Medical biology最新文献_第4页

Serum prolactin levels after buspirone in man. 丁螺环酮后血清催乳素水平。

Medical biology Pub Date : 1987-01-01

T Seppälä, T Ranta, R C Shrotriya

引用次数: 0

Neuroanatomy of morphine-modulating peptides. 吗啡调节肽的神经解剖学。

Medical biology Pub Date : 1987-01-01

P Panula, L Kivipelto, O Nieminen, E A Majane, H Y Yang

引用次数: 0

Deamination rates of 1-beta-D-arabinofuranosylcytosine, deoxycytidine and 5-methyl-2'-deoxycytidine in seven hematopoietic cell lines. 7种造血细胞系中1- β -d -阿拉伯糖醛基胞嘧啶、脱氧胞苷和5-甲基-2'-脱氧胞苷的脱胺率。

Medical biology Pub Date : 1987-01-01

A Jekunen

引用次数: 0

Growth inhibitory polypeptides in the regulation of cell proliferation. 生长抑制多肽对细胞增殖的调控作用。

Medical biology Pub Date : 1987-01-01

J Keski-Oja, H L Moses

引用次数: 0

Monoaminergic mechanisms in affective disorders. 情感性障碍的单胺能机制。

Medical biology Pub Date : 1987-01-01

E Syvälahti

{"title":"Monoaminergic mechanisms in affective disorders.","authors":"E Syvälahti","doi":"","DOIUrl":"","url":null,"abstract":"The monoamine hypothesis of depression originally proposed that depression is caused by a central deficiency of biogenic amines, and antidepressants were considered to work by correcting this deficiency. In the course of time, many studies have analysed monoamine metabolites in the urine, plasma and cerebrospinal fluid of patients and healthy controls under different conditions to test the hypothesis. These studies have failed to identify a robust metabolic disorder in depressive patients as a group. Certain subgroups of depressed patients have shown deviations in biogenic amine metabolism, the most consistent being reduced levels of the major serotonin and dopamine metabolites in the cerebrospinal fluid. Noradrenaline metabolism is influenced by the activity of the sympathetic nervous system, and thus increases in anxious patients regardless of their clinical diagnosis. On the other hand, development of new antidepressants and advances in receptor techniques, together with modern electrophysiologic and behavioural studies have given increasing support to a receptor supersensitivity hypothesis of depression, based on the evidence that antidepressants lead to subsensitivity or down regulation of beta-adrenoceptors, and adaptive changes may occur also in other receptor systems after two three weeks of antidepressant treatment. There is also growing evidence on the manifold interplay of noradrenergic and serotonergic systems in the mechanism of actions of effective antidepressant treatments, including the new and more selective therapeutic compounds. The rapidly increasing knowledge of the neurotransmitter receptors as well as of the relations between the different regulatory systems may lead to more specific intervention strategies in efforts to correct the biological malfunction in the heterogeneous collection of diseases classified as affective disorders.","PeriodicalId":18313,"journal":{"name":"Medical biology","volume":"65 2-3","pages":"89-96"},"PeriodicalIF":0.0,"publicationDate":"1987-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14025008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Calcium entry blocking drugs: their classification and sites of action in smooth muscle cells. 钙进入阻断药物的分类及其在平滑肌细胞中的作用部位。

Medical biology Pub Date : 1987-01-01

D Raeburn

引用次数: 0

Immunobiology of acute graft-versus-host disease. 急性移植物抗宿主病的免疫生物学。

Medical biology Pub Date : 1987-01-01

R Renkonen

引用次数: 0

Regulation of oxidative metabolism by interferon-gamma during human monocyte to macrophage differentiation. 干扰素- γ对单核细胞向巨噬细胞分化过程中氧化代谢的调节作用。

Medical biology Pub Date : 1987-01-01

E Karhumäki, H Helin

{"title":"Regulation of oxidative metabolism by interferon-gamma during human monocyte to macrophage differentiation.","authors":"E Karhumäki, H Helin","doi":"","DOIUrl":"","url":null,"abstract":"The capacity of human peripheral blood monocytes to generate highly reactive oxygen-derived molecules was studied during differentiation of the cells to macrophages in vitro. The effect of semipurified native interferon gamma (IFN gamma) on the differentiation-associated production of active oxygen intermediates was assessed by continuous exposure of the cells to IFN gamma or by adding it to the cultures at different stages of in vitro differentiation. Chemiluminescence (CL) response, triggered by opsonised zymosan, was highest in fresh isolated monocytes and fell constantly during a two-week culture. IFN gamma had little effect on CL. Generation of intracellular O2- was determined by the reduction of nitroblue tetrazolium (NBT). Zymosan-induced NBT reduction increased slightly during monocyte to macrophage differentiation and was further enhanced by continuous presence of IFN gamma. Hydrogen peroxide (H2O2) release, triggered by phorbol myristate acetate (PMA), was low in monocytes, increased slightly, reaching a maximum on day 3, and declined thereafter. H2O2 secretion was greatly enhanced by the presence of IFN gamma and remained raised for at least 14 d. When added at intervals to spontaneously matured monocytes, IFN gamma had only modest and transient effects on the generation of intracellular O2- and H2O2. It is concluded that IFN gamma seems so to modulate human mononuclear phagocyte differentiation that they maintain or increase their oxidative metabolic capacity.","PeriodicalId":18313,"journal":{"name":"Medical biology","volume":"65 5-6","pages":"261-6"},"PeriodicalIF":0.0,"publicationDate":"1987-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13975211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tyrosine kinases in control of cell growth and transformation. 酪氨酸激酶控制细胞生长和转化。

Medical biology Pub Date : 1986-01-01

T P Mäkelä, K Alitalo

引用次数: 0

Evidence for the involvement of alpha-2 adrenoceptors in the sedation but not REM sleep inhibition by clonidine in the rat. 有证据表明-2肾上腺素受体参与了可乐定对大鼠的镇静作用而非快速眼动睡眠抑制作用。

Medical biology Pub Date : 1986-01-01

J P Mäkelä, I T Hilakivi

{"title":"Evidence for the involvement of alpha-2 adrenoceptors in the sedation but not REM sleep inhibition by clonidine in the rat.","authors":"J P Mäkelä, I T Hilakivi","doi":"","DOIUrl":"","url":null,"abstract":"Rats with implanted electrodes for recording of EEG and EMG underwent 12-h recordings during the light period starting after i.p. injections of clonidine (0.1 mg/kg) alone or in combination with different alpha-adrenoceptor antagonists. Clonidine increased the proportion of time the rats spent in the drowsy stage of wakefulness which corresponds to behavioural sedation and inhibited both deep slow wave sleep and REM sleep for 6-9 hours. The amount of active wakefulness or light slow wave sleep were unaffected by clonidine. Yohimbine (1 mg/kg) reversed the increase in drowsy wakefulness by clonidine and increased active wakefulness without affecting sleep. Phentolamine (10 mg/kg) was ineffective against clonidine. Phenoxybenzamine (20 mg/kg) accentuated the sedative effect and prolonged the REM sleep inhibiting effect of clonidine. Prazosin (3 mg/kg) prolonged both the drowsy stage inducing and deep slow wave plus REM sleep inhibiting effects of clonidine. These electrophysiological results support the view that the sedative effect of clonidine in the rat is mediated by alpha-2 adrenoceptors, whereas in this species other mechanisms, possibly another population of alpha-2 receptors, may be involved in the clonidine-induced suppression of deep slow wave sleep and REM sleep.","PeriodicalId":18313,"journal":{"name":"Medical biology","volume":"64 6","pages":"355-60"},"PeriodicalIF":0.0,"publicationDate":"1986-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14162508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0