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Nutritional and Motor Functional Status in Parkinson’s Disease: The NutriSPark Protocol 帕金森病的营养和运动功能状态:NutriSPark协议
Medical Sciences Forum Pub Date : 2021-07-21 DOI: 10.3390/MSF2021005029
M. Grunho, C. Godinho, D. Sousa-Catita, F. Vicente, L. Proença, Ricardo Carregosa, Frederico Marx, Morgane Tomé, Josefa Domingos, J. Fonseca
{"title":"Nutritional and Motor Functional Status in Parkinson’s Disease: The NutriSPark Protocol","authors":"M. Grunho, C. Godinho, D. Sousa-Catita, F. Vicente, L. Proença, Ricardo Carregosa, Frederico Marx, Morgane Tomé, Josefa Domingos, J. Fonseca","doi":"10.3390/MSF2021005029","DOIUrl":"https://doi.org/10.3390/MSF2021005029","url":null,"abstract":"A growing body of evidence suggests that nutritional status may play an important role in the development and course of Parkinson’s disease (PD). Nutritional status is known to influence PD motor and non-motor features and is in turn influenced by disease duration and severity. A proper nutritional status assessment and intervention should be incorporated in the management and follow-up of PD patients. This study aims to characterize the impact of nutritional status in multiple domains of PD and to explore the feasibility and the effectiveness of a customized and intensive nutritional intervention compared to standard care.","PeriodicalId":147460,"journal":{"name":"Medical Sciences Forum","volume":"40 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115565959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Inflammatory Bowel Disease, Alpha-Synuclein Aggregates and Parkinson’s Disease: The InflamaSPark Protocol 炎症性肠病，α -突触核蛋白聚集体和帕金森病:InflamaSPark协议
Medical Sciences Forum Pub Date : 2021-07-21 DOI: 10.3390/MSF2021005028
M. Grunho, C. Godinho, M. Patita, I. Mocanu, A. Vieira, A. De Matos, Ricardo Carregosa, Frederico Marx, Morgane Tomé, D. Sousa-Catita, L. Proença, T. Outeiro, J. Fonseca
{"title":"Inflammatory Bowel Disease, Alpha-Synuclein Aggregates and Parkinson’s Disease: The InflamaSPark Protocol","authors":"M. Grunho, C. Godinho, M. Patita, I. Mocanu, A. Vieira, A. De Matos, Ricardo Carregosa, Frederico Marx, Morgane Tomé, D. Sousa-Catita, L. Proença, T. Outeiro, J. Fonseca","doi":"10.3390/MSF2021005028","DOIUrl":"https://doi.org/10.3390/MSF2021005028","url":null,"abstract":"The hallmark of Parkinson’s disease (PD) is the accumulation of alpha-synuclein (AS) aggregates. Prior to the central nervous system involvement, PD establishes itself in the gut as a result of the complex interplay between microbiota, the host’s immune/neural systems and increased intestinal permeability. Inflammatory Bowel Disease (IBD) patients present a higher number of AS aggregates in the intestinal wall and an increased risk of developing PD. By studying AS aggregates in gut biopsy specimens of IBD patients and controls, this project aims to further clarify the pathophysiology of PD and to explore the potential of gut a biopsy for AS aggregates as a biomarker for prodromal PD.","PeriodicalId":147460,"journal":{"name":"Medical Sciences Forum","volume":"69 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125066843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Incidence of Oral Mucositis in Patients Undergoing Head and Neck Cancer Treatment: Systematic Review and Meta-Analysis 头颈癌治疗患者口腔黏膜炎的发生率:系统回顾和荟萃分析
Medical Sciences Forum Pub Date : 2021-07-21 DOI: 10.3390/MSF2021005023
R. Pacheco, M. A. Cavacas, P. Mascarenhas, Pedro Guedes de Oliveira, C. Zagalo
{"title":"Incidence of Oral Mucositis in Patients Undergoing Head and Neck Cancer Treatment: Systematic Review and Meta-Analysis","authors":"R. Pacheco, M. A. Cavacas, P. Mascarenhas, Pedro Guedes de Oliveira, C. Zagalo","doi":"10.3390/MSF2021005023","DOIUrl":"https://doi.org/10.3390/MSF2021005023","url":null,"abstract":"This systematic review and meta-analysis aimed to assess the literature about the incidence of oral mucositis and its degrees (mild, moderate, and severe), in patients undergoing head and neck cancer treatment (radiotherapy, chemotherapy, and surgery). Addressing this issue is important since oral mucositis has a negative impact on oral health and significantly deteriorates the quality of life. Therefore, a multidisciplinary team, including dentists, should be involved in the treatment. The overall oral mucositis incidence was 89.4%. The global incidence for mild, moderate, and severe degrees were 16.8%, 34.5%, and 26.4%, respectively. The high incidence rates reported in this review point out the need for greater care in terms of the oral health of these patients.","PeriodicalId":147460,"journal":{"name":"Medical Sciences Forum","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134157571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Characterization of CYP2C19*17 Polymorphism in a Portuguese Population Sample Relevant for Proton Pump Inhibitor Therapy—A Pilot Study CYP2C19*17多态性在葡萄牙人群样本中与质子泵抑制剂治疗相关的特征-一项初步研究
Medical Sciences Forum Pub Date : 2021-07-21 DOI: 10.3390/MSF2021005019
A. M. Ferraz, S. Bandarra, P. Mascarenhas, I. Barahona, Rui Martins, A. C. Ribeiro
{"title":"Characterization of CYP2C19*17 Polymorphism in a Portuguese Population Sample Relevant for Proton Pump Inhibitor Therapy—A Pilot Study","authors":"A. M. Ferraz, S. Bandarra, P. Mascarenhas, I. Barahona, Rui Martins, A. C. Ribeiro","doi":"10.3390/MSF2021005019","DOIUrl":"https://doi.org/10.3390/MSF2021005019","url":null,"abstract":"The interindividual variability of Proton Pump Inhibitor (PPI) therapy results from the phenotype variability associated with the cytochrome P450 2C19 (CYP2C19) gene, namely the CYP2C19*17 allele. Our aim was to characterize patients’ genetic variability undergoing PPI therapy. A sample of 33 oral mucosa cells from Portuguese pharmacy patients was collected, followed by genotyping. The allelic frequencies of CYP2C19*1 (-806C) and CYP2C19*17 (-806T) were 71.2% and 28.8%, respectively. The genotypic frequencies for CYP2C19*1/*1 and CYP2C19*1/*17 were 42.4% and 57.6%, respectively, and 19 of these patients may have a Rapid Metabolizer (RM) phenotype pharmaceutical opinion letter, based on genetic evidence.","PeriodicalId":147460,"journal":{"name":"Medical Sciences Forum","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115169442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Adverse Childhood Experiences and Empathy: The Role of Interparental Conflict 不良童年经历与共情:父母间冲突的作用
Medical Sciences Forum Pub Date : 2021-07-21 DOI: 10.3390/MSF2021005030
A. Antunes, Patrícia Oliveira, J. Cardoso, T. Almeida
{"title":"Adverse Childhood Experiences and Empathy: The Role of Interparental Conflict","authors":"A. Antunes, Patrícia Oliveira, J. Cardoso, T. Almeida","doi":"10.3390/MSF2021005030","DOIUrl":"https://doi.org/10.3390/MSF2021005030","url":null,"abstract":"The literature shows that adverse life experiences may harm individuals. The main objectives of this research were to study the relationship between adverse childhood experiences and empathy in adulthood and analyse differences between victims and nonvictims of interparental conflict. Our research evidenced that adverse childhood experiences affect individuals’ empathy in adulthood, and victims of interparental violence experienced other childhood victimization.","PeriodicalId":147460,"journal":{"name":"Medical Sciences Forum","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117074539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
COVID-19 Risk Perception and Confidence among Clinical Dental Students: Impact on Patient Management 临床牙科学生的COVID-19风险认知和信心:对患者管理的影响
Medical Sciences Forum Pub Date : 2021-07-21 DOI: 10.3390/msf2021005026
Mariana Morgado, J. Mendes, L. Proença
{"title":"COVID-19 Risk Perception and Confidence among Clinical Dental Students: Impact on Patient Management","authors":"Mariana Morgado, J. Mendes, L. Proença","doi":"10.3390/msf2021005026","DOIUrl":"https://doi.org/10.3390/msf2021005026","url":null,"abstract":"This study aimed to assess COVID-19 perceived risk, confidence and its impact on potentially infected patients’ management practices, in a clinical dental education setting. The survey was conducted by application of a self-administered questionnaire amid the COVID-19 pandemic. Results indicate high COVID-19 perceived risk and confidence levels (86.7% and 72.8%, respectively). A significantly lower risk perception was identified for individuals classifying COVID-19 as a moderately dangerous disease and confidence was significantly lower for women and for individuals not previously exposed to confirmed or suspected cases of COVID-19. No factor-related significant differences were found on potentially infected patients’ management practices.","PeriodicalId":147460,"journal":{"name":"Medical Sciences Forum","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132935061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Cow’s Milk Protein Allergy: The Hidden Danger of Medicines’ Excipients 牛奶蛋白过敏:药物辅料的隐患
Medical Sciences Forum Pub Date : 2021-07-21 DOI: 10.3390/MSF2021005032
M. Santo, M. Auxtero, A. Figueiredo, I. Costa
{"title":"Cow’s Milk Protein Allergy: The Hidden Danger of Medicines’ Excipients","authors":"M. Santo, M. Auxtero, A. Figueiredo, I. Costa","doi":"10.3390/MSF2021005032","DOIUrl":"https://doi.org/10.3390/MSF2021005032","url":null,"abstract":"In patients with a cow’s milk protein allergy, the presence of these allergens in medicines, even in trace amounts, can trigger serious allergic reactions. The study of milk-related excipient prevalence in 165 antiasthmatic medicines, based on the information included in the Summary of Product Characteristics, revealed the presence of lactose in more than one third of these medicines. Since lactose may suffer cross-contamination with cow’s milk protein, these results are an alert to health professionals.","PeriodicalId":147460,"journal":{"name":"Medical Sciences Forum","volume":"170 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131719257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Personality and Aggressive Behavior: The Relation between the Five-Factor and Aggression Models in a Domestic Violence Suspects Sample 人格与攻击行为:五因素与家庭暴力犯罪嫌疑人攻击模型的关系
Medical Sciences Forum Pub Date : 2021-07-20 DOI: 10.3390/MSF2021005018
R. Baúto, Ana Filipa Carreiro, M. Pereira, R. Guarda, Iris Almeida
{"title":"Personality and Aggressive Behavior: The Relation between the Five-Factor and Aggression Models in a Domestic Violence Suspects Sample","authors":"R. Baúto, Ana Filipa Carreiro, M. Pereira, R. Guarda, Iris Almeida","doi":"10.3390/MSF2021005018","DOIUrl":"https://doi.org/10.3390/MSF2021005018","url":null,"abstract":"The purpose of this study is to demonstrate the relationship between the five-factor model of personality and its association with aggression in 30 men and eight women who are suspects of domestic violence. The results show a positive correlation between neuroticism and hostility, a negative correlation between openness to experience and overall aggression, a negative correlation between agreeableness and physical aggression and anger, and a negative correlation between conscientiousness and anger. These results show us the need for personality assessment in domestic violence suspects and future research about personality and aggression.","PeriodicalId":147460,"journal":{"name":"Medical Sciences Forum","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130673172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Candida spp. Colonization among Intensive Care Unit Patients, Preliminary Results 念珠菌在重症监护病房患者中的定植，初步结果
Medical Sciences Forum Pub Date : 2021-07-20 DOI: 10.3390/MSF2021005014
T. Nascimento, J. Inácio, I. Ferreira, P. Diaz, P. Freitas, H. Barroso
{"title":"Candida spp. Colonization among Intensive Care Unit Patients, Preliminary Results","authors":"T. Nascimento, J. Inácio, I. Ferreira, P. Diaz, P. Freitas, H. Barroso","doi":"10.3390/MSF2021005014","DOIUrl":"https://doi.org/10.3390/MSF2021005014","url":null,"abstract":"Candida spp. colonization is recognized as a major risk factor for invasive candidiasis. To assess patient colonization, upon admission and during their stay in intensive care units (ICU), a surveillance study has been conducted since January 2020, in the Lisbon area of Portugal. A total of 219 swab samples were obtained from 113 ICU patients. The yeast identification was conducted by microbiological conventional and molecular methods. Upon admission to the ICU, 27% of patients were already colonized, and 17% became colonized during their ICU stay. Candida albicans was the most isolated species. These results may offer an opportunity for prevention of candidemia.","PeriodicalId":147460,"journal":{"name":"Medical Sciences Forum","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127022133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Influence of the Infill Geometry of 3D-Printed Tablets on Drug Dissolution 3d打印片剂填充形状对药物溶出度的影响
Medical Sciences Forum Pub Date : 2021-07-20 DOI: 10.3390/msf2021005015
Nuno Venâncio, Gabriela G Pereira, João Pinto, Ana Fernandes
{"title":"Influence of the Infill Geometry of 3D-Printed Tablets on Drug Dissolution","authors":"Nuno Venâncio, Gabriela G Pereira, João Pinto, Ana Fernandes","doi":"10.3390/msf2021005015","DOIUrl":"https://doi.org/10.3390/msf2021005015","url":null,"abstract":"Patient-centric therapy is especially important in pediatrics and may be attained by three-dimensional printing. Filaments containing 30% w/w of theophylline were produced by hot-melt extrusion and printed using fused deposition modelling to produce tablets. Here, preliminary results evaluating the effect of infill geometry (cross, star, grid) on drug content and release are reported.","PeriodicalId":147460,"journal":{"name":"Medical Sciences Forum","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121657743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
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