Journal of Bone and Joint Surgery-british Volume最新文献

{"title":"John E. Hall, MD 1925-2018","authors":"","doi":"10.2106/jbjs.18.01047","DOIUrl":"https://doi.org/10.2106/jbjs.18.01047","url":null,"abstract":"","PeriodicalId":15048,"journal":{"name":"Journal of Bone and Joint Surgery-british Volume","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2106/jbjs.18.01047","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41683102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"British Orthopaedic Trainees’ Association (BOTA) Meeting 2017","authors":"","doi":"10.2106/jbjs.18.00030","DOIUrl":"https://doi.org/10.2106/jbjs.18.00030","url":null,"abstract":"","PeriodicalId":15048,"journal":{"name":"Journal of Bone and Joint Surgery-british Volume","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2106/jbjs.18.00030","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47698417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"FUSION OF THE LUMBAR SPINE","authors":"M. Krismer","doi":"10.1302/0301-620X.84B6.0840783","DOIUrl":"https://doi.org/10.1302/0301-620X.84B6.0840783","url":null,"abstract":"","PeriodicalId":15048,"journal":{"name":"Journal of Bone and Joint Surgery-british Volume","volume":"20 1","pages":"783-794"},"PeriodicalIF":0.0,"publicationDate":"2018-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89382310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Re-rupture rate following primary flexor tendon repair of the hand with potential contributing risk factors: case series","authors":"M. Ibrahim, M. Khan, Mai Rostom, A. Platt","doi":"10.1016/J.IJSU.2012.06.358","DOIUrl":"https://doi.org/10.1016/J.IJSU.2012.06.358","url":null,"abstract":"","PeriodicalId":15048,"journal":{"name":"Journal of Bone and Joint Surgery-british Volume","volume":"54 1","pages":"87-87"},"PeriodicalIF":0.0,"publicationDate":"2018-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77349150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"THE SPREAD OF FOOT INFECTION AND ITS IMPACT ON THE OUTCOMES OF MAJOR AMPUTATIONS OF LOWER EXTREMITIES IN DIABETIC PATIENTS","authors":"D. Važnaisienė, R. Šulcaitė, D. Jomantienė, É. Beltrand, Artūras Špucis, Anatolijus Reingardas, Vytautas Kymantas, A. Mickienė, É. Senneville","doi":"10.1302/1358-992X.2017.22.001","DOIUrl":"https://doi.org/10.1302/1358-992X.2017.22.001","url":null,"abstract":"Aim To assess the spread of foot infection and its impact on the outcomes of major amputations of lower extremities in diabetic patients. Method In a multicentre retrospective and prospective cohort study, we included adult diabetic patients (≥ 18 years) who underwent a major amputation of a lower limb in 5 hospitals between 2000 and 2009, 2012 and 2014. A total of 51 patients were included (of which 27 (52.94%) were men and 24 (47.06%) were women) with the mean age of 65.51 years (SD=16.99). Concomitant section9s osseous slice biopsy (BA) and percutaneous bone biopsy of the distal site (BD) were performed during limb amputation. A new surgical set-up and new instruments were used to try and reduce the likelihood of cross-contamination during surgery. A positive culture was defined as the identification of at least 1 species of bacteria not belonging to the skin flora or at least 2 bacteria belonging to the skin flora (CoNS (coagulase negative staphylococci), Corynebacterium spp, Propionibacterium acnes ) with the same antibiotic susceptibility profiles. A doubtful culture was defined as the identification of 1 species of bacteria belonging to the skin flora. The patients were followed-up for 1 year. Stump outcomes were assessed on the delay of complete healing, equipment, need of re-intervention and antibiotics. Results In total, 51 BA were performed during major lower limb amputations (17 above the knee and 34 below the knee) in diabetic patients. Nine (17.65%) bacterial culture results from BA specimens were positive, 7 (13.73%) doubtful and 35 (68.63%) sterile. Before amputation, 23 patients (45.1%) had not received any antibiotics, including 16 (31.37%) with an antibiotic-free interval of 15 days or more. Microorganisms identified in BA were also cultured from the distal site in 33.33% of the cases. Positive BA was associated with prolonged complete stump healing, delay of complete healing (more than 6 months), re-amputation and the need of antibiotics Conclusions The microorganisms identified from BA play a role in stump healing in diabetic patients. BA is useful during major limb amputation due to infectious complications and antibiotic therapy could be corrected on the basis of the BA culture results.","PeriodicalId":15048,"journal":{"name":"Journal of Bone and Joint Surgery-british Volume","volume":"23 1","pages":"1-1"},"PeriodicalIF":0.0,"publicationDate":"2017-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84572586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ACHILLES TENDON LENGTH, ATRS AND FUNCTIONAL OUTCOMES FIVE YEARS AFTER ACUTE ACHILLES TENDON RUPTURE TREATED CONSERVATIVELY","authors":"Rasmus Kastoft, J. Bencke, M. Speedtsberg, R. M. Søndergaard, K. Barfod, J. Penny","doi":"10.1016/J.ARTHRO.2017.08.152","DOIUrl":"https://doi.org/10.1016/J.ARTHRO.2017.08.152","url":null,"abstract":"","PeriodicalId":15048,"journal":{"name":"Journal of Bone and Joint Surgery-british Volume","volume":"8 1","pages":"16-16"},"PeriodicalIF":0.0,"publicationDate":"2017-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75157794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RATIONALE FOR MOLECULAR TARGETING THE COMMUNICATION OF MULTIPLE MYELOMA AND BONE MARROW NICHE: WHY NOTCH?","authors":"M. Colombo, F. Baccianti, L. Cantone, A. Moschini, N. Platonova, S. Garavelli, S. Galletti, V. Bollati, C. Goodyear, A. Neri, R. Chiaramonte","doi":"10.1302/1358-992X.99BSUPP_1.EORS2016-127","DOIUrl":"https://doi.org/10.1302/1358-992X.99BSUPP_1.EORS2016-127","url":null,"abstract":"Multiple myeloma (MM) is an incurable hematological tumor stemming from malignant plasma cells. MM cells accumulate in the bone marrow (BM) and shape the BM niche by establishing complex interactions with normal BM cells, boosting osteoclasts (OCLs) differentiation and causing bone disease. This unbalance in bone resorption promotes tumor survival and the development of drug resistance.\u0000\u0000The communication between tumor cells and stromal cells may be mediated by: 1) direct cell-cell contact; 2) secretion of soluble factors, i.e. chemokines and growth factors; 3) release of extracellular vesicles/exosomes (EVs) which are able to deliver mRNAs, miRNAs, proteins and metabolites in different body district.\u0000\u0000Primary CD138+ MM cells were isolated from patients BM aspirates. MM cell lines were cultured alone in complete RPMI-1640 medium or co-cultured with murine (NIH3T3) or human (HS5) BMSC cell lines or murine Raw264.7 monocytes in DMEM medium supplemented with 10% V/V FBS. Silencing of Jagged1 and Jagged2 was obtained by transient expression of specific siRNAs or by lentiviral transduction using a Dox-inducible system (pTRIPZ). EVs were isolated using differential ultracentrifugation. EVs concentration and size were analyzed using Nano Track Analysis (NTA) system. The uptake of PKH26-labelled MM-derived EVs by HS5 or Raw264.7 was measured after 48 hours by confocal microscopy and flow cytometry. Osteoclast (OCL) differentiation of Raw264.7 cells was induced by 50ng/ml mRANKL, co-culturing with MM cells, CM or EVs. OCLs were stained by TRAP Kit and counted. Bone resorption was assessed by Osteo Assay Surface plates. Flow cytometric detection of apoptotic cells was performed after staining with Annexin V. Gene expression was analyzed by qRT-PCR, while protein levels were determined using flow cytometry ELISA or WB.\u0000\u0000Notch oncogenic signaling is dysregulated in several hematological and solid malignancies. Notch receptors and ligands are key players in the crosstalk between tumor cells and BM cells. We have demonstrated that: 1) the dysregulated Jagged ligands on MM cells trigger the activation of Notch receptors in the nearby stromal cells by cell-cell contact. This results in the release of anti-apoptotic and growth stimulating factors, i.e. IL6 and SDF1; 2) MM cells promote the development of bone lesions boosting osteoclast differentiation by secreting soluble factors (i.e. RANKL) and by the activation of Notch signaling mediated by direct contact with osteoclast precursors; 3) Finally, we present evidences that EVs play a crucial role in the dysregulated interactions of MM cells with the microenvironment and that Notch signaling regulates their release and participate in this cross-talk.\u0000\u0000These evidences supports the hypothesis that Jagged targeting on MM cells may interrupt the communication between tumor cells and the surrounding milieu, blocking the activation of the oncogenic Notch pathway and finally resulting in the a reduction of MM-associate","PeriodicalId":15048,"journal":{"name":"Journal of Bone and Joint Surgery-british Volume","volume":"32 1","pages":"127-127"},"PeriodicalIF":0.0,"publicationDate":"2017-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83105038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of operating lights on laminar flow","authors":"R. Refaie, P. Rushton, P. McGovern, D. Thompson, I. Serrano-Pedraza, K. Rankin, M. Reed","doi":"10.1302/0301620X.99B8.BJJ20160581.R2","DOIUrl":"https://doi.org/10.1302/0301620X.99B8.BJJ20160581.R2","url":null,"abstract":"AimsThe interaction between surgical lighting and laminar airflow is poorly understood. We undertook an experiment to identify any effect contemporary surgical lights have on laminar flow and recom...","PeriodicalId":15048,"journal":{"name":"Journal of Bone and Joint Surgery-british Volume","volume":"54 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78207013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A NEW SURGICAL TECHNIQUE FOR THE POSITIONING OF HIP PROSTHETIC IMPLANTS: THE MEDIAL-INGUINAL APPROACH","authors":"L. Lucente, A. Palmesi, D. Longo, M. Papalia","doi":"10.17265/1548-6648/2017.03.005","DOIUrl":"https://doi.org/10.17265/1548-6648/2017.03.005","url":null,"abstract":"Introduction seeking full compliance with the Tissue Sparing Surgery principles, we introduced this new surgical approach to the coxa-femoral joint via the medial inguinal region. Patients/Materials and Methods we performed total hip arthroplasty on 20 patients suffering from hip arthritis while 15 cases of medial femoral fracture received hemiarthroplasty with bipolar prostheses implants. Results reduced surgery times, lower blood loss, zero complications and significantly speedier recovery were observed in all the above cases. Discussion/ Conclusion this new surgical approach we devised enables a quick, safe and easy replacement of the hip. The muscles of the hip remain totally unharmed; maximum exposure is gained, with visualization of the acetabulum, directly fronting the surgeon, at its very best, favourably comparing with any other known approach. No particular equipment is needed and no special operating table. And it does not in the least imply a steep learning curve. Dislocation risks are non-existent allowing the patient any position in bed immediately after surgery. It is aesthetically preferable, the scar remaining almost invisible in between the inguinal skin lines. The patient can at once resume a steady walk, Canadian crutches being needed only for the first few days. It is the authors9 opinion that such a technique, thanks to its being safe, fast, economical and easy to replicate, results in undoubted benefits for the patient, not least because it requires much shorter and far easier rehabilitation; and it can be counted as a valid alternative for surgeons to the most common approaches currently in use.","PeriodicalId":15048,"journal":{"name":"Journal of Bone and Joint Surgery-british Volume","volume":"119 1","pages":"127-127"},"PeriodicalIF":0.0,"publicationDate":"2017-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79421650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of Gender-Specific Aspects of the Morphology of the Distal Femur","authors":"M. Asseln, C. Hänisch, Fabian Schick, K. Radermacher","doi":"10.29007/X8VD","DOIUrl":"https://doi.org/10.29007/X8VD","url":null,"abstract":"In total knee arthroplasty (TKA) the implant design is one key factor for a proper functional restoration of the diseased knee. Therefore, detailed knowledge on the shape (morphology) is essential ...","PeriodicalId":15048,"journal":{"name":"Journal of Bone and Joint Surgery-british Volume","volume":"23 1","pages":"64-64"},"PeriodicalIF":0.0,"publicationDate":"2017-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76537559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}