms. In addition, there is growing interest in exploring the potential of phytotherapy. This review aims to identify suitable phytotherapy approaches by examining relevant articles on nephrolithiasis. The research methodology involved searching PubMed articles using the keywords of ((\"Plant Extracts\") AND (\"Nephrolithiasis\")) OR (\"Ureterolithiasis\"). The articles obtained from the initial search were n =123. 2 authors screened articles for their eligibility. The inclusion criteria were limited to articles written in English, topics related to nephrolithiasis and not other kidney diseases, the botanical names of the plants and the method of extraction are clearly described, complete studies with clear descriptions regarding the methods and results, not synthetic drugs, and not involving medical instruments or laser to remove the stones. Articles included in the review were n = 17. Water and hydro-alcohol were the solvents used to extract the plants. Twenty-two plants have confirmed their anti-nephrolithiasis activity, and nine articles described the assay by in vivo study, two by in vitro study, three by both in vitro and in vivo study, and only one article mentioned a study in humans by a randomized-control trial on a mixture of herbs. It is concluded that Rhizoma alismatis, Poria cocos, Polyporus umbellatus, Atractylodis macrocephalae, and Cinnamomi Cassiae prepared as a mixture in the Wu-Ling-San formula have a potential therapeutic effect on nephrolithiasis, as this formula has been studied in humans.","PeriodicalId":197039,"journal":{"name":"Jurnal Ilmiah Farmako Bahari","volume":"88 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140477511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ANTI-ACNE FACIAL WASH FORMULATION FROM RED BETEL LEAF EXTRACT (PIPER CROCATUM RUIZ & PAV) 红槟榔叶提取物（Piper Crocatum ruiz & pav）抗痤疮洗面奶配方

Jurnal Ilmiah Farmako Bahari Pub Date : 2024-01-31 DOI: 10.52434/jifb.v15i1.3259

Siti Hindun, A. M. Gazzali, A. Najihudin, Siva Hamdani, Nopi Rantika, Winanda Nur Azizah

{"title":"ANTI-ACNE FACIAL WASH FORMULATION FROM RED BETEL LEAF EXTRACT (PIPER CROCATUM RUIZ & PAV)","authors":"Siti Hindun, A. M. Gazzali, A. Najihudin, Siva Hamdani, Nopi Rantika, Winanda Nur Azizah","doi":"10.52434/jifb.v15i1.3259","DOIUrl":"https://doi.org/10.52434/jifb.v15i1.3259","url":null,"abstract":"Acne can be caused by dust, sweat, and dirt that stick to the skin, forming blackheads. When blackheads become infected with bacteria, inflammation can occur. Therefore, it is essential to maintain good skin hygiene. One way to do this is by using natural ingredients with antibacterial properties. Red betel leaf is known to have antibacterial activity. This study aims to create a facial wash using red betel leaf extract that exhibits antibacterial properties against Propionibacterium acnes. The red betel leaf was extracted using the maceration method. Antibacterial testing was conducted against Propionibacterium acnes bacteria using the suitable diffusion method with a combination of red betel leaf extract at 10%, 15%, and 20%. The study found that facial wash products containing extract concentrations of 10%, 15%, and 20% demonstrated good physical stability, meeting the requirements of SNI-19-4380-1996 for pH, viscosity, specific gravity, and foam height. Additionally, the products showed potent antibacterial activity against Propionibacterium acnes bacteria, with inhibition zones of 29.0 mm, 32.6 mm, and 35.3 mm for the 10%, 15%, and 20% concentrations, respectively.","PeriodicalId":197039,"journal":{"name":"Jurnal Ilmiah Farmako Bahari","volume":"75 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140477207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

SYNTHESIS OF TETRACYCLINE IMPRINTED POLYMERS WITH METHACRYLIC ACID AS FUNCTIONAL MONOMER IN METHANOL-CHLOROFORM MIXTURE USING BULK AND PRECIPITATION POLYMERIZATION METHOD 在甲醇-氯仿混合物中，采用体积聚合法和沉淀聚合法合成以甲基丙烯酸为功能单体的四环素印迹聚合物

Jurnal Ilmiah Farmako Bahari Pub Date : 2024-01-31 DOI: 10.52434/jifb.v15i1.2790

Shendi Suryana, Kharisma Devy Shabrina, Dang Soni

{"title":"SYNTHESIS OF TETRACYCLINE IMPRINTED POLYMERS WITH METHACRYLIC ACID AS FUNCTIONAL MONOMER IN METHANOL-CHLOROFORM MIXTURE USING BULK AND PRECIPITATION POLYMERIZATION METHOD","authors":"Shendi Suryana, Kharisma Devy Shabrina, Dang Soni","doi":"10.52434/jifb.v15i1.2790","DOIUrl":"https://doi.org/10.52434/jifb.v15i1.2790","url":null,"abstract":"The content of tetracycline residues in poultry meat products can cause antibiotic resistance in humans who consume these products, so it is necessary to develop sensitive analytical techniques to determine the levels of tetracycline residues to assess the safety of these products for consumption. The molecular imprinting technique is a method to produce sorbents with molecular recognition capability of target compounds that can be used to increase the selectivity of solid phase extraction to extract tetracycline residues for further analysis. This study aimed to obtain a sorbent synthesized by molecular imprinting technique to analyze tetracycline in poultry meat products. The stages of the research began with the study of the interaction of functional monomers with template molecules, determining the association constants of functional monomers with template molecules, synthesis of imprinted polymer molecules using bulk and precipitation methods, evaluating the ability and adsorption capacity of the synthesized polymers, assess the selectivity of polymers for analog structures and physical characteristics with FTIR. The research showed that methacrylic acid was the best functional monomer with a binding energy value of -27.3776 kcal/mol. The higher adsorption capacity was achieved by Molecularly Imprinted Polymer (MIP) that was synthesized by precipitation method (MIP2) than the other MIP synthesized by bulk polymerization (MIP1) with a value of 0.8748 mg/g and 0.4077 mg/g, respectively. The analogous compounds' imprinting factor values for each MIP were 1.197 and 1.1272. The polymer synthesized by molecular imprinting technique is selective for extracting and analyzing tetracycline from poultry meat matrix.","PeriodicalId":197039,"journal":{"name":"Jurnal Ilmiah Farmako Bahari","volume":"254 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140475877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

PENINGKATAN KELARUTAN DAN LAJU DISOLUSI GLIKLAZID DENGAN POLIMER SILIKA MIKROSFER (SM) 用聚合二氧化硅微球（SM）提高甘氨喹的溶解度和溶解速率

Jurnal Ilmiah Farmako Bahari Pub Date : 2024-01-31 DOI: 10.52434/jifb.v15i1.3109

Aris Purwanto, Mustika Muthaharah, Andika Andika

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FUCOIDAN NANOENCAPSULATION FROM BROWN ALGAE (Sargassum polycystum) AS A POTENTIAL MARINE IMMUNOMODULATORY AGENT 从褐藻（多囊马尾藻）中提取的 FUCOIDAN 纳米胶囊可作为一种潜在的海洋免疫活性剂

Jurnal Ilmiah Farmako Bahari Pub Date : 2024-01-31 DOI: 10.52434/jifb.v15i1.3207

U. Purwanto, Endang Diyah Ikasari, I. Bagiana, Lia Kusmita, Ni Nyoman Ayu Indah Trisnayanthi, I. W. Mudianta, Rahmadi Prasetijo

{"title":"FUCOIDAN NANOENCAPSULATION FROM BROWN ALGAE (Sargassum polycystum) AS A POTENTIAL MARINE IMMUNOMODULATORY AGENT","authors":"U. Purwanto, Endang Diyah Ikasari, I. Bagiana, Lia Kusmita, Ni Nyoman Ayu Indah Trisnayanthi, I. W. Mudianta, Rahmadi Prasetijo","doi":"10.52434/jifb.v15i1.3207","DOIUrl":"https://doi.org/10.52434/jifb.v15i1.3207","url":null,"abstract":"The quest for better and more effective treatments has encouraged the search for therapies derived from natural sources to obtain effective immune therapy, considering that several pandemics have arisen caused by viruses. Developing fucoidan from brown algae in drug encapsulation as an immunomodulator could be more promising. This study aimed to produce nanoencapsulation loaded with fucoidan-purified extract from brown algae and to evaluate the influence of nanoencapsulation formulation on the immunomodulatory activity of fucoidan. Fucoidan was obtained from brown algae and extracted by hot aqueous, followed by ethanol purification. Nanoencapsulation of fucoidan purified extract was prepared using the ionic gelation method. The carbon clearance method was carried out for the immunomodulatory activity test of the nanoencapsulation of fucoidan purified extract. Nanoencapsulation of fucoidan purified extract with the optimum composition of maltodextrin 9.9% and S-TPP 0.1% (1:5) resulted in particle size of 715.4 nm, zeta potential -0.1 mV, pH 7.54, transmittance 97.54%+0.08, and entrapment efficiency 89.94%+0.17. The carbon clearance test showed that the nanoencapsulation of fucoidan was a strong immunostimulant with a phagocytosis index of 1.65. The development of nanoencapsulation could increase the phagocytosis index of fucoidan purified extracts from brown algae. Further molecular studies are needed to demonstrate the molecular activity of this preparation as an immunomodulator.","PeriodicalId":197039,"journal":{"name":"Jurnal Ilmiah Farmako Bahari","volume":"874 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140474173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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ANALISIS KADAR EUGENOL DAUN CENGKEH (Syzigium aromaticum) HASIL DESTILASI UAP AIR MENGGUNAKAN METODE KROMATOGRAFI GAS-SPEKTROMETRI MASSA 分析水蒸气用色谱谱法解构了多少次

Jurnal Ilmiah Farmako Bahari Pub Date : 2023-07-31 DOI: 10.52434/jifb.v14i2.2629

Lilis Tuslinah, Ade Yeni Aprilia, Lusi Nurdianti, I. Indra, Devita Septiani

{"title":"ANALISIS KADAR EUGENOL DAUN CENGKEH (Syzigium aromaticum) HASIL DESTILASI UAP AIR MENGGUNAKAN METODE KROMATOGRAFI GAS-SPEKTROMETRI MASSA","authors":"Lilis Tuslinah, Ade Yeni Aprilia, Lusi Nurdianti, I. Indra, Devita Septiani","doi":"10.52434/jifb.v14i2.2629","DOIUrl":"https://doi.org/10.52434/jifb.v14i2.2629","url":null,"abstract":"Pemanfaatan daun cengkeh belum digunakan secara optimal karena pada daun cengkeh mengandung Eugenol, senyawa ini yang memiliki efek farmakologis bagi kesehatan. Penelitian ini bertujuan untuk mengetahui perbedaan kandungan eugenol dari daun muda dan daun tua cengkeh (Syzigium aromaticum) dengan menggunakan metode GC-MS. Pengambilan minyak atsiri daun muda dan daun tua cengkeh dilakukan dengan menggunakan destilasi uap air. Rendemen minyak atsiri pada daun muda menghasilkan 0,575% dan daun tua menghasilkan 0,625%. Kadar senyawa eugenol pada daun muda 79,98% sedangkan pada daun tua 84,86% dan kadar senyawa caryophyllene pada daun muda 14,18% dan pada daun tua 13,18% . Uji mutu minyak atsiri pada pemeriksaan organoleptik daun muda dan daun tua berwarna kuning dan bau khas cengkeh, kelarutan minyak atsiri dalam etanol 70% dengan perbandingan 1:2, nilai indeks bias daun muda dan daun tua memiliki nilai yang sama yaitu 1,534. Bobot jenisminyak pada daun muda 1,037 g/mL sedangkan daun tua 1,035 g/mL. Uji Kualitas mutu minyak atsiri pada daun muda dan daun tua cengkeh (Syzigium aromaticum) telah memenuhi syarat SNI 06-2387-2006.","PeriodicalId":197039,"journal":{"name":"Jurnal Ilmiah Farmako Bahari","volume":"47 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131396026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0