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Study of the Phenolic Content and the Antioxidant Capacity of Rubus idaeus L. Genotypes within the Development of a National Cultivar 国家品种培育过程中不同基因型山楂酚类物质含量及抗氧化能力的研究
Medical Sciences Forum Pub Date : 2021-07-22 DOI: 10.3390/MSF2021005041
Rita Cornamusaz, F. Luz, P. B. Oliveira, M. Moncada, Madalena Bettencourt da Câmara
{"title":"Study of the Phenolic Content and the Antioxidant Capacity of Rubus idaeus L. Genotypes within the Development of a National Cultivar","authors":"Rita Cornamusaz, F. Luz, P. B. Oliveira, M. Moncada, Madalena Bettencourt da Câmara","doi":"10.3390/MSF2021005041","DOIUrl":"https://doi.org/10.3390/MSF2021005041","url":null,"abstract":"The production of raspberries in Portugal has increased considerably in the last two decades, assuming a great economic interest today. Here, we studied the phenolic content and the antioxidant capacity of selected genotypes within a breeding program. The results suggest that this program may be unintentionally selecting raspberry phenolics. If so, this would be of particular interest, since there is scientific evidence that raspberry phenolics or their metabolites may have beneficial health effects, namely antioxidant activity.","PeriodicalId":147460,"journal":{"name":"Medical Sciences Forum","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130233581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Phytochemicals from Cocoa Shell Protect Mitochondrial Function and Alleviate Oxidative Stress in Hepatocytes via Regulation of ERK and PI3K-AKT Pathways 可可壳植物化学物质通过调控ERK和PI3K-AKT通路保护线粒体功能并减轻肝细胞氧化应激
Medical Sciences Forum Pub Date : 2021-07-22 DOI: 10.3390/MSF2021002025
M. Rebollo-Hernanz, Y. Aguilera, M. Martín-Cabrejas, E. D. de Mejia
{"title":"Phytochemicals from Cocoa Shell Protect Mitochondrial Function and Alleviate Oxidative Stress in Hepatocytes via Regulation of ERK and PI3K-AKT Pathways","authors":"M. Rebollo-Hernanz, Y. Aguilera, M. Martín-Cabrejas, E. D. de Mejia","doi":"10.3390/MSF2021002025","DOIUrl":"https://doi.org/10.3390/MSF2021002025","url":null,"abstract":"This research aimed to assess the impact of an aqueous extract from the cocoa shell and its major phytochemicals on preventing oxidative stress and mitochondrial dysfunction in hepatocytes using an in vitro model of nonalcoholic fatty liver disease (NAFLD). The phytochemicals from cocoa shell were extracted using water and characterized by UPLC-MS/MS analysis. HepG2 cells were cotreated with either the aqueous extract from cocoa shell (CAE, 20–100 µg mL−1) or 10–50 µmol L−1 of pure theobromine, protocatechuic acid, procyanidin B2, epicatechin, and catechin in the presence or absence of palmitic acid (PA, 500 µmol L−1) to mimic NAFLD conditions in vitro. Biomarkers of mitochondrial function and oxidative stress were evaluated 24 h after the cotreatment in cell supernatants and lysates using chemical, biochemical, and immunochemical techniques. CAE and the phytochemicals therein significantly (p < 0.05) protected mitochondrial content (15–100%) and preserved mitochondrial function, promoting O2 consumption (1.2- to 1.8-fold) and ATP production (1.3- to 2.1-fold). Phytochemicals from cocoa shell significantly (p < 0.05) decreased PA-triggered oxidative stress. The mitochondrial membrane potential was maintained (62–100%), and the production of mitochondrial superoxide (26–100%) and total ROS (17–100%) was abrogated. CAE significantly (p < 0.05) modulated cell signaling pathways associated with ROS production and mitochondrial dysfunction, including an increase in the phosphorylation of ERK1/2 (2.8-fold), protein kinase B (AKT) (2.8-fold), GSK3 (2.3-fold), Raf-1 (1.9-fold), and mTOR (1.7-fold). In conclusion, results suggested that the cocoa shell’s phytochemicals could protect mitochondrial liver function and alleviate oxidative stress by modulating key pathways involved in their regulation.","PeriodicalId":147460,"journal":{"name":"Medical Sciences Forum","volume":"194 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121848971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Oral Health among Athletes at the Egas Moniz Sports Dentistry Practice 在Egas Moniz运动牙科诊所运动员的口腔健康
Medical Sciences Forum Pub Date : 2021-07-22 DOI: 10.3390/MSF2021005040
C. Fernandes, Inês Allen, Leonor Sá Pinto, A. Júdice, F. Vicente, C. Família, J. Mendes, C. Godinho
{"title":"Oral Health among Athletes at the Egas Moniz Sports Dentistry Practice","authors":"C. Fernandes, Inês Allen, Leonor Sá Pinto, A. Júdice, F. Vicente, C. Família, J. Mendes, C. Godinho","doi":"10.3390/MSF2021005040","DOIUrl":"https://doi.org/10.3390/MSF2021005040","url":null,"abstract":"The sports dentistry consultation at the Clínica Universitária Egas Moniz is guaranteed by a multidisciplinary team of health professionals that provide a customized service to high performance athletes. Over the last year, 99 athletes were evaluated in terms of their oral health through extraoral, intraoral and radiographic exams. In this population a high prevalence of dry mouth, erosive wear, gingivitis, periodontitis and DMF index was observed, which may have a profound and negative impact on sports performance. Of the athletes, 40.4% attended follow up consultations, where restoration and scaling were the majority of the clinical procedures performed. This data highlights the importance of a dedicated sports dentistry consultations.","PeriodicalId":147460,"journal":{"name":"Medical Sciences Forum","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122440905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Oral Complications of Chemotherapy on Paediatric Patients with Cancer: A Systematic Review and Meta-Analysis 儿科癌症患者化疗的口腔并发症:系统回顾和荟萃分析
Medical Sciences Forum Pub Date : 2021-07-21 DOI: 10.3390/MSF2021005025
A. Alves, G. Kizi, A. R. Barata, P. Mascarenhas, I. Ventura
{"title":"Oral Complications of Chemotherapy on Paediatric Patients with Cancer: A Systematic Review and Meta-Analysis","authors":"A. Alves, G. Kizi, A. R. Barata, P. Mascarenhas, I. Ventura","doi":"10.3390/MSF2021005025","DOIUrl":"https://doi.org/10.3390/MSF2021005025","url":null,"abstract":"The goal of cancer treatment is to fight and/or control cancer. The aim of this study was to review and meta-analyse the incidence of main oral complications in paediatric oncology during chemotherapy. The search results were obtained from B-on, Web of Science, Scopus, Cochrane Library and PubMed databases. Of 1032 articles potentially relevant, 13 were included in this review. The overall incidence of caries, gingivitis, ulcers, mucositis, and candidiasis was 67.8%, 55.6%, 44.2%, 41.6%, and, 29.5%, respectively. During chemotherapy, paediatric patients with cancer present higher incidence of caries and gingivitis. Incidence rate meta-analysis show high heterogeneity. More studies should be done to reduce uncertainty.","PeriodicalId":147460,"journal":{"name":"Medical Sciences Forum","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128039290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mouth Breathing and Atypical Swallowing in Adult Orthodontic Patients at Egas Moniz Dental Clinic: A Pilot Study Egas Moniz牙科诊所成人正畸患者的口腔呼吸和非典型吞咽:一项试点研究
Medical Sciences Forum Pub Date : 2021-07-21 DOI: 10.3390/MSF2021005020
A. R. Barata, G. Kizi, L. Proença, V. Alves, A. Delgado
{"title":"Mouth Breathing and Atypical Swallowing in Adult Orthodontic Patients at Egas Moniz Dental Clinic: A Pilot Study","authors":"A. R. Barata, G. Kizi, L. Proença, V. Alves, A. Delgado","doi":"10.3390/MSF2021005020","DOIUrl":"https://doi.org/10.3390/MSF2021005020","url":null,"abstract":"Background: Mouth breathing and atypical swallowing are myofunctional problems, emerging as a pathological adaptation. This exploratory study was aimed to investigate the possible relation between breathing and swallowing patterns in adults. Methods: A total of 58 patients referred to the Orthodontic Department at Egas Moniz Dental Clinic were enrolled. Results: Atypical swallowing was more prevalent in women (78.0%) than in men (47.1%). A significantly higher proportion of patients exhibiting both mouth breathing and atypical swallowing were identified (46.6%). Swallowing pattern was found to be significantly associated with gender and breathing pattern.","PeriodicalId":147460,"journal":{"name":"Medical Sciences Forum","volume":"74 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117326506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploring Inequalities in HPV Vaccine Uptake among Cape Verdean Immigrant and Portuguese Native Women 探讨佛得角移民和葡萄牙土著妇女在HPV疫苗接种方面的不平等
Medical Sciences Forum Pub Date : 2021-07-21 DOI: 10.3390/MSF2021005021
V. Alarcão, Pedro Candeias, Sónia Pintassilgo, F. L. Machado
{"title":"Exploring Inequalities in HPV Vaccine Uptake among Cape Verdean Immigrant and Portuguese Native Women","authors":"V. Alarcão, Pedro Candeias, Sónia Pintassilgo, F. L. Machado","doi":"10.3390/MSF2021005021","DOIUrl":"https://doi.org/10.3390/MSF2021005021","url":null,"abstract":"Based on data from the FEMINA study, this communication aims to explore inequalities in HPV vaccine uptake. Results highlighted differences between the Portuguese and the Cape Verdean women: 97% vs. 67% had heard about the HPV vaccine; 30% vs. 9% had been vaccinated, and 71% vs. 82% had reported a lack of medical recommendation as a major reason for not having been vaccinated. Further research on the mechanisms that operate in the production of health disparities is needed to promote equity-focused interventions.","PeriodicalId":147460,"journal":{"name":"Medical Sciences Forum","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125903520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Awareness and Use of Heat-Not-Burn Tobacco among Students of Egas Moniz—Cooperative of Higher Education 高校学生热不燃烟草认知与使用情况
Medical Sciences Forum Pub Date : 2021-07-21 DOI: 10.3390/MSF2021005027
Ana Sofia Pintado, Duarte Sousa-Tavares, Patrícia Cavaco-Silva
{"title":"Awareness and Use of Heat-Not-Burn Tobacco among Students of Egas Moniz—Cooperative of Higher Education","authors":"Ana Sofia Pintado, Duarte Sousa-Tavares, Patrícia Cavaco-Silva","doi":"10.3390/MSF2021005027","DOIUrl":"https://doi.org/10.3390/MSF2021005027","url":null,"abstract":"Heated tobacco products (HTP) use a device that heats tobacco to generate an aerosol containing nicotine instead of burning it as it happens with combustion tobacco. This study aimed to determine the prevalence of heat-not-burn tobacco use among students of a Healthcare University Institution—Egas Moniz—and identify the factors that influence this use. A questionnaire adapted from the WHO Global Health Professional Students Survey was applied between May and July 2019 in the study population. Subsequently, an exploratory analysis of the data was carried out and a logistic regression was applied in order to determine the factors that influence students to consume heated tobacco.","PeriodicalId":147460,"journal":{"name":"Medical Sciences Forum","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125464704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Treatment of Patients with Somatic Tinnitus Attributed to Temporomandibular Disorder: A Case Report 颞下颌紊乱所致躯体性耳鸣的治疗1例
Medical Sciences Forum Pub Date : 2021-07-21 DOI: 10.3390/MSF2021005022
P. Moleirinho-Alves, P. Cebola, A. Almeida, H. Haider, J. Paço
{"title":"Treatment of Patients with Somatic Tinnitus Attributed to Temporomandibular Disorder: A Case Report","authors":"P. Moleirinho-Alves, P. Cebola, A. Almeida, H. Haider, J. Paço","doi":"10.3390/MSF2021005022","DOIUrl":"https://doi.org/10.3390/MSF2021005022","url":null,"abstract":"Tinnitus is a common symptom described in patients with temporomandibular disorders (TMDs), affecting quality of life and frequently causing distress. Somatic or somatosensory tinnitus can be attributed to the somatic system of the temporomandibular or cervical spine. Due to the multifactorial etiology of TMD, its management should be based on a multidisciplinary approach. Dentists and physical therapists may play a role in the individual and multimodal management of such patients. The aim of this case study is to analyse the effects of the conservative multidisciplinary management of tinnitus in patients with coexisting tinnitus, TMD and bruxism.","PeriodicalId":147460,"journal":{"name":"Medical Sciences Forum","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114446699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gut Status in Parkinson’s Disease: The GutSPark Protocol 帕金森病的肠道状态:GutSPark协议
Medical Sciences Forum Pub Date : 2021-07-21 DOI: 10.3390/MSF2021005031
M. Grunho, C. Godinho, A. De Matos, H. Barroso, Ricardo Carregosa, Frederico Marx, Morgane Tomé, Josefa Domingos, D. Sousa-Catita, J. Botelho, V. Machado, J. Mendes, T. Outeiro, J. Fonseca
{"title":"Gut Status in Parkinson’s Disease: The GutSPark Protocol","authors":"M. Grunho, C. Godinho, A. De Matos, H. Barroso, Ricardo Carregosa, Frederico Marx, Morgane Tomé, Josefa Domingos, D. Sousa-Catita, J. Botelho, V. Machado, J. Mendes, T. Outeiro, J. Fonseca","doi":"10.3390/MSF2021005031","DOIUrl":"https://doi.org/10.3390/MSF2021005031","url":null,"abstract":"The neuropathological hallmark of Parkinson’s disease (PD) is the accumulation of alpha–synuclein (AS) aggregates. The identification of AS aggregates in gut biopsy specimens from people with PD may provide an opportunity to identify PD at a very early stage, prior to symptom onset. Changes in gut microbiota and inflammatory conditions (such as periodontitis) may be linked with PD onset/evolution. This project aims to explore the concept of microbiota–gut–brain axis in PD, studying gut biopsy specimens for AS aggregates, oral and intestinal microbiota, associated digestive disorders and oral health, of both patients with PD and controls.","PeriodicalId":147460,"journal":{"name":"Medical Sciences Forum","volume":"53 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133077884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Children’s Oral Health on Pico Island, Azores (Portugal) 亚速尔群岛Pico岛儿童的口腔健康(葡萄牙)
Medical Sciences Forum Pub Date : 2021-07-21 DOI: 10.3390/MSF2021005024
J. Pereira, G. Kizi, A. R. Barata, I. Ventura
{"title":"Children’s Oral Health on Pico Island, Azores (Portugal)","authors":"J. Pereira, G. Kizi, A. R. Barata, I. Ventura","doi":"10.3390/MSF2021005024","DOIUrl":"https://doi.org/10.3390/MSF2021005024","url":null,"abstract":"Pediatric dentistry focuses on children’s oral health. The aim of this study was to describe the prevalence of malocclusion in a pediatric population. Eighty-two children (3–12 years old), of both genders, who belong to a Social Solidarity Institution for Children in Pico Island were clinically examined. Half were female and half were male, in which most were 7 years old (20.7%) with mixed dentition (58.5%). The highest prevalence was in canine class I and vertical molar. Most children did not have malocclusion characteristics (56.1%).","PeriodicalId":147460,"journal":{"name":"Medical Sciences Forum","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129742152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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