Bulletin "Biomedicine and sociology"最新文献

{"title":"NOVEL HYDROXYPYRIDINE DERIVATIVE PROTECTS NEURONS AGAINST ISCHEIC DAMAGE","authors":"Turmulaeva R.M., Belanov K.I., Bunyatyan N.D., Eliseikina E.A., Vasilkina O.V., Timoshkin D.E., Zamyshlyaev P.S., B. E.V.","doi":"10.26787/nydha-2618-8783-2022-7-4-73-78","DOIUrl":"https://doi.org/10.26787/nydha-2618-8783-2022-7-4-73-78","url":null,"abstract":"In this work, the cytoprotective effect of the original substance 3-hydroxypyridine ascorbate (3-EA) was studied. Cells for mixed cortical neuroglial culture were isolated from the brain (GM) of neonatal NMRI mice. The cell density in culture was adjusted to 15000 cells per 1 cm2. For experiments, 10-day-old cultures were used. To register the intracellular concentration of calcium ions ([Ca2+]i), cells were loaded with an intracellular fluorescent probe Fura-2AM dissolved in Hanks solution at a concentration of 4 μM, followed by 40-minute incubation at a temperature of 370C. Cells were washed three times before the experiment. Potassium chloride was applied to identify neurons, and short-term addition of ATP to the medium was used to detect glial cells (astrocytes). Cell cultures of the mouse cerebral cortex were preincubated for 24 hours with various concentrations (10, 50 and 100 μM) of 3-EA. The amplitude and shape of calcium responses were determined under conditions of oxygen-glucose deprivation (oxygen-glucose deprivation, OGD) and glutamatergic excitotoxicity (GluTox). Using fluorescence microscopy, cell viability tests, and PCR analysis, 3-EA has been shown to dose-dependently inhibit cortical cell death under glutamate excitotoxicity and ischemia/reoxygenation. Preincubation of cerebral cortex cells with 3-EA in the concentration range of 10–100 μM leads to a significant inhibition of the increase in Ca2+ ions in the cytosol ([Ca2+]i) of neurons and astrocytes in modeling glutamate excitotoxicity (GluTox) and oxygen-glucose deprivation (OGD). Decreasing [Ca2+]i and establishing a lower baseline [Ca2+]i inhibits necrotic cell death in an acute experiment.","PeriodicalId":161741,"journal":{"name":"Bulletin \"Biomedicine and sociology\"","volume":"35 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122653121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"THE EFFECT OF METABOLIC AND IMMUNOCORRECTIVE THERAPY ON THE DYNAMICS OF IMPAIRED INDICATORS OF NEUROLOGICAL AND MENTAL FUNCTIONS IN CHRONIC OCCUPATIONAL MERCURY INTOXICATION IN A CONTINGENT OF DISABLED PEOPLE AGED 18 YEARS AND OLDER","authors":"Kolmykova N.A., Boynova I.V., Kiryukhina S.V., Ignatieva O.I., Labunskiy D.A., Podsevatkin V.G.","doi":"10.26787/nydha-2618-8783-2022-7-4-91-99","DOIUrl":"https://doi.org/10.26787/nydha-2618-8783-2022-7-4-91-99","url":null,"abstract":"The use of drugs with antioxidant and antihypoxant activity in combination with immunocorrectors for chronic occupational mercury intoxication in a contingent of disabled people aged 18 years and older makes it possible to increase the effectiveness of medical rehabilitation of this contingent. The developed treatment regimens affect the main links of pathogenetic tissue damage by mercury vapor. In order to increase the objectivity of the results of the study, the predominant neurological disorders occurring in the lower extremities must be diagnosed on a complex computer-dynamic complex \"ZEBRIS\" with the function of a diagnostic track with a power platform, which allows to identify the degree of distribution of force and pressure of the feet when walking, violations of static support capacity on a moving platform. We have analyzed statistical data on disability due to exposure to chronic mercury intoxication for the period 2019- 2021 in the Republic of Mordovia. Risk groups have been identified according to the degree of loss of professional ability to work, depending on age, duration of work in mercury production, concomitant diseases. Contingents of disabled people with impaired mental and statodynamic functions were identified. Groups of disabled people in need of medical and social rehabilitation measures have been identified.","PeriodicalId":161741,"journal":{"name":"Bulletin \"Biomedicine and sociology\"","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125363933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CHARACTERISTICS OF DEMOGRAPHIC PROCESSES IN THE PRE-ARCTIC GROUPS OF THE EUROPEAN NORTH","authors":"Sannikov A.L., Mustafin R.A., Mustafina V.A., Kubasov R.V., Lukashov A.G.","doi":"10.26787/nydha-2618-8783-2022-7-4-39-44","DOIUrl":"https://doi.org/10.26787/nydha-2618-8783-2022-7-4-39-44","url":null,"abstract":"Relevance: conducting a comparative analysis of demographic processes in two Arctic regions of the European North of Russia makes it possible to determine the main directions for improving the demographic policy of the territories. The aim of the study is to analyze mortality rates in the Komi Republic and the Arkhangelsk Region to assess demographic prospects in these regions. Materials and methods: the main demographic indicators that form the population decline in the Arkhangelsk region and the Komi Republic over the past 20 years were analyzed. A comparative study was conducted between them, as well as with the average statistical values in the Russian Federation. The main source of information was the website of the database of the Federal State Statistics Service. Results and discussion. Fluctuations in demographic indices in the Komi Republic and the Arkhangelsk Region as a whole have a similar trend and a common nature. Population losses in the Arctic territories of the country – the Arkhangelsk region and the Komi Republic as a whole are higher than the average for the Russian Federation. The greatest losses in these regions are formed due to high mortality from cardiovascular diseases in people of working age. Among the external causes of mortality, attention is drawn to the high suicide rate, which exceeds the national average in the Arkhangelsk region by 2.36 times, in the Komi Republic by 2.2 times. The deterioration in the level and structure of mortality in one region compared to another can be interpreted as a change in the quality of medical care during the period of negative changes associated with the COVID-19 pandemic. The analysis of the main demographic indicators in dynamics and in specific territorial entities makes it possible to identify possible predictors, causes of fluctuations in different time periods, the duration of responses to specific challenges and incentives.","PeriodicalId":161741,"journal":{"name":"Bulletin \"Biomedicine and sociology\"","volume":"36 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128406782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CHOICE OF A RECONSTRUCTION METHOD FOR POSITRON-EMISSION ECG-GATED STUDIES AND ITS EFFECT ON CALCULATED VOLUMETRIC PARAMETERS OF THE LEFT VENTRICULAR FUNCTION AND VISUAL IMAGE QUALITY","authors":"Mosin D.Yu., Kondakov A.K., Moshkova E.N., Kharina D.S., Khasanboev S.G., Znamenskiy I.A., Butenko A.V.","doi":"10.26787/nydha-2618-8783-2022-7-4-59-66","DOIUrl":"https://doi.org/10.26787/nydha-2618-8783-2022-7-4-59-66","url":null,"abstract":"Ischemic heart disease is one of the leading causes of mortality in the Russian Federation. Timely diagnosis of this condition allows you to determine the optimal treatment tactics. Positron emission tomography with 18-fluorodeoxyglucose is a method for verifying viable cardiac tissue in patients with myocardial infarction. The methods used for the reconstruction of positron emission tomograms can affect the quantitative indicators of the contractile function of the myocardium.\u0000Materials and methods. The study retrospectively included 12 patients who underwent PET/CT with 18-fluorodeoxyglucose, the results of which were reconstructed using filtered back projection methods and iterative reconstruction, with ECG synchronization and division of ECG R-R intervals into 8, 10 and 16 frames. The obtained images were evaluated visually by two radiologists, and the quantitative parameters characterizing the contractile function of the left ventricular myocardium were compared in pairs.\u0000Results. There were no significant differences in the assessment of quantitative indicators such as end-systolic and diastolic volumes, stroke volume and ejection fraction. However, the iterative reconstruction results show less data scatter than the filtered back projection reconstruction method. In visual analysis, the best quality of reconstructions by iterative methods is noted.\u0000Conclusions. Thus, the recommended method for both visual analysis and quantification is iterative reconstruction, regardless of the number of timing windows used. A spread in the number of used reconstructed fragments of the cardiac cycle in the range of 8-16, commonly used in clinical practice, can be recommended.","PeriodicalId":161741,"journal":{"name":"Bulletin \"Biomedicine and sociology\"","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130532199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EVOLUTION, CURRENT STATE OF DOMESTIC SANITARY AVIATION AND PERSPECTIVES OF ITS USE","authors":"Menshutin I.Yu., Kubasov R.V., Kubasova E.D., Kalinin A.G., Martynova N.A.","doi":"10.26787/nydha-2618-8783-2022-7-4-79-85","DOIUrl":"https://doi.org/10.26787/nydha-2618-8783-2022-7-4-79-85","url":null,"abstract":"The use of air transport makes it possible to quickly evacuate patients from areas that are difficult to reach for land transport. It allows to quickly deliver patients over long distances to medical facilities. The evolution of air ambulance in the regions of Russia, the experience of medical support of natural disasters and catastrophes in recent years indicates an increasing role in ensuring timely delivery of patients to the stages of medical evacuation to provide the necessary medical care. Currently, it is generally recognized that this method of evacuation is irreplaceable and its importance cannot be overestimated. Evacuation by destination by air transport includes a set of measures. The outcome of treatment of patients and victims in extreme and emergency situations largely depends on the effectiveness of their implementation. In modern conditions, the evacuation of patients by air acquires a special, sometimes decisive role in preserving human life. The importance of air ambulance during natural disasters and catastrophes is increasing. However, it is in the case of sanitary aviation that careful consideration of all the features of the use of air transport is necessary in order to ensure maximum safety during evacuation.\u0000International and domestic experience of using aviation to transport patients has shown the high importance of this type of medical evacuation. Thanks to it, the treatment of patients affected by natural disasters and catastrophes can be carried out on the spot, in nearby medical organizations (paramedic and obstetric center, outpatient clinic, district, district, central district hospital), as well as in hospitals located at a great distance. Medical evacuation measures should be planned taking into account the availability and location of specialized medical institutions of various state structures and departments of the Russian Federation, primarily the Ministry of Health, the Federal Medical and Biological Agency, medical services of the Ministry of Defense, the Ministry of Internal Affairs, the Ministry of Emergency Situations. At the same time, their equipment with modern medical equipment, the state of evacuation routes, sanitary transport and general-purpose transport available to the medical service and other factors are crucial.","PeriodicalId":161741,"journal":{"name":"Bulletin \"Biomedicine and sociology\"","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130477901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DIAGNOSIS OF THE DEVELOPMENT OF ISCHEMIC STROKE IN PREGNANT WOMEN IN CONSIDERING MAIN AND ADDITIONAL RISK FACTORS: A CLINICAL ILLUSTRATION","authors":"Taitubaeva G.K., Petrova E.V., Gribacheva I.A., Popova T.F.","doi":"10.26787/nydha-2618-8783-2022-7-3-12-18","DOIUrl":"https://doi.org/10.26787/nydha-2618-8783-2022-7-3-12-18","url":null,"abstract":"Abstract. Taking into account the strong connection between autonomic dysfunction and cerebrovascular disorders, the difficulty in diagnosing stroke in pregnant women and the severity of the pathology, as well as the great social significance of these disorders, a search was made for additional risk factors for the development of stroke in pregnant women, which include the presence of cephalgic syndrome, signs of autonomic dysfunction before pregnancy, burdened vascular history, contraception, signs of venous dysfunction with hypercoagulability in the hemostatic system and the presence of hereditary thrombophilia, as demonstrated in the clinical illustration.","PeriodicalId":161741,"journal":{"name":"Bulletin \"Biomedicine and sociology\"","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127743100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"THERAPEUTIC ISSUES OF GASTROINTESTINAL DISEASES AND REVIEW OF THE RANGE OF DRUGS USED FOR THE TREATMENT AND PREVENTION OF DISEASES OF THE DIGESTIVE TRACT","authors":"A. I.S.","doi":"10.26787/nydha-2618-8783-2022-7-3-80-84","DOIUrl":"https://doi.org/10.26787/nydha-2618-8783-2022-7-3-80-84","url":null,"abstract":"Abstract. The article considers data on diseases of the digestive system, causes, relationship with gender, age, dynamics of changes in the overall incidence of the gastrointestinal tract in the Russian Federation according to Rosstat, and finally, the structure of the range of drugs prescribed for the treatment of these pathologies, including including chronic pancreatitis, as one of the most common diseases of the digestive tract, in a hospital setting. Diseases of the gastrointestinal tract is an urgent problem in modern clinical therapy, which is associated with an annual increase in the number of patients suffering from certain pathologies. The concept of \"quality of life\" and its features are given. According to the Russian Ministry of Health, calculated by the Federal State Statistics Service, the number of patients with general morbidity of the gastrointestinal tract in our country has increased from 2000 to 2018. An example of a survey of a number of patients diagnosed with gastroesophageal reflux disease is considered, during which it was revealed that heartburn, as a symptom of this disease, reduces the quality of life of patients, which is associated with a deterioration in work activity, sleep and wakefulness, quality of nutrition and satisfaction and quality of sexual life. Studies of the assortment structure showed the prevalence of imported drugs over domestic ones, in the used structure. Most drugs are imported from India, France and Germany, which account for about 55% of all drugs used. Nevertheless, the Russian market has a sufficient number of domestic drugs involved in the treatment and prevention of diseases of the digestive system. A list of drugs used in stationary conditions was compiled.","PeriodicalId":161741,"journal":{"name":"Bulletin \"Biomedicine and sociology\"","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126224443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"METHODS FOR PREDICTING THE TIME OF PROBABLE ACUTE INFECTIOUS DISEASES","authors":"Vybornov Yu.D.","doi":"10.26787/nydha-2618-8783-2022-7-3-60-69","DOIUrl":"https://doi.org/10.26787/nydha-2618-8783-2022-7-3-60-69","url":null,"abstract":"Abstract. The purpose of the research is to determine with high accuracy the frequency of occurrence of infections and its use for forecasting. According to the dates of pathologies suffered by a person, the frequency of diseases of 2400 parents and children, men and women, was determined. To improve the accuracy of determining the frequency of diseases, astronomical units for fixing the time of occurrence of pathologies were used: 4 phases of the moon, 4 components of the declination of the moon, day. The hereditary periodicity of diseases (hereditary frequency of diseases) was revealed, which manifests itself in graphical and digital forms. hereditary frequency of diseases was used to predict the time of probable acute infectious diseases and their complications. The purpose of forecasting is timely prevention. 6 forecasting methods have been developed, 2 computer programs have been created in which 5 coordinate systems are used, more than 1600 computer forecasts have been made. With an error of + 1-4 days, 50% - 62% of diseases of children, women and men who fell ill on average 3 times a year and more often are predicted. In 2014, an application for invention No. 2014116101 “Method for simultaneous prediction of the time of probable acute human infectious diseases and the optimal date of vaccination” was registered. The conclusion of Rospatent experts: “. the invention can be implemented”, but “. practical applicability has not been confirmed”. Verification of the invention and its practical use proved to be an insoluble problem. Forecasts of the time of probable diseases are “warning signs” on our life path, allowing us to get sick less and live longer.","PeriodicalId":161741,"journal":{"name":"Bulletin \"Biomedicine and sociology\"","volume":"372 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133213947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"THE USE OF ATORVASTATIN IN MODERN CARDIOLOGY TO REDUCE THE RISK OF CORONARY HEART DISEASE","authors":"A. I.S.","doi":"10.26787/nydha-2618-8783-2022-7-3-75-79","DOIUrl":"https://doi.org/10.26787/nydha-2618-8783-2022-7-3-75-79","url":null,"abstract":"Abstract. This article discusses issues regarding the use of drugs of the statin group for the prevention of diseases of the cardiovascular system, namely the use of atorvastatin in the prevention of coronary artery disease.\u0000The study involved 80 patients. at the same time, 65 participants in the study suffered from coronary artery disease, they were diagnosed with angina pectoris of functional class 2, 15 people were potentially healthy, all participants had a common average age and gender characteristics.\u0000All patients included in the study were divided into two groups: main and control. The first group received atorvastatin as therapy for IHD, the second group received standard IHD therapy, which included beta-blockers, antianginal drugs, etc. The results of the study were evaluated after 6 weeks and six months. An auxiliary instrumental method was the veloergometric test, as the most optimal option relative to others. This technique was used to verify the ischemic heart disease. To conduct a veloergometric test, the Cardiovit AT-10 apparatus was used, which allows you to gradually increase the load. The study included several stages, each stage assumed a 3-minute load. The load power was determined by a number of factors, such as weight, height of the patient, comorbidities, and age. In the first group, there is a clear positive trend and changes in the lipid profile, which persist for six months. In patients of the second group, such dynamics were not reliably detected. Also, all patients with coronary heart disease underwent a determination of the correspondence of biological age to chronological age. In this case, a formula based on the results of a well ergometric study was used.","PeriodicalId":161741,"journal":{"name":"Bulletin \"Biomedicine and sociology\"","volume":"70 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114830486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PHARMACOLOGICAL ACTIVITY OF LHT-17-19 IN CULTURES OF EGFR-EXPRESSING EPITHELIAL TUMORS","authors":"Kudryavtsev M.Yu., Tumutolova O.N., D. O.N., Epishkina A.A., Vavilova O.S., Gilevskaya Yu.S., B. E.V.","doi":"10.26787/nydha-2618-8783-2022-7-3-70-74","DOIUrl":"https://doi.org/10.26787/nydha-2618-8783-2022-7-3-70-74","url":null,"abstract":"Abstract. . In the study, the pharmacological activity of the pyridine derivative LHT-17-19 was studied in relation to the culture of pancreatic cancer cells PANC-1 and the culture of bladder cancer cells HT-29 expressing the epidermal growth factor receptor. The cultures were obtained from the library of tumor strains of the Moscow Research Institute of Oncology. P.A. Herzen - a separate structural subdivision of the Federal State Budgetary Institution \"NMITs Radiology\" of the Ministry of Health of Russia. LHT-17-19 was synthesized in the Department of Chemistry, Technology of Synthetic Medicines and Analytical Control of JSC VNTs BAV (Russia). LHT-17-19 and the reference drug \"Doxorubicin\" 50 mg each were added to the cultivation medium in the concentration range from 10-8 to 10-v. Compounds LHT-17-19 were shown to be able to induce death and suppress the growth of pancreatic cancer squamous culture (PANC-1) and bladder (HT-29) tumor cells expressing EGFR over a wide range of concentrations. So for pancreatic cancer (PANC-1), the effective inhibitory concentration for the compound LHT-17-19 was 1.3 × 10-7 M, while for the reference substance doxorubicin it was 6.0 × 10-5 M. bubble (NT-29) - 2.4 × 10-7 M and 5.2 × 10-4 M, respectively.","PeriodicalId":161741,"journal":{"name":"Bulletin \"Biomedicine and sociology\"","volume":"51 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127077055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}