Journal of Clinical & Experimental Ophthalmology最新文献

{"title":"Effects of Electrical Stimulation on Retinal Morphology as Seen with Optical Coherence Tomography","authors":"Alej, ra Gonzalez-Calle, V. Jeganathan, M. Humayun, J. Weil","doi":"10.35248/2155-9570.20.11.858","DOIUrl":"https://doi.org/10.35248/2155-9570.20.11.858","url":null,"abstract":"Retinal prostheses provide blind patients with the ability to detect motion and locate large objects. Future implants will require smaller electrodes to improve resolution, but increased charge density may result, creating a safety concern. We developed a novel in vivo method to study the effects of electrical stimulation in the retina using real time Optical Coherence Tomography (OCT) imaging combined with micropositioning a stimulating electrode. We observed that electrical stimulation settings with both pulse rates at and greater than 100 Hz as well as charge density 1.22 mC/cm2 and above resulted in retinal thickening within minutes of stimulation, that affected several retinal layers. We showed with statistical significance that the median difference between the retinal thickness before and after stimulation was different from zero. In summary, both high rate and high charge density were required to create retinal thickening. The stimulus levels at which thickening was noted in our study were significantly higher than the parameters currently used in humans.","PeriodicalId":15372,"journal":{"name":"Journal of Clinical & Experimental Ophthalmology","volume":"1 1","pages":"1-9"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82730449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemio-Clinical Profile of the Symbpharon during Toxic Epidermal Necrolysis (TEN) at the Institute of African Tropical Ophthalmology-Teaching Hospital","authors":"Elien Gyrr, Bakayoko Seydou, D. Adam, Théra Jp","doi":"10.35248/2155-9570.20.11.831","DOIUrl":"https://doi.org/10.35248/2155-9570.20.11.831","url":null,"abstract":"Introduction: Symblepharon is a lesion on the ocular surface associated or not with ocular adnexa damage. Symblepharon is characterized by the formation of an adhesion between the palpebral conjunctiva and the bulbary conjunctiva. There are many causes of symblepharon, among which toxic epidermal necrolysis is the most well-known and documented due to the extreme severity of ocular damage. Hence the purpose of this study is to describe the epidemiological-clinical profile of the symbpharon during the toxic epidermal necrosis for adequate and appropriate management. Methodology: This was a cross-sectional study, lasting 24 months from 18 March 2018 to 17 March 2020 at CHUIOTA. All patients who consented and had the symblepharon regardless of sex and age were compiled in a nonprobability sample. Results: During the 2 years, 11 patients were collected. There were 4 Men and 7 Women. The average age of our patients was 36.81 14.60 years, the age extremes ranged from 7 years old to 65 years old. The association of Nevirapine and Cotrimoxazole was frequently incriminated in 36.4% of our patients. More than half of the symblepharon were anterior (55% of the cases). Discussion: The bilaterality of ocular damage would be related on the one hand to the immunological mechanisms of toxic epidermal necrolysis, and the association of Nevirapine with Cotrimoxazole on the other. Conclusion: A rare disease, toxic epidermal necrolysis often leads to severe ocular complications.","PeriodicalId":15372,"journal":{"name":"Journal of Clinical & Experimental Ophthalmology","volume":"33 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77041262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Congenital Bilateral Glaucoma in a Patient with Neurofibromatosis Type I","authors":"S. Jabbehdari, Jonathan H. Lin, Yangyan Sun","doi":"10.35248/2155-9570.20.11.827","DOIUrl":"https://doi.org/10.35248/2155-9570.20.11.827","url":null,"abstract":"","PeriodicalId":15372,"journal":{"name":"Journal of Clinical & Experimental Ophthalmology","volume":"195 1","pages":"1-3"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86827786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Atypical Idiopathic Retinal Vasculitis, Aneurysms and Neuroretinitis IRVAN: Case Report","authors":"Kawtar Zaoui, I. Tarib, R. Messaoudi, K. Reda","doi":"10.35248/2155-9570.20.11.824","DOIUrl":"https://doi.org/10.35248/2155-9570.20.11.824","url":null,"abstract":"Rare idiopathic clinical entity, described by Chang et al. in 1995 for the first time, then in 2007 Samuel et al. published a classification according to the progressive stages of the disease. It is a condition which generally affects young women aged 30 to 40. Its evolution is variable and can be serious. Several therapeutic modalities are possible.","PeriodicalId":15372,"journal":{"name":"Journal of Clinical & Experimental Ophthalmology","volume":"7 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87770933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retinitis Pigmentosa (RP) at a Glance","authors":"Beena Alam","doi":"10.35248/2155-9570.20.11.861","DOIUrl":"https://doi.org/10.35248/2155-9570.20.11.861","url":null,"abstract":"Retinitis Pigmentosa, abbreviated as RP, is a global eye retina disorder. In this mini review paper, my focus just only its basic causes, prevalence, symptom, and factors and also discuss retina syndrome related to this disease, to provide a basic knowledge for beginners and readers to understand about what is retinitis pigmentosa disease.","PeriodicalId":15372,"journal":{"name":"Journal of Clinical & Experimental Ophthalmology","volume":"33 8 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77459467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Three Intraocular Lens Calculation Formulas for Predicting Postoperative Diopter in Patients with Cataract and High Myopia","authors":"Ze-Peng Xu, Song-Tiao Li, Kun-Meng Li, Ruoxi Geng, Haike Guo, Hong-Yang Zhang, Haiyin Jin, AN Mei-Xia, N. Tian","doi":"10.35248/2155-9570.20.11.845","DOIUrl":"https://doi.org/10.35248/2155-9570.20.11.845","url":null,"abstract":"Objective: To evaluate the accuracy of three calculation formulas of intraocular lens (IOL) on the refractive state of cataract patients with high myopia after cataract surgery, to study the influence of three formulas on axial length (AL), and to verify the advantage of Olsen formula over SRK/T and Haigis formula in predicting postoperative refraction in patients with high myopia and cataract, so as to provide a basis for selecting the degree of IOL in cataract patients with high myopia, so as to provide a basis for selecting the degree of IOL in cataract patients with high myopia. Methods We collected the data of sex, age, axial length, predicted value of SRK/T, Haigis, Olsen formula and postoperative true diopter of 101eyes of 10z eyes hospitalized in the First Affiliated Hospital of Guangzhou University of Chinese Medicine from 2016-10-10 to 2019-8-20. 101 cases were divided into three groups according to the AL. The prediction accuracy of the three formulas for different eye axis length was evaluated respectively,and the stability of the same formula for the prediction of different axial lengths was compared. Results Within the range of 26mm0.05) and there was significant difference between Olsen formula with SRK/T formula and Olsen formula and Haigis formula(p 30mm, the comparison of the three formulas was statistically significant. SRK/T formula showed significant difference in eye axis length among the three groups(p<0.05). For Haigis formula, there was significant difference between 26mm30mm group respectively(P<0.05). In Olsen formula, the statistical difference only existed between 26mm","PeriodicalId":15372,"journal":{"name":"Journal of Clinical & Experimental Ophthalmology","volume":"22 1","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77792820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Lockdown due to COVID-19 on a Large Emergency Eye Department: The Manchester Experience","authors":"James F. Young, K. Harron, Loreena Bilal, Jay Richardson, F. Dhawahir-Scala","doi":"10.35248/2155-9570.20.11.859","DOIUrl":"https://doi.org/10.35248/2155-9570.20.11.859","url":null,"abstract":"Aim: This study assesses the impact of the UK COVID-19 lockdown on Ophthalmology Emergency Services at one of the largest dedicated Emergency Eye Departments in the UK. Methods: We evaluated differences in attendances between 2019 and 2020 according to ethnicity, deprivation scores, age, clinician grade, diagnosis, discharge rate and follow up length. Results: The mean number of attendances started to drop on the 17th March 2020. The mean number of attendances before versus after 17th March decreased by a factor of 2.2 with a 95% (CR) of (2.1,2.3); from 72 (95%CR 70,75) per day to 33 (95%CR 31,35). Attendance rates to the Emergency Eye Department during a 9-week period of lockdown dropped by 51% (95%CI 47-52%) compared with the same period in 2019 and 48% (95% CI50-54%) compared with 2018. There was no significant difference in patient age, ethnicity or index of deprivation quintile between 2019 and 2020. There was a 61% drop (95% CI 48-70%) in the number of eye emergencies presenting in the second week of lockdown (30/04/2020–05/04/2020) compared to the corresponding period in 2019. Community eye emergencies dropped by 74% (95%CI 64-80%) and non-eye emergencies dropped by 64% (95%CI 47-75%). Conclusion: Government measures to reduce the transmission of COVID-19 have had a significant impact on the attendance of patients to our Emergency Eye Department. Severe blinding conditions are not presenting as frequently. This raises the concern that once the restrictions of COVID-19 are fully lifted some patients might start to present with potentially incurable chronic ocular conditions with devastating secondary complications.","PeriodicalId":15372,"journal":{"name":"Journal of Clinical & Experimental Ophthalmology","volume":"15 4","pages":"5-5"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91421069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Intravitreal Ranibizumab Injection on Systemic Blood Pressure: A Prospective Study","authors":"M. M. Ali, Z. Hussein","doi":"10.35248/2155-9570.20.11.830","DOIUrl":"https://doi.org/10.35248/2155-9570.20.11.830","url":null,"abstract":"Introduction: Hypertension is a common disease, which may be induced or precipitated by antivascular endothelial growth factor therapy with many studies reporting this complication of this therapy. Methods: This is a prospective study to evaluate blood pressure changes in normotensive, controlled and uncontrolled hypertensive patients on regular medical treatment after a 0.05 ml (0.5 mg) intravitreal Ranibizumab injection. It was held in Ibn-alhaitham eye teaching hospital in Baghdad between May 2019 and December 2019. It included patients with variable retinal diseases receiving either unilateral or bilateral intravitreal Ranibizumab injections, their blood pressure was measured before the treatment as a baseline, and then 2 hours, 1 month, and at 3 months from the first injection(s). These were allocated to three groups; Group A included normotensive patients without history of hypertension; Group B included controlled hypertensives and those with grade 1 hypertension with antihypertensive treatment. Group C included those with Grade 2 hypertension or more with antihypertensive treatment. Blood pressure was measured in all patients using the manual sphygmomanometer in sitting position. Paired t-test was used to analyze blood pressure measurements and compare mean arterial, systolic and diastolic pressure. A P-value of ≤ 0.05 was considered significant, and a P-value of ≤ 0.001 was considered highly significant. Results: Seventy-five patients (n=75) were included in the study with a mean age of 59.1 ± 11.4 years 58.7% males and 41.3% females, 44% were controlled-hypertensives, 26.7% were uncontrolled-hypertensives, 29.3% were normotensives. Group C showed highly significant reduction in the mean arterial, and systolic pressures in all three measurements after baseline (P ≤ 0.001), and significant reduction of diastolic blood pressure at one and three months after baseline (P ≤ 0.05). Both groups A and B showed a reduction in most measurements, but most were statistically insignificant (P ≥ 0.05). Unilateral and bilateral injection groups showed similar reduction in the mean arterial pressure at 2 hours and 3 months (P ≤ 0.05), mean systolic blood pressure was reduced in unilateral group in all 3 measurements (P ≤ 0.05, P ≤ 0.05, P ≤ 0.001, respectively) and also in the bilateral group at 2 hours and 3 months (P ≤ 0.001, P ≤ 0.05 respectively), and mean diastolic blood pressure was reduced at 2 hours in the unilateral group (P ≤ 0.05), and at 3 months in the bilateral injection group (P ≤ 0.05). Conclusion: There is an overall reduction of blood pressure with Ranibizumab Intravitreal injections especially in the moderate to severely uncontrolled hypertensive patients, while controlled-hypertensive, mildly uncontrolled hypertensive showed statistically insignificant changes which indicates that, it is acceptable to continue using Ranibizumab in both normotensive and hypertensive patients in the short ","PeriodicalId":15372,"journal":{"name":"Journal of Clinical & Experimental Ophthalmology","volume":"55 1","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84919487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of the Association between the Oral and the Gut Microbiome inGlaucoma","authors":"A. K. Toft-Kehler, Jeppe Vibæk, M. Kolko, G. Gazzard","doi":"10.35248/2155-9570.20.11.826","DOIUrl":"https://doi.org/10.35248/2155-9570.20.11.826","url":null,"abstract":"Objective: Glaucoma is characterized by a progressive degeneration of retinal ganglion cells (RGC) and their axons leading to painless damage of the visual field and finally blindness. The exact pathophysiology of RGC loss remains unknown. Alterations in the microbiome may be linked to neurodegenerative conditions such as Alzheimer’s and Parkinson’s diseases, possibly due to associated chronic low-grade inflammation. A recent study linked alterations in the oral microbiome and glaucoma. Methods: We investigated the microbiome of salivary and fecal samples in patients with normal tension glaucoma (10), ocular hypertension (11) and controls (11) using a case-control design with 16S rDNA sequencing. Results: For controls, but not the patient groups, salivary and fecal microbiome diversity was correlated in a given patient, suggesting an uncoupled saliva and fecal microbiome in the diseased groups. Such findings suggest that normal tension glaucoma (NTG) and ocular hypertension (OHT) might have similar characteristics. However, ocular hypertension patients seem to be resistant to neurodegenerative disease progression indicating that the uncoupled microbiome might affect characteristics linking ocular hypertension and normal tension glaucoma together. Moreover, we found the salivary microbiome to contain more differential taxa-level abundances of microorganisms suggesting the salivary microbiome might be advantageous to use in future studies investigating novel biomarkers in ophthalmic neurodegenerative diseases. Conclusion: The finding of an uncoupled microbiome might indicate comparable characteristics among glaucoma patients and ocular hypertension patients.","PeriodicalId":15372,"journal":{"name":"Journal of Clinical & Experimental Ophthalmology","volume":"24 1","pages":"1-8"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90802511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Concurrent Pars Plana Vitrectomy and DSAEK to Manage Pseudophakic Bullous Keratopathy and Intraocular Lens Dislocation: A Case Report","authors":"H. Torabi, Seyed-Hashem Daryabari","doi":"10.35248/2155-9570.21.11.853","DOIUrl":"https://doi.org/10.35248/2155-9570.21.11.853","url":null,"abstract":"This report describe the anatomical and visual outcomes of concurrent pars planavitrectomy (PPV) and Descemet stripping automated endothelial keratoplasty (DSAEK) for the management of a case with pseudophakic bullous keratopathy (PBK) and intraocular lens (IOL) dislocation following complicated phacoemulsification surgery. A 72-year-old woman was referred to our clinic 7 days after complicated phacoemulsification surgery. Severe corneal edema and IOL dislocation into the vitreous cavity was noticed on examination. After 2 months of conservative treatment, corneal edema remained persistent, so concurrent 23-gauge PPV, DSAEK and iris supported IOL implantation were performed in the single surgical procedure. One year after operation, the cornea was clear, retina was attached and best corrected visual acuity was 20/32. This report showed that concurrent PPV and DSAEK may be safe and effective option for the management of severely complicated Phacoemulsification surgery with PBK and IOL dislocation into the vitreous cavity.","PeriodicalId":15372,"journal":{"name":"Journal of Clinical & Experimental Ophthalmology","volume":"22 1","pages":"1-3"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90865374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}