ISRN Pharmacology最新文献_第4页

Effects of thyroid hormone analogue and a leukotrienes pathway-blocker on reperfusion injury attenuation after heart transplantation. 甲状腺激素类似物和白三烯通路阻滞剂对心脏移植后再灌注损伤衰减的影响。

ISRN Pharmacology Pub Date : 2013-09-17 eCollection Date: 2013-01-01 DOI: 10.1155/2013/303717

Fadhil G Al-Amran, Najah R Hadi, Haider S H Al-Qassam

{"title":"Effects of thyroid hormone analogue and a leukotrienes pathway-blocker on reperfusion injury attenuation after heart transplantation.","authors":"Fadhil G Al-Amran, Najah R Hadi, Haider S H Al-Qassam","doi":"10.1155/2013/303717","DOIUrl":"https://doi.org/10.1155/2013/303717","url":null,"abstract":"Background. Global myocardial ischemia reperfusion injury after heart transplantation is believed to impair graft function and aggravate both acute and chronic rejection episodes. Objectives. To assess the possible protective potential of MK-886 and 3,5-diiodothyropropionic acid DITPA against global myocardial ischemia reperfusion injury after heart transplantation. Materials and Methods. Adult albino rats were randomized into 6 groups as follows: group I sham group; group II, control group; groups III and IV, control vehicles (1,2); group V, MK-886 treated group. Donor rats received MK-886 30 min before transplantation, and the same dose was repeated for recipients upon reperfusion; in group VI, DITPA treated group, donors and recipients rats were pretreated with DITPA for 7 days before transplantation. Results. Both MK-886 and DITPA significantly counteract the increase in the levels of cardiac TNF- α , IL-1 β , and ICAM-1 and plasma level of cTnI (P < 0.05). Morphologic analysis showed that both MK-886 and DITPA markedly improved (P < 0.05) the severity of cardiac injury in the heterotopically transplanted rats. Conclusions. The results of our study reveal that both MK-886 and DITPA may ameliorate global myocardial ischemia reperfusion injury after heart transplantation via interfering with inflammatory pathway. ","PeriodicalId":14662,"journal":{"name":"ISRN Pharmacology","volume":" ","pages":"303717"},"PeriodicalIF":0.0,"publicationDate":"2013-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/303717","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40274354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Therapeutic Effect of Ficus lacor Aerial Roots of Various Fractions on Adjuvant-Induced Arthritic Rats. 不同部位的无花果气根对佐剂性关节炎大鼠的治疗作用。

ISRN Pharmacology Pub Date : 2013-09-17 eCollection Date: 2013-01-01 DOI: 10.1155/2013/634106

Rakesh K Sindhu, Sandeep Arora

{"title":"Therapeutic Effect of Ficus lacor Aerial Roots of Various Fractions on Adjuvant-Induced Arthritic Rats.","authors":"Rakesh K Sindhu, Sandeep Arora","doi":"10.1155/2013/634106","DOIUrl":"https://doi.org/10.1155/2013/634106","url":null,"abstract":"The present study was carried out to evaluate antiarthritic potential and phytochemical screening of various extracts of Ficus lacor aerial roots. The antiarthritic activity was evaluated by adjuvant-induced arthritis at the dose of 50 and 100 mg/kg body weight and the standard drug used was indomethacin. The extracts administered in higher doses reduced the lesions to a greater extent showing a dose-dependent decrease in lesions comparable with standard drug indomethacin. The extracts of FLPE and FLET showed significant increase in body weight as compared to arthritic control group as well as an increase in liver weight, a decrease in liver weight, and an increase in spleen weight in arthritis control. The extracts of FLPE and FLET showed significant decrease in WBC count, increase in hemoglobin contents, and RBC count as compared to control group. FLEA and FLCF were not able to produce a significant effect. There was significant reduction in production of IL-1 and TNF- α level between model group and control group in serum. In conclusion, we demonstrate that, at 100 mg/kg body weight, doses of FLPE and PLET extracts were highly effective in preventing and suppressing the development of adjuvant-induced arthritis. ","PeriodicalId":14662,"journal":{"name":"ISRN Pharmacology","volume":" ","pages":"634106"},"PeriodicalIF":0.0,"publicationDate":"2013-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/634106","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40274356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13

Protective nature of mangiferin on oxidative stress and antioxidant status in tissues of streptozotocin-induced diabetic rats. 芒果苷对链脲佐菌素诱导的糖尿病大鼠组织中氧化应激和抗氧化状态的保护作用

ISRN Pharmacology Pub Date : 2013-09-12 eCollection Date: 2013-01-01 DOI: 10.1155/2013/750109

Periyar Selvam Sellamuthu, Palanisamy Arulselvan, Subban Kamalraj, Sharida Fakurazi, Murugesan Kandasamy

{"title":"Protective nature of mangiferin on oxidative stress and antioxidant status in tissues of streptozotocin-induced diabetic rats.","authors":"Periyar Selvam Sellamuthu, Palanisamy Arulselvan, Subban Kamalraj, Sharida Fakurazi, Murugesan Kandasamy","doi":"10.1155/2013/750109","DOIUrl":"10.1155/2013/750109","url":null,"abstract":"Oxidative stress plays an important role in the progression of diabetes complications. The aim of the present study was to investigate the beneficial effect of oral administration of mangiferin in streptozotocin (STZ)-induced diabetic rats by measuring the oxidative indicators in liver and kidney as well as the ameliorative properties. Administration of mangiferin to diabetic rats significantly decreased blood glucose and increased plasma insulin levels. The activities of antioxidant enzymes superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) and level of reduced glutathione (GSH) were significantly (P < 0.05) decreased while increases in the levels of lipidperoxidation (LPO) markers were observed in liver and kidney tissues of diabetic control rats as compared to normal control rats. Oral treatment with mangiferin (40 mg/kg b.wt/day) for a period of 30 days showed significant ameliorative effects on all the biochemical and oxidative parameters studied. Diabetic rats treated with mangiferin restored almost normal architecture of liver and kidney tissues, which was confirmed by histopathological examination. These results indicated that mangiferin has potential ameliorative effects in addition to its antidiabetic effect in experimentally induced diabetic rats. ","PeriodicalId":14662,"journal":{"name":"ISRN Pharmacology","volume":" ","pages":"750109"},"PeriodicalIF":0.0,"publicationDate":"2013-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3791832/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40274357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

N-Phenylpropyl-N'-(3-methoxyphenethyl)piperazine (YZ-185) Attenuates the Conditioned-Rewarding Properties of Cocaine in Mice. n -苯丙基- n '-(3-甲氧基苯乙基)哌嗪(YZ-185)减弱小鼠可卡因的条件奖励特性。

ISRN Pharmacology Pub Date : 2013-09-05 eCollection Date: 2013-01-01 DOI: 10.1155/2013/546314

Andrew S Sage, Scott C Vannest, Kuo-Hsien Fan, Matthew J Will, Susan Z Lever, John R Lever, Dennis K Miller

{"title":"N-Phenylpropyl-N'-(3-methoxyphenethyl)piperazine (YZ-185) Attenuates the Conditioned-Rewarding Properties of Cocaine in Mice.","authors":"Andrew S Sage, Scott C Vannest, Kuo-Hsien Fan, Matthew J Will, Susan Z Lever, John R Lever, Dennis K Miller","doi":"10.1155/2013/546314","DOIUrl":"https://doi.org/10.1155/2013/546314","url":null,"abstract":"Sigma receptor antagonists diminish the effects of cocaine in behavioral assays, including conditioned place preference. Previous locomotor activity experiments in mice determined that the sigma receptor ligand YZ-185 (N-phenylpropyl-N'-(3-methoxyphenethyl)piperazine) enhanced cocaine-induced hyperactivity at a lower (0.1 μ mol/kg) dose and dose-dependently attenuated cocaine-induced hyperactivity at higher (3.16-31.6 μ mol/kg) doses. The present study investigated the effect of YZ-185 on cocaine's conditioned-rewarding properties in mice. YZ-185 (0.1, 0.316, 3.16, and 31.6 μ mol/kg) did not have intrinsic activity to produce conditioned place preference or aversion. A higher (31.6 μ mol/kg) YZ-185 dose, but not lower (0.1-3.16 μ mol/kg) YZ-185 doses, prevented the development of place preference to cocaine (66 μ mol/kg). YZ-185 did not alter the expression of cocaine place preference. To further characterize YZ-185's behavioral profile, its effects in the elevated zero maze and rotarod procedures were also determined; YZ-185 produced no significant change from baseline in either assay, indicating that the sigma receptors probed by YZ-185 do not regulate anxiety-like or coordinated motor skill behaviors. Overall, these results suggest that YZ-185 is a sigma receptor antagonist at the 31.6 μ mol/kg dose and demonstrate that sigma receptors can mediate the development of the conditioned-rewarding properties of cocaine. ","PeriodicalId":14662,"journal":{"name":"ISRN Pharmacology","volume":"2013 ","pages":"546314"},"PeriodicalIF":0.0,"publicationDate":"2013-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/546314","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31777518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Antimutagenic and Antiapoptotic Effects of Aqueous Root Extract of Inula racemosa Hook. f. on 4-NQO-Induced Genetic Damage in Mice. 总状菊水提物的抗诱变和抗细胞凋亡作用。f. 4- nqo诱导的小鼠遗传损伤。

ISRN Pharmacology Pub Date : 2013-09-03 eCollection Date: 2013-01-01 DOI: 10.1155/2013/768359

P Arumugam, M Murugan

{"title":"Antimutagenic and Antiapoptotic Effects of Aqueous Root Extract of Inula racemosa Hook. f. on 4-NQO-Induced Genetic Damage in Mice.","authors":"P Arumugam, M Murugan","doi":"10.1155/2013/768359","DOIUrl":"https://doi.org/10.1155/2013/768359","url":null,"abstract":"The present study was performed as part of an attempt to authenticate the use of Inula racemosa root extract as traditional medicine in India by experimentally investigating their protective effects on 4-nitroquinoline-1-oxide (4-NQO) induced DNA damage and apoptosis in mice bone marrow cells. Aqueous root extract (ARE) of Inula racemosa (100, 200 and 400 mg/kg bw) with and without 4-NQO along with vehicle control (H2O) were administered orally for five consecutive days. 4-NQO (7.5 mg/kg bw) was injected intraperitoneally to the mice on the sixth day. After 24 h, the animals were sacrificed and extracted bone marrow cells were used for micronuclei and apoptotic analysis. Antiapoptotic effect of ARE (400 mg/kg bw) was measured by the use of Annexin V-FITC assay kit. 4-NQO generated the frequency of micronucleated polychromatic erythrocytes (MnPCEs) by about 4.7 times the control value, 14.29 MnPCEs/2500 PCEs. Pretreatment with ARE significantly reduced the MnPCEs frequency (39-72%) with respect to their doses, and increased PCEs/NCEs ratio was observed over the 4-NQO alone. 4-NQO-induced total apoptotic cells were about 12% over the control which was significantly (P < 0.05) brought down to 3.5% by pretreatment with 400 mg/kg bw of ARE. This was the first report that recorded the protective effects of I. racemosa on 4-NQO-induced DNA damage and apoptosis in mice bone marrow cells. ","PeriodicalId":14662,"journal":{"name":"ISRN Pharmacology","volume":"2013 ","pages":"768359"},"PeriodicalIF":0.0,"publicationDate":"2013-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/768359","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31769067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

Antitussive Efficacy and Safety Profile of Ethyl Acetate Fraction of Terminalia chebula. 天竺葵乙酸乙酯部位的止咳效果及安全性研究。

ISRN Pharmacology Pub Date : 2013-08-19 eCollection Date: 2013-01-01 DOI: 10.1155/2013/256934

Rizwan Ul Haq, Abdul Wahab, Khurshed Ayub, Khalid Mehmood, M Azhar Sherkheli, Rafeeq Alam Khan, Mohsin Raza

{"title":"Antitussive Efficacy and Safety Profile of Ethyl Acetate Fraction of Terminalia chebula.","authors":"Rizwan Ul Haq, Abdul Wahab, Khurshed Ayub, Khalid Mehmood, M Azhar Sherkheli, Rafeeq Alam Khan, Mohsin Raza","doi":"10.1155/2013/256934","DOIUrl":"https://doi.org/10.1155/2013/256934","url":null,"abstract":"Antitussive effects of ethyl acetate fraction of Terminalia chebula on sulphur dioxide (SO2) gas induced cough have been examined in mice. Safety profile of Terminalia chebula was established by determining LD50 and acute neurotoxicity. The result showed that extract of Terminalia chebula dose dependently suppressed SO2 gas induced cough in mice. Terminalia chebula, after i.p. administration at dose level 500 mg/kg, offered maximum cough suppressive effects; that is, number of coughs at 60 min was 12 ± 1.52 (mean ± SEM) as compared to codeine 10 mg/kg; i.p., dextromethorphan 10 mg/kg; i.p., and saline, having frequency of cough 10.375 ± 0.866, 12.428 ± 0.81, and 46 ± 2.61, respectively. LD50 value of Terminalia chebula was approximately 1265 mg/kg, respectively. No sign of neural impairment was observed at antitussive doses of extract. Antitussive effect of Terminalia chebula was partly reversed with treatment by naloxone (3 mg/kg; s.c.) while rimcazole (3 mg/kg; s.c.) did not antagonize its cough suppression activity. This may suggest that opioid receptors partially contribute in antitussive action of Terminalia chebula. Along with this, the possibility of presence of single or multiple mechanisms activated by several different pharmacological actions (mainly anti-inflammatory, antioxidant, spasmolytic, antibacterial, and antiphlegmatic) could not be eliminated. ","PeriodicalId":14662,"journal":{"name":"ISRN Pharmacology","volume":"2013 ","pages":"256934"},"PeriodicalIF":0.0,"publicationDate":"2013-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/256934","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31723480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13

Inhibition of endoplasmic reticulum stress and atherosclerosis by 2-aminopurine in apolipoprotein e-deficient mice. 2-氨基嘌呤对载脂蛋白e缺乏小鼠内质网应激和动脉粥样硬化的抑制作用。

ISRN Pharmacology Pub Date : 2013-07-31 eCollection Date: 2013-01-01 DOI: 10.1155/2013/847310

Lichun Zhou, Dezhi Yang, Dong Fang Wu, Zhong Mao Guo, Emmanuel Okoro, Hong Yang

{"title":"Inhibition of endoplasmic reticulum stress and atherosclerosis by 2-aminopurine in apolipoprotein e-deficient mice.","authors":"Lichun Zhou, Dezhi Yang, Dong Fang Wu, Zhong Mao Guo, Emmanuel Okoro, Hong Yang","doi":"10.1155/2013/847310","DOIUrl":"https://doi.org/10.1155/2013/847310","url":null,"abstract":"We previously reported that the apolipoprotein (apo) B48-carrying lipoproteins obtained from apoE knockout (apoE (-/-) ) mice, so called E(-)/B48 lipoproteins, transformed mouse macrophages into foam cells and enhanced the phosphorylation of eukaryotic translation initiation factor 2 α (eIF-2 α ). Furthermore, the eIF-2 α phosphorylation inhibitor, 2-aminopurine (2-AP), attenuated E(-)/B48 lipoprotein-induced foam cell formation. The present report studied the effect of 2-AP on atherosclerosis in apoE (-/-) mice. Our results showed that the level of food intake, bodyweight, plasma cholesterol, and triglycerides was comparable in apoE (-/-) mice treated with or without 2-AP. However, the mean size of atherosclerotic lesions in the aorta sinus as well as the surface area of the entire aorta of 2-AP-treated apoE (-/-) mice were reduced by about 55% and 39%, respectively, compared to samples from untreated control apoE (-/-) mice. In addition, the 2-AP-treated apoE (-/-) mice showed a significant decrease in glucose-regulated protein 78 (GRP78) and phosphorylated eIF-2 α in their aortic samples as compared to levels in untreated control apoE (-/-) mice. These observations suggest that endoplasmic reticulum stress is a causal mechanism for the development of atherosclerosis in apoE (-/-) mice and that therapeutic strategies can be developed for using eIF-2 α phosphorylation inhibitors, such as 2-AP, to prevent or treat atherosclerosis. ","PeriodicalId":14662,"journal":{"name":"ISRN Pharmacology","volume":"2013 ","pages":"847310"},"PeriodicalIF":0.0,"publicationDate":"2013-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/847310","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31689539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Some Haematological and Biochemical Investigations on Duck Virus Hepatitis following Administration of Glycyrrhizin. 甘草酸对鸭病毒性肝炎的血液学和生化研究。

ISRN Pharmacology Pub Date : 2013-07-30 eCollection Date: 2013-01-01 DOI: 10.1155/2013/849412

Faten A Okda, Safaa Yassein, Alaa R Ahmed, Hamdy Soufy, Soad M Nasr

{"title":"Some Haematological and Biochemical Investigations on Duck Virus Hepatitis following Administration of Glycyrrhizin.","authors":"Faten A Okda, Safaa Yassein, Alaa R Ahmed, Hamdy Soufy, Soad M Nasr","doi":"10.1155/2013/849412","DOIUrl":"https://doi.org/10.1155/2013/849412","url":null,"abstract":"The present study aimed to investigate the protective effect of glycyrrhizin (locally isolated and purified from licorice root) against duck hepatitis virus through the assessment of some hematological and biochemical parameters. One hundred and sixty white Pekin ducklings-one day old-were randomly divided into four equal groups. Group (1) was kept as normal control. Group (2) was inoculated I/P with 10 mg glycyrrhizin/kg BW, three times per week for four weeks. Group (3) was inoculated I/M with 0.5 ml of live attenuated DHV vaccine. Group (4) was inoculated with both glycyrrhizin (10 mg/kg BW I/P, three times per week for four weeks) and live attenuated DHV vaccine (0.5 ml, I/M). Then, all groups of treatment were challenged using virulent DHV except for 20 ducklings from the normal control group which were continued to be kept as negative control. The results revealed that duck hepatitis virus (DHV) caused macrocytic hypochromic anemia, leukopenia, hypoproteinemia, hypoalbuminemia, hyperglycemia, hypercholesterolemia, and marked elevation of liver enzymes and renal parameters. In conclusion, glycyrrhizin injected alone or in combination with DHV vaccine protected or ameliorated the deteriorating effects induced by DHV vaccine and/or duck hepatitis virus infection by improvement of erythrogram and leukogram, as well as liver and kidney functions. ","PeriodicalId":14662,"journal":{"name":"ISRN Pharmacology","volume":"2013 ","pages":"849412"},"PeriodicalIF":0.0,"publicationDate":"2013-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/849412","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31689541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Heparin and related drugs: beyond anticoagulant activity. 肝素及相关药物：超越抗凝活性。

ISRN Pharmacology Pub Date : 2013-07-30 eCollection Date: 2013-01-01 DOI: 10.1155/2013/910743

Clive Page

引用次数: 0

A Scientific Validation of Antihyperglycemic and Antihyperlipidemic Attributes of Trichosanthes dioica. 薯蓣抗高血糖和抗高血脂特性的科学验证。

ISRN Pharmacology Pub Date : 2013-07-25 eCollection Date: 2013-01-01 DOI: 10.1155/2013/473059

Prashant Kumar Rai, Sharad Kumar Gupta, Amrita Kumari Srivastava, Rajesh Kumar Gupta, Geeta Watal

{"title":"A Scientific Validation of Antihyperglycemic and Antihyperlipidemic Attributes of Trichosanthes dioica.","authors":"Prashant Kumar Rai, Sharad Kumar Gupta, Amrita Kumari Srivastava, Rajesh Kumar Gupta, Geeta Watal","doi":"10.1155/2013/473059","DOIUrl":"https://doi.org/10.1155/2013/473059","url":null,"abstract":"The present study was undertaken to scientifically validate the antidiabetic activity of aqueous fruit extract of Trichosanthes dioica Roxb. (Family: Cucurbitaceae) which has been traditionally used for managing diabetes mellitus. This plant commonly known as \"Sespadula\" in English has not been explored scientifically so far for its glycemic potential except by our research group. The study was conducted with variable doses on normal, mild, and severe diabetics models, and several biochemical parameters including blood glucose level (BGL) were assessed. Maximum fall in BGL of 23.8% in normal rats and of 31.3% in mild diabetic rats was observed during their fasting blood glucose (FBG) and glucose tolerance test (GTT) with the dose of 1000 mg kg(-1). In severely diabetic animals after 4 weeks treatment with FBG, postprandial glucose, total cholesterol, and triglyceride levels were reduced by 28.7, 30.7, 57.2, and 18.5%, whereas high density lipoprotein, total protein, hemoglobin, and body weight were increased by 33.0, 36.7, 15.7 and 16.7%, respectively. Moreover, urine sugar was reduced from +4 to +1. Thus, the study scientifically validates the traditional use of T. diocia in diabetes management and could be developed as an effective oral agent for treating diabetes mellitus and complications associated with it. ","PeriodicalId":14662,"journal":{"name":"ISRN Pharmacology","volume":"2013 ","pages":"473059"},"PeriodicalIF":0.0,"publicationDate":"2013-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/473059","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31689538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 22